Researchers at the Salk Institute discovered that genetic mutations disrupt RNA splicing in Wiskott-Aldrich syndrome, leading to bleeding and immune deficiencies. This finding suggests new targets for treatment with small molecule drugs and sheds light on the basic biology of RNA splicing.
Researchers discovered a new prion structure using electron microscopy, revealing key similarities and differences between distinct strains. This finding could lead to better understanding of how shape variations affect disease outcomes.
A new Caltech project, COMAP, will peer beneath the 'tip of the iceberg' of galaxies to unveil a hidden era of star formation. The project aims to answer questions about what caused the universe's rapid increase in star production.
MIT researchers create microparticles that release their payload at different times, enabling self-boosting vaccines. The particles degrade over time and break down once released, allowing for potential use in regions with limited access to medical care.
A study of 1,581 children aged 6-11 from six European countries found that exposure to more green spaces is associated with healthier habits, including increased physical activity, reduced sedentary activities, and better sleep. Urban design plays a crucial role in promoting healthy behaviors in children.
A study by UC Davis researchers found that cultural habits around waiting to eat (emphasized in Japan) and waiting to open gifts (emphasized in the US) shape distinct profiles of delaying gratification. Japanese children waited three times longer for food, while U.S. children waited nearly four times longer for gifts.
Scientists argue that system thinking can better understand the world's rapidly changing dynamics, considering both social and ecological factors. The article highlights the importance of this approach in addressing climate change-induced natural disasters, such as increased frequency and danger of wildfires.
A new framework developed by researchers at Wayne State University aims to help state and local water authorities prioritize funding for infrastructure improvements on drinking water lead service line replacement programs. The study incorporates drinking water quality characteristics with community and environmental quality attributes,...
Children born to mothers with polycystic ovary syndrome (PCOS) are at a higher risk of developing infections, allergies, and other childhood illnesses by age 13. The study found that children of mothers with PCOS were 32% more likely to be admitted to hospital for various health problems.
Researchers developed an AI system that classifies IBDN lesions accurately, displaying image-based diagnostic ability with 64.5% sensitivity and 89.5% specificity. The correct diagnosis rate of the AI system was 79.0, surpassing that of endoscopists, who achieved a 77.8% accuracy rate.
A new study published in the American Journal of Ophthalmology found that paintball gun assaults can cause vision-threatening emergencies, including ruptured globes and permanent blindness. The research revealed a significantly higher rate of severe eye injuries than previously known, with some patients requiring multiple surgeries.
Researchers discovered a molecular switch in flavivirus that controls virus assembly, maturation, and entry into new cells. This switch is triggered by pH-dependent conformational changes in viral envelope proteins.
Researchers developed a novel approach to detecting hidden malicious codes in websites by analyzing common attack patterns and user-side scripts. The method can identify malicious distribution patterns with high accuracy and speed, including zero-day attacks.
Researchers found that six years before a stroke, people who later developed a stroke had similar scores to those who didn't have a stroke. However, at two years before the stroke, scores of those who had a stroke started increasing, reaching a total of about 2.1 points and staying high for 10 years after the stroke.
A Columbia University team created a robot that can learn and understand its own body, planning motion and avoiding obstacles without human assistance. The robot's self-model was accurate to about 1% of its workspace, paving the way for more self-reliant autonomous systems.
Researchers introduced a strategy to regulate the electrochemical reactivity and performance of Sn-based anodes for Mg storage by introducing a second phase and phase boundary. The introduction of Al enhanced the electrochemical reaction with Mg in both nanoscale and bulk phases, leading to superior long-term stability.
A new study emphasizes the need for clearer guidelines on how countries like the UK, USA, and Australia will respond militarily to imminent armed attacks. The UN Charter requires a country to establish it has been attacked before responding in self-defence.
Researchers identified a unique metabolic adaptation in AML patients with FLT3-ITD+ mutations, using lactate as a substrate for mitochondrial respiration. This discovery could lead to customized therapies combining complex II inhibitors and MCT1 transporters.
Scientists at the University of Nottingham have developed a new dressing that can prevent the recurrence of melanoma by killing cancer cells while promoting healthy cell growth. The dressing is made with graphene oxide, elastin, and ethanol, and requires only 15 seconds of Near Infrared light every 48 hours to be effective.
The new grant aims to address structural racism and discrimination affecting Asian-Americans with chronic hepatitis B virus infection and liver cancer. Researchers will examine factors such as socio-historical hardship, segregation, and mistrust of the health system to improve quality of care.
