A new US study found that preschool-age children's persistence in the face of challenges is influenced by adults' actions, successes, and failures. When adults succeed at a task, speaking about the value of effort encourages persistence in children. Conversely, failure can discourage children from persisting.
Jacques Miller's discovery of immune cells T and B cells has had a profound impact on modern medicine, underpinning innovations in vaccine development, organ transplants, and cancer treatment. The Lasker Award recognizes his seminal work, which has also been recognized as a predictor of Nobel Prize success.
Scientists have identified a new strain of Streptococcus pyogenes causing more serious Strep A infections, including invasive diseases like bloodstream infections. The emm1 clone, M1UK, produces nine times more toxin than other strains, and its increased production may contribute to the severity of these infections.
A pipeline program called Saturday Academy at NYU College of Dentistry has shown to increase interest in the health professions, particularly dentistry, among underrepresented high school students. The program exposes students to the field through instruction and hands-on learning, mentoring them through the college application process.
Researchers have found the earliest direct evidence of milk consumption in human teeth dating back 6,000 years to Neolithic Britain. The discovery suggests that dairy products were a widespread dietary practice among ancient farmers.
A new clinical trial, EAZ171, is recruiting black women with breast cancer to investigate and treat taxane-induced neuropathy. The study seeks to identify the most effective chemotherapy regimen for African American women, who are disproportionately affected by this debilitating side effect.
Researchers at the University of Rhode Island have discovered a link between prenatal HIV exposure and reduced infant immunity. The study found two clusters of HIV-exposed but uninfected infants, one with a significantly reduced immune repertoire, which may explain their increased risk of morbidity.
Research highlights existing studies and recommended areas for further investigation into cannabis use among older adults, addressing concerns about public health policy and potential harms. Insights from five articles explore topics such as cannabis use disorders, co-occurring substance use disorders, and related comorbidities.
Dr. Qing Gu is researching a new technology using optical signals to transport data on microchips, aiming to increase speed and efficiency. Her goal is to develop nanoLEDs as a better alternative to nanolasers for chip-scale data transportation.
A new study published in Psychological Science found that children as young as 4 years old exhibit a strong tendency to retaliate against those who wrong them, rather than showing gratitude towards their benefactors. Researchers discovered that kids readily punish the thieves but struggle to reciprocate kindness.
A team of researchers found that the amino acids, a fundamental set of life's building blocks, may have special properties that helped bootstrap themselves into their modern form. The study suggests that each time a modern amino acid was discovered and embedded in biology's toolkit during evolution, it provided an adaptive value unusua...
Researchers have identified a novel biomarker for dementia, IGFBP-2, which is associated with an increased risk of all-cause dementia and Alzheimer's disease. Elevated circulating levels of IGFBP-2 significantly improved dementia risk classification when added to traditional risk factors.
A team of researchers, led by Sean Ryan, documents the invasive history of the small cabbage white butterfly, which they attribute to human activities such as trade and migration. The study uses DNA analysis from over 3,000 submitted butterflies to reveal the butterfly's spread across Europe, Asia, Siberia, North America, and New Zealand.
A new blood test detects early cancer cells in the bloodstream, predicting aggressive prostate cancer with high accuracy. Combining this test with the current PSA test reduces unnecessary biopsies and overtreatment of benign conditions.
A study of nearly 1.5 million patients found that receiving dialysis at for-profit facilities was linked to lower likelihoods of being placed on the kidney waiting list and receiving a transplant. The authors suggest that more research is needed to understand this association.
A new study by Massachusetts General Hospital researchers has identified slowing brain rhythms as a biomarker for detecting delirium and predicting poor clinical outcomes. The study found that generalized EEG slowing was associated with longer patient hospitalizations, worse functional outcomes, and increased mortality.
Researchers found functional mosaicism, where individual cells use different protein molecules to carry out the same function, which could explain antibiotic resistance and cancer relapse. This discovery suggests that therapeutic treatments may not be effective against all cells of the same type.
The National Institute on Alcohol Abuse and Alcoholism has awarded $3.1 million to the Medical University of South Carolina to continue testing medications that could help individuals with alcohol use disorder. The goal is to reduce vulnerability to relapse and improve treatment options for those affected by alcohol misuse.
Researchers discovered how breastfed babies absorb large amounts of calcium, building healthy bones. This mechanism could be key to treating osteoporosis and other bone diseases later in life.
