Scientists have developed a new vaccine delivery method using powdered vaccines and a system driven by compressed gas, called MOF-Jet. The device can deliver therapeutics against cancer and other diseases in a relatively painless way, eliminating the need for needles and potentially reducing pain.
A new plant species, Carex quixotiana, has been discovered in the La Mancha region of Spain, specifically known for being the setting of Miguel de Cervantes' classic novel Don Quixote. The species is a type of sedge with unique characteristics and limited distribution.
A study published in Science Translational Medicine has identified immature Natural Killer (NK) cells as a key factor in promoting disease progression in triple-negative breast cancer. The researchers suggest that targeting these rogue NK cells could lead to new and more effective treatments for this aggressive form of breast cancer.
A new study confirms that HIV can persist in myeloid cells for months to several years, even in virally suppressed individuals. The findings suggest that these cells contribute to a long-lived HIV reservoir and may be an important target for cure efforts.
Researchers have described two new species of butterworts (Pinguicula) with striking appearances, found in the high Andes of southern Ecuador. The discovery has tripled the number of Pinguicula species recorded in Ecuador and highlights the region's exceptional biodiversity.
Researchers at University of California San Diego School of Medicine found a significant reduction in disease growth when combining immunotherapy with chemotherapy in patients with advanced endometrial cancer. The study resulted in a 70% risk reduction in the deficient mismatch repair group.
The James Webb Space Telescope detected the thermal emission of TRAPPIST-1 b, indicating a temperature of about 500 kelvins and no substantial atmosphere. This finding marks an important step in determining habitability around small, active stars like TRAPPIST-1.
A new study suggests that acetyl tributyl citrate (ATBC), a leading phthalate alternative, can disrupt neuron-like cells and interfere with the growth and maintenance of neurons. The findings indicate that ATBC could harm brain development and health.
A study by Duke-NUS Medical School researchers analyzed tens of thousands of student data to determine the impact of early class start times on attendance, sleep behavior, and academic performance. The findings suggest that students who attend early morning classes often lose an hour of sleep and experience lower grades.
A new study from the University of Surrey found that Water Safety Plans are not widely used in small drinking supplies in vulnerable rural areas due to a lack of awareness and training. This could put countless lives at risk, as these plans aim to improve the quality of small drinking water supplies.
Researchers have developed a multidisciplinary approach using a new microscope, artificial intelligence algorithm, and voltage indicators to better measure brain activity. The technique enables the imaging of up to 100 neurons at a time, far surpassing previous limits.
A study of global clinical practice guidelines found close alignment in recommending daily intake of fruits, vegetables, legumes, and whole grains for treating and preventing major chronic diseases. The findings aim to increase clinician confidence in providing optimal care.
Researchers propose using a constellation of space interferometers to map the flat and almost perfectly homogeneous background signal, detecting subtle fluctuations known as anisotropies. These fluctuations hold information on the distribution of gravitational wave sources on the largest cosmological scale.
Researchers at King Abdullah University of Science & Technology (KAUST) successfully integrated two-dimensional materials on silicon microchips, achieving high integration density, electronic performance, and yield. The resulting hybrid devices exhibit special electronic properties that enable low-power consumption artificial neural ne...
Researchers developed a new form of omega-3 fatty acid DHA that can cross into the retina, increasing retinal DHA content and preserving function. This approach overcomes previous barriers and shows promise for preventing Alzheimer's-related declines in visual function.
A joint research team from KIST and GIST has developed a new anode material using carbon fiber paper to improve the durability of lithium metal batteries. The technology enhances cycling stability and energy density, leading to potential applications in next-generation secondary batteries for electric vehicles.
Researchers found that thermotolerant methanogens have smaller genomes with a higher fraction of core genes, while psychrotolerant organisms are enriched in uncharged amino acids. This suggests that temperature adaptation is a gradual process involving fine-scale changes rather than large-scale genome modifications.
A new study by Yale University researchers suggests that protecting wildlife can significantly enhance natural carbon capture and storage. By conserving or restoring populations of nine key species, the world can collectively facilitate the additional capture of 6.41 billion tons of carbon dioxide annually.
The study sheds light on the molecular mechanisms of deep-sea adaptation in Ilyophis brunneus. Researchers identified critical genes, including TUGBCP3 and ITGA, that underwent specific mutations related to cytoskeleton maintenance and regulation.
A study of 1,678 participants found that low benefit expectations, negative experiences, and catastrophizing are associated with COVID-19 vaccination adverse effects. Clinician-patient interactions and public vaccine campaigns may be optimized by contextualizing information about vaccines.
