A team of scientists at IISc has created tiny molecular devices that can be tweaked to perform diverse functions, including behavior as a memory unit, logic gate, selector, analog processor or electronic synapse. The devices' unique chemistry enables adaptability and the ability to store information, compute and adapt in real time.
A recent study by University of Eastern Finland found that prediabetes has increased significantly in Finnish children living with overweight or obesity, rising from 11% to 50% over two decades. The study suggests a potential link between maternal overweight and the rise in child prediabetes prevalence.
The EdUHK research team has developed a novel material, a natural and biocompatible silica nanomatrix, to enhance cancer immunotherapy. This breakthrough technology promotes DC maturation, enhances T-cell recognition and killing of cancer cells, and improves targeting precision.
Researchers found that over half of IVF cycles in the US were performed at clinics affiliated with private equity firms, sparking concerns about the impact on quality and accessibility. The study's authors emphasize the need for further research to understand the benefits and risks of this business model.
A new compound has been developed that can absorb carbon dioxide directly from untreated ambient air, outperforming existing methods. The compound's ease of releasing captured CO2 is a key advantage, as it only requires heat at 70°C.
Insilico Medicine raised a total of HKD 2.277 billion in its largest Hong Kong biotech IPO, with 94,690,500 shares offered globally and oversubscribed by approximately 1427 times. The company aims to advance its mission of extending human productive longevity using AI-powered drug discovery and development.
A study led by Dr. Zhao identified key molecular mechanisms driving human scalp aging, including the decline of hair follicle stem cells and altered signaling pathways. The research offers potential pathways for future drug development and sheds light on the causes of age-related pigment changes.
The study introduces a spatiotemporal resilience model that integrates temporal and spatial dimensions to evaluate USS performance. The proposed model leverages the IoT framework to optimize prevention and recovery strategies, demonstrating improvements in spatiotemporal resilience.
Researchers have identified a key protein that produces hydrogen sulfide gas as a therapeutic target for Alzheimer's disease. Experiments in genetically engineered mice show that this protein, Cystathionine γ-lyase (CSE), plays a critical role in cognitive function and memory formation.
A global study reveals correlation between PFAS contamination in edible marine fish and human health risks. Consumers may be exposed to elevated levels of toxic compounds through imported fish, increasing food-safety risks despite low environmental pollution.
Current Molecular Pharmacology has achieved a major milestone with its real-time CiteScore advancing to 7.2, indicating the journal's high-quality research and rigorous peer-review process. The journal continues to strengthen its position as a key platform for innovative pharmacological research.
A new study introduced epigenetic clocks in skeletal muscle from an Asian population, identifying DNA methylation sites associated with age and developing accurate age prediction models using NGS and SBE. The findings offer a reliable method for estimating age and its potential applications in forensic science.
Researchers developed an AI model that detects unemployment-related social media posts with high precision, capturing nearly three times more disclosures than previous approaches. The method reduced forecasting errors by 54.3% compared to industry consensus forecasts and proved valuable during the COVID-19 pandemic.
Children exposed to high levels of screen time before age two showed changes in brain development linked to slower decision-making and increased anxiety by their teenage years. Parent-child reading may offer protection against these effects.
A study published in Nature Sustainability finds that climate policies targeting lifestyle changes can erode existing 'green' values, leading to unintended negative effects. Researchers surveyed over 3,000 Germans and found a 52% greater negative response to climate mandates than COVID-19 mandates.
Professor Dan Stein was a visionary who bridged neuroscience, clinical care, and philosophy to transform psychiatric research in Africa. His integrative approach produced scholarship of extraordinary range, with over 1,600 peer-reviewed publications and a Google Scholar h-index exceeding 220.
Researchers at KIST develop an eco-friendly palladium recovery technology that enables the efficient recovery of high-purity palladium in weakly acidic environments. The technology features a novel material that can recover 99.9% of palladium within 30 minutes, reducing energy consumption and carbon emissions by up to 80%.
Scientists have developed a platform for generating and detecting ultrashort UV-C laser pulses using atomically-thin semiconductors. The system demonstrates a free-space communication system and has the potential to unlock new opportunities in non-line-of-sight communication systems.
Researchers Min Chen and Liangchen Guo developed a new system using Fengyun-4B satellite data and regional numerical forecast model RMAPS-ST to improve ultra-short-term solar irradiance forecasting. The system achieved significant reductions in forecast errors, particularly in warm seasons and short-term forecasts.
Researchers developed a hierarchical Physics-Informed AI framework to balance model fidelity with speed, paving the way for reliable Digital Twins in solid oxide cell engineering. The new approach improves both physical consistency and computational efficiency.