A new University of Maryland School of Medicine study examines the impact of food insecurity among children from birth to age four, finding a steady rise in obesity rates as they grow. Despite food insecurity, toddlers are more likely to experience poor overall health and developmental problems.
Researchers at Johns Hopkins have developed a universal screening approach for vaginal microbiota transplantation (VMT) donors to ensure only beneficial microbes are transferred. The pilot study found that 35% of participants might be eligible VMT donors, and the success rate may depend on a small number of willing 'super donors'.
Researchers investigate Mediator complex's function in transcription, shedding light on its conserved role across evolution. The study reveals the complex's involvement in developmental regulation and provides insights into gene expression.
A national survey of primary care physicians reveals significant knowledge gaps about prediabetes risk factors, diagnostic criteria, and management practices. The study highlights the need for improved healthcare education and reimbursement systems to prioritize preventive measures over treatment.
The $4.28 million grant will fund the W2R Scholars program, supporting at least 150 transfer students in math, life sciences, physical sciences, engineering, and computer sciences. The program aims to increase participation of low-income, first-generation, and underrepresented students in STEM fields.
A new study found that Japanese-American adults with a normal body mass index have a significantly higher risk of developing diabetes compared to their non-Hispanic white counterparts. The study revealed that younger respondents, never smokers, and those with higher education levels were less likely to have diabetes.
A nurse-led follow-up service has improved patient care for those with early-stage lung cancer by increasing clinic capacity, reducing waiting times, and ensuring continuity of care. The service also promotes junior medical training and is well-received by patients and the multidisciplinary team.
Researchers created a virtual 300,000-year-old fossil skull with relatively modern features, similar to some fossils only 100,000 years old. The study suggests that the species Homo sapiens arose through hybridization of South and East African populations, contradicting previous theories.
Researchers found that bus drivers who received a serving of fresh fruit in addition to their box lunch experienced significantly decreased depression levels and increased self-efficacy. These small gestures can make a big difference in improving worker performance and health.
A narrative review highlights the crucial role of caregivers in managing patients' cardiovascular health, but also exposes them to poor health outcomes. A couples-based intervention has shown promise in reducing caregiver stress and improving relationships.
Research by Oregon State University found that stricter arsenic standards have led to a significant decrease in public water system violations, dropping from 1.3% in 2008 to 0.55% in 2017. This translates to nearly 1 million fewer people exposed to out-of-arsenic-compliance water.
Scientists from Tomsk Polytechnic University have developed a concept for an 'optical vacuum cleaner' that can manipulate and capture nanoparticles using optical properties. This technology has the potential to improve air purification in lab-on-a-chip operations and clean rooms.
Research at a bonobo community found that female-female sex increased oxytocin levels, promoting social bonding and cooperation. This suggests that same-sex interactions may play a crucial role in maintaining high levels of cooperation among female bonobos.
Bengio will discuss recent successes and limitations of deep learning, as well as research directions for building human-level AI. The event is part of the Heidelberg Laureate Forum, a networking event bringing together young researchers and award recipients.
A study found that most European expedited approvals for new medicines are based on non-validated surrogate endpoints instead of proven clinical outcomes, casting doubt on their effectiveness.
Researchers developed a reconfigurable electronic platform that can morph into three different shapes, including quatrefoils, stars, and irregular ones. This innovation opens doors to new engineering challenges and opportunities for biomedical technologies such as drug delivery, health monitoring, and implants.
A new study from Finland found that adolescents with higher levels of physical activity performed better in school during a two-year follow-up period. However, the results also showed that increasing physical activity did not necessarily result in improved academic performance, and may even lead to lower grades for some participants.
Researchers at Michigan Technological University discovered a long-lost parody of Gilbert and Sullivan's 'The Mikado' that pokes fun at the rigors of math class in Victorian college culture. The parody, titled 'The Mathematikado,' offers insights into student experiences and gender dynamics.
The INTERfaces project, funded by the EU's Horizon 2020 programme, aims to replicate natural bioprocesses for use in the chemical industry. Researchers will mimic nature's metabolism to produce pure and sustainable chemical products.
A new study from the University of Technology Sydney reveals that heat is a greater killer in Australia than cold, with up to 9% of deaths linked to heat in warmer regions. The elderly are particularly vulnerable to heat-related mortality.
