Researchers designed novel phosphine ligands based on a 3D benzene ring simulation strategy, achieving superior stereo and electronic properties. The ligands exhibit exceptional performance in palladium-catalyzed C–N coupling, with a record-breaking TON of 490,000.
Researchers develop a nickel carbene catalyzed asymmetric reduction of internal alkenes, achieving highly regioselective and enantioselective functionalization of inner alkenes. The method uses sterically hindered and tunably flexible NHC ligands, suppressing side reactions and achieving precise stereocontrol.
Researchers review recent progress in supramolecular polymer science, highlighting key advancements in material morphology, physical mechanisms, and engineering applications. The field holds promise for developing recyclable materials, devices, and intelligent systems with adaptable properties.
Researchers propose two physical embedding solutions to improve machine learning force fields' accuracy and stability in organic systems. The first method uses adaptive bond length sampling, effectively covering high-energy bond length regions prone to simulation collapse. The second method employs top-down model correction using physi...
Researchers developed a highly efficient dual-copper catalyzed asymmetric tandem reaction for synthesizing chiral N-unprotected cyclic imine esters, achieving excellent stereoselectivity and high substrate universality. The method demonstrates potential in medicinal chemistry and has shown significant antiviral activity.
A research team successfully developed an electrochemically mediated dearomatization saturation strategy for pyridine, resulting in efficient multifunctional modification of the molecule. The strategy achieves chemo, regio, and stereoselective transformation of pyridine into complex piperidine skeletons.
Researchers developed a novel design strategy for constructing flexible COF photocatalysts, achieving precise control over pore curvature and photoelectric properties. The constructed photocatalyst exhibited excellent photocatalytic uranium removal performance in contaminated groundwater and tap water.
Researchers propose a new electrolyte additive strategy to solve three core challenges in zinc-iodine batteries: sluggish iodine reaction kinetics, polyiodide shuttle effect, and zinc dendrite growth. The study achieved ultra-long cycle stability and excellent performance with minimal capacity decay.
A green and efficient photo-redox/hydrogen atom transfer synergistic catalytic strategy successfully synthesizes chiral α-aryl cyclic ketones. Thiophenols activate carbonyl compounds through Brønsted acid and HAT catalyst roles.
This method successfully solves the challenge of generating C,N,N-trialkyl α-amino radicals in aliphatic amides, enabling gram-scale reactions with low catalyst loadings. The reaction exhibits good functional group tolerance, making it suitable for late-stage modification of complex molecules.
Researchers developed a palladium-catalyzed tandem cyclization strategy to construct chiral bridged oxazole bicyclic skeletons with high diastereoselectivity and enantioselectivity. The method exhibits excellent substrate universality, providing an efficient route for synthesizing complex three-dimensional structures.
Researchers develop cascaded van der Waals heterostructures to simulate neural signal transmission and neuromorphic visual information processing. The novel material platform achieves efficient photoelectric-ion coupling, enabling synaptic plasticity and neural signal processing capabilities.
Researchers have developed a new, efficient method for synthesizing benzoxoxetine ligands through a tandem nucleophilic addition/SNAR cycloning reaction. This approach yields oxoheterocyclic phosphine ligands with excellent diastereoselectivity and scalability.
Researchers at Tsinghua University developed a novel method for synthesizing chiral alpha-amino acids using a photo-driven nitrogen heterocyclic carbene catalyst. The reaction achieves good to excellent enantioselectivity and substrate versatility, enabling the rapid preparation of structurally diverse chiral alpha-amino acid derivatives.
Researchers created a two-dimensional MOF-based nano-impeller that achieved efficient photoisomerization and on-demand cargo delivery. The study found that mechanical activation and dimensionality synergistically regulate the photo-switching dynamics, enabling 99% cargo release within 50 minutes.
Researchers design a novel molecular machine that controls both rotational and shuttle motions in a single molecule. The system, composed of a sterically hindered olefin motor, H-type benzimidazole, and crown ether, demonstrates the tuning effect of two motion modes within a single machine.
Researchers developed molecular sieve-confined Pt-FeOx catalysts for efficient reversible hydrogen storage and release, overcoming limitations of traditional metal catalysts. The catalyst exhibited excellent mass transfer performance, improved stability, and high hydrogen production rates.