A five year field study shows biochar can boost sugarcane growth while reshaping soil life around the roots and reducing carbon dioxide emissions from the field for years without additional fertilization. The treatment improved soil fertility, nutrient use efficiency and beneficial bacterial groups in the rhizosphere.
This special issue explores the relationship between climate change and business, examining how firms access capital, manage risk, leverage opportunities, and navigate policy shifts in an era of climate uncertainty. The research highlights that climate change is reshaping financial markets, corporate valuation, and investment logic.
A new study has validated a non-destructive method to detect 'forever chemicals' on protective equipment, reducing the risk of cancer to firefighters. Researchers found PFAS in every set of firefighter gear examined, including breathing masks, with concentrations reaching hundreds of nanograms per gram.
Researchers developed LSTM-assisted optical fiber interferometric sensing to overcome the limitation of free spectral range, achieving simultaneous high sensitivity and wide measurement range. The technology uses gating mechanisms and sequence learning capabilities of LSTM to model long-term dependencies in complex interference spectra.
This study examines the relationship between digital transformation and systemic risk in China's banking system, using a fixed-effects model to analyze the effects of big data, AI, blockchain, and cloud computing. Digital transformation is found to enhance resilience but also poses new risks.
Researchers developed a unified multimodal framework to analyze joint aging changes in brain function and structure. The study identified two primary aging patterns: synergistic declines in motor control and higher-order cognition, and contradictory adaptations in visual areas.
Research shows that a liquid byproduct from wastewater sludge can recycle nutrients for agriculture, but high concentrations of this byproduct may disrupt key ecological processes. The study found that periphyton communities retained ability to remove pollutants even at high exposure levels.
A new catalytic system achieves simultaneous enantiomeric transformation of silicon chiral centers and precise control over olefin Z/E configurations, enabling efficient synthesis of all four stereoisomers. The method exhibits excellent yields, good to excellent enantiomeric selectivity, and 100% atom economy.
A new study reveals urban tributaries play a significant role in driving phthalate pollution in the Yangtze River, with higher concentrations found during seasonal changes. The research highlights the need for targeted monitoring and management strategies to address this environmental risk.
A large cohort study found that statins significantly reduce the risk of death and major cardiovascular events in adults with type 2 diabetes. The findings challenge long-standing uncertainty about whether patients at low risk benefit from preventive statin therapy, suggesting that the drugs may have broader protective value.
The MONEAD study provides practical guidance for clinicians to manage epilepsy during pregnancy, reducing the risk of seizures and improving outcomes. The study's week-by-week playbook offers dose adjustments for antiseizure medications, empowering healthcare providers to provide the best possible care.
Researchers discovered that female brain immune cells called microglia express more interferon-related genes when responding to amyloid-β plaques, causing more harm to neuronal connections. This finding suggests a potential sex-specific treatment approach for Alzheimer's disease.
Researchers discovered that an insect-pathogenic fungus Beauveria bassiana can turn the defensive substances of bark beetles into more toxic aglycones. These aglycones serve as an effective defense against fungi and increase fungal infestation, particularly in beetles with high phenol content.
Researchers at Harvard Medical School have uncovered crucial insights into how a new class of antiviral drugs works, shedding light on an important tool for fighting drug-resistant strains of herpes simplex virus. The discovery may lead to new pathways for treating herpesviruses and other kinds of DNA viruses.
The journal has achieved a real-time CiteScore of 2.4, doubling its Impact Factor from the previous year to 1.5. This advancement highlights CPA's commitment to quality and its expanding role in disseminating high-quality research across pharmaceutical sciences.
Researchers compared brains of stroke patients with healthy controls to reveal differences in language processing mechanisms. People with verbal speech processing issues from stroke have weaker processing of speech sounds than healthy participants.
Candida auris is a highly virulent fungus spreading globally, affecting 6.5 million people annually with high mortality rates. New review highlights strategies for combating its spread, including vaccination and treatment, as well as improving diagnostics and surveillance mechanisms.
Researchers highlight how minimal residual disease detection is changing breast cancer management by capturing molecular traces of cancer at extremely low levels. CTDNA-based monitoring reveals relapse risk months ahead of clinical symptoms, enabling clinicians to identify high-risk patients and adjust treatment strategies in real time.
A new model predicts cerebral blood flow using carotid ultrasound and brain MRI data, enabling non-invasive monitoring of astronauts' cognitive function during long-duration spaceflight. The CatBoost algorithm outperforms other models, providing a practical solution for safeguarding brain health in space.
Two studies reveal that insufficient glutamine in macrophages drives atherosclerosis progression. Researchers identified new ways to detect high-risk plaques using protein markers like TREM2 and SLC7A7, which could lead to PET imaging and blood tests for early detection.