The 2019 Lasker Awards recognize Max D. Cooper and Jacques Miller for their discovery of the function of B and T cells in the adaptive immune system. The awards also honor H. Michael Shepard, Dennis J. Slamon, and Axel Ullrich for their development of Herceptin, a monoclonal antibody therapy that targets HER2-positive breast cancer.
Tropical Storm Faxai has transitioned to an extra-tropical storm in the Pacific Ocean, characterized by a strong gale-force cold core low-pressure area. The system is expected to continue tracking through the Northern Pacific Ocean over the next several days with weakening winds.
A team of researchers has developed a new volcano eruption forecasting technique using the Kalman filtering method, which captures the unique unrest patterns of the Okmok volcano in Alaska. The study reveals that past eruptions are key to understanding the likelihood of future volcanic activity.
Research by University of Kansas plant biologists reveals that abandoning one pollinator for another compromises a flower's long-term survival. The study found that hummingbird-pollinated species are less likely to form new species, while insect-pollinated species tend to be more successful in speciating and resisting extinction.
Researchers studying the Ross Ice Shelf's paleo-pinning points aim to understand how and why it unpinned from Ross Bank. The study focuses on a crucial 30-year period, with data collection set for January 2021 in Antarctic waters.
A new study found that children are interested in politics and can provide information about candidates, but have gaps in their knowledge. The researchers argue that children need more input and guidance from adults to learn about politics and government.
The study found a decline in vaccine-type oral HPV infections among unvaccinated men, suggesting herd protection. However, the prevalence of oral HPV infections remained unchanged in unvaccinated women, possibly due to low statistical power.
Researchers from the GLOBE Institute found that massive fluctuations in ocean oxygen levels during the Cambrian explosion were influenced by animal behavior. The discovery suggests that animals may have controlled their own development through adjustments to oxygen levels, shedding light on Earth's 'heartbeat' and its impact on life.
Worcester Polytechnic Institute (WPI) has received a $25 million award from the US Army Combat Capabilities Development Command Army Research Laboratory to advance 3D printing technology. The new technique, called cold spray, can repair metal parts or make new ones by layering metal powders in a process known as additive manufacturing.
A study on foot painters reveals they have finely tuned toe maps in their brains, which were previously thought to exist only in non-human primates. The findings suggest a critical period for brain plasticity early in life and raise questions about how humans adapt to limb loss or changes.
A study published in PLOS Biology has identified conserved proteins and pathways in four major animal models and humans, revealing unique sets of proteins mutated in human disease states. This discovery allows researchers to select the most appropriate model systems for studying cardiac development and investigating diseases.
Lataisia C. Jones, a postdoctoral fellow at Children's National Hospital, has been selected as an AAAS IF/THEN Ambassador to serve as a STEM role model for middle school students. She will share her passion for research and science with young people near and far, inspiring them to pursue their own STEM dreams.
New research reveals that microorganisms in the Pacific Ocean's oxygen-free zone remove up to 80% of the methane produced, reducing its release into the atmosphere. The discovery has significant implications for understanding the ocean's role in regulating greenhouse gas emissions.
Researchers at Penn State developed a new method to measure network changes over time, revealing key insights into the world economy's response to the 2008-2009 financial crisis. The study found significant rewiring in the global economy during this period, and its impact on countries' economic growth rates.
Researchers used numerical simulations to study sediment motion and flow conditions, identifying three stages of dune formation and clarifying the mechanism. The findings can help predict riverbed morphology evolution and prevent hazards like riverbank failure.
Researchers found that 23% of participants in one group and 18% in another could walk over 300 meters in six minutes after a 16-week home-based intervention. While both groups showed significant improvement, the difference was not statistically significant.
Researchers at Carnegie Mellon University have created a computer model that can translate text describing physical movements into simple computer-generated animations. The Joint Language-to-Pose model enables sentences and physical motions to be jointly embedded, learning how language is related to action, gestures, and movement.
Researchers are developing a vaccine to counteract opioid addiction, with the goal of helping people stop the addiction and regain control of their lives. The vaccine, consisting of one shot and two boosters, aims to develop antibodies against opioids, alleviating symptoms and potentially saving lives during overdose.
