The National Institutes of Health has awarded a $2.5 million Phase II Small Business Innovation Research (SBIR) grant to Case Western Reserve University to develop medical technology that can track specific cells in the body, including cancer cells. This technology aims to enhance the ability to locate therapeutic cells or diseased cells.
Researchers at UC San Diego found that cancer cells use non-genetic mechanisms to regrow after targeted therapy, which could help prevent tumor recurrence. By blocking these signaling pathways, future treatments may be able to stop tumors from relapsing during therapy.
A new report by the University of Warwick finds that artificial intelligence is being developed primarily for efficiency and service improvements, rather than benefits for local communities. The report calls for greater public participation in AI policy design to ensure technologies deliver tangible benefits where they are needed most.
A new survey by Morning Consult and Physicians Committee finds that 65% of adults support a program allowing migrant farmworkers to remain in the US. This would help grow and harvest sweet potatoes, cranberries, and other holiday foods. The survey also shows that 75% of adults find turkey-free dishes appealing, and 64% consider focusin...
A team of scientists at the University of Tokyo has developed an automated, high-throughput system that uses machine learning to analyze droplets of biofluids for disease diagnosis. The technology relies on imaging drying processes to distinguish between normal and abnormal samples.
Low-dimensional halide perovskites offer unique light-matter interactions, enabling advanced optoelectronic functionalities. The review highlights emerging device applications, synthesis strategies, and dimensional engineering for enhanced optoelectronic performance.
A team of scientists discovered a unique radio emission, the hectometric continuum, that appears after sunset and disappears before sunrise. This phenomenon is linked to processes in the near-Earth plasma and may be related to exoplanetary magnetic fields.
This study evaluates the long-term effects of IMRT on HNC patients' vision, patient well-being, and morbidity. A cohort study of adults with HNC treated with IMRT in Ghana will investigate visual outcomes and quality of life.
Researchers used CRISPR to increase fungal production efficiency and cut environmental impact by 61% without adding foreign DNA. The genetically tweaked fungus tastes like meat and is easier to digest than its naturally occurring counterpart.
A metabolomics study found galangin accelerates yeast sedimentation and promotes premature flocculation in beer fermentation. Researchers identified galangin as a key promoter of yeast aggregation and propose strategies to improve fermentation control.
PtBi2 exhibits topological superconductivity with paired electrons confined to surfaces, forming a natural superconductor sandwich with normal metallic interior. The material also produces long-sought-after Majorana particles along its edges, which could be used as fault-tolerant quantum bits.
Research universities see no correlation between non-academic staff and efficiency, but teaching-oriented universities experience a positive correlation. Administrative staff play a key role in improving performance in these institutions.
A new AI tool, SMMILe, can rapidly analyze complex cancer images and provide detailed information about tumor lesions, including their locations and proportions. This could lead to more accurate diagnoses and personalized treatment options for patients.
This study found that applying 180 kg N ha⁻¹ with short-term low-intensity shading significantly improved plant growth, photosynthesis, and antioxidant capacity. Shading deepened leaf greenness and increased chlorophyll a and b content without altering their ratio.
Researchers are developing neoantigen-based dendritic cell vaccines that aim to train the immune system to recognize tumor-specific mutations and trigger targeted immune responses against cancer cells. Clinical trials have shown promising results, with patient-derived DC vaccines triggering strong, durable immune responses, delaying tu...
The review highlights the progress in gene-editing nucleases and delivery vectors for in vivo gene therapy, enabling targeted correction of genetic errors. Key examples include FDA-approved products targeting monogenic disorders and cancers, showcasing the therapeutic promise of combining genome editors with advanced delivery platforms.
Lung cancer screening has the potential to prevent 3 times more deaths and gain 3 times more life-years than current levels. Increasing awareness and accessibility of lung cancer screening could lead to wider adoption.
A global survey of 858 ECT recipients found women are more likely to experience long-term memory loss and other adverse effects. Women were also less likely to report improved mood after treatment.
A review of machine-learning innovations in the tea industry highlights breakthroughs in non-destructive assessment, cultivation, harvesting, processing, and quality assurance. These technologies achieve accuracy rates exceeding 95% in tea grading and chemical prediction.
The study reveals that the Five Great Forests of Central America support between one-tenth and nearly one-half of global populations of 40 migratory bird species. These forests provide crucial food and shelter for birds like Wood Thrushes and Magnolia Warblers during their annual migrations.
Researchers differentiate true 2D passivation from amorphous capping in perovskite solar cells using a single-atom fluorine substitution. The n-type crystalline 2D layer achieves high efficiency and stability, offering a design rule for next-generation modules.
