Researchers developed a new treatment strategy using the cancer medicine Teclistamab to reduce antibodies against potential transplants, improving transplant prospects for patients with unfavorable immunological profiles. The study successfully performed a kidney transplant in a patient who had been on the waiting list for over a decade.
A new peptide derived from cone snail venom has been shown to significantly reduce inflammation-induced pain in an animal model. The peptide specifically inhibits the noradrenaline transporter, supporting the body's own pain-inhibiting mechanisms.
Researchers developed a multimodal rehabilitation platform combining virtual reality with targeted sensory nerve stimulation to improve arm and hand function in stroke patients. The platform showed greater improvements in motor impairment, sense of touch, and perception of the affected arm compared to conventional rehabilitation.
Researchers discovered that the epidermal growth factor receptor (EGFR) influences certain immune cells in the tumour microenvironment, affecting how the body defends against the tumour. Silencing EGFR in myeloid cells led to reduced production of factors inhibiting T cells, allowing them to attack cancer cells more effectively.
A study using a mouse model demonstrates that microplastics can exacerbate respiratory tract inflammation and alter immune responses associated with allergies. The researchers found that the particles remained detectable in the lungs for at least 14 days, leading to an increased migration of lymphocytes and eosinophils.
A study published in Nature Communications has identified sialylation as a key mechanism by which breast tumours evade the immune system, leading to limited effectiveness of immunotherapies. Targeting this process may improve the efficacy of these therapies, providing new hope for patients with breast cancer.
A study by Medical University of Vienna shows that PET/CT scans can detect aggressive forms of head and neck cancer at an early stage due to specific patterns reflecting biological activity. Modern imaging helps identify targeted treatment strategies for a type of cancer difficult to treat.
Researchers discovered brown adipose tissue protects against atherosclerosis and inflammation in humans with obesity, showing lower arterial inflammation and healthier blood profiles. Higher brown fat activity correlates with reduced vascular inflammation and improved cardiovascular health.
A new paradigm shift in cancer research defines valid primary study endpoints for oligometastatic disease, focusing on treatment-free time and minimal side effects. The consensus paper establishes two new metrics: STFS (Start or Switch of Systemic Therapy–Free Survival) and pPFS (polymetastatic Progression–Free Survival), which capture...
Researchers from MedUni Vienna have developed a new approach to drug discovery by targeting intracellular signalling proteins, such as β-arrestins, to control disease-relevant signalling pathways. This approach holds promise for personalized therapies, particularly for the treatment of neurological diseases.
Structured exercise improves depression, psychotic symptoms, cognitive performance and cardiometabolic health in people with mental illness. Integration into psychiatric care using the 5A model can help address lack of exercise as a symptom and risk factor, reducing mortality.
A study by MedUni Vienna found that up to one-third of patients with advanced alcohol-related cirrhosis can achieve complete regression of liver-related complications through consistent abstinence from alcohol. This 're-compensation' also leads to simultaneous recovery of liver function and a significant reduction in mortality rates.
A new approach to treating KRAS-mutated lung adenocarcinomas has been identified, using a combination of ERBB inhibitors and Aurora kinase inhibitors. This therapy shows significant effectiveness against existing treatments, offering hope for patients with limited options.
A study by the Medical University of Vienna found that plastic particles can increase intestinal inflammation and disrupt the gut microbiome, leading to ulcerative colitis. The research shows that MNP exposure triggers a pro-inflammatory immune response and alters the balance of beneficial and harmful bacteria in the gut.
Researchers have discovered how Candida auris uses carbon dioxide to survive on the skin and resist antifungal treatments. The study identified several new therapeutic targets that could curb the spread and infections caused by the fungus.
Researchers have identified a potential biomarker for targeted psoriasis therapy by discovering the link between fat metabolism and skin inflammation. FABP5 drives ferroptosis, amplifying inflammatory processes in the skin, which can be blocked to improve skin changes associated with psoriasis.