A community-led approach to understanding and addressing soil pollution in Troy, New York and Tierra Amarilla, Chile. The project aims to raise awareness of the issue and develop strategies for protecting public health through do-it-yourself testing and community engagement.
Researchers have identified a new way to target the third most common oncogene, TERT. The study reveals that TERT messenger RNA is held up in the nucleus, and keeping it trapped could be an effective strategy for treating cancer. This discovery offers a promising new approach in the fight against TERT over-activation.
Gnashing teeth's secret strength lies in the microarchitecture of brittle materials, where adding small defects can increase glass strength 200 times over. Researchers developed two models to describe fracture propagation and contact mechanics, paving the way for stronger ceramics, biomedical implants, and building materials.
Researchers have identified three species of electric eels, including one that can produce up to 860 volts, the strongest discharge ever recorded. The discovery opens new avenues of research into strong electric discharges in other fish species.
Nine corporations and a university research team participated in the Mobile Monitoring Challenge, testing 10 promising technologies for finding natural gas leaks swiftly and cheaply. The technologies were effective at detecting leaks, but most need to improve their ability to quantify the size of the leaks.
The KEYNOTE-024 trial found that pembrolizumab significantly improved progression-free and overall survival in patients with advanced non-small-cell lung cancer. Patients treated with pembrolizumab had a median overall survival of 26.3 months compared to 14.2 months for those on chemotherapy.
New research shows software firms tend to set up close to established businesses, creating clusters that persist due to the ready supply of skilled employees. This clustering leads to sustained employment in certain areas, but does not necessarily result in increased profitability.
Researchers discovered that E-cadherin promotes metastasis in invasive ductal carcinoma by allowing breast cancer cells to survive during travel and form new tumors. The study reveals that the process of metastasis is inefficient, with only 1% of cells surviving and forming new tumors.
Researchers identified a genetic flaw in the ZCCHC8 gene that decreases protein production necessary for maintaining telomere length. This finding may lead to the development of diagnostic markers for inherited 'short telomere' diseases.
Researchers at the University of Georgia have discovered a new use for an existing insulin compound to treat glioblastoma, a fast-growing and often fatal form of brain cancer. The study found that surfen-treated cells were blocked from tumor growth and the spread of tumor cells in the brain.
NASA satellite data tracks large-scale trends in fire activity, consistent with a warming climate, particularly in the western US, Canada, and Northern Hemisphere forests. Research reveals that high temperatures, low humidity, and warmer nighttime temperatures contribute to increased fire risk and activity.
A study by University of Notre Dame researchers confirms that HUD-VASH vouchers lead to a reduction in homeless veterans. The vouchers provide chronically homeless veterans with stable housing and supportive services, resulting in a 45% drop in homelessness among US veterans since 2008.
Researchers have synthesized a novel organic substance called C6 OAHCQ with potential as an n-type semiconductor. It exhibits unique properties such as electron-accepting behavior and excellent solubility in common organic solvents.
A third family welcomes a baby after participating in a landmark uterus transplant clinical trial at Baylor University Medical Center. The successful birth is the largest program in the world, having performed a total of 20 uterus transplants.
Researchers at Brown University and Hebrew SeniorLife will create a collaborative research incubator to support trials aimed at improving care for people living with dementia. The grant will fund up to 40 pilot projects that test non-drug, care-based interventions.
A new liquid biopsy test can detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating which patients are likely to benefit from immune checkpoint inhibitors. The test produced a specificity of greater than 99% and sensitivity of 78% for MSI, and 67% for TMB.
A four-year research project aims to improve sleep patterns for night-shift workers over 50 years old, reducing the risk of depression, cardiovascular diseases, and accidents. The study will test two alternative sleep schedules, providing insights into the impact on productivity and overall health.
Scientists have discovered that the Trypanosoma cruzi parasite, responsible for Chagas disease, can reproduce sexually after analyzing its genomic code in unprecedented detail. The study reveals that some groups of parasites exhibit high levels of sexuality, while others remain abstinent.
Researchers found that fluoroquinolone antibiotics, such as Ciprofloxacin, are associated with an increased risk of heart problems, including aortic and mitral regurgitation. Current users face a 2.4 times greater risk compared to patients taking amoxicillin.
A telemedicine program using remote blood pressure monitoring has shown promising results in engaging newly postpartum women in cardiovascular monitoring, with 88% of participants returning to the clinic for follow-up appointments. The program aims to bridge care from obstetricians to ongoing cardiovascular monitoring, empowering patie...
