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Science News for December 14, 2021


PCR: Activated by light

Researchers at LMU developed a new approach to create photoactivatable DNA processing enzymes that can be triggered by UV light pulses. This breakthrough overcomes the limitations of traditional hot-start methods, enabling more precise diagnostics without sacrificing sensitivity.

SourceLudwig-Maximilians-Universität München·JournalNucleic Acids Research·DateDec 14, 2021

What is treatment-resistant depression? New report calls for clearer definition to inform research and improve treatment.

A new report proposes a clearer definition of treatment-resistant depression, aiming to improve treatment outcomes. The study found that only about a third of studies in TRD enroll participants who met the most common definition, highlighting the need for a standardized approach.

SourceKing's College London·JournalMolecular Psychiatry·TypeLiterature review·DateDec 14, 2021

Gas-passing plankton illumine another piece of the carbon cycle puzzle

A recent study by Oregon State University reveals that a type of bacteria called SAR11 consumes acetone and isoprene, volatile organic compounds produced by phytoplankton. These findings suggest that the marine carbon cycle is not fully understood and highlights the importance of studying plankton's role in gas exchange.

SourceOregon State University·JournalEnvironmental Microbiology·TypeObservational study·DateDec 14, 2021

Overweight children are developing heart complications

A new study from the University of Georgia found that overweight youth are developing signs of artery stiffness, a significant risk factor for cardiovascular disease. Researchers measured visceral fat levels and arterial stiffness in over 600 children, adolescents, and young adults, revealing higher levels of visceral fat and arterial ...

SourceUniversity of Georgia·JournalPediatric Obesity·DateDec 14, 2021

Astronomers just got better at finding “bright” black holes

A team of astronomers has developed a new technique to detect active black holes in galaxies, measuring their impact on galaxy evolution. The method can be applied to millions of galaxies, searching for bright supermassive black holes at the centre of galaxies and studying their effect on star formation.

SourceInternational Centre for Radio Astronomy Research·JournalMonthly Notices of the Royal Astronomical Society·TypeObservational study·DateDec 14, 2021

New Wilderness Medical Society guidelines may help reduce tick-borne illness

The Wilderness Medical Society has developed clinical practice guidelines for reducing tick-borne illness, emphasizing low-risk interventions in resource-limited settings. Lyme disease accounts for nearly 70% of reported cases, with other TBIs like anaplasmosis and spotted fever rickettsiosis also on the rise.

SourceElsevier·JournalWilderness and Environmental Medicine·TypeSystematic review·DateDec 14, 2021

Precise insights into the supermassive black hole in the Milky Way’s heart

A team of astronomers has made the most precise measurements yet of the motions of stars around Sagittarius A*, the supermassive black hole at the center of the Milky Way. The research, using cutting-edge facilities like Gemini Observatory and the European Southern Observatory's Very Large Telescope, shows that nearly all of the mass c...

SourceAssociation of Universities for Research in Astronomy (AURA)·JournalAstronomy and Astrophysics·TypeObservational study·DateDec 14, 2021

Researchers test physics of coral as an indicator of reef health

Researchers at Stanford University have demonstrated that measuring the physics of just a small portion of a coral reef can reveal insights about the entire reef system. This new approach provides low-cost methods for scaling up monitoring efforts, which are crucial for understanding the impact of climate change on these ecosystems.

SourceStanford University·JournalJournal of Geophysical Research Oceans·DateDec 14, 2021

Spacecraft enters the Sun's corona for the first time in history

The Parker Solar Probe successfully entered the corona of the Sun, a region approximately 2 million degrees Fahrenheit, and collected data using the Solar Probe Cup instrument. The probe's historic achievement sheds light on phenomena such as solar flares, high-speed solar winds, and the Sun's atmosphere's heat and magnetic fields.

SourceCenter for Astrophysics | Harvard & Smithsonian·JournalPhysical Review Letters·DateDec 14, 2021

MSK Chief of the Lymphoma Service Gilles Salles Presents Promising New Treatment for Patients with Diffuse Large B-Cell Lymphoma

Researchers at Memorial Sloan Kettering Cancer Center found that pola-R-CHP reduces the risk of DLBCL disease progression, relapse, or death by 27 percent. The treatment, combining Polatuzumab vedotin with Rituximab and other chemotherapy agents, shows improved progression-free survival rates compared to current standard R-CHOP therapy.

