Researchers developed a reliable and affordable purification technique for chromatography using calcium chloride, applying to organic compounds like amines and peptides. The technique has shown promising results in purifying APIs with high accuracy.
A cross-sectional study found associations between HbA1c levels and modern diabetes technologies and insulin accessibility. Efforts to ensure universal accessibility are crucial to reduce global inequities in glycemic outcomes for children with type 1 diabetes.
Researchers developed a groundbreaking solution to tackle both energy efficiency and ride comfort challenges in electric vehicles. The innovative Teamwork Optimization Algorithm (TOA) dynamically adjusts the motor's magnetic flux for optimal performance, resulting in reduced energy consumption by up to 15%, smoother acceleration with 4...
Researchers at the University of Vaasa developed smart packaging that can detect subtle color changes in printed packages, enabling cost-effective solutions for industries like food and beverage, healthcare, and logistics. This technology provides a human-eye accurate and environmentally friendly alternative to electronic sensors, pavi...
Researchers discovered that disordered regions of the ZFTA-RELA fusion protein cause the formation of droplets within cells called condensates, which are essential for ependymoma development. The study provides a new therapeutic frontier by targeting the interacting partners within these condensates.
A new investigational drug, ION224, shows promise in treating metabolic dysfunction-associated steatohepatitis (MASH), a serious form of fatty liver disease. By targeting the DGAT2 enzyme, the drug helps reduce fat buildup and inflammation, two major drivers of liver damage.
A new study found that Native Hawaiian or Pacific Islander people had the highest rate of stroke among all racial and ethnic groups, with a rate of 591 cases per 100,000 people. The study also showed significant disparities in stroke risk among different racial and ethnic groups.
Dr. Valentin Fuster, a renowned cardiovascular expert, has been awarded the inaugural World Heart Federation oration lecture for his groundbreaking work in promoting global cardiovascular health. He will discuss early detection and education as key strategies for preventing heart disease, focusing on low- and middle-income countries.
Scientists have developed a method to make a juvenile mouse's scalp transparent, allowing them to image the developing connections in a living mouse's brain. This breakthrough enables researchers to study neurodevelopmental disorders and potentially lead to new interventions.
A new study by Cornell University researchers found that certain pond plant communities can increase greenhouse gas production, transport, and emissions. The composition of aquatic plant communities in shallow freshwater bodies can have significant effects on greenhouse gas concentrations and fluxes.
A new study reveals that drought and ozone pollution significantly reduce soybean yield, regardless of drought stress levels. Researchers found that elevated ozone concentrations disrupt photosynthesis and hormone signaling in plants, leading to reduced yield and seed development.
Researchers have identified specialized immune cells in the intestine that produce chemical messengers triggering anaphylaxis. Targeting these chemicals, like zileuton, may offer a new approach to preventing food-triggered anaphylaxis.
A study found that hormone therapy type impacts memory performance in postmenopausal women, with transdermal estradiol patches enhancing episodic memory and pill form improving prospective memory. The type of hormone therapy taken during and after menopause may influence cognitive performance differently across various types of memory.
A high protein diet, rich in tryptophan, increases the risk of cancer-associated venous thrombosis. The study found that inhibiting tryptophan metabolism and blocking its metabolite Kynurenine can mitigate this risk.
Late-breaking clinical trials and science at TCT 2025 will present pivotal data on novel therapies, devices, and techniques aimed at preventing and treating cardiovascular conditions. The symposium delivers high-impact findings that shape clinical practice and enhance outcomes for patients with heart and vascular disease.
Researchers used ancient DNA and computer simulations to determine that migration of farming groups was the dominant factor in the expansion of farming, while cultural adoption by hunter-gatherers played a minimal role. The study found that the adoption of new ideas and practices did not significantly accelerate the spread of agriculture.
Scientists have developed wheat plants that produce their own fertilizer through a bacterial work-around, opening the path toward less air and water pollution worldwide. This breakthrough could be a boon for food security in developing countries, especially Africa where fertilizers are often unaffordable.
A new study by University of Wisconsin-Madison researchers found that life expectancy gains made in high-income countries have slowed significantly since the first half of the 20th century. As a result, none of the generations born after 1939 will reach 100 years of age on average.
Researchers from SUTD developed a generative urban model that optimizes designs for both pedestrians and vehicles, challenging the assumption that walkable neighbourhoods must come at the expense of road access. The study found examples of well-balanced layouts that enhanced pedestrian reach without drastically compromising road access.
Kanishka Thiran Jayasundera has been appointed professor and chair of the Department of Ophthalmology and Vision Science at UC Davis Health. He is recognized for his research on retinal diseases and integrating mental health support with eye care.
