A new study identifies a specific mechanism of faulty DNA repair in tumors as a key factor in determining patient outcomes with immunotherapy. Tumors with defective DNA repair proteins had significantly better responses to immunotherapy, whereas those with silenced production of DNA repair proteins did not.
Researchers have successfully isolated parathyroid stem cells and maintained them in lab as organoids for an extended period. These patient-derived parathyroid organoids (PTOs) closely mimic human parathyroid tissue, enabling the study of parathyroid diseases and drug development.
A new study using wearable devices found that moderate-to-vigorous physical activity significantly reduces cardiovascular disease risk, even when total physical activity volume is increased. Increasing the proportion of intense physical activity within overall activity levels has an additional substantial benefit.
The researchers developed a novel approach to infrared spectroscopy called Infrared Diffusion-Ordered Spectroscopy (IR-DOSY), which separates molecules with different sizes into distinct sets of IR peaks. This method has potential applications in fields such as proteins, polymers, pharmaceuticals, and biomedicine.
Researchers at HKU have developed a novel technique to measure the rotational and translational motion of cell markers with high precision. This breakthrough technology uses single nitrogen-vacancy centers in nanodiamonds to tackle the long-standing challenge in mechanobiology research.
Researchers developed investigational monoclonal antibodies targeting EBV's gH and gL proteins, blocking infection in human cells and providing nearly complete protection against EBV infection in mice. The findings highlight viable vaccine targets and potential treatment options for immunocompromised patients.
A new two-year project is being launched to reduce the spread of retracted research and improve confidence in scientific discovery. The goal is to create a system that can signal retraction status consistently to humans and machines.
The American Heart Association is launching a two-year initiative to expand and enhance post-acute stroke care across Montana, Nebraska, and North Dakota. The project aims to maximize recovery of function lost during a stroke, reduce risk of secondary effects, and extend high-quality guideline-directed care for all patients.
A recent BYU study found that socioeconomically disadvantaged children report higher levels of worry than advantaged peers, leading to lower math and reading scores. The study suggests that targeted support for disadvantaged children can enhance their academic outcomes and flourishing.
A new therapy combining Imagery Rehearsal Therapy with Targeted Memory Reactivation has been shown to significantly reduce nightmare frequency and increase positive dreams in patients. The treatment, which involves associating a major piano chord with positive scenarios, resulted in lasting benefits even three months after the experiment.
A University of Central Florida researcher is leading a $1.25 million project to map and manipulate materials at the nanoscale. The research aims to unlock new capabilities of materials at the nanoscale, potentially leading to new catalysts and compounds applicable in quantum science, renewable energy, life sciences and sustainability.
Researchers at the University of Kentucky have created a new class of gold(III) compounds that show promise in treating aggressive breast cancer. These chiral compounds possess a unique mechanism of action that causes cancer cells to dysfunction, depriving them of energy and inhibiting growth.
A new technology called RADARS allows scientists to detect and target specific cell types and states, opening up potential applications in diagnostics and therapeutics. The platform detects a particular RNA sequence in live cells and produces a protein of interest in response.
Curtin researchers have discovered two massive meteorite impact craters on Mars, with one containing ice at the lowest altitude ever observed. The findings provide valuable insights into Mars' subsurface structure and water ice reservoir, shedding light on the planet's formation and evolution.
Researchers have discovered a way to create ductile ceramics that can exhibit ultimate strength of up to 11 GPa, potentially leading to improved energy efficiency and reduced material usage. However, further studies are needed to scale up the process and apply it to larger materials.
A new study published in NEJM Evidence found that crossword puzzle training significantly improved cognitive function and daily activities, reducing brain shrinkage in individuals with mild cognitive impairment. The findings suggest that engaging with familiar activities like crossword puzzles may be more effective than computerized co...
Researchers at Nagoya University identified the pheromone PGE2 involved in puffer fish spawning behavior, which is synchronized with the lunar cycle. The study found that applying PGE2 to puffer fish triggers their characteristic writhing motion during spawning.
Scientists from Ural Federal University have proposed a new material for transporting electrons in perovskite solar cells, achieving an efficiency of 12%. The new material is twice as cheap, easier to produce, and has technological advantages over current electron-transport materials.
A study by international researchers found that descendants of transmigrants dominate and become influential actors in host community knowledge networks. This has led to the marginalization of native communities, who are now positioned at the margins of their local knowledge system.
Researchers at the University of Copenhagen develop a low-fat, more sustainable whipped cream alternative using lactic acid bacteria as building blocks. The bacteria-based foam can be whipped, peaks up, and retains liquid, making it a potential game-changer in the food industry.
