Researchers have found that CAR T-cell therapy with cilta-cel leads to higher rates of complete remission and longer progression-free survival compared to ide-cel. Treatment success is linked to factors such as tumour burden, T-cell fitness, and systemic inflammation.
A recent study found that changes in a single gene can cause mental illnesses, with the GRIN2A gene identified as a key culprit. Variants of this gene are associated with schizophrenia and other mental disorders, which can manifest in childhood or adolescence rather than adulthood.
A study by Leipzig University found that non-native plant species can quickly integrate into natural ecosystems, with some species becoming hosts for native animals and fungi in just a few centuries. This challenges the assumption that non-native plants spread aggressively but are poorly accepted by native species.
Plant functional diversity varies greatly depending on seasonal cycles and wet-dry periods, according to a new study that analyzed 4,000 satellite images. The researchers used AI algorithms to derive plant traits from the images and calculated quantitative measures of functional diversity.
Adhesion G protein-coupled receptors (aGPCRs) use a self-cleavage process to monitor their function. This process relies on multiple domain-extrinsic factors, ensuring efficient receptor activation and preventing faulty proteins from reaching the cell surface. The discovery provides new insights into how cells maintain quality control.
Researchers discover cerebellum's contribution to spinal muscular atrophy, revealing independent driver of symptoms. Purkinje cell damage and disruptions in cerebellar networks lead to motor and social deficits.
The study reveals that MRAP2 fundamentally alters the localisation and behaviour of brain receptor MC4R within cells, facilitating appetite-suppressing signals. This new understanding holds the potential to develop effective treatments for obesity and related metabolic disorders.
Researchers investigated the role of flexible N-terminal segment in Y2 receptor when messenger NPY binds, affecting cellular partner protein arrestin-3. The study found that short regions with high density of negative charge are important for stable binding of peptide hormone to the receptor.
Congenital diaphragmatic hernia is a deadly malformation of the lungs and diaphragm that causes underdeveloped lungs, leading to high mortality rates. Researchers discovered increased numbers of inflammatory cells in human lung tissue, both before and after birth, which may influence lung structure development.
A study published by the University of Leipzig found that adults with Avoidant/Restrictive Food Intake Disorder (ARFID) who have a higher body weight are at risk of malnutrition and related health issues. The research also highlighted the importance of accurate diagnosis and tailored treatment strategies for this overlooked population.
A large-scale genetic study found ten new regions associated with the ability to detect specific odours, with three showing sex-specific effects. The research also uncovered a link between the risk of Alzheimer's disease and the sense of smell, highlighting the interconnectedness of these senses.
Scientists at Leipzig University have discovered that the adhesion G protein-coupled receptor GPR133 plays a central role in building and maintaining healthy bone. By mimicking natural activation, a new active substance AP503 can strengthen bones and potentially treat osteoporosis.
A new citizen science project by Leipzig University uses drones to capture images of Galapagos marine iguanas, which are then analyzed by online volunteers. The results show that volunteers can reliably count the animals, even in challenging conditions, providing a valuable contribution to conservation efforts.
Researchers have made significant breakthroughs in understanding the complex interactions between climate drivers and the Southern Hemisphere's Eddy-Driven Jet. By analyzing historical data and applying innovative statistical methods, they found that 50% of the observed shift in the jet stream is directly attributable to global warming.
Researchers at the Carl Ludwig Institute discovered that synaptotagmin 1 in the cerebral cortex responds to lower calcium concentrations, triggering signal transmission and making cortical synapses more reliable and plastic. This knowledge provides a foundation for understanding brain disorders and developing new therapies.
A new meta-analysis of global research on climate anxiety reveals a complex relationship between climate concerns and behavior. The study found that climate anxiety is linked to environmentally friendly behavior and support for climate policy measures, but also negatively impacts well-being.
A recent study from the University of Leipzig Medical Center reveals that fibroblasts respond differently depending on their organ and disease context. The research provides a comprehensive picture of human fibroblast diversity, opening new avenues for targeted therapies.
A study by Leipzig University researchers has provided high-resolution insights into the energy balance of brain neurons during spreading depolarizations. The findings show that even in 'healthy' brain tissue, these waves cause a temporary drop in ATP levels.
The study provides an overview of the fruit fly connectome, enabling scientists to intelligently design experiments to investigate individual neurons or circuits. Sex-specific differences were identified between male and female specimens, shedding light on behavioural differences such as egg-laying and mating.
Researchers found that high tree mortality in upper canopy can promote oak regeneration when maple is removed from understorey. Plantings on thinned forest plots showed fewer signs of drought stress, supporting oak growth.
The human brain can learn to suppress early visual processing of distracting stimuli, such as roadside billboards, after repeated exposure. This learned suppression enhances attention to relevant stimuli and improves performance in tasks that involve frequent distractions.
A rare case of T cell lymphoma developed in a patient with multiple myeloma nine months after CAR-T cell therapy. Genetic alterations in the patient's haematopoietic cells played a role in tumour development, highlighting the importance of genetic predispositions for potential side effects.
Researchers identified three key principles in language recovery after stroke: rapid reinforcement of damaged areas by unaffected network regions, activation of homologous mirror-image areas, and increased communication between affected areas.
In a groundbreaking study, researchers observed flies displaying play-like behaviors, such as swinging and sliding, in response to a rotating carousel. The findings provide valuable insights into the genetic and neuronal factors underlying playful behavior in insects.
Researchers have identified a new mechanism for the male sex hormone 5α-DHT, which increases bone mineral density and promotes skeletal muscle growth. The discovery of the GPR133 receptor's activation by AP503 could lead to the development of new muscle-strengthening drugs with a lower side-effect profile.
