Researchers at UT Health Sciences Center have developed an AI-enhanced platform called ENRICH, which leverages advanced analytics with community-based human support to reduce treatment interruptions and improve cancer outcomes. The program identifies patients at highest risk for interruption and deploys targeted support resources.
Researchers at the University of Tennessee Health Science Center are using a human brain-on-a-chip system to study lethal encephalitis viruses and develop treatments. The chip replicates the function of the human brain, allowing scientists to test antiviral drugs in a more accurate and human-like environment.
A research team led by Jianyang Du, PhD, has received a grant to investigate the cellular and molecular mechanisms behind neurological disorders caused by long COVID-19. The study aims to provide insights into how SARS-CoV-2 alters neuronal activity, which could lead to effective therapeutic strategies.
The National Institute of Neurological Disorders and Stroke has awarded researchers at the University of Tennessee Health Science Center $2.18 million to investigate a new small molecule that activates SERCA2, aiming to correct calcium imbalances caused by diabetes after a stroke.
Researchers are using genetic data from Le Bonheur and UT Health Science Center to better diagnose patients with childhood interstitial and diffuse lung diseases. The goal is to identify genetic causes and provide earlier diagnosis and treatment for this rare disease.
A research team led by Dr. Bernd Meibohm is working on developing new treatments for tuberculosis that require fewer pills, shorter treatment periods, and reduce the risk of resistance. They aim to replace linezolid with Spectinamide 1810, a safer alternative that can be administered directly to the lungs.
The NoNO Trial, a seven-year randomized controlled trial, aims to study the efficacy of using nitric oxide in treating congenital diaphragmatic hernia (CDH) in newborns. The study will compare outcomes before and after de-implementation of nitric oxide at participating centers.
A team of researchers has developed an AI-powered system to provide evidence-based caregiver training information and support to individuals with Alzheimer's and related dementia. The system is designed to be personalized and accessible, using validated resources and tools to address the unique needs of caregivers.
Dr. Harish Manyam has developed a groundbreaking system that addresses potentially dangerous problems associated with traditional pacemakers and defibrillators. The leadless pacemaker, in combination with a novel subcutaneous defibrillator, eliminates the need for lead extraction procedures.
Researchers at UT Health Science Center, in collaboration with Oak Ridge National Laboratory and the University of Tennessee, Knoxville, will develop new radiopharmaceutical therapies to treat cancer. The team aims to advance precision cancer treatment using targeted alpha-emitting radioisotope constructs.
A collaborative project led by UTHSC researcher Dr. Liza Makowski is exploring the complex interplay between obesity, the immune system, and cancer. The team aims to identify biomarkers that may provide therapeutic guidance for obese patients with specific types of cancers.
Researchers at the University of Tennessee Health Science Center have received a $423,500 grant to study molecular pathways in Aspergillus fumigatus that mediate inflammatory host responses. The team aims to develop novel therapeutic approaches to improve outcomes for patients suffering from Aspergillus infections.
UTHSC researchers are studying the role of balanced sex hormones in DNA repair in human melanocytes to determine if hormonal imbalances contribute to melanoma risk. The study aims to find novel prevention methods to decrease melanoma cases and potentially save lives.
Researchers are developing a new treatment for ischemic stroke by targeting the prostaglandin receptor EP2, which could have a wider therapeutic window and improve behavioral outcomes. The potential new treatment has the potential to reduce inflammation and provide protection for neurons after an ischemic stroke.
The UTHSC College of Pharmacy received a record-high $19.2 million in NIH funding in fiscal year 2022, jumping six places from No. 12 the previous year. The college's rise to No. 6 is attributed to its culture of scholarship and collaborative research.
A team of researchers at the University of Tennessee Health Science Center has received a $3.07 million grant from the National Cancer Institute to develop new drugs targeting microtubules for breast cancer treatment. The goal is to improve overall survival and quality of life for patients with metastatic breast cancer.
Researchers from UTHSC have made a foundational discovery about chromosome biology through their work on the first-ever human pangenome reference. The draft pangenome uses complete genome assemblies to provide a diverse look at the genetic makeup of humans, shedding light on variation in parts of the genome that could not be seen before.
A UTHSC research collaboration has been awarded a national grant to develop a new treatment for ovarian cancer. The project will test a newer generation of sabizabulin, a clinical candidate targeting microtubules in cancer cells.
A newly funded research project is exploring the link between HIV-induced aging and Alzheimer's disease. The team aims to develop a drug delivery system to increase HIV suppression in the brain and decrease associated neurocognitive disorders.
Researchers at UTHSC are conducting a study on interactive technology to aid weight loss in overweight and obese adults. The CHAMPS program will deliver a weight loss program via internet, patient portal, text messaging, and phone calls to reduce barriers and promote significant weight loss.
Researchers at UTHSC are working on a project to find the first therapeutic intervention to prevent frontotemporal dementia or slow its progression in a mouse model linked with the condition. They aim to use DNAzymes to target pathological tau aggregates, which cause cognitive impairment and progressive neuropathological symptoms.
A UTHSC team developed a unique community-focused COVID-19 data registry, MEMPHI-SYS, to guide public health policies and interventions nationwide. The registry collects demographic information, geographic locations, medical history, and risk factors, providing insights into the spread and presentation of COVID.