Scientists have created a new type of battery that stores sodium ions in combination with their solvate shell, enabling reversible co-intercalation. This innovation could improve efficiency and performance at low temperatures, making it suitable for alternative cell concepts.
A new study warns that a lack of support for children's non-attendance from teachers and local authorities can lead to parents losing faith in the education system. Experts call for policies to be reformed to take account of underlying causes, rather than adopting a punitive approach.
Researchers will map developing brains, identifying cell types, activities, and locations as they differentiate during development and change throughout childhood and adolescence. The project aims to learn more about normal, healthy brain development and better understand how diseases like autism, schizophrenia, and Parkinson's emerge.
Johns Hopkins Medicine researchers have developed a novel genetic engineering approach to deliver gene therapy by utilizing a cell's natural process to
Researchers found high-end hotels inflate their ratings on platforms like Tripadvisor and Expedia when facing greater competition from Airbnb. The study, published in MIS Quarterly, suggests that hotels use fake positive reviews to counter negative reviews from rival hotels., Low-end hotels remain unaffected by Airbnb's presence.
Researchers found that playing a sound associated with a positive daytime experience during sleep can reduce nightmare frequency and increase emotional positivity in dreams. The study's findings support the development of new therapies for treating nightmares, which affect up to 4% of adults.
Researchers have discovered new routes to create strong metal-support interactions, enabling the stabilization of nanoparticles for industrially important reactions. These novel methods outperform traditional SMSI approaches in modulating geometric/electronic structures.
Researchers designed nanoscale ion-channel MXene electrodes with enhanced ion accessibility and high mechanical strength for high-capacity zinc-ion energy storage. The electrodes showed excellent anti-self-discharge properties and self-healing capabilities, making them suitable for flexible electronics.
Researchers have found conclusive evidence of a 3.5-billion-year-old shoreline with substantial sedimentary accumulation on Mars' northern hemisphere. The discovery provides key insights into the planet's ancient climate and its evolution, as well as the potential for life.
Research suggests that climate change can increase trust among Vietnamese rural households, particularly during periods of poor rice yields. As temperatures rise, communities come together to help each other, leading to increased social cohesion and trust.
Researchers have discovered that two seismic events detected by NASA's InSight lander were caused by meteor impacts, sending surface waves across the planet. These collisions provide valuable information about Mars' interior structure, with one study finding a denser crust than previously inferred.
A study published in Animal Behaviour found that bumble bees engage in playful behavior by rolling wooden balls repeatedly. The research showed that younger and male bees rolled the balls more than older and female bees, respectively.
The annual report shows a continued decline in overall cancer death rates among men, women, children, and adolescents. Additionally, there are modest improvements in survival for pancreatic cancer, with declines seen in lung cancer and melanoma.
Researchers aim to identify electrical activity in brain consolidation and test targeted brain stimulation to strengthen memories. The study could advance understanding of neural mechanisms involved in memory formation, potentially benefiting people with Alzheimer's disease.
Research published in European Heart Journal found that accumulating short bouts of vigorous activity across the week can help live longer. The study also showed that increasing intensity was associated with a reduced likelihood of cardiovascular disease.
The University of Minnesota has released four years of high-resolution imagery data to create the most detailed polar region terrain maps ever created. These maps will provide new insights into the effects of climate change over time, revealing glacier change, erosion, landslides, and flooding in incredible detail.
Researchers propose innovative solution to identify physical items uniquely and securely. Cholesteric spherical reflectors (CSRs) are used to create 'fingerprints' on surfaces, making them detectable by robots and AR devices but invisible to humans.
Researchers at Oregon Health & Science University have counted more than 10,000 nerve fibers in the human clitoris, exceeding previous estimates of 8,000. This discovery could lead to better outcomes for phalloplasty surgery and improved sensation for transmasculine patients.
Researchers have controlled a one-dimensional electron fluid to an unprecedented degree, discovering new properties of Tomonaga-Luttinger liquids in two-dimensional materials. The team's findings could pave the way for more robust quantum computers with enhanced fault-tolerance.
Researchers analyzed data from bike share stations in NYC, Chicago, and Philadelphia to understand disparities in bike share use. Key findings include concerns about traffic safety and personal safety among lower-income and people of color residents.
The study infers the dimensionality of complex networks using hyperbolic geometry, which captures relational structures in real-world domains. It reveals extremely low dimensions for molecular networks and higher dimensions for social networks and the Internet, with implications for network characterization and predictive capability.