Scientists at UvA have created a new, highly improved bright red fluorescent protein called mScarlet3. This variant combines maximum brightness with fast and complete folding, making it an ideal tool for researchers studying cellular processes.
A new finger-prick test for Trichomonas vaginalis has been developed by Washington State University researcher John Alderete. The test detects an antibody specific to the organism and provides rapid, affordable results, making it a potential game-changer in the fight against this prevalent but neglected STI.
Researchers suggest that biochar produced from straw pyrolysis can significantly reduce methane and nitrous oxide emissions from Chinese staple crops. The addition of an integrated energy system also produces biogas and bio-oil, which can replace fossil fuels and further reduce greenhouse gas emissions.
A new photocatalyst, COF-TpHt, is designed to improve the efficiency of hydrogen peroxide production. It exhibits a high production rate and apparent quantum efficiency under visible-light irradiation, outperforming other organic and inorganic counterparts.
Research published in Annals of the Rheumatic Diseases found that people with atopic diseases like asthma or eczema are at a heightened risk of developing osteoarthritis. Drugs used to dampen down allergic reactions may help lessen this risk, suggesting a potential new approach to treating the condition.
The NCATS Platform Vector Gene Therapy (PaVe-GT) program utilizes FDA guidance to prepare applications for Orphan Drug Designation (ODD) and Rare Pediatric Disease Designation (RPDD), stimulating gene therapy development. The PaVe-GT program has already helped receive ODD and RPDD designations for a gene therapy product treating PCCA-r...
Scientists found that oxocarbon-based dyes have intermediate electronic configurations between closed-shell and open-shell forms. The study reveals that longer wavelengths of near-infrared light absorption increase the contribution of open-shell forms in the dye.
A University of Illinois study finds that two human-grade vegan diets provide adequate nutrition for dogs, with benefits including lower blood triglycerides and cholesterol. The research also shows positive changes in the fecal microbiome and reduced stool, indicating a potential shift towards improved gut health.
Researchers found that incubators dampen some sounds but also cause a booming effect at low frequencies, raising noise levels by up to 28 decibels. The study highlights the importance of considering sound in NICU design and use to protect premature infants' hearing.
Researchers from the Earth4All initiative project that global population could peak at 8.5 billion people by mid-century with unprecedented investment in poverty alleviation. The team's analysis also suggests that extreme poverty can be eliminated in a generation, leading to a decline in global population trends.
A new study reveals that lianas play a crucial role in amplifying the effects of lightning strikes, resulting in more severe damage to neighboring trees. High liana density is positively associated with the number of trees killed and damaged by lightning.
An international team of researchers has successfully demonstrated the formation of fullerene and its derivatives in the universe. The reaction involves a corannulene radical and vinyl acetylene, which deposit layers of carbon onto each other to form the desired molecules.
Researchers have identified four distinct patterns of anti-Müllerian hormone (AMH) concentrations in infant girls, including two previously unknown patterns. These patterns may help researchers understand ovarian function and identify potential reproductive conditions earlier.
Researchers developed a new method to monitor methane releases in deep-sea sediments, showing that small-scale dissociation events are occurring more often than previously detected. Fossils of benthic foraminifera from the order Miliolida have been found to record these smaller-scale events.
A study of over 1,186 participants from various countries found that art evokes positive emotions, often despite dealing with sad or scary topics. The researchers discovered that human figures in art pieces can elicit empathy and mirroring, which contributes to the emotional experience.
Researchers have created two novel adjuvants that significantly enhance the immune response to vaccines. The new adjuvants target toll-like receptors and are designed to be tailored for every individual vaccine, potentially reducing side effects and increasing effectiveness.
A rare species of beetle, Bembidion brownorum, was rediscovered on Jerry Brown's ranch in Colusa County after 55 years. The beetle is notable for its unusual shape and metallic shimmer, and its population likely collapsed due to urbanization and agricultural development.
Researchers at UMass Amherst have discovered that beneficial microbes in infant gut use nitrogen from human milk to support pediatric nutrition and development. The study provides new insights into the molecular underpinnings of these processes, which could lead to improved infant health around the world.
A new high-resolution simulation shows different pollutants accumulate along highways and over Lake Michigan, affecting communities in distinct ways. The study provides a detailed, neighborhood-by-neighborhood estimate of air pollution, highlighting areas that need targeted solutions to address poor air quality.
The unemployment rate for persons with disabilities in the US is more than double that of those without a disability, particularly youth. New research highlights the importance of community and business awareness of vocational services to increase work participation and quality of life.
