Researchers at MedUni Vienna have identified AF1Q as a promising biomarker to predict gastric cancer recurrence risk. The study found that 97.8% of tumour samples had elevated AF1Q levels, associated with higher recurrence risk and lower survival chances.
A new combined cell therapy for kidney transplants uses a combination of bone marrow cells from the donor and Treg cells from the recipient to reduce the donor-specific reaction. This approach preserves the overall diversity of the T-cell receptor repertoire, crucial for immune defence.
A recent study published in Allergy found that COVID-19 leads to long-term changes in the immune system, even in mild cases. The research team identified significant reductions in immune cells and alterations in cytokine levels, suggesting an impaired immune response to new challenges.
A scientific team has identified pentamidine as an active substance that can prevent chlamydial infections, even at low concentrations. The compound suppresses the growth of intracellular bacteria by inhibiting host cell metabolism, offering a promising alternative to existing treatments.
Researchers have identified three new variants of MDMA as promising alternatives for controlled psychotherapeutic use, retaining therapeutic potential while reducing side effects. The new compounds show a similar effect on clinical target structures in the brain and are broken down more favorably, resulting in fewer toxic products.
A recent study has identified three subgroups of gestational diabetes with different treatment needs, enabling personalized therapy and reducing complications for mothers and children. The analysis used cluster methods and machine learning to analyze data from 2682 women with gestational diabetes.
Researchers have identified two distinct types of dysbioses in cystic fibrosis, which differ in their ecological organization and response to treatment. These findings suggest that antimicrobial drugs may be more effective in hierarchically organized microbiota, potentially leading to improved treatment outcomes for patients.
A recent study suggests that inhibiting epigenetic control enzymes in immune cells, specifically HDAC1, improves anti-tumor immunity and tumor surveillance. This finding could lead to new therapeutic strategies in cancer immunotherapy.
Researchers identified protein JUN as a potential therapeutic option to slow tumor growth in prostate cancer, contradicting previous findings that linked high JUN levels to increased tumor growth. The study showed that JUN slows tumor progression and improves immune response, providing a new starting point for therapy development.
A recent study published in Anesthesiology found that liposomal bupivacaine is not sufficient to control pain during surgery, with successful blockade achieved in only a third of test subjects. However, the substance did lead to a reduction in pain sensitivity for 3.5 days post-operatively.
A study of over 470,000 adults found that those who frequently add salt to their food are 39-40% more likely to develop stomach cancer. The research highlights the connection between high salt consumption and stomach cancer in Western countries, raising awareness of the negative effects of extremely high salt consumption.
Researchers found PLS occurs significantly more frequently in unequal AB0 settings, leading to haemolysis and anaemia in patients. Blood group A patients with O transplants are particularly at risk.
A new genetic testing procedure identifies patients at high cardiovascular risk due to clonal haematopoiesis and carotid artery stenosis. This allows for early detection of increased mortality and a personalized cardiovascular risk profile, enabling therapy adaptation and prevention of atherosclerotic disease progression.
A study from Medical University of Vienna reveals a new molecular signaling pathway crucial to liver cancer development, offering potential new therapeutic targets. The research also identifies the c-Jun/Fra-2 complex as essential in triggering tumour growth.
A team of researchers has developed the world's first 3D-printed brain phantom, which can be imaged using dMRI. The brain model is made up of microchannels that mimic nerve cells in the brain, allowing for more accurate analysis and research into neurodegenerative diseases.
A study led by Leopold Eckhart found that the genetic programme controlling keratinized claws originated in a common ancestor of humans and frogs. The research team used the tropical clawed frog as an experimental model and discovered that important hair components, including keratins, share similarities with human hair.
Researchers have made progress in understanding atherosclerosis, identifying potential new approaches for early detection and therapy. The study found that TREM2 regulates the activity of macrophages, playing an important role in forming unstable plaques that increase heart attack and stroke risk.
Research reveals micro- and nanoplastics can persist in the human body for longer than previously thought, being passed on to newly formed cells during cell division. The study also suggests these tiny plastic particles may promote the spread of cancer by increasing tumor migration.
A recent study published in the Journal of Clinical Medicine identifies potential biomarkers for ME/CFS diagnosis and treatment. Researchers found that patients can be divided into subgroups based on immune system function, revealing differences in intestinal barrier function and immune competence.
A recent study published in Hepatology has investigated the connection between platelet function and complications in patients with cirrhosis. The researchers found that decreased platelet activation predicts hepatic decompensation and mortality, highlighting the importance of personalized therapeutic approaches.
A systematic analysis by MedUni Vienna's Center for Public Health found that people experiencing homelessness are twice as likely to develop cancer due to increased exposure to risk factors. Key barriers include lack of access to preventive services, inadequate support from healthcare systems, and traumatic experiences.
Researchers identify successful treatment of granulomas in the skin with mTOR inhibitor sirolimus, which showed partial complete remission of symptoms in 7 out of 10 patients. The study suggests targeting both immune and non-immune cells in granulomas may prevent recurrence.
A study found rectal examinations offer no advantages over PSA blood tests for detecting prostate cancer. The research analyzed data from 85,738 participants and concluded digital rectal examination alone or with PSA is not more effective than the PSA test.
Researchers have developed a new technique that provides a previously unattainable view of the mechanical properties inside the cell nucleus. The study reveals the peculiar dynamic structural features in living cells, which appear to be crucial for cell function.
Chronic kidney disease and cardiovascular disease significantly worsen prognosis for severely burned patients. The study analyzed data from 1,193 patients and found that nearly half did not survive their burns with impaired kidney function. Researchers highlight the need to integrate these findings into burn treatment scores.
