Researchers have unraveled a mechanism to reactivate 'back-up genes' on the inactive X chromosome, which could help treat Rett syndrome and other X-linked disorders. The study found that different genes require varying amounts of time to become active again, with location and proteins playing key roles.
Researchers from China have updated the soybean genome to a golden reference, improving its assembly quality and completeness. The new genome has increased accuracy in gene annotation and expression profiling, facilitating fundamental research and molecular breeding.
Two companion papers reveal that mountain regions are hotspots of biodiversity, with tropical mountains hosting more than 85% of the world's species. The high level of biodiversity is linked to unique climate conditions and geological dynamics.
A new study identifies a crucial stopover region in southern Mexico and Guatemala where songbirds fuel up before crossing the Gulf of Mexico. Researchers found that birds preparing for migration spend most of their time in this region to build energy reserves.
A new study at Binghamton University's First-year Research Immersion (FRI) program found that instructors with extra training improved student outcomes. The FRI program provides STEM students with research experience, while the training program for research educators helped them develop skills in teaching and mentoring.
Researchers discovered that bone marrow-derived cells contribute to embryo implantation and pregnancy by differentiating into decidual cells in the uterine environment. The study suggests a potential role of these cells in human implantation and pregnancy, potentially leading to new treatments for recurrent implantation failure and pre...
The new clock platform combines near-continuous operation with strong signals and high stability, featuring unique possibilities for enhancing clock performance. Preliminary data suggest the design is promising, with the tweezer clock providing self-verifying performance 96% of the time.
A team of researchers from UMass Amherst created a mathematical model to predict the degradation of vitamins in spaceflight food over time. The model enables NASA to accurately schedule resupplying trips and provide astronauts with essential nutrients, particularly thiamine, which degrades rapidly in certain foods like beef.
A new study from Swansea University shows that a structured approach to medicine monitoring, using the Adverse Drug Reaction (ADRe) Profile, can lead to positive impacts on patients in care homes. The study found that nurses using ADRe picked up issues that resulted in changes to nursing care and medication reviews for many residents.
A recent study by University of Kansas researcher Gabriel de Oliveira analyzed satellite data to understand the effects of deforestation on Amazonian ecosystems. The research revealed significant differences in soil and air temperatures, evapotranspiration rates, and energy exchanges between forested and non-forested areas.
A recent analysis reveals that kidneys from donors infected with hepatitis C virus (HCV) are now routinely used in transplants at many US centers. These organs function just as well as uninfected kidneys throughout the first year after transplantation, providing strong evidence for their safe and effective use.
Twelve emerging scientists from Argentina, Brazil, Chile, Mexico, Spain, and Uruguay have won PROLAB travel grants to collaborate with top researchers in the US, Canada, and Spain. They will work on various projects, including reproductive biology, neuronal proteostasis regulation, exercise-induced mood changes, and cancer progression.
A team of researchers has identified a new circular RNA that promotes tumor activity, contradicting its role as a cancer suppressor. The discovery opens up new opportunities to understand the genetics of cancer and potentially develop targeted treatment protocols.
A Wistar team is advancing a synthetic DNA technology called DNA-encoded monoclonal antibodies (DMAbs) to combat multidrug-resistant Pseudomonas aeruginosa. The researchers have demonstrated the effectiveness of DMAbs in controlling infection in mice, paving the way for further development and clinical testing.
Researchers found that people value diversity when making decisions for others, but prioritize similarity when working with their own teams. This discrepancy has implications for organizational diversity and highlights the need to involve multiple perspectives in hiring and team decisions.
Researchers evaluated China's success in controlling coal-fired power plant (CPP) emissions, finding significant reductions in air pollution and premature deaths since 2005-2020. The upgrading of end-pipe control facilities and early retirement of small units led to substantial emissions reductions.
New research at the University of Saskatchewan reveals that neonicotinoid pesticides can cause weight loss and delayed migration in wild birds, threatening their survival. Birds exposed to these insecticides suffered significant negative consequences, including appetite suppression and longer stopover times.
The Journalists in Aging Fellows Program has selected 14 new reporters to produce in-depth stories on aging issues. The projects span topics including cultural challenges faced by immigrant communities, health issues for African Americans, and the crisis of loneliness among older adults.
