A randomized clinical trial investigated the effectiveness of low-use vs high-use physical restraint strategies in critically ill patients receiving mechanical ventilation in the ICU. The study found no significant reduction in days free of delirium or coma at 14 days, regardless of the restraint strategy used.
Two-year-olds exhibit surprisingly good understanding of turn-taking in conversations, predicting when someone else will speak. Children with Developmental Language Disorder (DLD) also understand when it's their turn, but may be slower to respond.
A new species of leaf warbler, Tokara Leaf Warbler, has been discovered in Japan through DNA analysis. The species is found only on two island groups and is considered vulnerable due to low genetic diversity and potential population declines.
Researchers at RMIT University developed a smart bandage that monitors wound infections and delivers healing therapeutics in one simple dressing. The dressing uses carbon dots to sense pH changes in the wound and combat inflammation, allowing for real-time monitoring and treatment.
A single blood test can accurately forecast the future risk of six major cardiovascular diseases with CardiOmicScore, a novel AI-based tool developed by HKUMed. The system captures subtle biological changes and provides early warning signals up to 15 years before clinical onset.
Researchers from Flinders University emphasize the need to consider mental and physical health, school performance, and digital literacy when evaluating the ban's success. They also warn that restricting access may have limited impact unless platforms build safer environments.
A new study finds that multilateral development banks are failing to adequately address environmental and social risks in green hydrogen projects. The current guidelines lack hydrogen-specific criteria, leaving critical policy gaps.
Scientists have developed a light-activated material that can convert carbon dioxide into carbon monoxide, a key building block for fuels and chemicals, using sunlight and water. The material, which combines ideas from biology and materials science, produces CO extremely efficiently with no detectable by-products.
Researchers discovered that three anesthesia drugs, propofol, ketamine, and dexmedetomidine, have the same destabilizing effect on the brain, causing a loss of consciousness. This common mechanism could lead to the development of a universal anesthesia-delivery system to monitor patients more effectively.
A new study from Michigan Medicine found that over 7% of Americans have thought about shooting someone, while 8.7 million adults considered it in the last year. Firearm owners were no more likely to have these thoughts than non-owners, but 21% of those who had thoughts said they would consider giving their gun to someone for safekeeping.
Researchers break thickness limit for lead-free films, discovering a metastable phase that unlocks latent piezoelectric potential. The films exhibit a piezoelectric coefficient four times higher than conventional forms, paving the way for ultra-miniaturized sensors and devices.
Researchers at Chalmers University of Technology have developed a new material design that enables superconductivity to operate at higher temperatures and withstand strong magnetic fields. This breakthrough could pave the way for far more energy-efficient electronics and quantum technologies.
Researchers analyzed 11,000-year-old bowhead whale fossils to reveal the devastating impact of commercial whaling on the species' genetics. The study found that genetic diversity will continue to decline, severely impacting the species' resilience to climate change.
A team of researchers developed a fully biodegradable and compostable soft robotic electronic system that maintains high performance and durability during operation yet completely returns to nature after use. The system was made from a water-free biodegradable elastomer and integrated biodegradable inorganic electronic components, exhi...
Researchers suggest changing flight paths to avoid contrails could slash aviation's global warming impact by nearly half. Implementing such a policy could recover around 9% of the temperature budget the world has left before breaching the Paris Agreement's 2°C limit.
Scientists at Linköping University successfully created quantum bits using perovskite materials, overcoming previous theoretical limitations. The breakthrough enables the creation of more affordable quantum computers with improved scalability.
A specialized AI model, AMIR-GPT, has been developed to improve radiology guideline alignment, outperforming general purpose models in 33.3% of test responses. However, the model's performance varied across performance bands, and qualitative review revealed limitations, such as omissions and deviations from standard recommendations.
Maintaining a healthy lifestyle, including a high-quality diet, moderate exercise, and low alcohol consumption, was associated with lower cardiometabolic disease risk. The study found that adhering to these healthy behaviors reduced the risk of major cardiometabolic diseases independent of medication use.
This mixed-methods cohort study reveals pervasive violence against Australian women who inject drugs, with severe consequences. Despite this, rates of seeking healthcare remain low due to structural and social barriers.
A new tool, metapipeline-DNA, automates and standardizes genome sequencing analysis, reducing the complexity of large and complicated data. The open-access resource, developed by Sanford Burnham Prebys and the University of California Los Angeles, aims to improve collaboration and reproducibility across research labs.
A new project at the University of Bonn's BCDSS Cluster of Excellence and the Department of History aims to analyze and render visible nameless individuals in historical records. This study sheds light on the identities and power dynamics of the past, particularly in the context of slavery and colonialism.