A team of Rutgers physicians successfully treated a 5-year-old girl with anti-NMDAR encephalitis, a rare brain disorder, using blood plasma exchanges. The treatment, which involved nearly a dozen exchanges, led to the child's full recovery, highlighting the potential for late-stage treatment.
Researchers developed a new method to represent cell communication using graph neural networks, which uncovers the effects of tissue niche composition on gene expression. The node-centric expression models (NCEMs) identify cell-cell dependencies and molecular processes underlying cell communication.
A new study reveals that gut microbiota from patients with inflammatory bowel disease produce genotoxic metabolites called indolimines, which may contribute to the development of colorectal cancer. The study identified a previously unknown family of DNA-damaging compounds produced by the CRC-associated gut microbe Morganella morganii.
A new study in PNAS suggests that the spread of COVID-19 in US counties followed a hybrid lognormal-Pareto distribution, with 99% of counts conforming to Taylor's Law and the top 1% matching the Pareto distribution with infinite variance.
Researchers review emerging field of 2D ferroelectric materials with layered van-der-Waals crystal structures, offering new properties and functionalities not found in conventional materials. These materials show easily stackable nature, making them attractive as building blocks for post-Moore's law electronics.
Researchers found that immune checkpoint blockade therapy may be beneficial for certain cases of severe COVID-19. In pre-clinical trials, treatment with a PD-1 inhibitor restored T cell functionality and reduced inflammation in mice infected by MHV-A59, another betacoronavirus.
Scientists have detected seismic surface waves on Mars for the first time, providing new insights into the planet's crust and structure. The study estimates the average properties of the Martian crust between 3 to 18.6 miles below the surface, revealing faster seismic velocities that suggest compositional differences or reduced porosity.
Researchers identified a new clinical syndrome, Neuro-Ocular DAGLA-related Syndrome (NODRS), in children with termination variants in the diacylglycerol lipase alpha (DAGLA) gene. The study found that enzymatic activity was preserved despite mis-localization of the truncated protein.
Research from Portland State University suggests that taking music courses in higher- or mid-income schools leads to better math scores. The study found a positive relationship between arts course-taking and math achievement, but only among socio-economically privileged students.
Researchers at Kyoto University have developed a prodrug form of curcumin called TBP1901, which has shown anti-tumor effects without causing harm. The study found that TBP1901's conversion to active curcumin is dependent on the enzyme GUSB, suggesting its potential therapeutic targets.
A new study published in the Journal of Autism and Developmental Disorders found that autistic parents are three times more likely to report prenatal depression and anxiety compared to non-autistic parents. The research highlights the need for effective mental health screening and support for autistic individuals during pregnancy.
Two NIH-funded studies show long-term e-cigarette use can impair blood vessel function, increasing the risk for cardiovascular disease. The findings also suggest combining e-cigs with tobacco may increase health risks compared to using them individually.
Graphdiyne, a synthetic carbon-based material, shows promise as a key component in next-generation battery technology. Its unique properties make it an ideal interface for high-energy density batteries, potentially revolutionizing energy storage and conversion.
Researchers at Brigham and Women's Hospital developed a novel bioink capable of constructing functional and mechanically strong blood vessels. The bioink enables bioprinting of conduits with key physiological characteristics similar to native vessels, potentially serving as vascular models for grafts in surgeries and disease studies.
Researchers at Baylor College of Medicine found that initiating bone repair triggers bone metastasis, with cancer cells 'riding' NG2-positive stem cells to tumor sites. This finding offers new directions for preventing tumor recurrence and controlling bone metastasis.
Two closely related Drosophila species, biauraria and triauraria, coexist due to differences in seasonal occurrence and habitat use. Hybridization between the species is possible, despite reproductive interference mechanisms.
Researchers at the University of New South Wales have developed optrodes that can measure neural activity using light, potentially revolutionizing medical technologies like nerve-operated prosthetics. The new approach addresses long-standing issues with impedance mismatch and crosstalk, paving the way for more complex neural networks.
A recent study found that individuals who strongly believed in COVID-19 conspiracy theories were more likely to develop an increased tendency to believe in conspiracy theories in general. The study also showed that these individuals were more likely to believe in other conspiracy theories, such as voter fraud.
Researchers found that CaMKII β promotes sleep onset and inhibits awakening, with its phosphorylation state controlling the transition from wakefulness to sleep. The study provides clues for ideal sleep control methods, aiming to maintain sleep duration.