Researchers have identified a mechanism to control R-loop regulation, which could lead to new drugs for cancer and dementia. The study found that three proteins work together in a pathway to optimize R-loop levels, with potential applications for treating various conditions.
Researchers at the University of Bradford say naked mole rats' long lifespan and resistance to cancer could lead to new treatments for degenerative diseases like cancer and dementia. The animals' unique DNA repair mechanism may provide insights into preventing these conditions, with potential applications in humans.
A new study by the University of Bradford reveals that people with early-stage glaucoma see contrast in a similar way to those without it, despite measurable vision loss. This underlines the importance of regular eye checks to detect glaucoma before damage is established.
A meta-analysis of 24 trials involving over 17,500 older patients found that support with medication for three months after discharge significantly reduces hospital admissions. The study identified transitional support and medicines reconciliation as effective strategies in reducing readmissions.
Researchers at the University of Bradford have found a link between the diet of Roman Britons and their mortality rates using stable isotope data from bone collagen. Higher nitrogen isotope ratios were associated with a higher risk of mortality, while higher carbon isotope ratios were linked to a lower risk. The study provides new insi...
Researchers analyzed ear ossicles from 20 juveniles excavated in 18th-19th century burial grounds to understand maternal pre-pregnancy and late pregnancy diets. The study provides a unique link between diet and early pregnancy health.
A new computer software can detect genuine facial expressions, especially around the eyes. Researchers at the University of Bradford used a video analysis method to identify differences between real and posed smiles, finding that the eyes show more movement in genuine expressions.
Researchers from the University of Bradford have developed a facial recognition system that can accurately identify individuals even when only half or three-quarters of their face is visible. The study found that the bottom half of the face, eyes, and nose were most useful for recognition.
Researchers at the University of Bradford discovered a protein, EN2, released by cancer cells that alters normal cell behavior, promoting tumour growth and evading the immune system. The study found that both cancer and normal cells take up the protein, leading to changes in shape or fusion, allowing cancer cells to reactivate and spread.
Researchers at the University of Bradford have identified a new biomarker that could help diagnose PAH earlier, potentially leading to better treatment options. The study reveals how a faulty gene affects cell death regulation in the blood vessels.
The article highlights the threat of future chemical attacks during a period of rapid scientific change. The authors emphasize the need for collective review and strengthening of global measures to prevent the re-emergence of chemical weapons.
Researchers at the University of Bradford have developed a universal blood test that can detect cancer in patients under suspicion of the disease with high accuracy. The test measures DNA damage caused by ultraviolet light and uses Artificial Intelligence to analyze thousands of cells, improving predictability beyond 93%.
A commonly-used anti-psychotic drug has shown promise in treating aggressive triple negative breast cancer by inhibiting the growth and spread of cancer cells. The study found that up to 90% of cancer cells died following treatment with Pimozide, reducing tumour size and metastases.
Researchers from the University of Bradford analyzed Anglo Saxon children's milk teeth to identify modern children at risk for conditions like diabetes and heart disease. The study found that teeth provide a more reliable indicator of diet and health than bones, revealing biomarkers for stress in early life.
A single molecule expressed in the brain affects how we learn new tasks and acquire new memories. Mice with a mutated Arc protein showed cognitive inflexibility, highlighting the importance of proteins being switched on and off at the correct times.
A new diagnostic technique has been successfully tested at the University of Bradford, allowing for the isolation of responses from S-cone photoreceptors. This breakthrough could help in the diagnosis of diseases such as Types 1 and 2 diabetes, glaucoma, and high blood pressure.
Researchers at the University of Bradford have developed an AI system that can automatically assign gender based on a smile. The system uses dynamic movement analysis to distinguish between men and women, finding that women's smiles are more expansive than men's.
A new interaction between proteins could provide a breakthrough in the prevention of healthy blood vessel damage. The study found that stabilizing caveolae regions prevents damage by binding protein SOCS3 with Cavin-1, maintaining healthy vascular function.
A new 'checkpoint' model can identify potential drugs to treat genetic disorders by allowing compounds to bypass premature stop instructions once, reducing the risk of harmful protein generation. The model has been used to screen hundreds of genes and existing FDA-approved drugs, identifying two promising targets for drug development.
Researchers at the University of Bradford have discovered a new drug candidate, HXR9, that targets HOX genes to prevent cancer cell growth and induce apoptosis. Combining HXR9 with another drug shows enhanced results in reducing cancer growth.