SourceMemorial Sloan Kettering Cancer Center·JournalNew England Journal of Medicine·DateDec 14, 2021

Night lights: New global atlas maps out artificial light at night under the sea

A new global atlas reveals that up to 1.9 million km2 of the world's coastal waters are affected by artificial light at night, with significant impacts on marine organisms. The study uses a novel metric to determine the depth of light penetration and highlights the need for further research into the effects of ALAN pollution.

SourceUniversity of Plymouth·JournalElementa Science of the Anthropocene·TypeExperimental study·DateDec 14, 2021

Closing in on the first light in the Universe

Researchers have reduced background noise using new antennas in the Australian hinterland, allowing them to refine their search for a 13-billion-year-old signal known as the Epoch of Reionisation. By surveying over 80,000 radio signal sources, they produced models that significantly improved efforts to locate the elusive signal.

SourceARC Centre of Excellence for All Sky Astrophysics in 3D (ASTRO 3D)·JournalPublications of the Astronomical Society of Australia·TypeObservational study·DateDec 14, 2021

Change in buprenorphine use in US jails, prisons

The study found that buprenorphine use for opioid use disorder increased substantially in US jails and prisons over the past five years. Despite being rare among incarcerated individuals with opioid use disorder, this increase suggests potential improvements in treatment access.

SourceJAMA Network·JournalJAMA Network Open·DateDec 14, 2021

City of Hope researchers help find improved treatment options for patients with advanced colorectal cancer

A Phase 2 clinical trial showed sotorasib can shrink tumors and achieve disease control in heavily pretreated patients with advanced colorectal cancer. The study results exceeded the historic benefits linked to approved therapies, offering new hope for a population with limited treatment options.

SourceCity of Hope·JournalThe Lancet Oncology·TypeRandomized controlled/clinical trial·DateDec 14, 2021

A longstanding mystery in manufacturing has been solved

Researchers at Aarhus University have developed a simple analytical model to predict chip formation and optimize surface finish in manufacturing processes. The study reveals the critical cutting depth for almost every material, tool geometry, and running conditions, minimizing tool wear and improving product quality.

SourceAarhus University·JournalPhysical Review Letters·TypeComputational simulation/modeling·DateDec 14, 2021

Researchers develop platform to screen for new class of coronavirus antiviral compounds

Researchers developed a high-throughput platform to screen for new class of coronavirus antiviral compounds, targeting the macrodomain protein. The platform identified existing drugs that block macrodomain activity, including dasatinib, which shows promise as a potential treatment for COVID-19 and other coronaviruses.

SourceJohns Hopkins Bloomberg School of Public Health·JournalACS Chemical Biology·DateDec 14, 2021

New model accurately describes COVID-19 waves and plateaus: Adding random nature of social activity to traditional model, graphs match waves and plateaus of regional US data

A new epidemiological model, the stochastic social activity (SSA) model, combines real-world observations with mathematical equations to accurately describe COVID-19 wave and plateau dynamics. The model suggests that COVID-19 may become endemic in the global population, like the common cold or flu.

Improving drug options for colorectal cancer patients

Researchers have discovered that a common class of targeted therapies can help more colorectal cancer patients than previously thought. By analyzing cell studies and computer modeling, the team identified 10 distinct RAS mutations that do not preclude the use of EGFR inhibitors, which are already approved for other uses.

SourceSalk Institute·JournalCell Reports·DateDec 14, 2021

Menus need to be at least 75% vegetarian for meat eaters to choose plant-based food, study finds

A recent study by the University of Westminster found that meat eaters are more likely to choose vegetarian meals when they make up a majority of food offered. The choice tipping point occurred at 75% vegetarian menu options. Increasing plant-based food availability influences consumers' choices, promoting sustainable eating behaviors.

SourceUniversity of Westminster·JournalJournal of Environmental Psychology·DateDec 14, 2021

Primary care clinicians adjust recommendations for colorectal cancer screening to accommodate patient needs and preferences, study finds

A study found that primary care clinicians prefer noninvasive options for patients who are unwilling to undergo invasive procedures, concerned about work time, or unconvinced of the need for screening. The researchers suggest tailoring recommendations to patient preferences to improve adherence to colorectal cancer screening.

SourceMayo Clinic·JournalMayo Clinic Proceedings·DateDec 14, 2021

The first map showing the risk of exposure to the Crimean-Congo virus in deer populations in Spain

A research study has developed the first national map showing the risk of exposure to the Crimean-Congo hemorrhagic fever virus in Spain's deer populations. The study, which analyzed over 1,500 deer from 82 populations, identified hot spots where most tick bites leading to human cases have occurred.