Researchers developed a novel photoredox catalytic radical-polar cross-reaction to achieve precise bifunctionalization of inert C–N bonds and para-C–H bonds in olefin-substituted aniline derivatives. The strategy utilizes sulfur dioxide to capture Meisenheimer intermediates, suppressing the classical free radical aryl migration pathway.
The study reports the synthesis of two novel boron-hexane Z-type and bilayer benzobenzenes, exhibiting narrow-spectrum fluorescence and amplified spontaneous emission properties. The researchers demonstrate their potential application as gain mediators in luminescent functions and spin properties.
Researchers developed ultrasound-responsive in-situ antigen nanocatchers that efficiently capture tumor antigens, activating dendritic cell maturation and migration. This system achieved high primary tumor inhibition rates and complete distant tumor regression in a mouse model, providing a universal personalized immunotherapy platform.
A modular machine learning framework using LoRA fine-tuning can accurately predict single organic reactions and handle multiple reaction types. The model demonstrates high prediction accuracy comparable to expert experience, achieving results on classic reaction datasets and showing strong adaptability.
Academician Yu-Zhong Wang's team proposes a novel recycling method that degrades polyethylene into oligomers, which are then assembled with functional monomers through dynamic imine bonds. The resulting material exhibits excellent mechanical properties and multiple functions such as flame retardancy, antistatic properties, and UV shiel...
A new catalytic system achieves simultaneous enantiomeric transformation of silicon chiral centers and precise control over olefin Z/E configurations, enabling efficient synthesis of all four stereoisomers. The method exhibits excellent yields, good to excellent enantiomeric selectivity, and 100% atom economy.
A novel acid-promoted radical substitution strategy achieves selective synthesis of m-phenylenediamine compounds from aromatic amines, offering a more efficient and regioselective approach than current methods. The reaction exhibits good substrate versatility and functional group compatibility.
Researchers developed a copolymer hydrogel fiber with reversible humidity-responsive characteristics, achieving high mechanical strength in dry state and rapid transformation into adhesive state upon contact with water. The fiber's unique nano-confined phase-separated structure enables cyclical switching between adhesion and detachment.
A new circular single-stranded DNA molecule has been developed to simultaneously silence multiple oncogenic miRNAs. The molecule, called circAMO, exhibits high biostability and can inhibit tumor cell proliferation, migration, and invasion in a concentration-dependent manner. It shows superior efficiency compared to existing anti-miRNA ...
A new palladium-catalyzed tandem cyclization reaction has been developed to synthesize trifluoromethyl-substituted 2H-pyran compounds with high efficiency and chemoselectivity. The method involves a cascade reaction of trifluoroacetylsilane and 1,3-enyne, followed by oxa-6π-electrocyclization.
Researchers developed an ultra-high temperature flash vacuum pyrolysis device to synthesize giant fullerenes. The separation techniques of mechanical grinding and sublimation were optimized to separate the giant fullerenes from soot, allowing comprehensive characterization by laser desorption/ionization time-of-flight mass spectrometry.
A nickel-catalyzed hydrogen metallization cyclization strategy was developed to synthesize multi-substituted bicyclo[2.1.1]hexanol and its skeletal rearrangement product, a series of 1,2,4-trisubstituted bicyclo[2.1.1]hexanone derivatives. The method offers mild conditions, broad substrate scope, and easy product derivatization.
Researchers developed a single-atom Cu-N2O1 site that achieves high photocatalytic methane conversion to ethanol rates and selectivity. The novel strategy breaks the activity-selectivity seesaw effect in existing processes.
Scientists achieve on-demand reversible switching between dynamic covalent polymers and thermosetting polymers, integrating advantages of both types. The 'quench-activation' strategy enables material system to balance sustainability and thermal stability.
Researchers developed biodegradable cesium nanosalts that activate anti-tumor immunity by inducing pyroptosis and intervening in metabolism. The nanosalts disrupt intracellular ion homeostasis, causing osmotic pressure surges and triggering cell lysis, releasing damage-associated molecular patterns that activate a robust immune response.
Researchers have successfully developed an asymmetric synthesis method for quebracho indole alkaloids using a nickel-catalyzed [2+2] cyclobutanization reaction with flexible antenna ligands. The method achieved high yields and precise control in 7-10 steps, including the first-ever asymmetric syntheses of three naturally occurring comp...