Researchers from UTHSC and EPFL identified genetic determinants of longevity, with sex-specific regions and non-genetic effects like early growth and access to food affecting lifespan. The study provides a basis for future therapies targeting aging genes and enhancing healthspan.
A UTHSC-led research team has been awarded $5.2 million by the National Cancer Institute to investigate the relationship between obesity and cancer risk. The team, led by Dr. Liza Makowski, aims to understand how obesity affects the immune system's ability to fight cancer.
Researchers will investigate how information about new tastes is encoded in brain circuits, aiming to understand the neural basis of taste neophobia. The study aims to gain insights into how feeding behaviors are controlled by the brain, with potential implications for eating disorders and health outcomes.
A UTHSC-led team has received a $3.16 million National Cancer Institute grant to develop a cancer immunotherapy drug that boosts the immune system response to destroy tumor cells.
The UTHSC team will examine the process biochemically using baker's yeast as a genetic model to determine how mTORC1 regulates the epigenome. Understanding these biochemical mechanisms may identify novel targets for anticancer drug development and treat neurodevelopmental disorders.
A team of UTHSC investigators is testing a new otulin-inhibiting drug to promote tau clearance and reduce neurotoxicity in Alzheimer's patients. The study aims to investigate the link between oxidative stress and otulin activity, which may lead to breakthroughs in treating neurodegenerative disorders.
The UTHSC College of Nursing will utilize a mobile health unit to provide care to vulnerable populations in Lake and Lauderdale counties, which have high poverty rates and poor health outcomes. The grant also aims to increase the cultural competency of nurses serving patients in rural areas through education and training programs.
The UTHSC team will investigate how mitochondria affect the aging process and age-related diseases, including Alzheimer's. The five-year project will explore gene variants, diet, sex, age, and mitochondrial copy number to better understand these relationships.
The University of Tennessee Health Science Center has received $3.2 million to upgrade its Regional Biocontainment Laboratory, enhancing research on infectious diseases including COVID-19. The lab, a Biosafety Level 3 facility, will receive advanced equipment for basic research and preclinical studies.
A new $3 million study will investigate the link between weight loss and bone frailty in diabetics. The research aims to identify metabolomic changes causing increased fracture risk and explore ways to prevent bone loss during intentional weight loss.
Dr. Neil Hayes, MD, and Katherine A. Hoadley, PhD, will extend the Cancer Genome Atlas (TCGA) research for five years using a $1.8 million National Cancer Institute grant. The project analyzes cancer genetics and therapeutics to better understand patient responses to treatments.
Researchers are developing a new machine learning approach to reduce health disparities caused by biased cancer-related genomic and clinical omics studies. By using transfer learning on large-scale data, the team aims to create an open resource system for unbiased multiethnic machine learning.
Researchers at the University of Tennessee Health Science Center have found that obesity in mice models led to accelerated tumor growth, but anti-PD-1 immune checkpoint blockade successfully blocked this progression. The study suggests that obese patients with breast cancer may respond better to immunotherapies like checkpoint inhibitors.
A researcher at the University of Tennessee Health Science Center is studying the impact of a poverty-focused model on health outcomes for low-income individuals. The Transition to Success model aims to address social determinants of health, reducing healthcare use and improving conditions.
The Hamilton Eye Institute at University of Tennessee Health Science Center has received a $300,000 RPB Challenge Grant to continue its vision research initiatives. The grant will support the expansion of research faculty, innovative pilot studies, and new equipment for the institute's research efforts.
Researchers at UTHSC identified three drugs with antiviral properties that may improve efficacy when combined with remdesivir. The study proposes zuclopenthixol, nebivolol, and amodiaquine as potential candidates for clinical trials to combat COVID-19.
Dr. Adebiyi's research investigates newborn kidney functions and their alterations in acute and long-term disease, with a focus on growth-restricted infants. The new $3 million grant will explore the cellular mechanisms underlying progressive kidney insufficiency in these babies.
Scientists found that some COVID-19 antibodies provide stronger protection than others against reinfection, but not all individuals who have had the disease generate neutralizing antibodies. The study aims to answer how much neutralizing antibody is needed to prevent infection or reinfection.
A team of UTHSC researchers will study genetic differences in stress response, oxycodone consumption and stress-induced drug seeking in rats. The findings have great potential to translate to human conditions of opioid addiction.
Charisse Madlock-Brown's R15 grant aims to identify costly multimorbidity groupings and disease progression. Her project will use a large patient dataset to develop intervention strategies, contributing to simpler, less expensive treatment options.
Breast cancer support groups play a crucial role in helping underserved African-American women in Memphis overcome economic, social, and psychological barriers to diagnosis and treatment. The groups act as connectors between healthcare providers and the community, reducing death rates from breast cancer among black women in the city.
A new study suggests transplanting Hepatitis C-infected kidneys to uninfected recipients is safe and can be implemented as a standard of care. This approach could greatly expand the number of available kidneys and reduce waiting times for donors, saving thousands of lives annually.
A meta-analysis by ophthalmologists from the University of Tennessee Health Science Center indicates that LASIK surgery has a lower risk of infection compared to contact lens wear. The study found that after one year of daily soft-contact lens wear, there were fewer microbial keratitis cases than after LASIK, approximately two fewer ca...