The LIPLEG study found that liposuction is significantly superior to conservative therapy in terms of key treatment outcomes, with 68.3% of patients experiencing clinically relevant pain reduction. The procedure also led to a marked improvement in quality of life, with patients reporting a reduction in pain and an increase in mobility.
Researchers Dr Ninon Dubourg and Professor Dr Philipp Schommers receive ERC funding for projects on lymphoma treatment and medieval mobility aids. They aim to improve lymphoma treatment and understand the mechanisms of immune escape in lymphoma cells.
Researchers developed a method to quantify individual cell damage using molecular markers, enabling detailed analysis of disease progression in tissue samples. This method can distinguish early disease mechanisms and differentiate between patient-specific and general disease progression.
A study found that people, including retail investors and financial professionals, often have different expectations for stock market returns due to varying mental models. Despite receiving outdated news, many respondents continued to expect higher returns, focusing solely on future profits rather than current share prices.
Scientists discovered that ribosomes struggle synthesizing transmembrane proteins, triggering quality control mechanisms to eliminate defective proteins. This new insight sheds light on a novel role of protein quality control at the ribosome, potentially leading to treatments for genetic diseases like cystic fibrosis.
Astronomers have discovered water molecules in the envelope of star IRS 3, located near the supermassive black hole Sgr A*. The star's enormous envelope, fueled by rapid mass loss, has allowed water to thrive in its vicinity. This finding suggests that Sgr A* is being enriched with fundamental building blocks of life.
A research team has discovered a fungal protein responsible for defoliation caused by Verticillium dahliae, leading to significant crop losses. The findings can contribute to the development of novel methods for controlling plant diseases through improved detection and genetic modification of resistant plants.
A Germany-wide research project aims to improve care for patients with invasive fungal infections, analyzing current treatment and developing a new care model. The project will use routine data from over 74 million insured persons.
A novel treatment approach combining phage therapy and fecal microbiota transplantation has shown promise in treating recurring urinary tract infections. The study, published in Nature Microbiology, found that the treatment reduced UTI episodes and improved quality of life for patients.
The University of Cologne has been awarded €1 million in EU funding to support six EUniWell study programmes in their efforts to meet the criteria for the Joint European Degree Label. The project, PATH_ED, will focus on making necessary adjustments to curricula and governance structures.
Researchers at the University of Cologne have discovered a previously unknown mechanism that links two fundamental processes in mitochondria. The oxidative folding of proteins is closely linked to the formation of haem, which is essential for energy production and other biological processes.
Researchers discovered that certain bacteria produce an enzyme to break down antibiotics, enabling their survival. This 'altruistic cell death' mechanism allows the bacteria population to thrive, making existing and future antibiotics less effective.
A study by University of Cologne researchers found that sales system agility contributes to higher operating profit only when channel structure and management are aligned. Companies should review their sales channel mix and allocation of responsibilities to reap benefits from rapid adaptation.
A team of researchers has identified a previously unknown vulnerability in KRAS-mutated pancreatic cancer cells, making them susceptible to necroptosis. Blocking the tumor cells' defense mechanism by inhibiting caspase-8 leads to significant cell death and reduced tumor growth.
A new study reveals that the Atacama Desert's hyperarid core became arid 45 million years ago, contradicting previous assumptions. The research team used cosmogenic nuclide dating to analyze quartz clasts and found exceptionally high concentrations of rare isotopes, indicating that surface clasts remained undisturbed for tens of millio...
A new study by University of Cologne researchers found that political orientation significantly impacts romantic interests, with young Americans showing reluctance towards dating across party lines. The study suggests that people use politics as a filter to determine compatibility and social circle approval.
A new study led by Professor Dr. Anne Burmeister found that individuals seeking advice are more likely to reach out when they learn about the benefits for both parties involved, resulting in a 40% increase in contacts and high-quality advice received.
A study published in Nature Metabolism has found a crucial link between mitochondrial lipid deficiency and gut inflammation, revealing that cardiolipin plays a key role in maintaining immune homeostasis. The research suggests that targeting the metabolism of immune cells could be a new approach to treating inflammatory bowel diseases.
The University of Cologne's researchers will continue to work on innovative treatments for lymph node cancer and study plant responses to environmental changes. The Collaborative Research Centres have received a total of approximately €39 million in funding, highlighting the university's strength in collaborative research.
A new treatment approach has been developed to treat spinal cord injuries by activating signaling pathways in both injured and uninjured nerve cells. Using the protein hyper-interleukin-6 (hIL-6), the researchers showed consistent improvements in walking ability and coordinated gait patterns in mice with contusion injuries.
Researchers discovered that fungal effector proteins evolved from ancient antimicrobial proteins to weaken host immune systems and manipulate the surrounding microbiome. These findings provide new insights into how fungi attack both hosts and beneficial microorganisms, with potential applications in agriculture and medicine.
A new AI system, SPARK, enables autonomous scientific discovery in cancer pathology by generating biological hypotheses and translating them into analytical tools. The system identifies clinically relevant tissue markers linked to disease course, treatment response, and tumour progression.
A research team at the University of Cologne discovered that the protein cFLIP can be used to override the defences of Diffuse Large B Cell Lymphoma (DLBCL) against programmed cell death. Targeting cFLIP could re-activate cell death in lymphoma cells and provide a new therapy option.
A research team discovered that a protein complex consisting of SMG1, SMG8, and SMG9 ensures the efficient execution of nonsense-mediated mRNA decay (NMD). The study found that this complex is essential for maintaining the stability of NMD under various conditions.
