Researchers have identified a new regulator of eating behavior, the latrophilin 1 receptor, which is linked to obesity. The receptor, primarily studied for its role in synapse formation, was found to be present in brain regions controlling food intake and adipose tissue.
Researchers at Universität Leipzig have found a way to drive electric currents with light even when the material has minimal absorption. This breakthrough reveals the properties of 'Floquet Fermi liquid' states, which can display spectacular properties like superconductivity.
Researchers at the University of Leipzig Medical Center have identified biomarkers associated with the response to CAR T cell therapy in multiple myeloma. These biomarkers enable patients to predict their likelihood of responding well or less well to treatment before initiating therapy.
The study reveals how opioid receptors stabilize a state for effective signal transmission, making superagonists potent and dangerous. It also highlights the importance of understanding molecular interactions for drug development and developing safer medicines.
Researchers develop a new method to efficiently capture and isolate HIV particles using nanofibrils and magnetic beads. This innovation improves the sensitivity of existing diagnostic tools, enabling better monitoring of viral infections and resistance.
Leipzig scientists have identified a new adhesion GPCR gene in fruit flies that affects midgut development and promotes the growth of enterocytes. The study also shows a link between intestinal development and heart function, with the loss of this receptor accelerating heart rate and causing dangerous palpitations.
Researchers have discovered 23 genetic associations with kidney function and uric acid levels in men and women, revealing sex-specific differences in gene regulation. These findings may help explain why chronic kidney disease progresses faster in men and is more common in women.
Physicists at Leipzig University have developed a neural network that uses active colloidal particles for artificial intelligence. The system reduces noise and increases efficiency in calculations by utilizing past states of the reservoir.
A new international trial investigated the safety and efficacy of sabatolimab combined with hypomethylating agents in patients with myelodysplastic neoplasms. The study found manageable side effects, but no significant improvement in response rates or progression-free survival.
The ADAPT project is a new initiative to prevent antimicrobial resistance and neglected tropical diseases in sub-Saharan Africa. By analyzing biological-medical and socio-cultural factors, the network aims to enhance policy-makers' technical expertise and increase efficiency in disease prevention.
Researchers found that high plant diversity acts as a buffer against fluctuations in soil temperature, protecting ecosystems and agricultural productivity. Plant diversity increased shading and organic carbon content, reducing heat conduction and stabilizing soil temperature.
Imetelstat, a telomerase inhibitor, successfully treated anaemia in MDS patients for up to one year, reducing the need for red blood cell transfusions. The drug offers a novel mechanism of action for patients with lower-risk MDS who do not respond to standard treatment.
Researchers discovered that fat tissue supports nerve repair by stimulating Schwann cells with leptin. This activation optimizes metabolism, allowing the restoration of original nerve function.
Researchers at Collaborative Research Centre Transregio 172 are studying Arctic amplification, a phenomenon where the Arctic warms at twice the rate of the globe. They've found increased storm activity, wetter atmosphere, and reduced sea ice in recent years.
A new study examining 13,493 literary works by 2,900 authors found that women's works contained more biodiversity than men's, with regional differences also emerging. The research used machine learning methods to relate biographical information to the depiction of nature in literature.
Using 'aggressive' fragments of molecular ions, researchers created a new compound by incorporating unreactive nitrogen into a substance. This method could open up new possibilities for applications such as microchip production and solar cells.
A study in fruit flies reveals a potential connection between a respiratory system defect and the development of aortic aneurysms in humans. Researchers identified proteins that play a crucial role in maintaining tube structure and integrity, which may also be relevant to human tubular diseases.
A recent clinical study at the University of Leipzig Medical Center found that ultrasound scans of the liver and kidneys were significantly lower in quality in obese patients. Modern probes with matrix technology improve image quality by achieving greater penetration depth into tissue.
Research suggests that high-dose dietary prebiotics can reduce reward-related brain activation in response to high-calorie food stimuli. The study found a shift in the composition of the gut bacteria, which may underlie the altered brain response towards high-calorie food cues.
The study analyzed 10,000 gene expression signatures to assess their prognostic ability, finding that they lead to accurate patient prognosis in no more than 80% of cases. The researchers emphasize the need for a comprehensive approach incorporating molecular, clinical, histological, and other factors to ensure an accurate prognosis.
A Leipzig-based meta-analysis of over 400 neuroscientific experiments has provided new insights into the organisation of language processing in the human brain. The study found that brain regions below the cerebral cortex, including the cerebellum and amygdala, play a key role in language processes, influencing emotion and memory.
A recent study has developed an app providing lists of native, declining species suitable for gardening, increasing public engagement. The research found that over half of threatened species are commercially available and prefer dry soils, offering a promising approach to reversing biodiversity decline.
Research from Leipzig University shows that reductions in aerosol pollution can cause a delayed warming effect on the climate. The findings suggest that this warming may occur 20-30 years after improvements in air quality are made, particularly in heavily polluted regions.
A recent clinical trial led by Professor Holger Thiele found that ECLS does not reduce 30-day mortality after cardiogenic shock, but is associated with more complications. The study involved 420 patients and compared ECLS therapy with standard intensive care unit treatment.
A study found that male crested macaques are more likely to respond to their own offspring's screams during agonistic conflicts. The researchers observed that males were more likely to intervene if they had sired the infant or if the screaming infant and its mother were of low dominance rank.
