The team created a tile that captures, holds, and slowly evaporates water, cooling surfaces without fans or compressors. The tile's unique design, inspired by African elephant skin, allows it to maintain a stable temperature of 89.6° Fahrenheit under infrared heating and periodic watering.
Researchers have discovered a wave-interference effect that makes sound energy appear to outrun fundamental limits without breaking physics. This finding could improve whale tracking by pinpointing the location of whales based on the phase of their calls.
Penn researchers have developed a mobile microbiology laboratory allowing them to test water quality and track antimicrobial resistance in and around San Cristóbal in the Galápagos. The team identified sites of untreated wastewater contamination, including 'hot spots' of pollution around Puerto Baquerizo Moreno.
A multidisciplinary team of Penn researchers has developed a platform that delivers a combination of cancer-fighting therapies to treat oral squamous cell carcinoma. The findings show that the platform significantly reduces tumor burden and extends survival in aggressive, p53-therapy-resistant cancer models.
Two studies led by Montserrat Anguera investigate the process of X chromosome inactivation in immune cells and link impaired XCI maintenance to lupus-like disease. Impaired X chromosome inactivation in B cells has been linked to lupus, offering a novel pathogenic mechanism that accounts for the strong female sex bias of SLE.
Researchers have developed a gene-editing tool that unlocks the secrets of fungi, a kingdom rich in antibacterial compounds. The tool, called fPE7max, enables precise control over DNA sequences and has identified three novel molecules with anti-cancer properties.
Researchers developed a low-cost AI tool to forecast demand and optimize medicine allocation in Sierra Leone. The tool increased consumption of allocated medical products by 19% and improved access to essential medicines for over two million women and children under five, with no additional workforce costs.
A new study reveals that social networks can correct anchoring bias, a pervasive cognitive error. Participants in network groups showed significant improvement in their estimates after exchanging opinions with peers, while those working alone did not. The key to this effect lies in the confidence participants have in one another.
Researchers at Penn have created quasiparticles that combine the speed of light with strong matter interactions, enabling signal switching needed in computation. This advancement could lead to faster, more energy-efficient photonic AI chips and pave the way for basic quantum computing capabilities.
A high-resolution model developed by University of Pennsylvania researchers shows that river levels once expected every 50 years now occur every few years due to climate change. The 1-in-100-year threshold marks a tipping point when flooding spreads rapidly across the urban landscape.
The University of Pennsylvania has been awarded a three-year, $650,000 Institutional Challenge Grant to support a research-practice partnership focused on addressing youth homelessness across the Commonwealth. The partnership aims to examine the effectiveness of state policies in reducing homelessness and create an evidence-based polic...
A new study by Femida Handy and Sara Konrath found that voting is associated with reduced mortality risk in older adults for up to 15 years. Voting predicts a lower risk of mortality, even when the candidate loses, suggesting that voting itself is more important than who was voted for.
Researchers have shown that extracts from bioengineered chewing gum reduce levels of three microbes linked to worse outcomes in oral cancers, including HPV and bacteria Pg and Fn. The findings support the value of advancing these therapies to clinical trials as adjuvants or prophylaxis.
Researchers tracked galaxy clusters to test gravity's strength, finding it weakens with distance as predicted by Newton and Einstein. The study confirms the existence of invisible dark matter, closing the door on alternative theories like Modified Newtonian Dynamics.
Researchers developed a lab-grown organoid system that faithfully mimics human adrenal gland development and forms complex tissue structures. The system enables the study of adrenal biology, cortisol production in response to stress, and disease development, with potential applications for regenerative therapies.
New research demonstrates that restoring the physical stiffness of the gingival tissue can fundamentally change how cells respond to infection, potentially paving the way for new treatments. The study uses a hydrogel system to investigate how gum tissue stiffness impacts periodontal disease inflammation.
Researchers have developed a new CAR T therapy that targets tumor-supporting cells in pancreatic cancer, paving the way for a potentially safer and more effective treatment. The therapy uses lipid nanoparticles to deliver CAR instructions directly to patient T cells, resulting in higher expression rates and improved efficacy compared t...