The Impower131 Trial found that atezolizumab + chemotherapy improved overall survival by 3.9 months compared to chemotherapy alone, particularly among patients with high PD-L1 expression. Treatment-related side effects were common but manageable in both arms.
Patients taking nivolumab experience a significant five-fold increase in overall survival, with five-year rates of 13.4% compared to docetaxel's 2.6%. Long-term benefits and improved progression-free survival have been observed with nivolumab treatment.
A recent study by Kyoto University found that acute cerebellar inflammation causes 'depression-like' behavior in rats, characterized by decreased motivation and sociability. The research team discovered that microglia activation led to increased neuronal firing, causing the cerebellum to become hyperexcited.
New findings from the University of Kansas shed light on the behavior of gluons in protons. The researchers used ultra-peripheral collisions to study the energy and dipole sizes needed for gluon saturation, a hypothesized phase of matter thought to exist in high-energy protons.
A NIH-funded clinical trial found that methotrexate was more effective than mycophenolate mofetil in controlling inflammation and treatment success for patients with severe forms of uveitis. At six months, 74% of participants in the methotrexate group achieved control compared to 55% in the mycophenolate group.
Researchers at the University of Bradford have found a link between the diet of Roman Britons and their mortality rates using stable isotope data from bone collagen. Higher nitrogen isotope ratios were associated with a higher risk of mortality, while higher carbon isotope ratios were linked to a lower risk. The study provides new insi...
A new study by FSU ecologists found that golf ball-size clods of weathered crude oil can remain buried in sandy Gulf Coast beaches for decades. The oil takes at least 30 years to decompose due to limited oxygen, moisture, and nutrients available to its live-in microbes.
Researchers at Yale Cancer Center have identified a key metabolic pathway that enables cancer cells to adapt to their microenvironment and respond to nutrient availability. The study suggests that targeting this pathway with drugs may help treat various forms of cancer by preventing cancer cells from growing in nutrient-rich environments.
A new study suggests that measuring how quickly a person's pupils dilate during cognitive tests may be a viable method for detecting Alzheimer's disease risk before symptoms appear. The study links pupillary dilation responses to identified AD risk genes, providing proof-of-concept for this screening tool.
The Global Precipitation Measurement mission found heavy rainfall north of the center of Tropical Storm Gabrielle, with rates over 25 mm per hour. The storm is expected to weaken and dissipate over the far North Atlantic west of the British Isles on Thursday, Sept. 12.
Scientists uncover genetic variations in grapes, explaining differences in taste and color between wine varieties. The study's findings also have implications for plant breeding and understanding nutritional values of other fruits and vegetables.
Researchers at Lehigh University have developed a novel approach to determine when patients with tibial fractures can bear weight. The study used low-dose computed tomography scans and finite element analysis software to create 3D mechanical structural models that identified the regions of bone and new bone, or callus.
A new strain of group A streptococcus bacteria, M1UK, has been identified as the dominant cause of Strep A infections in England and Wales since 2010. The strain produces more toxin than existing strains, potentially leading to increased cases of invasive infections.
A new study by the University of Turku and Tampere University found that chronic enteroviral infection can modify broadly pancreatic cellular functions, including alterations in protein expression and secretion. The study suggests that such infections may have adverse health effects, particularly on the development of type 1 diabetes.
Researchers at EMSL and JGI selected proposals to study the impact of warming on soil microbial responses, algal photosynthesis, and plant-microbe interactions. The studies aim to understand how underground processes influence global nutrient cycles, with potential implications for climate change feedbacks.
Researchers at Clemson University discovered that salamanders use temperature rather than humidity to anticipate changes in their environment, and harness limb regeneration to minimize the impact of hot temperatures. This adaptation may have implications for other animals and plants, and could provide insights into regenerative medicine.
A study published in the Journal of the American Heart Association estimates that black men have a 30% lifetime risk of peripheral artery disease (PAD), while Hispanic men have a 22% risk. The researchers developed a risk calculator to identify high-risk patients who may benefit from PAD diagnostic screening.
Researchers at the Smithsonian's National Museum of Natural History have discovered three distinct species of electric eels in the Amazon basin, showcasing their remarkable diversity and adaptability. The newly identified species can produce up to 860 Volts of electricity, significantly more than previously known species.