Researchers have discovered pairing Spinraza with valproic acid (VPA) can boost its therapeutic effects without increasing toxicity. This approach allows for improved SMN protein production in SMA patients, leading to longer survival and better muscle function.
Researchers at University of Essex found no benefit from oxytocin administration on healthy men's ability to recognize emotions. Computer-based emotional training programs proved more effective in improving emotion recognition and mental health.
Researchers created a quasiparticle lattice that exhibits macroscopic quantum phenomena, including Bose-Einstein condensation and superfluidity. The lattice's spatial configuration allows for controlled formation of ordered vortex arrays and laser arrays.
Researchers at City University of Hong Kong have identified the key mechanism behind roundworms' precise bowel movements, revealing a synchronized nerve impulse between the brain and gut. The study found that the AVL nerve cell in the head regulates the defecation rhythm by relaying and modulating pacemaker signals from the gut.
An international team of scientists has discovered a new mathematical principle that explains how cells connect with each other to form tissues. The finding reveals important properties of cellular connectivity, including the relationship between cell geometry and energy consumption.
A systematic review found that around 1 in every 400 adults (0.23%) have sought help for gambling problems globally. The prevalence of help-seeking was greater among people with higher gambling severity, affecting 1 in 25 with moderate-risk gambling and 1 in 5 with problem gambling.
A low-cost device can capture 3D images of the retina, cornea, and back of the eye, revolutionizing eye screening and treatment globally. The technology has the potential to detect eye diseases like glaucoma and improve patient care.
A study by Prof. Peter Neff from Doshisha University found that students prefer spontaneous verbal humor, cartoons, and memes, while visual humor is the least preferred. The study also revealed that students who appreciate humor in language classes accept the view that language learning should not be dry or humorless.
Researchers analyzed germline variants in breast cancer patients to identify their role in metastasis development. The study found that host genetic makeup contributes to metastasis through dysregulation of gene expression, promoting the dispersion of metastatic seeds and establishing a conducive environment for their growth.
Women with conditions like MS, migraine, and epilepsy face increased unplanned pregnancy due to treatment effects on hormonal contraceptives. Teratogenic drugs used for neurological treatments may be restricted or unavailable during pregnancy.
A substantial increase in eating disorder diagnoses was found among Norwegian girls aged 6-16 after the onset of the COVID-19 pandemic. This finding is consistent with similar increases observed in North America, suggesting an international trend.
A nationwide study found that states with more generous SNAP policies had fewer children involved in Child Protective Services and sent to foster care. The study showed a 5% increase in SNAP beneficiaries reduced CPS and foster care caseloads between 7.6% and 14.3%.
Researchers demonstrate a new platform for guiding compressed mid-infrared light waves in ultra-thin van der Waals crystals, enabling strong light-matter interactions and improved detection limits. The use of atomically-smooth gold crystals provides a low-loss environment for the propagation of phonon-polaritons.
Researchers analyzed data from trauma centers to determine if patients with seat belt injuries and negative CT scans can be safely discharged. The study found that some patients with abdominal bruising from a seat belt following a car crash may not need hospital admission.
Researchers investigated long-term features of immune responses to SARS-CoV-2 in children and adults who experienced mild infections. The study found that both groups developed similar patterns of antibody responses, indicating a shared immune memory.
A molecular feedback-loop regulates plant growth by balancing high auxin levels, which stimulates cell division and elongation. The discovery involves PILS proteins that transport auxin into the endoplasmic reticulum, modulating its effect on plant development.
A recent study published in Nature Communications has uncovered the likely Martian origin of a 4.48-billion-year-old meteorite named Black Beauty. The team found that this ancient fragment may have come from a region on Mars similar to Earth's continents, providing valuable insights into our planet's geological past.
A study from the University of Kansas found that social support was crucial in predicting good sleep quality among individuals with multiple sclerosis. The research, conducted during the pandemic, revealed that tangible and positive social interaction support significantly predicted better sleep quality.
Researchers have uncovered how tissue stiffness determines cell positioning and regulates cell migration in various types of cancer, including brain tumors and breast cancer. The study provides new possibilities for stopping and directing cancer cell migration.
A new universal approach to mental health issues has been developed, utilizing 20 years of research on artificial intelligence, consciousness, perception, and mental health. This approach prioritizes patient control, allowing the conscious mind to work on resolving difficulties, similar to a mechanic assessing a car.