PRX Intelligence, a new open access journal from APS, publishes high-impact research on AI and machine learning advancing physical sciences. The journal accepts submissions starting Feb 2026, with flexible article formats and no publication charges for 2026 manuscripts.
The study found a positive shift in the prevalence of adverse childhood experiences (ACEs) among U.S. children between 2016 and 2023, with an increase in individuals reporting 0 ACEs and a decrease in severe ACEs. This trend suggests a reduction in severe ACEs among specific racial and ethnic groups and low-income families.
A systematic review suggests that garlic extract mouthwash may be a viable alternative to chlorhexidine, offering longer-lasting residual effects but potentially causing greater discomfort. The review found higher concentrations of garlic extract demonstrated antimicrobial efficacy comparable to chlorhexidine.
Researchers from ETH Zurich found that individuals with a positive uncertainty mindset are more supportive of social diversity and less likely to vote for right-wing populist parties. The study suggests that by influencing how people think about uncertainty, it is possible to shape attitudes towards diversity and societal change.
Researchers at the University of Cambridge have developed a new method to electrically power insulating nanoparticles using molecular antennas. This breakthrough creates a new class of ultra-pure near-infrared LEDs with applications in biomedical imaging, optical communications, and sensing. The devices can be turned on with low operat...
Lipid droplets, once considered inert fat storage units, are now recognized as dynamic organelles involved in cellular signaling and energy metabolism. Exercise is shown to promote lipid droplet degradation through critical pathways, reducing harmful lipid accumulation and mitigating associated risks in various organs.
A KAIST team has developed a modular co-culture platform to produce multicolored bacterial cellulose, overcoming the limitations of environmental challenges and complex processing requirements. The platform enables one-pot production of colored living materials without additional chemical processing.
Researchers from Keio University Global Research Institute successfully generated orbital currents using sound waves, establishing a foundation for integrating acoustic technology with orbitronics. The discovery paves the way for next-generation electronic devices.
A recent study published in JAMA Cardiology found that high blood pressure during adolescence can increase the risk of atherosclerosis in middle age. The study analyzed data from over 15,000 men and found that even mild hypertension at age 18 was associated with an increased risk of cardiovascular disease.
Researchers developed a comprehensive roadmap for additive-manufacturing of key components at <100 °C, reducing platinum use and assembly steps. The work showcases 3D-printed hydrogen components with ultra-low precious-metal loading and rapid prototype-to-test cycles.
Scientists discovered a novel way to fuse lipid vesicles without pre-treatment or harsh conditions using the diphtheria toxin's T domain. This breakthrough enables targeted membrane fusion at neutral pH for applications in lab-on-a-chip technologies, biosensors, and synthetic biology.
Researchers created non-precious single-atom catalysts for chlorine production, achieving low overpotentials and high selectivity comparable to commercial electrodes. The key to their performance lies in an oxygen atom positioned at the 'on-top' site of the catalyst.
A recent study found that young donors (18-35 years old) with minor HLA differences can provide better survival rates and outcomes compared to older sibling donors. Additionally, gender and CMV status also play a role in donor selection.
Adults with higher levels of physical activity during midlife and late life have a lower risk of all-cause and Alzheimer's disease dementia. This cohort study, part of the Framingham Heart Study Offspring cohort, found similar reductions in risk across different age groups.
Research highlights the role of ATAD2 in promoting glioma progression by co-activating PDK1 with E2F1, leading to poorer prognoses in patients. A personalized prognostic nomogram using CTARS has been developed for predicting clinical outcomes.
Researchers have uncovered how the motor cortex and striatum work together like an hourglass to flexibly control movement timing. By tracking neural activity patterns and manipulating specific brain regions using optogenetics, they identified the critical role of each region in the brain's internal timer.
Two Virginia high school students found that sea anemones experience stress due to hyposalinity caused by hurricane rainfall. They also discovered a threshold of 20 parts per thousand where protective mechanisms fail, highlighting the need for conservation strategies.
Researchers discovered that chromium dissolution in Co-Cr spinel oxide creates an oxyhydroxide, activating cobalt and maintaining its activity over a long period. This breakthrough could lead to more efficient and sustainable catalysts for hydrogen production.
Researchers identified six major genetic groups, including the small-leafed sinensis and five broadleaf assamica populations from India, Indochina, and Yunnan. The study provides a genetic roadmap for global tea conservation and breeding, defining clear population boundaries and uncovering underused germplasm.
