Researchers from 12 countries have launched a global effort to document and study 'heritage' diets before they are lost. These diets, shaped by local environments and traditions, may hold vital clues to better health.
PhD candidate Tommaso Zaccaria's research shows that microorganisms from Earth can survive in Martian hot springs and other celestial bodies. This has implications for astronaut health and the study of the human immune system on Earth.
A new DNA test offers a much more complete picture of DNA than current standard diagnostics, leading to a diagnosis more often. The test can replace fifteen other tests, making it faster and more efficient for rare genetic disorders.
A study by Radboud University Medical Center found that 75% of patients with stable psoriasis can safely reduce their biologic medication dosage by half, achieving similar symptom control. This reduction in dosage leads to fewer injections and saves up to €8,500 per patient per year.
A growing number of fungi are becoming resistant to medication, posing serious risks for patients with weakened immune systems. A five-step plan aims to monitor and prevent the rise of resistant fungi through awareness, surveillance, infection prevention and control, optimized use, and investments.
A new study shows that PSMA therapy can delay the need for hormone therapy in prostate cancer patients by an average of 20 months. The therapy is effective in earlier stages of the disease, improving survival and quality of life for approximately two out of three patients.
Research from Radboud University Medical Center and colleagues demonstrates the value of targeted tumor analysis of DNA in colorectal polyps. This study provides valuable insights into genetic predispositions, including APC mutational mosaicism and BRAF gene mutations.
Researchers have discovered new genetic causes of inherited blindness, identifying changes in RNA genes as a key factor. This breakthrough provides clarity for dozens of families globally and opens new possibilities for diagnostics and counseling in hereditary conditions, offering hope for affected individuals and their loved ones.
A study by Radboud University Medical Center found that pregnant women vaccinated against whooping cough transfer antibodies to their newborns, which provide long-lasting protection. This discovery supports the World Health Organization's recommendation to maintain whole-cell vaccines in low- and middle-income countries.
A recent study found that high doses of rifampicin do not improve survival rates among adults with tuberculous meningitis. The researchers are now exploring alternative treatments targeting inflammation in the brain membranes and investigating TNF inhibitors as potential therapies.
A precision medicine-based approach tailors treatment to each patient's unique immune status, improving disease severity and reducing organ failure. The study reveals a significant improvement in clinical outcomes for patients with specific types of sepsis.
Researchers developed a reliable dataset to determine the best AI model for pancreatic cancer detection, finding that AI outperformed clinicians in detecting and diagnosing the disease. The study suggests that AI can support radiologists in their work and potentially lead to earlier diagnosis and faster treatment.
Researchers found that waiting to treat narrowed coronary arteries after a heart attack is safe and can reduce the number of stent procedures. An MRI scan at a later stage can provide reassurance for patients.
Researchers have unraveled the structure of two key malaria parasite proteins, offering opportunities for new vaccines that block mosquito transmission. The discovery is a significant step towards eradicating the deadly disease.
A recent study from Radboud University Medical Center shows that AI can rapidly assess coronary arteries for vulnerable spots, allowing for more accurate prediction of recurrent heart attacks. This breakthrough could lead to tailored medication or preventive stents, improving patient outcomes.
A research study by Radboud University Medical Center found that an innovative backpack called Gyropack improves balance and reduces the need for walkers in patients with ataxia. The backpack uses gyroscopic technology to generate resistance to rotations, resulting in improved posture and balance.
Researchers at Radboud University Medical Center found that AI detects breast cancer on mammograms more frequently than radiologists. The study analyzed 42,000 breast scans and showed that one radiologist working with AI detects more tumors than two radiologists alone.
A study examining over 1,000 women aged 18-49 found that more than half with an ischemic stroke had experienced pregnancy complications. High-risk factors include preeclampsia, preterm birth, and gestational diabetes.
A 30-year study by Radboud University Medical Center found increased resistance in fungi, with over 2,000 resistant fungal strains collected. The fungus thrives in waste heaps and can cause aspergillosis in vulnerable patients, increasing the risk of death.
Clinical trials show sutezolid and delpazolid are safer alternatives to linezolid for treating drug-resistant TB, with no cases of nerve damage or blood toxicity reported. The findings suggest these drugs could replace linezolid in treatment regimens.
Researchers used metabolomics to analyze cerebrospinal fluid samples from tuberculous meningitis patients and found that certain metabolic pathways may contribute to poor outcomes. Three hydroxylated fatty acids with a maximum carbon length of eight were strongly associated with mortality, regardless of HIV status or disease severity.
Carriers of recessive genes for intellectual disability have shorter school careers, reduced reproduction, and increased medical diagnoses compared to other carriers. This research challenges existing theories on the impact of recessive genes on health and reproduction.
Research reveals lactate's crucial role in trained immunity, a process linking metabolism to epigenetics, enhancing innate immune responses. Lactate production influences DNA architecture, activating genes involved in inflammatory processes.
Researchers from Radboud University Medical Center found that an existing drug can revive immune cells paralyzed by sepsis, a leading cause of death in ICUs. The study provides new perspectives for the treatment of sepsis and may lead to potential treatments for patients with immune paralysis.
A study from Tanzania found that a Western diet can cause inflammation and reduce immune response, while an African diet rich in vegetables and fermented foods has positive effects on the immune system. The study suggests that short-term dietary changes can have long-lasting effects on health.