SourceUniversity of Córdoba·JournalTransboundary and Emerging Diseases·TypeNews article·DateDec 14, 2021

Stroke therapy: Learning from nematodes

A molecule found in a nematode worm has shown promise in protecting the brains of stroke patients by reducing cell death and decreasing affected region size. Experimental treatments using glycolic acid have successfully salvaged threatened tissue in animal models, offering potential for reduced mortality and disability in stroke patients.

SourceLudwig-Maximilians-Universität München·JournalAdvanced Science·DateDec 14, 2021

Creating the human-robotic dream team

A team of UBC Okanagan researchers has developed a system to enhance interactions between humans and robots in industrial settings. The system uses artificial intelligence and machine learning to capture and analyze the environment, allowing robots to respond in a timely manner to ensure human safety.

SourceUniversity of British Columbia Okanagan campus·JournalRobotics and Computer-Integrated Manufacturing·TypeMeta-analysis·DateDec 14, 2021

Einstein wins again

Researchers have conducted a 16-year experiment to challenge Einstein's theory with pulsars, revealing relativistic effects for the first time and confirming predictions with precision. The study uses the unique Double Pulsar system, which consists of two orbiting radio pulsars, providing an ideal laboratory for testing gravity theories.

SourceWest Virginia University·JournalPhysical Review X·DateDec 14, 2021

Extreme weather research shows household income impacts of Hurricane Katrina and Superstorm Sandy, need for more equitable climate resilience planning for cities

A new analysis found that low-income households in New Orleans lost nearly 35% of their income after Hurricane Katrina, while high-income households in NYC lost only 5.8%. The study highlights the need for diversified income sources to mitigate economic harm from extreme weather events.

SourceIllinois Institute of Technology·JournalApplied Geography·DateDec 14, 2021

Advanced analysis of Apollo sample illuminates Moon’s evolution

A new study published in Nature Communications reveals chemical heterogeneities in Apollo 17 sample troctolite 76535, indicating an early rapid cooling of the Moon. This finding challenges previous estimates of a 100-million-year cooling duration and supports initial rapid cooling of magmas within the lunar crust.

SourceUniversity of Hawaii at Manoa·JournalNature Communications·TypeComputational simulation/modeling·DateDec 14, 2021

Greater odds of overall satisfaction three months after lumbar fusion when surgery is minimally invasive

Researchers found that minimally invasive spinal fusion surgery (MIS) was associated with significantly greater odds of patient satisfaction 3 months post-operatively, but not at 12 months. MIS procedures were also linked to less disability and pain at both time points.

SourceJournal of Neurosurgery Publishing Group·JournalJournal of Neurosurgery Spine·TypeObservational study·DateDec 14, 2021

Study finds that classrooms with more Black and Latinx students receive lower quality of teaching

A new study by researchers at New York University Steinhardt found that classrooms with higher percentages of Black and Latinx students receive lower quality of teaching. The study, which analyzed data from the Measures of Effective Teaching database, suggests that racial biases among teachers contribute to these disparities.

SourceNew York University·JournalAmerican Journal of Education·TypeData/statistical analysis·DateDec 14, 2021

Respiratory discovery could improve survival of COVID-19 intensive care patients

A clinical trial has revealed that COVID-19 patients on ventilators have less surfactant in their lungs due to the virus. The researchers suggest that giving extra surfactant for a longer period could help save lives by supporting breathing and allowing lung cells to repair after the infection passes.

SourceUniversity of Southampton·JournalAmerican Journal of Respiratory and Critical Care Medicine·TypeRandomized controlled/clinical trial·DateDec 14, 2021

Researchers from Tel Aviv University identified the biological mechanism causing nerve destruction in the Motor Neuron disease ALS

Researchers from Tel Aviv University have identified the biological mechanism causing nerve destruction in ALS, a fatal neurodegenerative disease. They found that TDP-43 protein accumulation in neuromuscular junctions inhibits local protein synthesis and mitochondrial activity, leading to degeneration and death of motor neurons.

SourceTel-Aviv University·JournalNature·DateDec 14, 2021

Journal of Nuclear Medicine supplement addresses personalization of patient treatment through radiopharmaceutical dosimetry

A new Journal of Nuclear Medicine supplement explores personalization of patient treatment through radiopharmaceutical dosimetry, addressing its benefits and challenges. The study reveals that tailoring drug dosage can enhance the efficacy of radiopharmaceutical therapy for cancer patients.