A multicenter randomized controlled trial demonstrates the advantages of continuous real-time glucose monitoring over finger-prick testing in managing gestational diabetes. The study found that only four percent of women with rt-CGM gave birth to above-average weight children, compared to ten percent in the control group.
Scientists at MedUni Vienna and Imperial College London have created a new method to precisely detect nerve signals remaining after an arm amputation, allowing for the control of artificial arms. This breakthrough could form the basis for the development of next-generation prostheses.
A new chemotherapeutic agent, LiPyDau, has been developed to tackle drug-resistant cancers. The liposomal formulation delivers the active ingredient directly to tumour cells while minimizing damage to healthy tissues.
A study led by Olaf Merkel and colleagues identified thyroid hormone receptor TRβ as a key driver of prostate cancer growth, with blocking the receptor inhibiting tumour development. The findings offer new perspectives for treating castration-resistant prostate cancer and provide a potential target for new drugs.
A research team at the Medical University of Vienna has discovered a previously unknown mechanism that plays a decisive role in the development of pre-eclampsia. The study found that an amino acid transporter and transcription factor work together to control angiogenesis and protect cells from oxidative stress.
A research team has discovered a previously unknown genetic cause of hereditary optic atrophy, a degenerative disease of the optic nerve associated with gradual loss of vision. A genetic variant in the PPIB gene was found to impair mitochondrial function, detectable in most known forms of hereditary optic atrophy.
A study published in Frontiers in Immunology has identified pentraxin 3 (PTX-3) as a potential biomarker for existing tissue damage and long-term immune activation following severe COVID-19. PTX-3 levels were found to be significantly higher in convalescent patients with a severe disease course persisting ten weeks post-infection.
A research team from the Medical University of Vienna has identified a molecular mechanism that may play a role in the development of seizures. They found that paroxysmal depolarisation shifts (PDS) can lead to altered energy metabolism in neurons, paving the way for seizure-like electrical discharges.
A new study reveals that combining heart valve replacement with specific drug therapy offers significant survival benefits for patients with severe aortic stenosis and cardiac amyloidosis. The treatment significantly lowers the risk of death in both forms of treatment, especially when combined.
Researchers discovered that EGFR plays an active role in KRAS-mutated colon cancer, despite previous assumptions. The study found that blocking EGFR can slow down sugar metabolism and activate a gene signature associated with longer survival in patients with KRAS mutations.
A recent study confirms the benefits of rivaroxaban treatment even after extended use in children, providing reliable evidence for long-term anticoagulation. The research shows a low risk of VTE recurrence and serious bleeding with prolonged treatment, making it a scientifically proven age-appropriate option.
Research from the Medical University of Vienna found a connection between altered inflammatory markers, intestinal barrier disturbances, and post-viral fatigue in PCS patients. The study suggests that monitoring gastrointestinal symptoms and biomarkers could help identify at-risk patients and develop targeted treatment strategies.
A study published in Leukemia reveals that histone deacetylase 1 (HDAC1) acts as a tumor suppressor in ALK-positive anaplastic large cell lymphoma, delaying or preventing tumour development. HDAC inhibitors, such as entinostat, show promise as additional treatment options.
The introduction of standardized criteria for amino acid PET in brain metastases diagnosis and treatment could improve patient care and accelerate innovative treatment strategies. The new criteria may allow a more precise distinction between true tumour changes and therapy-related effects.
A recent study has identified similarities in the mechanisms of diabetes and prostate cancer, suggesting that diabetes drugs like pioglitazone could inhibit tumor growth. Researchers found that PPARγ activation states influence cell behavior, leading to potential new therapeutic approaches for prostate cancer treatment.
A study by Medical University of Vienna reveals high blood pressure can cause abnormalities in podocytes, specialized cells in the renal filter, before other conditions like diabetes. Early detection and treatment are crucial to prevent kidney damage.
New guidelines support safe and efficient use of JAK inhibitors for treating chronic inflammatory diseases like rheumatoid arthritis, psoriasis, and Crohn's disease. The updated consensus statement considers safety concerns, including cardiovascular disease and cancer risk, to ensure individualized treatment decisions.