A systematic review and meta-analysis found that brief interventions after a suicide attempt can significantly reduce re-attempts. Participants who received these interventions were 28% less likely to attempt suicide again than those receiving usual medical care.
A study of nearly 700,000 health records reveals that young people with cannabis use disorder are more likely to be diagnosed with psychiatric disorders, such as schizophrenia, recurrent major depression, and anxiety disorders. In contrast, adults with cannabis use disorder are less likely to develop these conditions.
Research from Stanford University reveals that warmer, wetter weather conditions linked to climate change are making disease epidemics more likely, with a study analyzing a 2023 cyclone and dengue fever outbreak in Peru estimating that 60% of cases were directly caused by extreme rainfall and warm temperatures. Targeted mosquito contro...
Professor Iwa Salami argues that stablecoins require strong regulation to support safe growth and innovation in UK finance. The expert calls for clear legal protections, robust operational standards, and close international cooperation to mitigate risks and ensure consumer protection.
Dr. Aliesha O’Raw, Principal Investigator at TIBI and Co-Founder of OnVagus, has been selected for the 2026 ACS BrightEdge Entrepreneurs Program. The program provides mentorship, entrepreneur training, and early-stage investment support to advance cancer diagnostic and therapeutic solutions.
Researchers at MDI Bio Lab studied zebrafish, which can form new nephrons and connect them to existing tubules. The team found a coordinated cellular choreography that involves intersecting signaling systems, including the Wnt pathway, to guide the connection. This technique could one day guide human repair of damaged kidneys.
Renowned historian Lyndal Roper has been awarded the 2026 Holberg Prize for her groundbreaking research on early modern European history and gender. Her work has reshaped understandings of witch persecutions, the German Peasants' War, and Martin Luther's life and thought.
Researchers at Kyoto University have discovered that targeting the CNP/GC-B signal pathway may provide a promising approach for treating Pulmonary Arterial Hypertension (PAH). The study reveals that CNP/GC-B signaling plays a protective role against PAH, and administration of CNP ameliorates experimental pulmonary hypertension.
Researchers have identified BCMA as a key switch maintaining harmful IgA-producing plasma cells in IgA nephropathy. A proof-of-concept study using BCMA-targeted therapy showed a deep reduction in serum IgA levels in cynomolgus monkeys, providing a robust scientific rationale for repurposing BCMA-directed treatments for IgAN.
A biologically inspired event camera measures vibrations accurately without expensive equipment, providing a cost-effective alternative to laser-based systems. The camera captures high-speed vibrations by recording brightness changes independently at each pixel, enabling precise amplitude, phase, and frequency estimation.
Early-life exposure to PFAS may influence how teens' bones develop during adolescence, leading to lower bone density. The study found that teens with higher PFAS levels had lower forearm bone density, with stronger associations among females.
Researchers at Case Western Reserve University have developed a new therapy called OSM CAR-T that successfully attacks osteosarcoma tumors in mouse models. This treatment harnesses the body's immune system to fight cancer, potentially offering better outcomes with fewer side effects than traditional chemotherapy.
The implementation of Japan's indoor smoke-free laws resulted in a modest increase in smoke-free establishments, with a 5.7% nationwide increase and 13.5% in areas with stricter ordinances. Despite this, a substantial number of establishments still permit indoor smoking due to exemptions under the current legislation.
Research reveals carbon monoxide poisoning from waterpipe smoking can occur after brief use, outdoor smoking, or secondhand exposure. The study identified 68 cases of acute CO poisoning, including 13 cases of polycythemia, a chronic condition caused by prolonged exposure to carbon monoxide.
Researchers identified Mrep, a macrophage population, that promotes muscle repair under normal conditions but triggers heterotopic ossification in FOP. Transplanting Mrep improves muscle repair in FOP mouse models, suggesting therapeutic approaches targeting Mrep could be effective.
A new study has developed biologically plausible dose-response models to better protect pregnant people from Listeria, a leading cause of foodborne illness in the US. The models, built on data from guinea pigs and gerbils, found that fetal brain infection is a more precise indicator of stillbirth risk than direct stillbirth outcomes al...
Researchers found juvenile smalltooth sawfish showing strong site fidelity to the South Fork of the Saint Lucie River, spending up to 87% of their time within a 0.4 square kilometer area. This suggests that the Indian River Lagoon is once again functioning as a nursery for this endangered species.
The bow and arrow replaced the atlatl and dart as primary hunting technology in western North America, debuting around 1,400 years ago, with rapid adoption across the region
A new AI model has been developed to predict floods with greater accuracy than traditional methods. The knowledge-guided approach combines elements of physics-based models with machine-learning techniques to automatically learn the state of a river's watershed, eliminating the need for manual recalibration.