Researchers developed tomoelastography, an imaging technique that maps tumor mechanical properties using MRI. Studies found consistent patterns between changes in tumor stiffness and increasing aggressiveness. The technique allows for precise measurement of tumor fluidity, enabling more accurate diagnoses and tailored treatment options.
Researchers develop new algorithm to effectively investigate long-range interacting systems, reducing runtime from quadratic to linear with system size. The new method opens up new questions and applications in nonequilibrium processes, including phase separation and structure formation in cosmology and solid state physics.
A recent study from Leipzig University found no significant link between oropharyngeal cancer and high-risk sexual behavior. The research, which analyzed data from over 300 patients with head and neck cancer, suggests that HPV infection is a key risk factor for the disease.
Researchers at Leipzig University have developed a new method to visualize the activity of CRISPR-Cas protein complexes, allowing for precise observation of gene recognition. The study reveals that base pairing with RNA is not energetically advantageous, but becomes stable only after the entire sequence is recognized.
Researchers found that migrant orangutan males use observational social learning to learn new ecological knowledge from local individuals after dispersing to a new area. They observed males peering at role models for at least five seconds, indicating attentive interest and learning how to process new foods.
A new clinical trial has found luspatercept to be significantly more effective than epoetin alfa in treating MDS anaemia, reducing the need for blood transfusions. The results have implications for treatment algorithms and may establish luspatercept as a first-line treatment option.
New research suggests that myelin can harm axons in people with multiple sclerosis, even when it's intact. Oligodendrocytes support the energy metabolism of axons, which rely on undamaged myelin for nutrients.
A new study by Leipzig University found that neurotic individuals experience greater variability in negative emotions, leading to more frequent mood swings. Researchers used Bayesian statistics to analyze data from over 2,500 people and confirmed the association between neuroticism and emotional instability.
The study shows that zolbetuximab delays tumor progression and improves overall survival by 25% compared to chemotherapy alone. Patients with CLDN18.2-positive tumors responded well to the treatment, indicating a new clinically relevant biomarker for gastric cancer.
An international study of 1,044 patients with head and neck squamous cell carcinoma found that combining radiotherapy with chemotherapy significantly improves survival rates compared to radiotherapy alone. The benefit was particularly notable in patients between 65-79 years old with good general health.
Researchers at Leipzig University have increased the efficiency of an enzyme that breaks down PET plastic, which has implications for bioplastics and a more sustainable future. The team used computer simulations and experiments to improve the enzyme's activity and stability.
Researchers have developed a new microfluidic chip that enables the visualization of rare cell types and disease patterns in tissue. This method combines imaging and sequencing techniques, providing spatially resolved information about individual cells and their environment.
A study published in Journal of Hepatology found that some patients with chronic hepatitis B can achieve sustained immune control by discontinuing antiviral therapy after four years. This suggests a potential cure for the disease, which affects an estimated 350 million people worldwide.
Researchers from Universität Leipzig have developed a molecular sensor system to detect when and where adhesion GPCRs break apart, activating receptors and transmitting biochemical signals. The breakthrough could lead to the development of drugs targeting these receptors for treating various diseases.
Researchers have found a way to increase the efficiency of fluorescence in phosphole-based compounds by modifying them with sulfonyl isocyanates. This modification method has been shown to significantly enhance the optical properties of these substances, making them suitable for use as efficient dyes or markers.
Researchers have created a new patient-specific cell model to investigate the cause of congenital diaphragmatic hernia and explore potential treatments. The study found that inflammation alters stem cells in affected lungs, but drug therapy can restore functionality.
Researchers at Leipzig University discovered that nanoplastics from PET particles accumulate in organs and cause liver function impairment, oxidative stress, and behavioral abnormalities in zebrafish embryos. The study provides insight into the toxicity pathways induced by PET nanoplastics.
The study found that oxidized membranes accelerate the aggregation of certain peptides associated with Alzheimer's disease, while others are prevented from aggregating. The research provides new insights into the mechanisms underlying peptide aggregation near lipid membranes.
Researchers have developed a potential treatment for autoimmune encephalitis by creating an NMDA receptor fusion construct that neutralizes pathogenic antibodies. This innovative approach has shown promise in reducing signal transmission to neurons and may lead to improved treatment options for patients with this rare and serious disease.
A team of scientists developed a simplified and efficient method for artificial production of terpenes, using fluorinated alcohol catalyst solutions. This approach allows targeted production of natural substances from simple starting materials, offering potential applications in food, cosmetics, and pharmaceutical industries.
Researchers at Universität Leipzig have developed a new method to analyze complex, tiny crystals like phosphorus oxide nitride. The technique successfully uncovers the structure of previously difficult-to-analyze compounds, offering potential for novel phosphors in future studies.
The study uses artificial intelligence to generate new molecules with optimized properties, applicable to various industries. The method enables finding Pareto-optimal solutions, leading to more efficient materials for optoelectronics, solar energy, and other fields.
A controlled clinical trial has shown that the new drug leriglitazone can prevent neurodegeneration and brain inflammation in patients with X-linked adrenoleukodystrophy. The study found improvements in neurological conditions such as balance disorders, which had a positive impact on quality of life.
Scientists have discovered that cuprates follow a charge distribution predicted in 2016, enhancing superconductivity under pressure. This finding brings researchers closer to achieving superconductors at room temperature, a goal long pursued by physicists.
Researchers at Leipzig University developed an experimental model of microswimmers that exhibit properties of natural swarm intelligence. The swimmers' internal states and navigation rules can be controlled, allowing for the observation of complex collective behaviors.