Researchers identified PDGFRA as a promising therapeutic target for pediatric high-grade gliomas. Inhibition of the PDGFRA signaling pathway leads to tumor cell death and has shown potential in laboratory and animal models, as well as initial clinical experience with avapritinib therapy.
Researchers found that semisynthetic bile acid NorUDCA inhibits pro-inflammatory T helper 17 cells and promotes anti-inflammatory regulatory T cells in the intestine. This could lead to new therapies for inflammatory bowel diseases such as ulcerative colitis or Crohn's disease.
Researchers have identified a new starting point for therapy by targeting SSAT enzyme in psoriasis, restoring regulatory T cell function and breaking inflammation cycle. This approach could lead to a promising alternative treatment option with fewer side effects.
A new therapy using Talimogene Laherparepvec (TVEC) has been successfully tested on patients with locally advanced basal cell carcinomas. The study showed that the treatment led to a significant reduction in tumour size and complete regression of some cases, improving surgical removal outcomes.
Researchers call for special ethical care as neural implants improve mobility and alleviate pain for patients with neurological disorders. However, concerns over data protection, psychological privacy and hacker risks pose significant challenges to the development of these technologies.
A new combination therapy combining systemic interferon-I with local imiquimod application showed promising results in treating melanoma and breast cancer. The therapy activated the adaptive immune system to fight distant metastases, reducing tumor relapses and increasing sensitivity to checkpoint inhibitors.
A recent study has discovered that saliva contains special vesicles with extrinsic tenase complexes, which trigger rapid coagulation of the blood in haemophilic patients. This finding provides significant contributions to understanding the disease and its treatment options.
A new study published in the European Respiratory Journal found that extracorporeal photopheresis significantly reduces acute rejection episodes and chronic rejection risk in lung transplant patients. The treatment involves exposure to UV light, leading to apoptosis of immune cells and minimizing side effects.
A study by MedUni Vienna identified a promising therapeutic approach for metabolic liver diseases by targeting fat metabolism inhibition, promoting liver health and reducing liver fat, inflammation and fibrotic remodeling. The approach involves blocking ATGL, an enzyme playing a central role in lipid metabolism.
Scientists discover that pregnant and nursing women's intestines undergo significant changes, doubling their surface area and reorganizing villi structure. This adaptation is crucial for the health of babies and may have long-term metabolic consequences.
Researchers identified three subtypes of fibroblasts in skin cancer: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs). The distribution of these subtypes varies with tumor aggressiveness. iCAFs produce signaling factors to activate immune cells, while mCAFs prevent T cell invasion.
Researchers discover SARS-CoV-2 hijacks three host proteins to shield itself from complement-mediated lysis, significantly impairing viral clearance. This may affect the course of acute and post-COVID-19 sequelae, deepening our understanding of immune evasion mechanisms.
A new strategy for treating prostate cancer has been developed by blocking the GP130 signalling pathway, contrary to current medical understanding. The study found that activating GP130 in prostate cells reduces tumour growth and stimulates the immune system to fight cancer cells.
A recent study revealed that nanoplastic particles impair antibiotic effects and promote bacterial resistance. The research team found that plastics like nylon bind strongly to antibiotics, increasing the risk of resistance.
Researchers at MedUni Vienna identified a potential way forward for targeted therapies that do not rely on antibiotics. The study focused on the restriction-modification system of Borrelia bacteria and discovered its importance in protecting the bacteria against foreign DNA.
Researchers from Medical University of Vienna discovered that TRPV1 is the primary detector of noxious heat in humans, but other molecular mechanisms contribute to protective heat avoidance. The findings have significant implications for research into heat damage prevention and potential new therapies.
Researchers have gained new insights into the cellular reactions to a cerebral infarction, identifying specific cell types and their roles in the early phase after a stroke. The study's findings hold promise for developing novel therapeutic strategies to promote nerve tissue regeneration after a stroke.