Researchers have developed a simple methodology to capture proteins implicated in Alzheimer's disease and other conditions. The new method uses engineered tails to trap sugar-modified proteins, which can then be identified using routine laboratory techniques.
Scientists at the University of Bradford have developed TRAPT, a measurement for assessing urban environments' relaxation levels. The tool helps planners and architects understand the impact of 'greening' measures on public spaces, aiming to create more tranquil environments.
A new face-aging technique uses sparse partial least squares to create photographic-quality images of faces at different ages. The method, developed by University of Bradford researchers, has been shown to be more accurate than existing techniques and could improve search efforts for missing people.
Researchers at the University of Bradford have developed a peptide that blocks RAN protein and kill cancer cells. The new treatment uses nanoparticles to deliver the peptide directly into cancer cells, showing promising results in lab tests.
Researchers have identified a new biochemical pathway that can be controlled using metformin and salicylate, two widely used medicines. This approach could lead to the development of new therapies for inflammatory disorders, including those caused by faulty Janus kinase proteins.
Researchers at the University of Bradford have discovered a way to prevent chemotherapy resistance in lung cancer by blocking a protein called Ran-GTP. Suppressing this protein also causes cancer cells resistant to gefitinib to become re-sensitized, offering new hope for treatment.
Researchers from UK universities are launching a project to digitally reconstruct archaeological sites destroyed or damaged due to conflict, cultural vandalism, and natural disasters. The 'Curious Travellers' initiative aims to collect publicly donated content to recreate 3D models of monuments and ancient sites.
Researchers found a strong five-gene signature in all patients who succumbed to the disease, regardless of their length of survival. The team also tested HXR9, which blocked HOX gene function, forcing cancer cells to close down and die, and found that combining it with cisplatin significantly increased cancer cell killing.
Researchers have discovered a new drug, HRX9, that targets the HOX gene family and induces apoptosis in mesothelioma cells. The study found that treatment with HRX9 resulted in complete loss of tumor blood vessels and widespread cancer cell death, offering new hope for patients.
A recent study published in Psychology and Aging suggests that depressive symptoms continue to increase throughout old age, contrary to previous studies which only examined the issue up to age 85. The research found that levels of physical impairment, medical conditions, and death's approach significantly contribute to these increases.
Researchers from the University of Bradford and Avant-garde Materials Simulation successfully predicted the crystal structures of five target compounds using computational methods. The ability to predict crystal structures could enable the design of materials with superior properties, such as brighter pigments or more effective pharmac...
Engineers from UK SME Sofmat Ltd and University of Bradford create a virtually invisible 3D barcode that can be read using laser scanners, making it difficult for counterfeiters to replicate. The technology has been verified in laboratory tests and is already generating interest from industries prone to counterfeiting.
A Neolithic skeleton from Scotland reveals the earliest case of rickets in the UK, dating back over 3,000 years. The woman's diet and lifestyle suggest she suffered from Vitamin D deficiency due to lack of sunlight, highlighting unusual circumstances that led to her condition.
Researchers will use digital methods to repopulate an ancient country called Doggerland, monitoring its development over 5,000 years. This project aims to reveal crucial information about early human life in Europe and develop new technologies for exploring lost landscapes.
The researchers found that all test subjects perceived similar color shades with varying lightness but not actual colors. The perception of daylight locus is influenced by the position of the sun, causing variations in lighting conditions.
Researchers found that Victorian-era babies' nitrogen isotope levels could predict their likelihood of survival and potential health issues later in life. High levels were linked to malnutrition and stress, while low levels indicated breastfeeding and a healthy start.
A team of archaeologists has discovered evidence of frankincense being used in Roman burial rites in Britain, shedding new light on the country's funerary practices. The analysis of debris and skeletal remains from across Britain revealed that these precious substances were transported to the empire's northern outpost despite its decline.
Researchers prove climate change could not have caused population decline in Europe at the end of the Bronze Age. Human activity decline and social stress are likely causes of sudden fall in numbers.
A new care bundle implemented in four UK hospitals has achieved a significant reduction in the number of deaths following emergency abdominal surgery. The bundle, which includes five key elements, resulted in a 38% decrease in death rate from 16% to 10%.
Researchers have devised a simple blood test that can diagnose cancer with high accuracy, saving time and preventing costly procedures. The Lymphocyte Genome Sensitivity (LGS) test measures DNA damage caused by ultraviolet light, distinguishing between cancerous and healthy cells.