A study found abnormal gut microbiota in veterans with PTSD and cirrhosis is tied to poorer cognitive performance. The research also identified beneficial bacteria like Ruminococcaceae as associated with better performance.
A study found that patients with gradual symptom onset took eight hours to get medical help, compared to 2.6 hours for those with abrupt symptoms. Patients with gradual symptoms began with mild discomfort that slowly got worse, while abrupt onset referred to sudden and severe pain.
A potential treatment for polycystic kidney disease has shown a significant reduction in kidney size in afflicted mice, with no evidence of toxicity in animal or human cell tests. The drug is now in early clinical trials in humans, offering hope for a new option for survival beyond dialysis or transplant.
The latest Hubble image of Saturn reveals a planet with a dynamic atmosphere, featuring turbulent storms and subtle changes in its banded structure. The iconic hexagon at Saturn's north pole remains unchanged, while the mysterious six-sided pattern continues to intrigue scientists.
A study by the University of Cologne found that expert feedback significantly reduces the length of antibiotic therapies and improves treatment decisions among pediatricians. The experiment showed that providing feedback can be a useful means to address excessive antibiotic use.
A recent study published in the Journal of Nutritional Biochemistry found that humans have highly individualized inflammatory responses to eating a high-fat meal. The researchers used a sensitive test to analyze gene expression in response to the meal, finding that responses by more than 13,000 genes differed between subjects.
A study published in Nature Communications reveals that microorganisms residing on plant leaves are connected to those living in the soil, forming a key part of the bioenergy community. The researchers identified hundreds of leaf microbiome members and compared them to thousands in the soil, using deep sequencing techniques.
Astrophysicists detected gravitational wave 'tones' emitted by a merging black hole, validating the 'no-hair theory' and confirming Einstein's general relativity. The breakthrough comes 10 years earlier than expected and opens the era of understanding black holes and their properties.
A new study by UMass Amherst researchers shows that out-of-state casino gambling among Massachusetts residents decreased significantly after the state's first slot parlor, Plainridge Park Casino, opened in 2015. The study found that only 3-10% of problem gamblers seek professional treatment, highlighting the need for alternative effect...
Researchers developed a new classification method using artificial intelligence to identify primary cancerous tissue in head and neck cancers. The method achieved an accuracy of over 99% in distinguishing between primary lung squamous cell carcinomas and head and neck metastases, offering potential benefits for patients.
The new website provides a resource for understanding why, where, and how tropical reforestation is occurring. It highlights eight key messages on livelihoods, local decision-making, planting trees, natural regeneration, and climate change, among others.
A VCU-led team, including professors from several institutions and two companies, is developing an open network for molecular sciences data using AI. The goal is to create a platform for combining and analyzing data from academia, industry, and government, enabling scientists to make predictions and designs with more accuracy.
A study found that young adults in the US report high rates of non-medical prescription drug use, binge drinking, and illicit drug use. Researchers recommend a multilevel approach to address potential harms related to polysubstance use throughout the life course.
Researchers at Karolinska Institutet found that only viable neurons survive in the developing nervous system, while immature ones die. This discovery challenges the long-standing neurotrophic theory and could lead to new treatments for neurological diseases like Parkinson's.
A new study found that mobile technology alters how people view the outside world based on battery life and charging points. Battery icons shape daily activities and user identities, with full batteries linked to feelings of positivity and control, while low batteries induce anxiety and discomfort. The research reveals a strong social ...
The University of Miami has received a $50,000 grant from the US Department of Health and Human Services' Office of Research Integrity to promote research integrity in Argentina. The grant aims to increase awareness of institutional policy and training in responsible conduct of research.
Scientists have developed a new method to measure polarization using ultra-thin metasurface holograms. The technique uses overlapping holographic images to determine the amplitude contrast and phase difference between polarized light waves, enabling fast and compact devices for spectroscopy, sensing, and communications applications.
The study highlights the importance of zeta potential in colloid surface chemistry and its effect on dispersion stability. The Navier boundary condition, considering relative velocity, is applied to particles with hydrophobic surfaces, leading to increased electrophoretic mobility and sedimentation potential.
This special issue highlights von Humboldt's lasting legacy on mountain ecology and environment. Research focuses on species richness, biodiversity evolution, and soil microbial communities in response to climate change.