SourceSociety of Nuclear Medicine and Molecular Imaging·JournalJournal of Nuclear Medicine·DateDec 14, 2021

Glioma invasion may be affected by the parietooccipital fissure and white matter fibers rather than being a random phenomenon

Research reveals that the parietooccipital fissure acts as an obstacle to glioma invasion, with tumor cells making a detour around it. This finding highlights the importance of this fissure in determining the invasion pattern of posterior medial temporal gliomas.

SourceJournal of Neurosurgery Publishing Group·JournalJournal of Neurosurgery·TypeObservational study·DateDec 14, 2021

High pressure (hyperbaric) oxygen resolves severe COVID-19 breathing difficulties faster than standard therapy

A small clinical trial found that high-pressure hyperbaric oxygen treatment resolved severe COVID-19 breathing difficulties faster than standard therapy, with significant improvements in oxygen saturation and reduced risk of complications. However, further larger trials are needed to confirm the treatment's effects on survival.

SourceBMJ Group·JournalEmergency Medicine Journal·TypeRandomized controlled/clinical trial·DateDec 14, 2021

Specific metabolic dependencies of cancer cells revealed by perturbation with tailored chemical library offer new therapeutic possibilities

Researchers identified specific metabolic vulnerabilities in leukemia cell lines, including sensitivity to PI3K and fatty acid synthase inhibitors. The study highlights the potential for targeted cancer therapy by exploiting these dependencies.

When the brain switches from hearing to listening

Researchers at the University of Basel traced the neuronal fingerprint of sound processing in mouse brains, finding ten distinct activity patterns that depend on factors like attention, arousal, and reward. These findings suggest that even simple sound detection is a cognitive process that profoundly shapes brain activity.

SourceUniversity of Basel·JournalCell Reports·TypeExperimental study·DateDec 14, 2021

Killing pain without hurting the body: Novel compound that is potentially safer than current drugs

Researchers discover novel compound AD732 with anti-inflammatory and analgesic properties, outperforming standard NSAIDs while causing minimal harm. The compound may be a safer alternative for treating pain and inflammation in difficult diseases like ulcerative colitis and Crohn's disease.

SourceRitsumeikan University·JournalEuropean Journal of Pharmaceutical Sciences·TypeExperimental study·DateDec 14, 2021

Study combines climatic, tectonic models to explain Andean conundrum

A new study reveals that modern top-down climate-related factors combined with traditional bottom-up tectonic models can help uncover the history of the Andes Mountains. The research suggests that a submerged volcanic hotspot chain, known as the Juan Fernandez Ridge, plays a crucial role in shaping the Andes' unique tectonic setting.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalNature Communications·TypeComputational simulation/modeling·DateDec 14, 2021

Darwin’s finches ‘evolve’

A new study found that Galápagos Islands Darwin's finch females who spend longer inside the nest can ward off deadly larvae of the introduced avian vampire fly, improving offspring survival. The maternal buffer is a life-saver, especially during the first days after hatching.

SourceFlinders University·JournalProceedings of the Royal Society B Biological Sciences·TypeObservational study·DateDec 14, 2021

Antibiotics can be first-line therapy for uncomplicated appendicitis cases

A recent review article by Duke University Medical Center suggests that antibiotics can be an effective first-line therapy for uncomplicated appendicitis cases, treating up to 70% of cases. However, the definitive treatment option remains surgery, usually done laparoscopically, for severely inflamed appendices or high-risk patients.

SourceDuke University Medical Center·JournalJournal of the American Medical Association·TypeLiterature review·DateDec 14, 2021

New algorithm by Pusan National University scientists can repair missing data in event logs with superior accuracy

Researchers from Pusan National University have developed an algorithm to restore missing data in event logs, improving restoration accuracy by 10-30% compared to existing algorithms. The high accuracy of the new algorithm ensures its widespread application in industries and potential improvements in AI technologies.

SourcePusan National University·JournalIEEE Transactions on Services Computing·TypeComputational simulation/modeling·DateDec 14, 2021

Anti-gay slurs not targeted just at gay men

A new study by Nathan Grant Smith and colleagues found that straight men use anti-gay slurs not due to their sexual orientation but to protect traditional masculine norms. The study suggests that threatening straight men's status can trigger the use of such slurs, highlighting a significant problem in our culture.

SourceUniversity of Houston·JournalCurrent Psychology·DateDec 14, 2021