A UC Riverside study reports that switching from combustible cigarettes to electronic cigarettes does not restore the nasal epithelium to that of a non-smoker. The researchers found alterations in gene expression profiles associated with cigarette smokers, indicating potential harm from prolonged EC use.
A research team, led by Rohit Pappu and Anthony Hyman, found that protein molecules form dynamic clusters at low concentrations, which have structures that encode function. This discovery challenges the long-held assumption that there is no further structure underlying biomolecular condensates.
Researchers at the University of Malaga study the global risk of yellow fever transmission to humans, finding high zoonotic potential in southeastern Brazil and western Amazon basin. The team proposes prioritizing vaccination efforts in regions with favorable conditions for virus presence and mosquito vectors.
Congenital syphilis cases are on the rise in California's small and medium-sized counties. A new study found that poverty and low education levels contribute to the spread of the disease. The researchers call for improved access to prenatal services to address this growing public health crisis.
Researchers track changes in fitness landscapes as viruses and hosts undergo ongoing survival competition. The study reveals that coevolution propels adaptations, with viruses innovating to overcome host resistance. This new understanding provides a quantitative framework for predicting evolution in coevolving ecological communities.
Researchers at NIMS and Osaka University successfully fabricate nickel single crystals with minimal crystalline defects, paving the way for widespread use in heat-resistant jet engine components. The technique eliminates grain boundaries, resulting in stronger high-temperature materials.
A recent study found that perovskite-on-silicon solar PV modules have 6-18% less environmental impact than traditional silicon modules over their 25-year lifetime. The tandem technology's higher power conversion efficiency compensates for its additional material and production costs.
A Dartmouth study provides a scientific basis for climate liability claims between individual countries, linking national emissions to global economic losses and warming. The research estimates $6 trillion in cumulative losses attributable to the world's top emitters from 1990 to 2014.
Researchers found that despite a powerful brain response to sound during sleep, the level of alpha-beta waves associated with attention and expectation is significantly reduced. This means the brain can analyze auditory input but fails to focus on it, resulting in no conscious awareness.
Researchers used a machine learning algorithm to identify the specific Mars crater that ejected the oldest and most famous Martian meteorite, offering critical geological clues about the earliest origins of Mars. The discovery provides insights into the region's unique rock formations and their similarities with Earth's continents.
A new study found that COVID-19 vaccine boosters significantly reduce the risk of breakthrough infections in patients with systemic lupus erythematosus. The research showed that those who received a booster dose had an immediate rise in antibody levels, but still required additional protection against severe disease.
A study by Norwegian University of Science and Technology found that parasites infesting farmed salmon have a distinct microbiome that interacts with the fish's microbiome. This interaction can impact the host's health, highlighting the importance of understanding the complex relationships between parasites and their hosts.
A study published in ACM Transactions on Computer-Human Interaction found that individuals who read text in a font better suited to their needs experienced a significant increase in reading speed, with an average gain of 35%. The research highlights the importance of personalization in improving reading efficiency and comprehension.
A new study found that volunteer healthcare workers who served in field hospitals during the COVID-19 pandemic experienced high levels of secondary traumatic stress, but those with higher compassion satisfaction showed milder symptoms. The researchers also found that avoidant emotional coping tactics significantly increased burnout and...
A study comparing ancient lungfish fossils to modern brain structures reveals the evolutionary history of these ancient fish. The research suggests that lungfish relied on their sense of smell to navigate environments, unlike other fish that use sight more powerfully.
A cluster of studies published in BMJ Group found that universal UK school-based mindfulness training had weak evidence for effectiveness and short-lived benefits. The research suggests that other approaches, such as social-emotional learning (SEL), may be more suitable for building psychological resilience in young people.
A recent study by Xi'an Jiaotong-Liverpool University provides a method to help farmers and policymakers decide whether organic farming is beneficial for the environment. The researchers analyzed international studies to find a threshold where organic farming's biodiversity gain outweighs its land requirements.
A survey study of over 12,000 high school students in Cleveland found substantial reductions in tobacco product use and decreased disparities across racial and ethnic groups. The findings support the potential of raising the minimum legal age to purchase tobacco to 21 to achieve equity.
Thousands of people with long covid are traveling abroad for expensive, unproven treatments like apheresis and anti-clotting therapy. Experts question the safety and effectiveness of these treatments, citing inadequate consent forms and lack of evidence.
A recent study published in The Lancet Global Health reveals stark differences in survival rates for children with retinoblastoma between high- and low-income countries. In low-income countries, the risk of death from retinoblastoma within three years of diagnosis is significantly higher, with over two-fifths of children dying within t...