Researchers found that measures of blood vessel health from routine blood pressure readings can identify adults at increased risk for dementia. Vascular aging patterns may provide meaningful insight into future dementia risk, and managing vascular health earlier in life may influence long-term brain health.
Single-atom catalysts (SACs) have emerged as a promising class of catalytic materials capable of addressing challenges in selective hydrogenation. Experimental advances and mechanistic insights highlight their potential to deliver high efficiency and selectivity with minimal metal usage. The review also discusses challenges and opportu...
A recent study found that people with atherosclerotic heart disease who received the shingles vaccine had nearly half the rate of serious cardiac events compared to those who did not get vaccinated. The vaccine was associated with significant reductions in cardiovascular risk, including heart attacks, strokes, and death.
Research suggests that amyloid beta and tau proteins compete for microtubule binding sites, driving Alzheimer's disease pathology. The microtubule nexus hypothesis proposes a unifying theory for the underlying cause of Alzheimer's, with potential therapeutic strategies targeting tau displacement from microtubules.
Genetic analysis reveals the Tokara Leaf Warbler, a small insectivorous songbird, has been isolated from a similar species for 2.8-3.2 million years. The discovery suggests a need for reevaluation of conservation status due to threats from introduced weasels and environmental modification.
Researchers at Binghamton University found a significant shift in moth flight patterns over a century, with some species emerging later in the year. The study also identified missing moth species in the region, highlighting the impact of anthropogenic change on ecosystems.
Consuming ultra-processed foods daily is associated with a higher risk of adverse cardiac events, particularly among Black Americans. The study found that each additional serving increases the risk by over 5%, with Black Americans seeing an amplified risk compared to other racial groups.
Researchers analyzed 2.2 million public statements from the 118th US Congress to understand the incentives behind divisive rhetoric. They found that a small minority of politicians, mostly Republicans, use personal insults to gain media attention, rather than policy gains.
Researchers reveal that skin-cell calcium channel TRPV3 is activated by plant-derived fragrant molecules, leading to enhanced immune responses and potential new vaccine adjuvants. The study provides a novel understanding of immune crosstalk and offers a safer approach to enhancing vaccine efficacy.
A study by Jeonbuk National University researchers highlights the potential risks of chemical-enhanced primary treatment (CEPT) sewage sludge, but also shows that thermal treatment can lead to secondary heavy metal pollution. The team recommends using lower pyrolysis temperatures to enhance sustainability.
Activation of hypoxia signaling improved metabolism and limited fat accumulation in obese mice, while preserving vascular networks and bone health. The intervention also enhanced fracture healing and glucose tolerance, suggesting a dual beneficial effect on metabolism and bone integrity.
Researchers developed an expert consensus to standardize the use of ultrasound-derived fat fraction for assessing liver steatosis. The study found that UDFF showed strong correlations with histological steatosis grades and MRI-PDFF, demonstrating excellent reliability and robust diagnostic accuracy.
Researchers at The Hospital for Sick Children have mapped how tuberculosis bacteria fuel themselves during infection. They discovered the protein EtfD, which extracts energy from lipids, and developed a laboratory test to measure its activity. This breakthrough provides new insights into treating TB and may lead to shorter treatment re...
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
The report highlights three major trends in democratic backsliding: democratic backsliding in stable democracies, reversals in democratized countries, and deepening autocracy in existing autocracies. Freedom of Expression and liberal aspects of democracy show the most drastic declines globally.
A study by Frontiers in Science argues that ultra-sensitive food safety tests may drive food waste and unavailability, but not always translate to health risk. The researchers propose a more balanced approach that considers trade-offs between food safety, sustainability, and nutritional health.
A new study reveals a dramatic increase in wildfires in tropical peatlands during the 20th century, releasing large amounts of stored carbon into the atmosphere. Human activities, such as agriculture and deforestation, are identified as the root cause of this surge.
Scientists from the University of Manchester led the discovery of the new Ξcc+- (Xi-cc-plus) particle, a heavy proton-like particle containing two charm quarks and one down quark. The particle was identified using the upgraded LHCb detector and has a mass of 3619.97 MeV/c².
Scientists have discovered that cancer cells exploit healthy lung cells to support metastatic tumor growth in the lungs. Decreasing lipid production in lung cells can hinder cancer growth. The study suggests targeting lung cell lipid production as a new approach to treating lung cancer.
Scientists have added millions of protein complex structures to the AlphaFold Database, shedding light on how proteins interact. The dataset prioritizes human health and disease research, enabling researchers to test, refine, and build upon it.