A new stem cell therapy has been developed by MUSC researchers, which shows promise in reversing Type 1 diabetes in a mouse model. The therapy uses mesenchymal stem/stromal cells genetically modified to produce alpha-1 antitrypsin, shielding surviving insulin-producing cells and stopping the overactive immune response.
Researchers found that a compound already in clinical trials for age-related muscle loss may mitigate the negative effects of GLP-1 on muscle health. In young adult mice treated with semaglutide, PGDHi enhanced muscle regeneration and recovery after injury, restoring strength without undermining fat loss.
A recent study found that Caribbean reef sharks prefer locations with dense prey populations, making food abundance an essential factor in their habitat choice. The research suggests that prey conservation should be considered alongside fishing bans to support shark conservation.
A new SFU study analyzed 87,000 grocery carts in Canada and Finland to understand why shoppers don't buy more plant-based proteins. The research found that while price is a factor, it's not the only consideration, and having a variety of options also plays a role.
Researchers have developed a new citation ranking system called EDM to identify and credit scientific breakthroughs. The system uses neural language models to provide stable representations of papers and can detect simultaneous discoveries, fixing a blind spot in the original disruption index.
Scientists have discovered a rare meteorite that provides definitive evidence of a massive early planet, possibly as large as Mars or the moon. The Northwest Africa (NWA) 12774 angrite meteorite's unique geological makeup suggests a distinct evolutionary path in planetary formation.
The SETI Institute has awarded $1 million in STRIDE grants to support cutting-edge research in astrobiology, exoplanet science, and public engagement. The awards will fund projects that push the boundaries of life detection, planetary climate modeling, and innovative education initiatives.
Dr. Mina Sedrak has been selected to co-lead the Cancer in the Older Adult Committee of The Alliance for Clinical Trials in Oncology, focusing on improving care and outcomes for older adults with cancer. As a leading expert on aging and cancer, Sedrak aims to expand research on this population and address their unique needs.
A difference-in-differences analysis found that Georgia's Pathways to Coverage program worsened mental health among low-income adults. This suggests that work requirements may create barriers to coverage and care access, affecting population health and equity.
A new model predicts retinal degeneration in diabetics based on 71 plasma proteins. The Pro-DRN model can help doctors identify patients at risk earlier, potentially preventing neurodegeneration and vision loss.
A new study has found that cancers with shrunken genomes are more widespread than previously thought, often associated with highly unstable tumours. Researchers developed a method to distinguish between two leukaemias based on recurring chromosome patterns, offering important clinical insights for patient treatment decisions.
Researchers have identified RET as a biomarker for neuroendocrine prostate cancer and developed a theranostic pair for PET imaging and radioligand therapy. The approach demonstrates high uptake in tumors and shows promise for treatment, offering an alternative to current PSMA-based imaging.
A study from Texas A&M University found a strong link between childhood trauma and depressive symptoms among college students. The study revealed that using multiple substances, particularly cannabis and stimulants, increases health risks and makes substance use disorders harder to treat.
The University of Liverpool has signed a Memorandum of Understanding with Mirion Technologies to expand collaboration in nuclear science, radiation protection and related strategic technologies. The partnership aims to strengthen education in radiation detection and measurement, as well as jointly pursue funding opportunities for large...
The global Brain Health accelerator aims to identify specific brain cells and circuits affected in neurodegenerative diseases. By prioritizing research using healthy and diseased human brain tissue, researchers will generate findings relevant to human disease and develop precision genetic therapies.
Researchers propose embedding AI foundation models into control software to enable robot swarms to achieve new levels of autonomy and adaptability. This enables robots to switch between tasks in real-time and interact more naturally with humans.
Researchers found that combining formoterol and methacholine speeds up mucociliary clearance, reducing chronic lung infections. The combination is safe and well-tolerated, offering a new approach to managing the disease.
Researchers at IRB Barcelona used AI to design new chemical entities that selectively target specific cell types, demonstrating superior activity compared to conventional screening strategies. The methodology, called phenotypic discovery, uses observable responses in cells rather than a specific molecular target.
Researchers found that CTHRC1, a secreted protein in tumor microenvironment, promotes colorectal cancer growth by limiting effective immune surveillance. The study suggests targeting CTHRC1 as a promising new strategy for future therapies.
Researchers developed an approach to dynamically distribute medical applications across the network, assessing requirements and resources to optimize processing. This enables future 6G networks to provide reliable, flexible, and digitally supported medical care with improved utilization.