Researchers successfully created functional ureter tissue from pluripotent stem cells, bringing them closer to developing transplantable kidneys that can produce and expel urine. The achievement is a significant step toward next-generation regenerative therapies.
A major international review found that targeted approaches such as regular supervised exercise, vitamin D supplements, and improved nutrition can significantly reduce falls in aged care homes. The study also highlights the importance of individualized programs delivered with strong staff engagement.
A study published in The BMJ found that women diagnosed with early breast cancer have a low long-term risk of developing a second primary cancer, with risks varying by age and treatment. Researchers used data from the National Cancer Registration and Analysis Service to estimate these risks.
A new study identifies a critical gene that regulates immune responses in female T cells but not in males. This discovery may lead to more effective treatments tailored to biological sex for diseases such as severe asthma and infections affecting millions of people worldwide.
Researchers found that sharks' teeth become structurally weaker and more prone to break in acidic oceans. The study suggests that even small damage can have significant effects on these apex predators.
Researchers developed a wax-assisted exfoliation method to fabricate high-quality MnBi2Te4 devices with dual-surface AlOx encapsulation. This approach significantly improved the robustness of topological phases in MnBi2Te4, leading to the observation of enhanced axion insulator states and quantum anomalous Hall effects.
Birdwatching tourism has seen significant growth globally, with countries in the tropics experiencing increased visitation and economic development. However, not all countries have benefited equally, with research from UC Santa Cruz identifying challenges and success stories that may inform future conservation efforts.
Research from Harbin University of Science and Technology and Edith Cowan University found that China's environmental regulations could enhance productivity in the new energy sector. The study investigated how environmental policies affect firm-level productivity, particularly in regions with varying levels of technological innovation.
SHEA expresses disappointment over the sudden departure of the CDC Director, emphasizing the agency's need for stability and authority to protect public health. Qualified, steady leadership is essential to guide the CDC through urgent challenges and prepare for future pandemics.
The study reveals data visualization primarily facilitates decision-making at the organizational and community levels, particularly for semi-structured problems. Recent trends indicate increasing support for broader types of decision-making, including individual-level and unstructured problems.
Migrating cells maintain a mechanical memory that allows them to retain their shape when passing through constrictions, enabling faster movement in complex environments. This study sheds light on the biophysical mechanisms underlying cell migration and its implications for processes like wound healing and immune defense.
The Conservation Soft Box is an airtight, controlled environment case that preserves cultural heritage with minimal maintenance. It achieves similar results to expensive display cases but at a much lower cost, making it accessible to countries with limited resources.
Researchers at Heidelberg University have discovered a key mechanism for Alzheimer's disease, identifying a neurotoxic protein-protein complex responsible for nerve cell death and cognitive decline. A novel pharmacological inhibitor, FP802, has shown promising results in slowing disease progression.
Researchers have developed a method to generate femtosecond polygonal optical vortices with square, pentagonal, and hexagonal intensity distributions. The technique utilizes a passive mode-locked solid-state Yb:KGW oscillator at quasi-frequency-degenerate state, delivering high-power FPOVs with excellent power stability.
Researchers found that self-efficacy is essential for positive emotions and flourishing, with a strong association between life meaning and feeling good about oneself. Despite differences in passion and self-efficacy, the sexes are remarkably similar in most areas.
The American Heart Association has extended its Rural Health Care Outcomes Accelerator program until 2028, expanding access to cardiovascular care and quality improvement resources for over 1,000 rural hospitals. This extension aims to address the significant disparities in health outcomes between urban and rural communities.
Researchers at Kennedy Krieger Institute have developed biomarkers to help identify children with Sturge-Weber syndrome at risk of developing the condition. These tools can monitor disease progression and guide individualized treatment plans, potentially changing a child's development trajectory.
A global study using disability data identified vulnerable populations at risk for long COVID, particularly in areas with underreported post-COVID conditions. The researchers call for urgent expansion of long COVID care and integration of disability data into early warning systems to address global health inequalities.
A new review in AI & Materials highlights the transformative potential of machine learning (ML) in nuclear materials research. ML techniques are being used to analyze complex microstructures, predict thermal conductivity and mechanical behavior, optimize processing and fabrication, and integrate with physics-based models.
Forskolin, a natural compound, significantly improves treatment outcomes for KMT2A-r AML by directly stopping leukaemia cell growth and enhancing chemotherapy effectiveness. Forskolin blocks P-glycoprotein 1, allowing more chemotherapy drugs to enter leukaemia cells, making treatments more potent.