The Italian Chemical Society and Elsevier have recognized three young chemists for their outstanding research in Italy. The Reaxys SCI Early Career Researcher Award highlights the work of these talented individuals, who are making significant contributions to the field of chemistry.
A study found high levels of pollutants, such as industrial fluids and mercury, in the blubber and skin of English Channel dolphins. The levels of pollutants were similar to those previously described for bottlenose dolphins in other contaminated areas.
Researchers found that noradrenaline is necessary for astrocytes to respond to local stimulation, effectively integrating sensory and behavioral information. Astrocytes can track distinct information during behavior, including arousal state and sensory experience.
A $40,000 grant from The Emergency Medicine Foundation is supporting a study to increase awareness among parents about sepsis signs in children. Researchers hope this will lead to improved recognition strategies and faster diagnosis of sepsis.
Researchers at Northwestern University have developed a method to create highly active catalysts from precious metal nanoparticles, improving fuel cells' efficiency. The new catalysts can also be recycled from spent catalysts, reducing waste and increasing their lifespan.
Researchers successfully grew Candidatus Liberibacter asiaticus, the bacterium causing Citrus Greening Disease, in a laboratory for the first time. This breakthrough enables studies on the disease and potential treatments.
A new antibiotic-coated shunt has been shown to significantly reduce infection rates in patients with hydrocephalus. The BASICS trial found that the innovative treatment saved the NHS approximately £130K per infection averted, resulting in estimated annual savings of £7 million.
A new simulation software aims to enhance process knowledge and speed up biopharmaceutical manufacturing. Christian Witz's software shortens simulation times from months to hours, enabling more efficient troubleshooting and insights into processes.
A new study found that songbirds exposed to neonicotinoid insecticides experience anorexic behavior, reduced body weight, and delayed migratory itineraries. This is the first direct evidence of a mechanistic link between the pesticide and declining migratory bird populations.
Scientists have identified thousands of novel messenger proteins in human microbiomes, which could lead to new medicines. A new TB drug has been approved, offering hope for treatment-resistant forms of the disease.
Researchers develop a low-cost thermoelectric generator that harnesses temperature differences to produce renewable electricity at night, when solar power is not available. The device can generate up to 25 milliwatts of energy per square meter and has the potential to be scaled for practical use.
Researchers at Carnegie Mellon University developed GymCam, a vision-based system that detects repetitive motions and recognizes exercise types. The system can track exercises in crowded gym environments without relying on facial recognition or explicit wearables.
Researchers investigated the role of SAGA1 protein in regulating pyrenoid shape and number. They found that loss of SAGA1 leads to multiple pyrenoids with fewer starch plates, which results from elongated starch plates pinching off matrix portions.
The team aims to understand how genetics contributes to driving aggressive pathology in prostate cancer by combining pathology, computational modeling, and genomics. They plan to identify therapeutic options by testing combinations of genes in mouse models of the disease.
Researchers at USC have developed a new method for repurposing cells, which they found to be significantly more reliable than existing techniques. The approach uses enzymes to untangle DNA and has been proven to work in mice and humans with near-perfect efficiency.
Researchers identified a potential new indication for anti-EGFR treatment in patients with metastatic colorectal cancer and specific BRAF mutations. Class 3 BRAF mutations showed enhanced response rates compared to class 2 mutations, offering hope for personalized oncology.
Researchers found a significant correlation between financial challenges and early ageing, using data from 5500 middle-aged persons. The study suggests that poor finances can lead to premature ageing, with effects on physical capability and cognitive function.
A major new study has found that cancer patients who miss an urgent referral appointment for their symptoms are 12% more likely to die within 12 months of diagnosis. The study also revealed that non-attending patients with cancer had a higher risk of advanced stage disease at diagnosis, which can lead to poorer outcomes.
Research at University at Buffalo finds that heroin exposure sharply reduces drebrin levels in the brain's reward pathway, leading to synaptic rewiring and increased risk of relapse. Restoring drebrin levels can reduce relapse behaviors, providing a potential new treatment avenue.
A new robot hand with a dynamic grip can adjust its stiffness to absorb shocks, keeping objects intact during collisions. This technology is valuable for industries like automotive and electronics packaging, enhancing worker safety and machine performance.