The new framework reduces processing time by an average of 87.7% compared to the state-of-the-art approach, achieving cache hit rates between 70% and 90%. It demonstrates linear scalability, handling high query loads efficiently.
A recent study using virtual reality found that men who embodied a female avatar subjected to catcalling experienced strong feelings of anger and disgust, closely linked to moral disapproval. This type of reaction reflects the ability to put oneself in the victim's shoes and indicates moral disapproval of the behavior.
Researchers discovered a mechanism allowing melanoma cancer cells to paralyze immune cells by secreting extracellular vesicles, which can disrupt immune cell activity and even kill them. This breakthrough has promising therapeutic implications, enabling strengthening of immune cells and blocking molecules that enable vesicle adhesion.
A study of over 12 million US births found a persistent rise in gestational diabetes rates every year since 2016, increasing health risks for mothers and babies. The condition affects all racial and ethnic groups, with American Indian and Pacific Islander populations showing significantly higher rates.
A new study evaluates a traditional Chinese herbal formulation for diabetic kidney disease and finds it significantly improves key indicators of kidney function. The treatment modulates inflammatory pathways linked to kidney damage, suggesting a complementary strategy for preserving renal function.
AIT has signed 5 MoUs with international partners to strengthen WASH systems, support digital innovation, and improve municipal governance across Asia. The partnerships aim to bring together governments, academia, development partners, innovators, and practitioners to accelerate the WASH agenda.
The study introduces a practical pathway to integrate realistic leaf optics into 3D canopy models, enabling more accurate simulations of light distribution. The approach achieves high predictive accuracy, linking leaf traits to optical behavior with coefficients of determination ranging from 0.83 to 0.99.
Yosra Barkaoui generalises Sebestyén's theorem to unbounded operators, essential in physics for describing concepts like kinetic energy and momentum. Her research provides new mathematical tools for working with unbounded operators.
A recent study found that Dlc1 deletion affects cardiac differentiation in mouse embryonic stem cells by activating the canonical Wnt pathway. The study showed that Dlc1 deficiency promotes mesoderm lineage specification, leading to the accumulation of cardiac progenitors and blocking their further differentiation into cardiomyocytes.
A novel protocol is presented for fabricating a human vascularized bile duct-on-a-chip (VBDOC), which models the vascular-biliary interface in three dimensions. The device maintains cholangiocyte polarity and barrier function, enabling manipulation of mechanical microenvironment components.
A new computational model of the brain based on biology and physiology learned a simple visual category learning task as well as lab animals, discovering counterintuitive activity in neurons. The model produced naturalistic dynamics and learning without training data, enabling researchers to identify new insights into brain function an...
A study published in EMBO Molecular Medicine has identified a combination of statins and phenothiazines that shows promise in treating aggressive neuroblastoma. The drug combination was found to impede tumour growth and improve survival rates in laboratory trials with mice.
The study elucidates interactions between membrane proteins and lipids using cryo-EM, highlighting the influence of lipids on protein functionality.
Researchers discovered a novel mechanism behind small cell lung cancer's aggressiveness, involving the lack of caspase-8, leading to necroptosis and inflammation that fosters tumor progression. This pre-tumoral inflammation suppresses anti-cancer immune responses, promoting metastasis and relapse.
A research team at Huazhong University of Science and Technology developed an Ag/Sb2O3/Au molecular-crystal memristor array for real-time edge computing in smart power grid inspections. The device enables ultra-low-power switching, supporting non-volatile and volatile modes for tasks like image convolution and transient event detection.
Researchers have developed a xenogeneic-free culture platform that significantly enhances the migration and regenerative capacity of intestinal stem cells. The technology, called PLUS, maintains identical performance even after storage at room temperature for three years, securing industrial scalability.
Researchers at OHSU discovered a promising new drug combination that may help people with acute myeloid leukemia (AML) overcome treatment resistance by pairing venetoclax, a standard AML drug, with palbociclib, a cell-cycle inhibitor approved for breast cancer. The study found that this combination produced significantly stronger and m...
A recent study found that adolescents with overweight or obesity who take glucagonlike peptide-1 receptor agonists (GLP-1RA) have a lower risk of acute asthma exacerbations. This association suggests a potential dual benefit, where GLP-1RA use could address both weight management and asthma prevention in this population.
Experimental evidence confirms that a single superconductor can induce electron pairing and synchronization in another material, enabling the creation of a Josephson junction with only one superconductor. This discovery has potential implications for topological superconductors and conventional quantum computers.
FLIM microscopy enhances spatial and temporal resolution through multimodal imaging approaches, outpacing traditional methods. Persistent challenges need to be addressed for high-speed live-cell imaging.