A large-scale study found that limiting fluid intake in patients with stable heart failure has no health benefits and may even cause increased thirst. Conversely, drinking more fluids without restriction did not lead to any negative outcomes, suggesting that fluid restrictions are unnecessary for these patients.
A remote booster program after cardiac rehabilitation significantly reduces daily sitting time and increases light physical activity, lowering the risk of cardiovascular diseases. Participants who received coaching via phone and digital communication showed a clear improvement in sedentary behavior and increased physical activity.
Research from Radboud University Medical Center found that people with intellectual disabilities are significantly less likely to participate in cancer screenings for cervical, breast, and colon cancer. The results highlight the need for better alignment of screening programs with the needs of individuals with intellectual disabilities.
A European consortium has successfully diagnosed over 500 patients with unknown conditions, including rare neurological disorders and hereditary cancers. The diagnoses were made possible by extensive collaboration and reanalysis of existing genome data.
Researchers have successfully used long reads to identify the genetic causes of rare diseases in 93% of cases, surpassing traditional short read techniques. The technique, which can map methylation and sequence longer DNA segments, has shown promising results in detecting complex genetic mutations.
A study found that propranolol reduces tremors in Parkinson's disease by inhibiting brain activity and reducing the amplifying effect of the stress hormone noradrenaline. Propranolol also works to reduce tremors at rest, suggesting a role for the stress system even when not under stress.
Research from Radboud University Medical Center shows that lockdowns during the COVID-19 pandemic strengthened the immune system's response to microorganisms. The study found that after lockdowns, inflammation levels in the body were low but the immune system reacted more intensely to viruses and bacteria.
Researchers at Radboud University Medical Center developed a super microscope that combines live imaging and electron microscopy, allowing visualization of protein complexes in real-time. This technique opens up new avenues for studying arterial calcification and its potential link to COVID-19 vaccine entry.
Researchers at Radboud University Medical Center found that an extra year of education does not protect against brain aging and has no effect on brain structure. Despite positive correlations between education and cognitive benefits, the study suggests caution in assigning causation when only correlation is observed.
A new study proposes an ethics-based approach to medication decisions in pregnancy, combining existing evidence with a woman's values. The approach aims to balance the benefits and risks of medications for individual pregnant patients and fetuses.
Researchers are combining large datasets to understand the impact of environmental factors on mental health and develop new ways to reduce the burden. A 4-step approach is being used to integrate complex data across many studies, resulting in a detailed perspective of individuals within their environment.
Researchers developed a new PET scan that accurately visualizes benign tumors in the pancreas, known as insulinomas, which can cause low blood sugar levels. The Exendin-PET scan uses a substance found in lizard saliva to detect these tumors, improving diagnosis and treatment outcomes.
A new publication provides essential guidance for conducting rigorous systematic reviews on studies with animals and cells. Regular narrative reviews are prone to biases, but systematic reviews follow a rigorous and transparent methodology, helping researchers make sense of conflicting reports and identify gaps in the field.
A new study found that immunotherapy can effectively treat prostate cancer in men with a specific genetic type, slowing disease progression by four to 33 months. This treatment approach may be beneficial for approximately 4-5% of patients, who experience significant cancer control.
A study by Radboud University Medical Center found that IVF success rates are the same whether embryos are transferred on day three or five after fertilization. This allows couples to make a personal decision about the timing of embryo transfer with their doctor.
Research reveals T cells regulate trained immunity, a process previously thought to be independent of the innate immune system. This discovery offers potential for new treatments in autoimmune disorders, cancer, and cardiovascular diseases.
A recent study published in JAMA Surgery found that about one-third of patients experience persisting abdominal pain five years after cholecystectomy. Researchers recommended caution with the procedure in patients with gallstones and abdominal pain, suggesting a restrictive selection strategy may be more effective.
A saliva test has been found to be more accurate than a blood test in assessing the severity of recurrent respiratory infections in children. The test measures broadly protective antibodies in saliva, which indicate disease burden and predict treatment needs. Saliva testing also holds promise for new treatments and therapies.
A recent study published in The Lancet Oncology found that an AI system can detect prostate cancer nearly seven percent more significantly than a group of radiologists using MRI scans. Additionally, the AI identifies suspicious areas less often, potentially reducing unnecessary biopsies by half.
A study of over 50,000 children with neurodevelopmental disorders reveals congenital abnormalities are at least ten times more common than in the general population. The analysis also maps medical consequences of new syndromes and offers opportunities for better guidance or treatment.
A new AI-powered system has been shown to detect 40% more polyps during colonoscopies, a crucial step in preventing colorectal cancer. This breakthrough technology uses artificial intelligence to examine every pixel in the image and alert doctors to potential issues, allowing for more accurate diagnoses.
A single-nucleotide polymorphism in non-coding RNA AMANZI drives the activation and deactivation of interleukin-1β, affecting the immune response to tuberculosis vaccination. The discovery opens up new possibilities for guiding the immune system.
Researchers at Radboud University Medical Center found that redispensing unused cancer medications can result in significant cost savings and reduced waste. The study, published in JAMA Oncology, suggests that by reissuing up to two-thirds of wasted medicine packaging, annual savings could amount to tens of millions of euros.
A new method, Chameleolyser, reveals previously invisible genetic variations in exome sequencing data. This has led to new patient diagnoses and the discovery of potential disease genes.
A nationwide study by Radboud University Medical Center found that approximately 32 patients in the Netherlands are in a minimally conscious state after severe brain injury. These patients were on average 45 years old and showed signs of consciousness, such as following simple commands or showing emotions.