A new study has deciphered the step-by-step assembly of eukaryotic proteasomes, revealing two alternative pathways and a flexible biogenesis process. The findings have far-reaching implications for understanding cellular protein quality control, ageing, and diseases like cancer and neurodegenerative disorders.
A new study suggests that Neanderthals used birch tar not only as an adhesive but also to treat wounds, showing effective antimicrobial properties against S. aureus bacteria. The research findings are relevant in light of the global rise in bacterial resistance to antibiotics.
Researchers found that treating severe fetal megacystis with a vesicoamniotic shunt in the first trimester can improve survival rates and kidney function. In the study, 75% of children were born alive and 68% survived their first year of life, with most showing normal or only slightly impaired kidney function.
Researchers discover enzyme ANKIB1 crucial for innate immune signalling, driving type I and type III interferon induction. This finding solves a long-standing puzzle in innate immunity and provides opportunities for new therapies for devastating diseases.
Researchers have identified a crucial mechanism behind nonsense-mediated mRNA decay (NMD), which removes faulty transcripts to prevent incomplete protein production. The study reveals that the SMG5 and SMG6 proteins interact directly, forming an endonuclease that cuts through RNA in a targeted manner.
A study by University of Cologne researchers found a significant increase in drug-related homicides along strategic trafficking routes after NAFTA came into force in 1994. The homicide rate among males aged 15-39 increased by 2.1 cases per 100,000 in these regions.
A study found distinct inflammatory biomarkers and brain signatures for early-stage depression and psychosis, differing even in the earliest stages. These findings support customized therapies and may reduce risk of severe progression.
Researchers have developed an artificial DNA base pair that relies on halogen bonds, enabling stable structures and recognizing naturally occurring enzymes. This breakthrough expands the genetic alphabet and could open up new possibilities in synthetic biology.
A newly described HIV antibody targets the V3 glycan site in a different manner than previously known antibodies, remaining effective against virus variants that are resistant to classical V3 antibodies. This breakthrough supports antibody therapy combinations that neutralize the virus more effectively.
A zebrafish model was used to test the functional significance of rare SMN1 variants in children with false positive SMA diagnoses. The research found that both variants were functional and did not cause the disease. This breakthrough could prevent unnecessary SMA therapies and provide families with security.
Researchers have identified a specific brain network that is mainly active in the fast beta frequency range and modulates motor symptoms of Parkinson's disease through deep brain stimulation. Stimulating this network, which communicates at 20-35 Hz, can improve motor symptoms in patients with Parkinson's disease.
Researchers found molecules such as syringic acid that protect neurons from aging, while others like resveratrol promote neurodegeneration. An AI-powered approach identified potential therapeutic substances to preserve brain function and prevent neurodegenerative diseases.
A mentoring program in Germany found that socio-economic status continues to influence educational outcomes. Children from lower-income families were less likely to enter the high track in secondary school, but a mentoring program improved equality of opportunity.
Scientists have developed a new way to track landscape development over millions of years using cosmogenic krypton in zircon minerals. This method reveals how climate, tectonics, and sediment transport are linked, providing insights into the Earth's surface history.
A new study reveals that resilient nematodes can persist in the Atacama Desert's hostile soil, with population diversity correlating to water profile and temperature fluctuations. The findings suggest that biodiversity in arid regions may be higher than previously assumed, but also warn of ecosystem damage.
Researchers discovered a novel mechanism behind small cell lung cancer's aggressiveness, involving the lack of caspase-8, leading to necroptosis and inflammation that fosters tumor progression. This pre-tumoral inflammation suppresses anti-cancer immune responses, promoting metastasis and relapse.
The study uses a numerical model to simulate encounters between Neanderthals and modern humans on the Iberian Peninsula. Climate fluctuations significantly influenced population dynamics, with mixing possible in certain regions. The research offers a broader explanatory framework for interpreting archaeological and genomic data.
The Konrad Adenauer Synergy Research Project explores how the 1990s shaped today's international order, shedding light on humanitarian norms, geopolitical alignments, and global governance institutions. The project aims to inform decision-making and strengthen responses to global challenges.
A new AI method, DISK, helps recover missing data in animal behavior recordings, enabling more accurate analysis of neuroscience experiments. This technology, developed by a team of researchers, can analyze movements at sub-second scales and provide real-time estimations of data quality.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
Large language models can help improve psychological questionnaires by avoiding redundant items and making diagnosis more efficient. The study found that LLMs recognize common symptom associations and can be used to develop precise and efficient questionnaires.
The team discovered a flat, spherical gas and dust structure resembling a diamond ring, formed by a massive star's radiation and winds. The 'Diamond Ring' is around 20 light years in diameter and shines strongly in infrared light.
Six University of Cologne researchers recognized for their groundbreaking work, with approximately 6,900 globally highly cited researchers featured this year. The university's research strength is highlighted by the achievement, which demonstrates its impact across various academic disciplines.
A study at the University of Cologne found that optional support is mainly used by students who need it most, making it a potentially effective tool for individualized support. However, relying solely on this type of support is not enough to address initial differences in prior knowledge.
Researchers are investigating co-evolution between viruses and the immune system to predict future variants and develop effective vaccines and preventive measures. The ERC Synergy Grant will fund a six-year project, CoEvolve, led by physicists Michael Lässig and virologist Florian Klein.
Nuclear chemists at the University of Cologne provide experimental proof of technetium-98's electron capture decay into molybdenum-98. The finding confirms a decades-old theoretical assumption and expands understanding of nuclear decay processes.