Researchers have found a new water reservoir on the Moon, discovered in impact glass beads, which can buffer the lunar surface water cycle. The study suggests that these beads can store and release solar wind-derived water, indicating their potential for in-situ resource utilization.
Breast tumor microbes vary significantly among women of different ethnicities, with potential implications for personalized care and disease progression. Researchers identified distinct microbial biomarkers associated with genes involved in tumor aggressiveness and immune response.
A cohort study of over 9,000 persons found that asymptomatic middle-aged individuals with subclinical coronary atherosclerosis are at an 8-fold increased risk for myocardial infarction. The study highlights the importance of identifying and addressing obstructive coronary artery disease in patients without known cardiovascular disease.
Researchers at Moffitt Cancer Center have discovered a combination strategy that targets the STING signaling pathway, resulting in improved antitumor activity. Inhibiting methylation increases STING expression and activates immune cells, leading to enhanced antitumor immunity.
A new study analyzed 183,780 non-birth related hospitalizations among 130,826 privately insured children covered aged 18 and under from 2017-2019. The average out-of-pocket spending was $1,300, with some families paying over $3,000. High deductibles and co-insurance payments were the main drivers of higher costs.
Researchers found that healthy individuals have a median of 16 antimicrobial resistance genes in their gut microbiome, varying across countries and antibiotic use. National antibiotic consumption levels correlate with resistance gene frequencies, highlighting the need for public health strategies to mitigate AMR.
Researchers discovered that 'dormant' cone photoreceptors in retinal degeneration continue to produce responses to light and drive retinal activity for vision. The study found that while cones have reduced sensitivity, ganglion cells retain their ability to respond to visual stimuli with similar spatial and temporal sensitivity.
A new American Heart Association scientific statement provides guidance on interpreting incidental genetic variants associated with cardiovascular disease risk. The statement aims to determine whether a variant truly carries a health risk and suggests next steps for individuals and healthcare professionals.
ENZAMET, a new drug combination, has shown significant improvement in survival rates for men with advanced prostate cancer. After five years, the treatment led to a 67% survival rate, compared to 57% for standard therapy.
Scientists at Tokyo University of Science generate vector vortex light beams and imprint their structure on electron spins in a semiconductor solid, creating helical spatial structures. This breakthrough enables higher information storage capacity by exploiting effective magnetic fields alongside structured light beams.
Researchers at the University of Bristol have found that the first land plants were likely to have been branched, contradicting previous theories. The discovery sheds new light on the origin of branching in plants and its role in shaping their evolution.
The study investigates the atomic flow behavior during joint formation, exploring processing time, temperature, and stress distribution on nanojoints. The results reveal that local stress and capillary interactions significantly impact joint quality, leading to advances in industrial applications of Ag nanowire interconnect networks.
A new species of ancient beaver, Anchitheriomys buceei, has been discovered in Texas and named after Buc-ee's. The beaver lived about 15 million years ago and was about 30% larger than modern beavers.
A new study found that specific biomarkers in blood can predict PTSD likelihood, diagnose disorder, or monitor treatment response. Researchers discovered four biomarkers with significant differences between those with PTSD or sub-threshold PTSD and those with high resilience.
A new research letter highlights how quickly Colorado's children and teenagers can access a loaded gun, increasing the risk of adolescent suicides and firearm injuries. Nearly one-third of middle and high school students report having access to a gun within 24 hours or under 10 minutes.
Researchers at the University of Surrey used a new technology called fluxomics to reveal how cells process nitrogen in TB-causing bacteria. The study identified glutamate as a crucial amino acid in the nitrogen metabolism, providing a target for new drug development.
A new study found that Hispanic, Black, and low-socioeconomic status smokers are less likely to use e-cigarettes as a quit-smoking tool and more likely to believe e-cigarettes pose greater harm than cigarettes. This perception may prevent e-cigarette uptake among these populations, exacerbating racial and health disparities in smoking.
A new study by the University of South Australia found that dedicated nature play areas are underutilized at schools, with most being used for play instead of learning. Researchers are encouraging teachers to incorporate more outdoor learning to boost student wellbeing and development.
A new article in The Journal of Nuclear Medicine explores the potential for using ChatGPT, an artificial intelligence chatbot, in nuclear medicine and molecular imaging. The authors discuss the strengths and weaknesses of current AI bots and highlight the benefits of collaborating with AI allies to cope with increasing workloads.
Researchers examine how chronological and biological age impact vaccine effectiveness, finding that both factors influence immune system capacity to mount responses. The study highlights the need for further research into 'immune aging' risk and departures from healthy aging.