A novel plant-based approach uses lettuce chloroplasts to produce functional GLP-1 peptides, paving the way for more affordable and better-tolerated oral medications. This method bypasses hurdles such as manufacturing cost, delivery system, and side effects associated with conventional approaches.
Researchers found that long-standing mating preferences led to sex-biased interbreeding, resulting in the loss of Neanderthal DNA on X chromosomes. The study reveals a complex social history of human evolution, challenging the idea that survival of the fittest drove human migration.
A new study finds that a novel GLP-1 receptor agonist, Exendin-4-Phe (Ex-Phe-1), preserves glycemic control while reducing malaise and vomiting behaviors in preclinical models. The compound uses biased agonism to selectively activate certain signaling pathways, achieving desired effects without triggering others.
Researchers at the University of Pennsylvania found that rewarding 'reformers' who improve the collective prediction regardless of their own personal accuracy leads to more accurate and diverse outcomes. This approach is more effective than rewarding 'niche experts' or 'experts', which can lead to a loss of diversity and accuracy.
Plants have a cellular strategy to adapt to environmental changes, balancing growth and flowering responses through dynamic protein relationships. This adaptation allows for continuous flower production, increasing the chances of seed production in changing conditions.
Researchers at Penn Vet have shown that trained dogs can identify the odor of hemangiosarcoma, a malignant cancer of blood vessel cells, with an accuracy rate of 70%. Early detection could lead to better outcomes, including prevention of disease spread and earlier removal of the spleen or initiation of chemotherapy.
Researchers have made a groundbreaking discovery about how bacteria swim upstream to cause infections, pointing to new designs for biomedical devices that can prevent contamination. The study found that wider channels with faster counterflows are more prone to invasion, but sharp corner designs can inhibit bacterial growth.
A study found that switching to electronic medical records at HIV clinics in Malawi led to a 28% reduction in deaths after five years, with the greatest impact on children. The introduction of EMR systems prevented approximately 5,050 AIDS deaths and improved healthcare efficiency.
A recent study by Professor Damon Centola and alum Douglas Guilbeault found that content moderators who worked in teams reached near-perfect agreement on classifying controversial material online. In contrast, individual participants showed only 38% agreement, with Democrats and Republicans agreeing on classifications for only about 30...
A team of researchers at the University of Pennsylvania has designed a new light-controlled cholesterol molecule that selectively targets two poorly understood sterol transport proteins, ORP1 and ORP2. This breakthrough enables precise spatiotemporal control over cholesterol's biological activity, paving the way for advanced therapeutics.
Scientists at Penn Vet have identified two genes, Ctnna1 and Bcl2l13, that suppress metastasis in preclinical models of colorectal cancer. These findings could lead to better treatments and therapies for patients with metastatic disease.
A team at the University of Pennsylvania has solved the mechanism of action of hydralazine, revealing its potential to halt the growth of brain cancer cells. By blocking an oxygen-sensing enzyme, hydralazine can reduce intracellular calcium levels, causing blood vessels to relax and tumor cells to enter a dormant state.
A study published in Nature found that wild birds, particularly ducks, geese, and swans, are driving the current US bird flu outbreak. The viruses were introduced to North America via migratory birds and have become better adapted to infect wild birds since 2020.
Researchers have developed a new large-scale brain data resource that integrates data from five studies of brain development in children and young adults across three continents. The Reproducible Brain Charts (RBC) project provides a harmonized dataset for tracking changes in brain structure and function, allowing researchers to better...
Researchers have identified a group of cells called Y1 receptor-expressing neurons in the brainstem's lateral parabrachial nucleus as critical for regulating long-term pain states. These neurons integrate information about hunger, fear and thirst, allowing pain signals to be modulated by other brain circuits signaling more urgent needs.
