A new study suggests that individuals with diabetes who focus on tightly controlling their blood sugar levels may be missing out on enjoyable activities due to the associated burden. Higher glucose variability and better sleep quality on the previous day were associated with improved quality of life on the following day.
JMIR Publications and ZB MED extend their Flat-Fee Unlimited Open Access Publishing Agreement for two years, covering over 30 Gold Open Access journals with zero Article Processing Charges (APCs) for participating German research institutions. The new agreement provides predictable and sustainable funding for open access publishing.
András Tilcsik, a University of Toronto researcher, has been elected to the College of New Scholars, Artists and Scientists of the Royal Society of Canada. His work on organizations, occupations, and work has been recognized with numerous awards and has appeared in top academic journals.
Researchers have discovered a rare population of neurons in the cortex that can synchronize activity across large areas of the brain and promote sleep. These Sst-Chodl neurons were found to be active during the transition to sleep and could even help drive the process, suggesting that the cortex is not simply passive during sleep.
The American College of Cardiology, Society of Thoracic Surgeons, and Society for Cardiovascular Angiography & Interventions released a joint statement on TAVR national coverage determination. The statement aims to preserve the quality framework that contributed to TAVR's success, emphasizing the importance of collaborations, registrie...
A new vision condition, EFEMP1-associated late-onset retinal degeneration (L-ORD), has been discovered, causing slow decline in peripheral vision and night vision loss. The p.Arg140Trp variant in the EFEMP1 gene leads to abnormally thick material building up between eye cells, affecting rod photoreceptors' recovery in darkness.
Researchers have discovered tiny constrictions in dendrite extensions of nerve cells, which may enable local information processing and shape synaptic integration. These constrictions, only a few hundred nanometers wide, occur in various types of neurons and are linked to NMDA receptor activation and learning processes.
A giant volcanic eruption 21.9 million years ago buried an entire landscape beneath volcanic deposits, preserving clues to how the Andes were built. The study found that the landscape was built slowly, with rocks pushed upward by 0.26 km every million years.
A new video game, