Nemours Children's Health neurologist Rodney Scott will investigate malfunctions in the brain's hippocampal region to identify shared therapies for patients with autism, epilepsy, and Alzheimer's disease. He aims to develop novel methods of brain stimulation that could restore healthy function across a range of disorders.
A new study by Nemours Children's Health reveals that prenatal diagnosis of OI does not accurately predict mortality, and many babies can survive with medical interventions. The study found that 16 out of 18 infants with lethal OI diagnoses survived and achieved significant mobility milestones.
The study found that early initiation of the HPV vaccine series led to significant improvements in vaccination rates across all racial and ethnic groups. Vaccination rates increased from 13.2% in 2019 to 42.2% in 2022, with notable increases for Hispanic or Latino, Black, Asian, and white patients.
A new study by Nemours Children's Health researcher finds that caregivers of prenatally exposed infants are twice as likely to be impaired at the time of death. Targeted efforts to prevent SUID in these infants are needed, with clear messages delivered to parents and caregivers emphasizing safe sleep practices and substance use prevent...
A study published by Nemours Children's Health and Endeavor Health found that states with high COVID-19 vaccination rates saw a significant decrease in pediatric asthma symptoms, with the largest decline seen in the highest quarter of vaccination rates.
Researchers will discuss key findings on pediatric mental health, vaccination, autism diagnosis, social determinants of cardiovascular health, and treatment of bronchiolitis. Studies examine the relationship between socioeconomic factors and hypertension in youth, long wait times for autism evaluations, and the impact of HPV vaccine up...
Researchers at Nemours Children's Health discovered that injecting neuroblastoma tumors with Zika virus shrank or eliminated those tumors in mice, suggesting a potential new therapy. The study showed promising results, with complete tumor elimination and no recurrence after four weeks of follow-up.
A study published by Nemours Children's Health found that laser epilation significantly reduced the risk of recurrence in patients with pilonidal disease. The procedure was compared to standard care, showing a 33% lower rate of recurrences in patients who received laser epilation.
Researchers have identified a group of babies born to mothers who used fentanyl during pregnancy with similar facial and musculoskeletal abnormalities. The study suggests the emergence of a novel syndrome, which may be caused by fentanyl exposure or another contaminant.
A retrospective cohort study found that Black, lower SES, and publicly insured teens are at higher risk of major complications after scoliosis surgery. These disparities also affect pre-operative care, including rates of brace prescription and second opinions.
Researchers from Nemours Children's Health present studies on body image, sports attrition, social determinants, and obesity, highlighting fresh approaches to keeping children healthy. Dr. Steven Selbst receives the prestigious Jim Seidel Distinguished Service Award for emergency medicine contributions.
A new study published in JAMA found that a consensus-based risk-stratification algorithm reduced unnecessary ovary removals in girls with benign masses from 16.1% to 8.4%. The algorithm accurately identified lesions highly likely to be benign, allowing for ovary-sparing surgery.
Gene therapy is being tested for rare skeletal dysplasia, affecting 1 in 200,000. Patients will receive a one-time infusion of viral vector containing correct gene sequence.
Researchers from Nemours Children's Health present findings on pediatric mental health, HPV vaccination strategies, primary hypertension in youth, and the effects of social media on pediatric care. The studies aim to improve child well-being and provide innovative approaches to addressing pressing topics.
Young children with autism spectrum disorder are less likely to undergo vision screening than their peers, despite a high risk of developing serious eye disorders. A recent study found that only 36.5% of children with ASD had completed vision screenings at well visits, compared to 59.5% for children without ASD.
Children from low-income neighborhoods are more likely to develop preventable heart disease due to high blood pressure, according to a new study. The research highlights the importance of considering neighborhood-related factors when diagnosing hypertension in youth.
A new exercise-testing approach detects asymptomatic cardiovascular abnormalities in pediatric cancer survivors, highlighting the need for routine monitoring before symptoms appear. The method assesses exercise data through a combination of peak and submaximal parameters simultaneously.
A bionic pancreas, which automatically delivers insulin based on blood glucose levels, was more effective than standard care at maintaining normal blood sugar levels. The study, funded by NIDDK and conducted at Nemours Children's Health, Jacksonville, found the device to require less user input and provide more automation.
Researchers found that standard scoring tools missed cases of depression in teenagers with Type 1 diabetes, leading to lower sensitivity. They recommend adjusting cut-off scores to detect depressive symptoms more accurately.
A study published in Nature Communications suggests that better glucose control can improve brain structure and function in youth with Type 1 diabetes. The findings indicate that participants using a hybrid closed-loop insulin delivery system showed significant improvement in key brain metrics compared to those receiving standard care.
A new consensus statement provides recommendations for the diagnosis, management, and care of individuals with achondroplasia across all life stages. The guidelines aim to improve clinical outcomes and quality of life for those affected by this genetic disorder.
Obstructive sleep apnea is common in kids and adolescents, affecting 1-6% of all children and 30-60% of obese adolescents. It can raise blood pressure and link to insulin resistance, abnormal lipids, and cardiovascular health issues. The American Heart Association calls for further studies on the topic.
According to Nemours Children's Health, over 21.5% of teen ER patients screened showed symptoms of severe depression, while 7.8% reported suicidal thoughts during the pandemic. This finding underscores the need for increased vigilance and support for adolescent mental health.
A new study published in Blood Advances has identified a gene variant, mesothelin (MSLN), that is abnormally expressed in more than one-third of childhood and young adult AML cases. This discovery could lead to the development of precision medicine treatments for children with AML.
