Researchers found that certain genetic variants increase the risk of steroid side effects, particularly osteoporosis and stroke. Integrating polygenic risk scores into steroid prescribing can improve risk assessment and identify patients at high risk, allowing for closer monitoring or alternative treatments.
A study presented at the Endocrine Society's annual meeting found that exposure to the plasticizer DEHP in early development can lead to increased anxiety-like behavior in adult male rats. The research suggests that humans exposed to endocrine disruptors before and shortly after birth may experience long-lasting behavioral changes.
A study of 336 mother-infant pairs found that breast milk and infant urine contained over 50 different chemicals, including BPA and phthalates, which can interfere with hormones during baby's development. These chemicals were detected in breast milk and urine up to 6 months after birth.
A nationwide study of over 5.7 million women aged 40 found a link between longer reproductive spans and an increased risk of thyroid cancer. The research also showed that hormone replacement therapy, especially for five years or more, was associated with a higher risk of developing the disease.
The study found a significant increase in type 1 diabetes cases among Hispanic/Latino adolescents in Puerto Rico, from 10.1 per 100,000 in 2009 to 24.1 in 2021, with an average annual increase of 4.1%. This trend has important implications for patient care and public health.
A study published by the Endocrine Society found that testosterone therapy was often prescribed without adequate diagnostic testing, highlighting opportunities for quality-improvement efforts. The research suggests that targeted interventions may be needed to improve guideline-concordant prescribing practices and prevent avoidable risks.
A study found that testosterone alone is not enough to prevent type 2 diabetes in older men; lifestyle interventions are crucial for improving blood sugar control and reducing obesity. Testosterone treatment can improve body composition and sexual desire, but its benefits diminish over time.
Researchers found that eliminating sugar from a low-fat diet can lead to impaired glucose control, insulin resistance, and gut microbial imbalance. Balanced dietary carbohydrates are essential for supporting gut and immune homeostasis.
A recent study of 42,000 adults taking blood pressure medications and GLP-1s found higher rates of hypotension events, including dizziness and fainting. The study highlights a potential safety concern for patients aged 65 and older and those with diabetes.
A new AI model analyzed 30 years of EHR data to identify patients with primary aldosteronism, a common cause of high blood pressure. The model correctly flagged over 90% of cases while missing fewer than 10%, suggesting it could improve screening for this condition.
A comprehensive analysis of solid-organ transplant recipients found that both existing and new-onset diabetes significantly increase mortality risk. Organ transplant recipients who developed or have diabetes after surgery had a higher risk of death compared to those without diabetes, with kidney recipients having the highest risk.
A study found that adults taking GLP-1 receptor agonist medications experienced significant decreases in daily step counts and moderate-to-vigorous physical activity, highlighting the need for targeted interventions to promote exercise alongside obesity treatment.
Children who start puberty earlier than usual may not need the same level of testing or treatment, according to a new Endocrine Society Clinical Practice Guideline. The guideline suggests different approaches for various subgroups, including monitoring girls with slow progression and using simpler testing methods.
A new DNA test offers a much more complete picture of DNA than current standard diagnostics, leading to a diagnosis more often. The test can replace fifteen other tests, making it faster and more efficient for rare genetic disorders.
A large-scale Phase 3 trial of CRISPR therapy has shown an 87% reduction in attacks for patients with hereditary angioedema. The treatment also improved quality-of-life scores and reduced the need for on-demand medication, paving the way for future genetic therapies.
Leading child psychologist Dr. Barish argues that grandparents have a crucial role to play in helping children develop a sense of purpose beyond personal success and in providing emotional support. He recommends practices like volunteering together and frequent family conversations about kindness and understanding.
Researchers create PhishLumos AI system to detect phishing campaigns by analyzing infrastructure clues, achieving 8-day faster detection than experts. The system uncovered over 190,000 new links, with 92% later flagged as malicious, outperforming content-centric approaches.