Telomeres, which cap chromosomes, are inherited from parents in a parent-of-origin effect, with mothers contributing short telomeres and fathers long ones. This process is linked to cancer risk and aging, and researchers hope to study it further using human genome sequencing.
A recent study found dramatic differences in how large language models classify hate speech, with significant variations for specific demographic groups. The analysis of seven models revealed that content moderation systems have inconsistent detection accuracy, which can erode trust and create perceptions of bias.
A new system developed by Penn researchers allows light to be guided through tiny crystals with minimal scattering or reflection. This breakthrough paves the way for more efficient and controllable photonic chips, enabling faster data transmission and reduced errors.
Researchers at the University of Pennsylvania have discovered a way to synthesize new multi-metal 2D materials by adding up to nine metals into the mix. This finding opens up possibilities for designing materials with precisely controlled properties for diverse applications.
Research finds that young children aged 3-5 can recognize happiness, sadness, calmness, and fear in music. However, children with higher callous-unemotional traits show poorer emotion recognition in music compared to facial expressions.
Researchers found that children unexposed to HIV had higher taxonomic turnover in their oral microbiomes, indicating less adaptability to environmental changes. Children living with HIV had more stable oral microbiomes and higher frequencies of cavity-causing bacteria.
A study of 365 adults found nearly one in four had a genetic condition causing their ICU admission, which was unknown to nearly half of those patients and their doctors. The researchers recommend offering genetic testing to all adults admitted to the ICU to improve care and reduce health disparities.
A team of Penn engineers and materials scientists have developed a biomineral-infused concrete that captures up to 142% more CO2 than conventional mixes while using less cement. The new material is stronger, lighter, and uses fewer materials like cement.
Researchers from Penn University propose a five-member particle package, known as the 5-plet, that string theory cannot accommodate. This particle family is absent in any known string-based calculation, raising concerns about the framework's validity.
Scientists have developed a miniature device that mimics human bone marrow and immune environment, enabling predictive testing of cancer immunotherapy success in patients. The device recreates three regions of bone marrow where leukemia develops and retains the complex immune environment of the tissue.
Researchers have discovered two signaling molecules that can reprogram ant duties, mirroring gene-expression patterns found in eusocial naked mole-rats. These findings suggest a convergent molecular mechanism dating back hundreds of millions of years, hinting at the evolutionary depth of social behavior.
Scientists have modified mRNA vaccines to include the cytokine IL-12, enhancing T cell responses and improving protection against diseases such as SARS-CoV-2, influenza, melanoma, and listeria infection. The study's findings suggest a promising approach to enhance immune stimulation against cancer and other pathogens.
Researchers at the University of Pennsylvania have created mirror-image molecules that both directly attack bacterial membranes and stimulate the immune system. The dual-action peptides have shown promise in treating infections by reducing bacterial counts and speeding healing, while also promoting sustained immune response.
Researchers at the University of Pennsylvania developed novel promoters that drive specific gene expression in rod and cone photoreceptors, outperforming most currently used promoters. These tools address the challenge of treating advanced stages of inherited retinal diseases, potentially restoring vision.
A team of researchers developed a machine learning model called Aurora that accurately forecasts various Earth systems, including air quality and tropical cyclone tracks. The model outperforms traditional systems at a fraction of the cost, enabling better preparedness for extreme weather events.
Researchers tested 17 behavioral strategies to overcome barriers to climate action, finding that emphasizing relevance and future thinking are most effective. Interventions like letter-writing and brainstorming short-term benefits increased intentions to act on both individual and collective levels.
Researchers at Penn's School of Dental Medicine and Perelman School of Medicine found that ACE inhibitors can inhibit the activity of ACE2, a critical cardioprotective enzyme. This discovery has implications for human patients prescribed these medications, who may benefit from additional ACE2 treatment.
A team of physicists at the University of Pennsylvania has discovered that pouring water from a height creates a stronger mixing effect, increasing extraction efficiency in pour-over coffee. By optimizing flow rates and pour heights, they found that more coffee grounds can be used without diminishing overall quality.