Researchers have linked mammalian behavior to its underlying neural code for the first time, shedding light on how a mammal's brain interprets signals from the eyes. This discovery is relevant to all neuroscientists studying perception and has implications for understanding individual 'words' in the brain.
Joshua Jacobs has won a $558,865 NSF Faculty Early Career Development award to study how the human brain supports spatial navigation and memory. The project aims to identify fundamental types of brain signals that support these processes.
The quantum technology company Q-CTRL has secured a $15 million funding round led by Square Peg Capital, placing it among the top 10 global quantum start-ups. The investment will support major growth for the company and geographic expansion to include a new office in Los Angeles.
A study published in Estuarine, Coastal and Shelf Science found that high-tide water in Willapa Bay's tidal flats takes multiple tidal cycles to fully replace, leading to differences in oyster growth. This slower turnover affects the quality of oyster beds, with regions having 'old' water showing lower levels of nutrients.
Researchers have created a widely applicable and affordable photomicroreactor that utilizes luminescent solar concentrators to efficiently power photochemical reactions. This innovation enables the synthesis of various substances, including pharmaceuticals, using sunlight as a sustainable energy source.
A key brain circuit has been identified as a critical regulator of reward cue-related behavior in rats. The study found that this circuit reduces the incentive value of food cues by controlling dopamine release, which may help explain why some individuals struggle to resist temptation.
A study by FAU researchers suggests that pooled-ride services like car-pooling and public transit can significantly reduce traffic congestion and environmental impacts. By putting more people in fewer vehicles, these services can improve energy efficiency and lower costs.
Researchers at Ohio State University have found a link between a genetic mutation and flu-related heart complications in mice. The study suggests that some people may be genetically predisposed to these complications, which could lead to new therapies.
The NUS-developed STAMP technology enables accurate detection and classification of cancer cells, as well as determination of disease aggressiveness from minimal clinical samples. This breakthrough could lead to earlier diagnoses and more effective treatment decisions.
On Saturn's moon Titan, nitrogen explosions create craters that fill with liquid methane, forming distinctive lakes. The research suggests a pressurized explosion model as the best explanation for these geological features.
Researchers analyzed over 4,000 Instagram photos from various cities worldwide and found that people tend to centre one of their eyes slightly to the left of centre of the selfie, with the left eye being more commonly centred than the right. This phenomenon is consistent with a previously observed cognitive bias known as pseudoneglect.
Researchers have created a targeted transport system using palladium-based exosomes to deliver chemotherapy drugs directly to cancer cells. This method has the potential to reduce side effects and increase treatment efficacy.
A prize has been awarded to researchers who investigated an experimental schizophrenia drug that didn't improve cognitive function but had a good safety profile. The study will inform the development of other treatments for patients with schizophrenia, including potential applications in other disease areas.
Researchers found organised 'hand-like' maps of toes in the brains of professional foot painters, as they used their feet similarly to how people use hands. The study demonstrates an extreme example of brain plasticity and suggests that all people may have innate capacity for forming such maps.
A survey of European patients with lung cancer revealed that many were unaware of or had never heard of clinical trials. Despite positive experiences by over 50%, respondents identified difficulties in accessing trials, including language barriers, limited information, and disparities across Europe.
A study published in Clinical Infectious Diseases found a significant reduction in UK ICU bloodstream infections over an 8-year period. The research used data from over 1 million patients admitted to 276 NHS adult ICUs, showing a 95% decline in MRSA infections and a 57% drop in E. coli infections.
Parkinson's disease is a neurodegenerative disorder characterized by motor and cognitive impairments. Scientists listed ways of applying genetic engineering to study and treat the disease, including manipulating mitochondria and iron homeostasis. CRISPR technology holds promise for finding new effective treatments.
A new study by Yale scientists identifies ancient prokaryotes with compartmentalized nuclei, shedding light on the origin of eukaryotic cells. They found ribosomal proteins in Archaea with NLS-motifs similar to those in eukaryotic species, suggesting a transitional phase.
The proposed framework assesses multiple brain-body interactions contributing to Alzheimer's disease, including environmental and genetic factors. Gene-environment interactions are shown to shift the onset curve of dementia by 10 years in carriers of dominant Alzheimer's genes.