A recent USF study found that smoking cannabis and consuming omega-6 enriched processed foods compromises the immune system, leading to weakened heart function and increased inflammation. The combination can weaken the body's defense mechanism, making it harder for the heart to repair damage caused by inhaling cannabis.
Two new studies found that ambient clinical documentation tools can cut down on administrative time and help physicians be more mentally healthy and present with patients. Clinicians who used the tool reported lower burnout and lighter cognitive load, while also spending less time interacting with electronic health records.
Researchers have discovered that ATAD2 promotes glioma progression by working with E2F1 to activate PDK1. The study also found that high levels of ATAD2 are associated with poorer outcomes in glioma patients.
Researchers developed a probe to visualize lipid breakdown in living cells, revealing differences in breakdown rates among individual droplets. The study found that an enzyme called ATGL drives these variations, which may contribute to abnormal lipid metabolism in liver cancer cells.
New research reveals VEGF(R) inhibitors induce arthritis through increased inflammatory responses and activation of pro-inflammatory pathways. The study provides important mechanistic insights into this treatment-related adverse event, ultimately enhancing oncology care safety.
Craniopharyngiomas are managed effectively with stereotactic radiosurgery (SRS), which provides high-dose radiation to tumors while minimizing risks to surrounding tissues. Studies have shown comparable control rates to conventional radiotherapy, but SRS is associated with lower incidence of hypothalamic obesity and long-term sequelae.
The review highlights the complex relationship between mitochondria and tumorigenesis, exploring molecular mechanisms underlying this association. Mitochondrial dysfunction is linked to various cancers, and targeting mitochondria represents an ideal anti-tumor therapeutic approach.
This study summarizes evidence on sedation monitoring in neurocritical care patients, highlighting best practices for improving monitoring accuracy and patient outcomes. It emphasizes the importance of establishing a dedicated sedation monitoring team in neurosurgical ICUs.
A Washington State University-led study in Guatemala found that community perceptions of water safety often do not align with actual water quality. Bottled water was found to be the most frequently contaminated source, with only 17% meeting World Health Organization standards.
The new HeiGIT dataset combines PlanetScope imagery with deep-learning models to analyze major transport routes, providing a high-accuracy global classification. The dataset supports better routing for logistics, infrastructure management, and emergency planning, highlighting disparities in road quality and its link to human development.
Wiley has expanded its spectral libraries with major updates to IR, Raman, and LC-MS collections, delivering researchers enhanced capabilities for faster and more confident compound identification. The expansion brings over 9.5 million high-quality spectra, including 1 million IR spectra and 161,000 Raman spectra.
Researchers at Virginia Tech's Fralin Biomedical Research Institute are studying how fluid flow contributes to the spread of glioblastoma tumors. They will use focused ultrasound and advanced MRI techniques to build a map of fluid flow in the whole brain and test the effectiveness of drug delivery.
Researchers develop tiny microspheres packed with blood-sensing bacteria that detect gastrointestinal disease markers. The sensors are easy to collect from stool and can diagnose conditions like colitis and colorectal cancer.
Middle-aged Australians are experiencing mounting pressures as they balance work, family, and financial demands, leading to declining life satisfaction and increased stress. Women face sharper declines in wellbeing due to unpaid care and time stress, with one in ten caring for both children and ageing parents.
A systematic review and meta-analysis found that lithium supplementation did not significantly improve cognitive function in individuals with mild cognitive impairment or Alzheimer's disease. Alternative formulations like LIT-O may be a potential alternative to harness lithium's neuroprotective properties more efficiently.
Top firms paradoxically fire good workers to maintain reputation and boost profits. Workers accept lower pay temporarily to signal elite status, while those who stay earn higher fees directly from clients. The firm's strategic underpayment of better workers increases profits by creating a stable equilibrium.
Researchers have developed a system called CytoDiffusion that uses generative AI to study the shape and structure of blood cells. The system can accurately identify normal blood cell appearances and spot unusual or rare cells that may indicate disease, outperforming existing systems in tests.
Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.
A new study by Complexity Science Hub researcher Rafael Prieto-Curiel challenges the assumption that larger cities are more violent. The study shows that isolated cities, with limited highway connections, experience nearly seven times more violence against civilians per 100,000 residents than well-connected cities.
Researchers at UC San Diego have developed a new method to combat antibiotic-resistant bacteria using bacteriophages, which target the Klebsiella pneumoniae species. The evolved phages demonstrated improved effectiveness in killing multiple bacterial strains, including multidrug-resistant and extensively drug-resistant K. pneumoniae.