Researchers developed a high-performance TA/DTTA-2-TMT photocatalyst that synergistically optimizes four key steps in photocatalytic hydrogen peroxide synthesis, significantly improving overall catalytic efficiency. The material achieves exceptional H2O2 yield with broadened light absorption range and enhanced charge carrier separation.
Researchers developed an organocatalytic method to create planar chiral cyclophanes with high stereoselectivity and diastereoselectivity. The method uses a chiral phosphoric acid catalyst and generates a reactive naphthoquinone methylene intermediate, leading to the formation of stable planar chiral type III cyclophanes.
This study introduces a novel kinetic control strategy to modulate supramolecular dissociation kinetics, enabling the regulation of dissociation rates over a wide range. The researchers found that steric hindrance controls supramolecular dissociation kinetics and material properties, resulting in stable networks with improved mechanica...
Researchers developed a novel photocatalytic carbon-carbon double bond cleavage strategy, achieving efficient synthesis of α-aryl ketones from anhydrides and aromatic olefins under mild conditions. The method exhibits metal-free nature, broad substrate applicability, and good functional group tolerance.
Researchers at Tsinghua University have achieved efficient construction of tricyclic core skeleton and total synthesis of multiple natural products through innovative strategy exploiting inherent symmetry within molecules. The method involves photoinduced [2+2] cycloaddition and ring-strain-driven oxidative ring expansion reactions.
Researchers at ShanghaiTech University have developed a highly selective method for exchanging functional groups on boron atoms in organic compounds. This strategy has been successfully applied to sugar-derived diboron compounds, enabling the efficient synthesis of complex molecules and exhibiting potential applications in drug discovery.
A new method for constructing heterojunctions using a small organic molecule containing multi-terminal pyridine and graphitic carbon nitride improves charge separation efficiency. This approach promotes the extensive deposition and uniform dispersion of metal atoms, leading to high photocatalytic hydrogen production rates.
Researchers developed a novel organic framework that stably incorporates a chlorine halogen bond, exhibiting excellent chemical stability and thermal resistance. The framework exhibits superior catalytic performance in palladium-catalyzed coupling reactions and can be easily recovered and recycled.
Researchers developed a post-treatment strategy based on ion exchange combined with displacement reaction to prepare zeolite-encapsulated PtCu alloy catalysts. The prepared PtCu₅@MFI-K sample exhibited excellent catalytic performance in propane dehydrogenation, with high conversion rates and selectivity.
Developed by Professors Yu and Gao, BNOSE exhibits excellent mechanical properties and efficient chemical recovery, breaking current bottlenecks in sustainable elastomers. Its unique boron-based dynamic bonds provide robust interchain forces and degradation in mild ethanol solvents.
Scientists at Nanjing University and Washington State University developed a three-dimensional ordered mesoporous carbon skeleton with Ni single atom support using superlattice blotting. The resulting Ni-N₂S₂ and Ni-N₃P catalysts exhibited excellent electrocatalytic activity, reaching overpotents of 239 mV (OER) and 90 mV (HER).
Researchers have synthesized four natural products using a novel biomimetic Schenck-ene/Hock/aldol tandem rearrangement reaction. The reaction conditions are mild, and the strategy can be used for molecular backbone editing of natural products.
Researchers discovered a cobalt-catalyzed anti-Markovnikov hydrosilylation reaction of terminal alkynes with tertiary silanes using a dinuclear cobalt carbonyl complex coordinated by the bidentate phosphine ligand Xantphos. The catalyst achieves excellent β/α selectivity and exhibits good compatibility with functional groups.
A team from Peking University successfully synthesized hemiketalTTX in 23 steps with a total yield of 0.7%, addressing the scarcity of this natural toxin. The synthesis utilizes a unique Prins cyclization reaction to construct the [3.2.1] bridged ring skeleton.
This review summarizes progress in dynamic biomacromolecular modifications, regulatory mechanisms, and chemical interventions. It highlights newly emerging chemical tools and technologies for precise labeling, detection, and functional regulation of dynamic modifications.
Researchers developed a novel cation recognition mode that synergizes various recognition modes and utilizes the allosteric effect to recognize cations. The capsule molecule undergoes conformational changes upon anion recognition, enhancing its ability to recognize cations.
Researchers at East China University of Science and Technology discovered a novel photo-rearrangement reaction in diarylethenes induced by intramolecular proton transfer, yielding polycyclic aromatic structures. Mechanistic studies revealed an electrocyclization process followed by IPT-driven decarboxylation.