Researchers discovered that immune hubs in the kidney create a unique metabolic environment, accumulating glutathione to counter oxidative stress. Blocking this process prevents TLS formation or causes existing structures to shrink. Urine glutathione levels can serve as a non-invasive biomarker for TLSs and disease progression.
A new study found that a cell-based vaccine using dendritic cells can improve progression-free survival time for patients with intermediate-stage primary liver cancer. The ImmunoTACE trial showed an average of 18 months of tumor progression compared to 10 months in the control group.
The study identified patterns in T cell receptor repertoires that are specific to both individual dogs and breeds of dog. This could lead to the development of simple blood tests to inform treatment and diagnostic decisions.
Researchers at DTU calculate the impact of everyday activities on the environment, providing a framework for consumers to make informed choices. The study assesses 23 common activities across six environmental categories, revealing that some lifestyle changes have a significant impact on the climate budget.
This novel anode design boasts excellent mechanical resilience, industrial durability, and fast-charging capabilities, while being green and scalable. The hydrolysis-engineered architecture delivers improved electrochemical performance, including high-rate capability and long cycle life.
Researchers have identified shared gene signatures and key mechanisms underlying the progression from chronic liver cirrhosis to acute-on-chronic liver failure. Metabolic dysfunction, including altered glycolysis and gluconeogenesis pathways, plays a central role in both conditions.
A Stanford-led study suggests that adopting a positive perspective on catastrophic experiences, such as the COVID-19 pandemic, can lead to reduced depression and lower levels of inflammation. The intervention group showed lower levels of depression and C-reactive protein compared to the control group.
Researchers explore the benefits of nucleic acid aptamers in targeted therapies for bone tissue regeneration, revealing their potential in managing orthopedic conditions. Aptamers can modulate key molecular pathways involved in bone repair, advancing the standard of care for fractures and various types of bone diseases.
Researchers have successfully produced antibodies that kill the parasite carried by the 'kissing bug' that causes the potentially deadly Chagas disease. These antibodies target the parasite's infective stage and show neutralization rates exceeding 95%, making them a key step towards developing an effective vaccine.
Researchers found that faster biological aging is associated with lower scores on digital cognitive tests, particularly among older adults. DNA methylation patterns were used to estimate biological age acceleration, and protein markers PAI1 and ADM showed strong associations with lower cognitive scores.
Researchers detected a new planet, WISPIT 2b, at an early stage of formation around a young analog of our Sun, estimated to be about 5 million years-old. The discovery provides valuable insights into planet-disk interaction and subsequent evolution.
A meta-analysis of 92 studies worldwide found that nearly one in three people avoid or are likely to avoid medical information. The strongest predictors of this behavior were not related to demographic factors but rather social and structural environment. Restoring trust in the medical system could lead to greater engagement with medic...
A new power flow algorithm for modern shipboard microgrids incorporating inverter-based resources has been developed, enabling the efficient management of energy at sea. The method incorporates grid forming control characteristics of inverter-based resources and can handle multiple energy sources sharing power proportionally.
Researchers from Japan and USA discover midline tissues use formation control to grow harmoniously, with the notochord leading elongation and adjacent tissues migrating together through fibroblast growth factor gradients and cell adhesion. Computer simulations confirm this mechanism is essential for synchronized tissue development.
Research reveals that women and girls exhibit higher levels of direct aggression towards their siblings compared to boys and men. In contrast, women and girls tend to engage in reputational aggression with non-siblings, similar to men and boys.
Researchers found that chemicals used to replace BPA can disrupt human ovarian cell function and change gene expression. The study calls for further investigation into the safety of these alternatives, which are not regulated or routinely tested.
A key contributor is the lab of Prof. Ayal Hendel at Bar-Ilan University's Goodman Faculty of Life Sciences, focusing on evaluating CRISPR-based gene editing precision and safety. The project aims to decentralize CAR-T cell therapy production, making it available to more patients by reducing costs and increasing accessibility.
Researchers uncover how EZH2 gene mutations sabotage healthy copy, leading to intellectual disability and overgrowth, with implications for related diseases and cancer. The study provides new insights into chromatinopathies and potential targeted therapies.
Researchers identified three distinct molecular subtypes of follicular lymphoma, offering insights into personalized treatment plans. The subtypes C1, C2, and C3 differ in their genetic profiles and tumor microenvironments, guiding the use of specific therapies.
Researchers based calculations on six different methods and found life expectancy for those born between 1939 and 2000 is rising more slowly. The rate of increase slowed by 37-52% depending on the method used, with forecasts indicating none of these cohorts will reach 100 years of life expectancy.