Researchers developed piezoelectric patch sensors that track finger movements to play rock-paper-scissors, promoting self-motivated healthcare and entertainment. The sensors provide quantifiable data and objective feedback, improving patient outcomes through accessibility, independence, and motivation.
Researchers have discovered a new way plants build regulatory diversity without changing protein-coding sequences, using miniature inverted-repeat transposable elements (MITEs) to carry binding sites for key transcription factors. This finding highlights the potential of noncoding mobile DNA as a resource for crop genetics and breeding.
A new AI-powered translation program developed by the National Weather Service (NWS) translates weather forecasts into multiple languages, including Spanish, Chinese, Vietnamese, Samoan, and French. The program aims to provide life-saving information to over 68 million US residents who do not speak English at home.
The University of Texas at San Antonio has received significant funding from the Cancer Prevention and Research Institute of Texas to develop innovative cancer research technologies and treatments. The institution will focus on pressing cancers such as Ewing sarcoma, obesity-related endometrial cancer risk, and AI in clinical oncology.
The 2025 Editor-in-Chief Choice Award recognizes exceptional original research article and review paper publications in the journal Advanced Photonics. The award honors innovative research in all areas of optics and photonics, including fundamental and applied research.
Researchers have identified Prionus imbricornis, a longhorn beetle species, as the culprit behind attacks on North Carolina blueberry fields. The larvae of this emerging pest can grow up to five inches long and destroy roots, potentially killing trees.
A multicenter clinical trial found that adding aglatimagene besadenovec to standard radiation therapy improved disease-free survival for intermediate- and high-risk localized prostate cancer patients. The treatment reduced the risk of recurrence by 27% compared to the placebo group.
A novel biomaterial containing jackfruit latex, pomegranate peel extract, and simvastatin shows promising efficacy in treating periodontitis. The material has adhesive properties, allowing for targeted release of therapeutic compounds, and has been shown to promote regeneration of periodontal tissues.
The Barcelona Supercomputing Center has inaugurated its third quantum computer, EuroQCS-Spain, integrating classical and digital computing with analog processing. This system enhances MareNostrum 5's capabilities, supporting European research and industry in quantum technologies.
A University of Cincinnati research team will examine how microplastics and nanoplastics accumulate in the body and affect cardiovascular health, with a focus on potential toxicity and worsening outcomes after a heart attack. The five-year study aims to advance understanding of microplastic impact on heart diseases.
The energy retail sector is a vulnerable part of the energy industry's value chain and critical infrastructure. A new study proposes concrete methods to strengthen cybersecurity resilience in retail organisations.
Researchers at Max Delbrück Center have found a way to improve CAR-T cancer therapy by engineering cells to express the receptor CCR7. This allows CAR-T cells to penetrate lymph nodes more efficiently and kill cancer cells quickly.
A recent study found that individuals with pathological internet use exhibit a strong tendency to approach internet-related stimuli, indicating automatic and unconscious processes play a major role in usage behavior. This insight could help identify risk groups and inform therapy strategies.
Researchers have discovered a previously underappreciated mechanism that helps immune cells respond rapidly to infections by altering RNA splicing. This study provides new insights into immune-mediated diseases such as rheumatoid arthritis and lupus, and may lead to more targeted therapies.
A Concordia University study reveals that Quebec's forests are recovering with an increase in conifer species, driven by the growth of balsam fir. The researchers used satellite imagery and ground-based forest inventory data to track changes over three decades.
Researchers at the Hebrew University of Jerusalem have created a novel method for cultivating meat using plant-derived cellulose scaffolds. This approach significantly reduces production costs by infusing growth factors directly into the scaffold, allowing for comparable tissue development with lower factor usage.
Astronomers at UNC-Chapel Hill played a key role in identifying the source of mysterious long-period radio transients. The discovery of ASKAP J1745–5051, a binary star system containing a white dwarf and red dwarf companion, provides strong evidence for the origin of these unusual bursts of radio waves.
Researchers have published a comprehensive guide on the use of routinely collected health data to improve research quality. The guide addresses key problem areas such as representativeness, data quality, and temporal alignment, and provides strategies for ensuring data quality and reporting studies transparently.
A new leishmaniasis vaccine, developed using CRISPR gene-editing technology, is set to begin testing in healthy people for its safety and immune response. The vaccine has shown strong results in mice and has cleared a key FDA hurdle, paving the way for Phase 2 trials aiming to understand its effectiveness.