A study found that social factors like household income, language, and insurance did not impact families' acceptance of telehealth for their children's cardiac care during the pandemic. The study suggests telehealth is a feasible option for families, with higher acceptance rates among patients with certain diagnoses or Hispanic ethnicity.
A new study published in Diabetes Care found that children with Type 1 Diabetes have lower brain volumes and IQ scores compared to non-diabetic children. The research suggests that hyperglycemia may adversely affect brain development, starting from childhood.
Researchers at Nemours Children's Health System have identified a new source of abnormal lymphatic flow between the liver and lungs in patients with plastic bronchitis. This discovery opens up treatment options for certain cases, allowing for more effective management of symptoms.
Despite COVID-19, Nemours Children's Health System increased patient immunizations by 4.6% through a hybrid approach combining in-person and telemedicine, with over 36,000 primary care telemedicine visits and nearly 10,000 'tele-well' visits.
A new study published in Pediatrics found that critically ill newborns who receive blood transfusions prior to surgery have a 50% increased rate of complications or death. The findings suggest that a 'wait and see' approach to giving infants blood during surgery may reduce surgical complications and the risk of death.
A new study has identified three gene variants that may help predict which children with eosinophilic esophagitis (EoE) are likely to respond to proton pump inhibitor (PPI) medication therapy. The research found that children carrying these variants are at increased risk of relapse after one year of PPI maintenance therapy.
The special journal issue features Nemours pediatric cardiologists' expertise on echocardiography and other imaging techniques used in children with cardiovascular disease. The articles highlight best practices for screening, diagnosing, and managing congenital heart disease to improve patient outcomes.
A 14-year-old boy's mysterious symptoms led to a rare diagnosis of multisystem inflammatory syndrome in children (MIS-C) caused by COVID-19. A new clinical pathway has been developed to quickly identify and treat cases, saving lives with timely information-sharing.
Researchers at Nemours have identified new genetic structural variants in childhood leukemia that can help assess minimal residual disease during chemotherapy. This breakthrough could lead to more precise diagnosis and targeted therapies for kids with cancer, improving treatment outcomes.
Researchers found that parents of children with CHD want individualized, formal psychosocial support to mitigate stress and improve long-term outcomes. The study outlines ways to optimize mental health for parents and supports positive child outcomes.
A Nemours study suggests genetic testing can personalize PPI dosing for eosinophilic esophagitis patients. This could improve efficacy and reduce side effects in up to 90% of children, according to researchers.
A collaborative project funded by the CDC improved healthy eating and physical activity standards in nearly 1,200 child care programs across ten states. The six-year initiative led to significant increases in best practices, particularly in outdoor play and learning, resulting in lower obesity risk among young children.
Researchers found that children with type 1 diabetes had slower growth in brain areas associated with mild cognitive deficits compared to children without T1D. The study suggests that glycemic exposure may adversely impact the developing brain in children with early-onset T1D.
Researchers at Nemours Children's Health System have found the military's Combat Application Tourniquet (CAT) to be effective in controlling blood flow in children's arms and legs, with a success rate of 100% for upper extremities and 93% for lower extremities.
A new genetic test accurately identified over 200 disease-causing gene variations in the Old Order Amish and Old Order Mennonite communities. The test could help reduce morbidity and mortality by detecting asymptomatic newborns with rare genetic disorders.
A new care model at Nemours Children's Hospital reduces the use of medication for children with autism spectrum disorders in emergency visits. The REACH Program uses distraction objects and rewards to manage anxiety and agitation, leading to improved patient experiences.
Researchers analyzed data from over 500,000 children, finding a significant association between obesity and increased asthma incidence. Obesity was identified as a modest risk factor for asthma, with 23-27% of new cases directly attributable to obesity.
A new study finds Transarterial Radioembolization with Yttrium-90 (TARE-Y90) effective and feasible in children with difficult-to-treat liver cancer. The treatment offers a less toxic alternative for patients who have not responded to chemotherapy.
Researchers at Nemours Children's Hospital investigated Zika's effects on neuroblastoma cell lines, finding potential as a treatment option. The virus targets developing nerve cells while leaving normal cells alone, providing hope for new therapies.
A Delaware team has developed a blood test that can identify spastic cerebral palsy (CP) patients with 73% accuracy, using DNA patterns in circulating blood cells. The study's findings have significant implications for early diagnosis and intervention.
A consensus statement from pediatric and law experts defines abusive head trauma (AHT) as a medical diagnosis, not a legal determination. Key findings include few infants with AHT having isolated injuries without retinal hemorrhages or other signs of abuse.
Researchers at Nemours Children's Health System developed a novel video-based informed consent process to improve participants' understanding and retention of trial information. The study found that caregivers of children who watched the video presentation retained more information about the study design five months later.
Families with elevated psychosocial risks, including parent mental health issues and child behavior problems, are more likely to drop out of weight management treatment. Psychosocial screening early in treatment may improve outcomes for children with obesity.
A new cancer drug has proven safe and effective in treating pediatric patients with tumor-specific gene mutations, particularly those with TRK fusions. The study found encouraging anti-tumor activity in all patients with solid TRK fusion-positive tumors, achieving sustained tumor regressions in over 90% of cases.
A new drug, larotrectinib, has been shown to be effective in treating cancers with specific genetic mutations. The study found that 75% of patients with TRK fusion-positive cancers responded to the treatment, with 13% achieving a complete response.
A clinical trial demonstrates the impact of nusinersen on older patients with spinal muscular atrophy (SMA), showing significant improvements in motor function scores. The study, known as CHERISH, enrolled 126 children aged 2-12 and found that 57% experienced an increase of at least three points in functioning scores.