Researchers at Texas Biomedical Institute have discovered that lung-specific chronic immune activation is responsible for the progression of disease in HIV patients. This dysfunction leads to a constant production of cytokines and chemokines, dysregulating the body's ability to fight off other infections.
Scientists at University of Illinois replicate Hall Effect with photons, enhancing one-way radio transmission and absorbing opposing signals. The technique could protect sources from interference and ensure accurate quantum measurements.
The NSF Convergence Accelerator program aims to accelerate use-inspired convergence research in areas of national importance. Two faculty teams at UNC Charlotte received Phase 1 awards to develop innovative solutions, including a digital resource hub and data analytics tools for studying public policy.
Scientists have developed a new technique for measuring the expansion of the universe using gravitational lensing, which yields a somewhat higher Hubble Constant value compared to standard measurements. The method provides a valuable alternative approach to addressing the long-standing discrepancy in the Hubble Constant's value
Two new studies published in Pediatric Blood and Cancer and Acta Oncologica demonstrate the potential benefits of proton therapy for children with brain cancer. Proton therapy shows promising outcomes in improving overall survival and recurrence-free survival rates, particularly in young patients. Additionally, a new technique called p...
Markey researchers identify nuclear glycogen's role in cancer progression and find epigenetic connections between glycogen metabolism and gene expression. The study reveals new therapeutic targets to treat non-small cell lung cancers.
A study by the University of South Florida and Eckerd College found four billion particles of microplastics in Tampa Bay's waters, highlighting the need to address plastic pollution. Microplastics, tiny plastic particles less than 1/8 inch, come from various sources and can harm marine life through ingestion or surface damage.
BotSlayer uses an anomaly detection algorithm to quickly identify trending activity likely driven by bots. The tool can also generate a network map to illustrate how a topic is spreading over time, providing insights into influential accounts and disinformation attacks.
Researchers at the University of Texas at Austin discovered that Komodo dragon armor is designed to protect against other dragons, not predators. The unique bone structure, featuring four distinct shapes, provides extensive coverage and suggests that young Komodo dragons do not have armor until adulthood.
The study highlights significant gaps in knowledge about underassessed foods, which represent more than half of animal production and over 25% of total food globally. The researchers argue that a more complete global food assessment is necessary to develop sensitive and versatile local solutions to environmental and food security issues.
Researchers at Michigan State University have discovered that many core microbes on bioenergy plant leaves originate from the soil and remain consistent across seasons. The study suggests that these microbes play a crucial role in the plant's growth and health, and their phyllosphere microbiome can be targeted for cultivation.
A new national study by Penn Medicine found that hepatitis C-infected kidneys can function comparably to uninfected kidneys in patients who do not already have the virus. The study showed a significant increase in the use of HCV-infected organs, but raised questions about why these organs are still assigned lower risk scores.
Physicists have developed a novel method to create high-performance spintronic devices using organic molecules, which can be easily configured for different functions. The new fabrication method uses layers of molecules that can be painted or printed onto metals, offering a promising alternative to traditional materials.
A new two-minute focused cardiac ultrasound protocol can help veterinarians detect heart disease in cats earlier, potentially saving lives. The test, developed by researchers at Tufts University, has been shown to be successful in detecting moderate and severe heart disease with high accuracy.
Researchers found short-term impairments in brain-to-muscle communication and decreased memory performance after nine-minute boxing sparring sessions. The study suggests that routine impacts in sports like football and other combat sports may pose health risks.
Scientists have found that cryptochromes from migratory birds have evolved a mechanism that enhances their ability to respond to light, allowing them to sense and respond to magnetic fields under nighttime conditions. This discovery sheds light on how vertebrate cryptochromes function in low-light environments.
Researchers have discovered a feedback loop that reinforces atmospheric inversions, locking smoke in valleys and worsening air quality. Understanding this loop enables scientists to predict when fire inversions are likely to occur, aiding firefighters and residents.
Researchers at the Netherlands Institute for Neuroscience have found that congenital nystagmus is caused by electrical oscillations in retinal neurons. The study shows that defects in just a few proteins result in erroneous movement signals sent to the brain, leading to the oscillating eye movements characteristic of the condition.
Research reveals how breast cancer cells use exosomes to bypass the blood-brain barrier and spread to the brain. Exosomes trick endothelial cells into taking them up, allowing cancer cells to metastasize, and can also manipulate astrocytes to facilitate tumor growth.