Researchers found that older adults' brains process balance information significantly slower than younger people's, taking almost 50% longer to process this information. This results in a substantial 'processing delay', requiring older individuals to actively maintain their balance.
During the most severe drought in the Amazon basin, vegetation emitted new sesquiterpenes as stress signals and protective compounds. These emissions persisted long after the stress ended, revealing an adaptive response to oxidative stress.
Researchers have found a widely available drug combination to be an effective treatment for patients with systemically active Sjögren's disease. The combination of leflunomide and hydroxychloroquine reduced disease activity while maintaining a favorable safety profile.
Researchers from Virginia Tech found that airborne particles have an outer alkaline shell, contradicting the traditional view of uniform droplets. This discovery has significant implications for understanding air quality and climate change.
A new detection method for PFAS chemicals in drinking water has been developed by University of Kansas researchers. The fast-flow solid-phase extraction (SPE) approach reduces the time and cost required to analyze ultra-trace amounts, making it feasible for widespread implementation.
Scientists at the University of Groningen have successfully elucidated the exact composition of tiny pheromones produced by the Trichogramma turkestanica, a type of parasitoid wasp. The team used advanced techniques to separate and analyze the volatiles, ultimately synthesizing the pheromone and revealing its structure.
A WVU study found that pregnant women who spend more time sitting are at a greater risk of developing gestational diabetes and preeclampsia. Sitting for over 10 hours a day was associated with twice as many adverse pregnancy outcomes as shorter periods of sitting.
Journalists from eligible European countries can submit entries in two categories: Women’s Health and Pharmaceutical Strategies. The total prize fund is €45,000, with €10,000 awarded to the first prize winner.
Researchers found habits transition from goal-directed to habitual behavior in a matter of seconds, contrary to the long-held theory of gradual strengthening. This rapid transition suggests a brain region plays a key role in altering entrenched habits.
Researchers discovered that a common rifampicin-resistance mutation in tuberculosis creates subtle metabolic weaknesses, which could be exploited with future combination therapies. The most common mutation slows bacterial RNA polymerase, creating vulnerabilities that other therapies may target.
A new study identified key warning signs for infection after ankle fracture surgery in older patients. Low protein levels, chronic alcohol abuse, and poor post-operative care were found to increase the risk of infection.
Researchers developed a personalized risk prediction model to identify cancer patients who may struggle with treatment costs, medical debt, and anxiety. The model uses patient information to estimate the likelihood of financial toxicity, balancing detection sensitivity with minimizing false alarms.
Researchers developed a miniaturized human intestine model to study EV-A71 infection, revealing the virus's ability to evade the immune system and persist for extended periods. The model showed long-term viral replication without triggering a strong immune response.
Researchers developed a cathode-modulated vacuum/air-channel electron tube that eliminates gate leakage current, enabling vacuum tubes to function in integrated circuits. The device operates at room temperature and atmospheric pressure, offering non-saturating output characteristics and potential for high-frequency applications.
The project aims to expand University Hospitals' collaborative care model from 26 practices to all 88 practices within the UH Primary Care Institute. It will also broaden services to include screening and treatment for conditions such as bipolar disorder and post-traumatic stress disorder (PTSD).
A new study published in Nature Water finds that wetland loss across the US has increased residential flood insurance claim payments by more than $10 billion since 1985. The analysis links changes in upstream wetland area to downstream National Flood Insurance Program claims, highlighting the critical role of wetlands in reducing river...
Researchers developed ultrathin CdS nanosheets decorated with Ru single atoms and S vacancies, enabling record-high performance for ethanol photoreforming. The catalyst achieved a hydrogen evolution rate 81.5 times higher than pristine CdS and 100% selectivity for valuable chemicals.
Research found that active pharmaceutical ingredients degrade at a higher rate when stored in resealable plastic bags compared to original packaging, posing risks for astronauts during space missions.
Scientists found that epigenetic changes can be inherited without altering DNA in certain animals, such as sea anemones. These changes can alter gene expression and potentially disrupt development, highlighting the importance of ancient systems of gene regulation.
Researchers at Stanford University have identified a new type of immune cell called ruptoblasts in flatworms, which can kill surrounding cells through an explosive process called ruptosis. This discovery could hold important insights for modern medicine and may lead to targeted treatments for bacterial infections or tumors.
Prediagnostic statin use showed no association with higher survival rates, but postdiagnostic use was linked to lower all-cause and breast cancer-specific mortality among hormone receptor-positive subtypes. Statin therapy may improve survival of these patient groups.