Researchers at Leipzig University developed a new standardised numberinng system for adhesion G-protein coupled receptors (GPCRs) to improve comparability and analysis. The system is based on AI analysis of over 14,000 modelled structures and facilitates deeper insights into disease-relevant mutations in GAIN domains.
The study combines experimental measurements with theoretical calculations to analyze the nature and strength of chemical bonding in antimony. The findings demonstrate a smooth transition between classical covalent bonding and electron-rich multi-centre bonding, with important implications for phase change materials.
Researchers have discovered a new strategy to efficiently create structural motifs with two carbonyl groups along a carbon chain. The use of hydrazones as key functional groups enables the targeted reversal of polarity, solving a major challenge in chemistry.
Scientists identify hederagenin, a highly selective antagonist of NPFFR1, to block chronic pain. The discovery could facilitate the rational design of future therapeutics for pain management.
Professor Robert Fledrich has been awarded an ERC Consolidator Grant for his research on the regeneration of peripheral nerves. His team aims to investigate the conditions required for successful nerve regeneration, focusing on glial cells' metabolic dynamics and communication pathways.
Researchers at Universität Leipzig focus on two-state systems, known as qubits, to improve conceptual understanding in learners. The study shows that teaching concepts based on two-state systems are more conducive to learning than traditional approaches.
Researchers found ocean temperatures were 0.26 degrees Celsius colder than land-based records during the early 20th century. This discrepancy suggests a need for improved data processing and analysis to better understand historical climate variability and future climate models.
Researchers found that sustainable land use enhances the activity of microbivores and predator control over microorganisms, maintaining ecosystem balance. This study demonstrates the potential benefits of reduced intensive land management for soil food web functionality in current and future climates.
Irene Coin's lab has developed a comprehensive overview of genetic code expansion technology and its application in membrane proteins. The technology allows for the modification of proteins directly in living cells, enabling the production of novel protein therapeutics and a deeper understanding of natural proteins.
Researchers identify signalling mechanism causing damage to kidney cells in diabetic patients, involving coagulation factor FXII. Detecting FXII in urine may serve as diagnostic marker for disease severity.
A new study reveals that extreme El Niño events are responsible for the increased sensitivity of CO₂ in the atmosphere to tropical temperatures. This finding challenges previous assumptions about climate change and highlights the importance of understanding internal climate variability.
Researchers have developed a new method for efficiently separating hydrogen isotopes using porous metal-organic frameworks. This breakthrough could lead to the production of highly pure deuterium and tritium, essential for pharmaceuticals and nuclear fusion, in a cost-effective way.
Researchers studied the effects of forest gaps on microclimate and soil biological activity in a European mixed floodplain forest. Temperature fluctuations increased in areas with gaps, but decomposition rates remained relatively stable. The study highlights complex interactions between forest structure, microclimate, and soil processes.
Deforestation leads to decreased cloud cover, which partially offsets surface albedo change's cooling effect on climate. Researchers analyzed idealized deforestation simulations using climate models to provide insights into the impact of large-scale deforestation on global low-level and tropical high-level clouds.
Researchers from Leipzig University studied cloud movement in the Arctic using a large-scale international research campaign called HALO (AC)³. They observed air mass transformations over open ocean, sea ice, and central Arctic sea ice.
A study with Rohingya refugee children found that they exhibit resilient prosocial behaviour and increased well-being after participating in an intervention programme. The programme promoted cooperation, emotional perspective-taking, and cognitive skills training, leading to improved prosociality and cooperation among the children.
A Leipzig study found that chronic kidney disease (CKD) activates microglial cells, disrupting potassium balance in nerve cells and leading to cognitive impairment. Researchers identified a mechanism involving the blood-brain barrier and potential therapeutic targets.
New research reveals that diaphragmatic hernia is associated with inflammatory processes involving immune cells, leading to underdeveloped lungs. Scientists have identified specific pro-inflammatory signalling processes and propose a novel therapy using amniotic fluid stem cell extracellular vesicles.
Researchers developed a new method to map gene expression changes in sebocytes, providing insights into sebum production and its role in skin health. The study identifies key players in sebum production and suggests new ways to modulate it, with potential implications for acne, eczema, psoriasis, and infectious diseases.
Scientists analyzed 21,000 cells from tissue samples to develop a cell atlas of regenerating liver tissue. The study reveals changes in cell composition, gene expression, and intercellular communication that facilitate liver regeneration after portal vein embolization.
Researchers analyzed underarm odour samples from 29 women over a menstrual cycle, finding no evidence that men prefer fertile days. Chemical analysis also showed no correlation between odour composition and fertility status.
A new surgical method developed in Leipzig offers significant benefits over conventional treatment for cervical cancer, with a 9.4% lower recurrence rate after five years. This innovative approach also leads to a 58% lower risk of mortality from the disease.
Researchers deciphered how the β2 adrenergic receptor transmits signals at an atomic level, revealing its three-dimensional structure and biochemical cascades. The study provides new insights into G-protein coupling and may lead to improved drug development for obesity research.
A recent study found that cloud cover changes more during the day than at night on a global scale, leading to increased greenhouse effect and amplified global warming. The asymmetry in cloud cover is attributed to stability in the lower troposphere due to rising greenhouse gas concentrations.
Genome sequencing outperforms exome sequencing in diagnosing rare genetic diseases, revealing new clues and mechanisms. The method's advantages include detecting non-coding mutations and gene segments outside the exome.