Three innovative minds received the 2019 CNRS innovation medallist award for their groundbreaking work in reducing satellite size and propulsion units. Ane Aanesland and Dmytro Rafalskyi developed new propellant technologies, while Vance Bergeron created electrostimulation solutions to improve paralysis rehabilitation. Livio de Luca pi...
The Georgia Cancer Center at Augusta University has received a six-year $6 million grant from the NCI to improve access to clinical trials for minority and rural populations. The grant will be used to recruit patients to conduct multi-site cancer clinical trials and care delivery studies in their communities.
Researchers at Yale University have discovered that a woman's bone marrow plays a crucial role in determining her ability to start and sustain a pregnancy. Bone marrow-derived stem cells travel to the uterus, where they help transform the uterine lining for implantation, essential for embryo implantation and pregnancy maintenance.
A collaborative project between the University of Washington and UCB will explore ways to enhance community pharmacist engagement in epilepsy care. The effort seeks to address fragmented healthcare services and medication adherence issues affecting the 3.4 million people living with epilepsy.
A recent study suggests that osteocalcin, a hormone released by the skeleton, is necessary for the fight or flight response to be triggered in bony vertebrates. This finding challenges the long-held assumption that adrenaline drives this response.
Tokyo University of Agriculture and Technology researchers have developed a more efficient method to produce polyene substructures, a crucial framework in many natural products and pharmaceutical molecules. The new 'one-pot' solution eliminates lengthy preparation steps and excess waste, making the production process more economical.
A recent study by Radboud University Medical Center found that exercising at home using motivating apps significantly improves cardiovascular fitness and motor disability in Parkinson's patients. The cycling exercise program was more effective than stretching exercises alone, with a notable impact on disease progression.
Researchers found that sevoflurane improved survival rates and reduced bacterial presence in organs of mice with induced sepsis compared to isoflurane or no anesthetic. The study suggests a critical role for the type of general anesthesia used in treating sepsis.
Research reveals that bone-derived hormone osteocalcin plays a critical role in mediating the acute stress response, which is distinct from hormones released by the adrenal glands. Osteocalcin levels rise in response to stress, triggering physiological responses such as increased energy expenditure and heart rate.
The SUTD researchers developed a strong, flexible and scalable multi-robots system that can be used in intelligence, surveillance and reconnaissance operations. The system includes a combination of a wheeled ground unit and miniature robots, allowing it to be scalable and explore dynamic environments.
Researchers discovered LH dipeptide as a potent anti-inflammatory agent that inhibits the secretion of inflammatory cytokines from microglia, reducing brain inflammation and depression symptoms. Consuming foods rich in LH dipeptide may be a safe method for maintaining good mental health.
Researchers at Brown University discovered that diet can mitigate or exacerbate changes in the gut microbiome caused by antibiotics. In a mouse study, diet high in fiber and low in simple sugars protected certain beneficial bacteria from antibiotic harm.
Researchers at Duke-NUS Medical School have identified a network of RNA-binding proteins that play a key role in the formation of disease-causing fibrous tissue in the heart. Inhibiting specific proteins may help prevent or treat cardiac fibrosis, which underlies many heart diseases.
New optical security features use a two-piece metamaterial system to create difficult-to-replicate optical phenomena, making it harder to counterfeit money or intercept secure information. The approach offers improved forgery protection and can be used for various applications, including banknotes and identification cards.
A plant-based diet has been shown to reduce inflammation and improve symptoms of rheumatoid arthritis through various mechanisms. Studies have found that plant-based diets are low in fat and high in fiber, which can reduce inflammatory markers and promote healthy gut bacteria.
A recent study found no long-term negative effects of time-outs on children's emotional and behavioral health. Despite previous alarming claims, researchers did not find a relationship between reported use of time-outs and increased behavior problems.
A team of researchers directly observed charge transfer and intermolecular interactions in artificial photosynthesis on a picosecond scale. They used time-resolved attenuated total reflection spectroscopy in the terahertz region to reveal the process, which involves rhenium complexes and Triethanolamine solvent.
A phase 2 clinical trial found that combining temsirolimus with chemotherapy improved patient outcomes for patients with relapsed rhabdomyosarcoma. The treatment resulted in a 54.6% event-free survival rate, compared to 69.1% for those receiving temsirolimus.