A team of scientists has identified a previously unrecognized control point in DNA repair processes, which could lead to novel cancer therapies by inhibiting the repair of damaged cancer cells. The newly discovered GSE1-CoREST complex contains three enzymes that control DNA repair and may form the basis for improved cancer treatments.
A new framework has been established for standardized imaging of diffuse gliomas using amino acid PET, enabling the evaluation of treatment success and improving therapies. The RANO group has developed criteria that enable reliable imaging of tumor activity and extent.
A study by researchers at the Medical University of Vienna found that natural killer cells may play a crucial role in protecting against multiple sclerosis (MS) disease. The investigation revealed that strong EBV-specific and autoreactive immune responses combined with poor autoimmunity control increase MS risk.
A plant-based diet has been shown to reduce the risk of type 2 diabetes by 24%, with benefits attributed to improved metabolism and liver function. Additionally, healthy eating patterns were found to improve organ function, particularly in individuals with genetic predispositions or other risk factors.
Researchers developed a new risk assessment system to identify patients with low-risk profiles who can benefit from liver stents. These patients have a significantly higher mortality rate than previously thought, highlighting the need for targeted treatment and further personalization.
A new smartphone app using the APRI+ALBI score increases the safety of liver surgery by providing an individualized risk assessment for patients prior to resection. The score offers a cheaper and less invasive option with comparable predictive power compared to standard preoperative tests.
A study by Medical University of Vienna found that AI algorithms in smartphone applications perform well in diagnosing pigmented skin lesions, but are outperformed by doctors in treatment decisions. The 7-class algorithm showed equivalent diagnostic accuracy to experts, while the ISIC algorithm performed worse.
Researchers identified YB-1 as an attractive therapeutic target for pleural mesothelioma, a cancer caused by asbestos exposure. Indirect targeting of YB-1 via histone deacetylase inhibitors showed promise in enhancing chemo- and radiotherapy sensitivity.
Macrophages produce polyamines spermidine and spermine, which benefit epithelial cells, promoting their proliferation and defense mechanisms. This "commensal metabolism" supports the efficient self-renewal of the intestinal epithelium.
A large-scale clinical study confirms the validity of the Vienna Prediction Model in identifying low-risk patients with venous thromboembolism who may not require long-term blood thinning. The model's accuracy was found to be 5.2% after one year for patients with a low relapse risk, but adjustments were made to correct imprecision.
Researchers at MedUni Vienna discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of P-glycoprotein, opening new possibilities for delaying relapse. This breakthrough could represent a step forward in treating aggressive triple-negative breast cancer, which has limited treatment options and ...
Researchers have identified viral components of the skin's microbiome that drive the development of innovative therapies for atopic dermatitis. Bacteriophages, or 'bacteria eaters', were found to help certain bacteria grow faster in AD patients, contributing to the overpopulation of the skin microbiome.
Researchers from MedUni Vienna developed a new approach to fighting resistant cell lines in small cell lung cancer by combining two already available therapeutic agents. The study reveals the molecular mechanism underlying therapy resistance and provides a promising basis for research into successful new therapies.
A research team at MedUni Vienna has discovered an immunoregulatory protein called Rinl, which could be linked to the development of autoimmune diseases. The identified component controls the development of follicular T helper cells in the immune system.
A study published in eBioMedicine identified the mechanism behind rapid vaccine waning in patients on TNF-α blockers for autoimmune diseases like Crohn's and rheumatoid arthritis. Regular booster vaccinations are crucial to maintain protection, especially for those receiving immunosuppressive therapy.
A new study has discovered that metformin, a common diabetes medication, can significantly slow the progression of STAT3-positive prostate cancer. The research team identified the key factors regulating tumour cell growth and found that permanent activation of STAT3 prevents prostate cancer development and metastasis.
Researchers developed a reinforcement learning model that incorporates human decision-making criteria to improve AI accuracy in skin cancer diagnoses. The study showed increased sensitivity for melanoma and basal cell carcinoma, leading to more accurate diagnoses and optimal treatment decisions.
A team of researchers identified a specific subtype of complement-producing macrophages in atherosclerotic lesions that exacerbate plaque necrosis and cardiovascular events. The study suggests a potential therapeutic target to control complement activation within cells, which may also apply to other chronic inflammatory diseases.
Research reveals that cancer screening awareness is low among people experiencing homelessness, making it difficult for them to receive timely treatment. The study's findings highlight the need for targeted prevention programs tailored to this underserved group's unique needs.
A large-scale study shows that repeated liver stiffness measurements can predict patient outcomes in chronic liver disease. The researchers found that monitoring changes in liver stiffness over time provides a more accurate assessment of patient risk than single measurements.
Researchers have confirmed that measuring retinal layer thickness can significantly improve MS diagnosis and predict progression. The study found a strong correlation between retinal damage and brain damage, paving the way for earlier treatment and better patient outcomes.
Researchers identified a new drug treatment option for peritonitis in patients on peritoneal dialysis, showing that a low dosage of ceftazidime and avibactam is sufficient to treat the infection. The study's findings could help gain control over peritonitis in patients with difficult-to-treat germs.
Researchers have made significant progress in understanding osteoarthritis, linking degradation of articular cartilage to inflammatory and metabolic processes. Elevated levels of the protein c-Fos are found in human and mouse cartilage samples with OA, suggesting a new target for therapy.
Researchers at MedUni Vienna's Department of Thoracic Surgery have made key findings in small-cell lung cancer, including the identification of tumor subgroups associated with varying clinical behaviors. They also propose promising therapeutic strategies for patients with characteristic molecular profiles.
Researchers have created a new prediction tool to evaluate the benefits of blood cancer treatments, filling a gap in previous versions. The ESMO-MCBS:H v1.0 tool uses a validated algorithm to assess clinical benefits, survival data, and quality of life, providing a transparent assessment for clinicians.