Researchers found that suppliers can enhance competitiveness by engaging in 'peacocking' behavior, embedding unique capabilities into RFPs, and providing innovative solutions. Price is also important, but its importance varies by service and product.
Researchers from the University of Pennsylvania have developed a reconfigurable topological insulator that can route photons around defects, increasing efficiency and speed. This breakthrough has potential applications in high-capacity data routing for future communication networks.
A simple epidemiological model accurately predicts measles transmission dynamics in London over almost a century, accounting for historical events like the 1918 pandemic. The study's findings suggest long-term disease dynamics can follow simple rules, with implications for understanding other ecological phenomena.
A new study from the Journal of Marketing finds that firms' own social media posts surrounding customers' experiences can influence digital sentiment. Informational content offers a substantial means to improve customer sentiment in negative interaction event outcomes, increasing positive sentiment by nearly 20%.
Researchers at Harvard University have discovered the architecture of a copper-nitrenoid complex that can transform carbon-hydrogen bonds into valuable building blocks for chemical synthesis. This breakthrough could lead to more efficient and sustainable production methods for pharmaceuticals, household products, and other chemicals.
A new study suggests that popular mobile phone games can provide a tool to detect early signs of cognitive decline, including dementia. The research found that patterns of tap, swipe, and rotational gestures correlate with brain function.
Scientists have found a way to protect hair follicles from chemotherapy, potentially preventing hair loss. Researchers used CDK4/6 inhibitors to halt cell division and reduce damage caused by taxanes, common anti-cancer drugs that can induce permanent hair loss.
A Nemours study suggests genetic testing can personalize PPI dosing for eosinophilic esophagitis patients. This could improve efficacy and reduce side effects in up to 90% of children, according to researchers.
Astronomers have discovered a rare form of carbon monoxide in the dust and gas disc around a young star, revealing it to be much heavier than previously thought. This finding provides new insights into the formation of planets and challenges existing theories about planetary system formation.
Researchers developed physiological-sensing textiles that can be woven into sleep garments to monitor heart rate and breathing rhythm. The technology, dubbed 'phyjama,' extracts signals from pressured regions of the textile to get a more accurate composite reading.
A new MRI analysis technique using diffusion tensor imaging (DTI) helped predict thinking problems and dementia related to small vessel disease. Participants with the most brain damage were more likely to develop these conditions, and the scan accurately predicted three-fourths of dementia cases.
A fossil skull found in a Bavarian town in the 1770s has been recognized as Mystriosaurus laurillardi, a now-extinct species that lived in tropical waters during the Jurassic Period. Researchers have also identified another skull discovered in Yorkshire, belonging to the same species.
Scientists identified a molecular pathway that contributes to PAH's development, targeting the EYA3 protein for new therapies. Blocking this protein prevents dangerous lung artery thickening and reversal of vascular remodeling was seen in laboratory rat models.
Quanex IG Systems has licensed a low-cost method to produce insulating material from Oak Ridge National Laboratory, enabling improved thermal insulation performance in building products. The technology reduces energy consumption and generates less waste, making it an attractive solution for the industry.
Researchers found that dislocations negatively impact carrier dynamics, leading to a four-fold increase in electron lifetime when defect densities are reduced. Halide perovskite has improved from 3% to 25% efficiency over the past decade.
A systematic review and meta-analysis suggests that people with drug-resistant epilepsy have better prospects of being seizure-free if they undergo surgical treatment at an earlier stage. The study found a 15-21% higher probability of attack freedom for those who underwent surgery early compared to later stages.
A new study by UBC researchers provides a comprehensive model for hydrogen adoption in British Columbia, recommending a refuelling infrastructure and production plants to support the adoption of hydrogen-powered cars. The study sees significant growth in hydrogen demand every year, provided policies like B.C.'s carbon tax are maintained.
A study found that desensitization from peanut oral immunotherapy can be maintained by continuing a modest dose of peanut protein, offering more protection against allergic reactions. Participants who passed food challenges had lower initial levels of antibodies and indicators of allergic activity in their blood.
Rats learn to play a simplified version of hide and seek with humans, exhibiting strategic gameplay and learning to alternate roles. They develop unique vocalizations and show intense activity in the prefrontal cortex during game events.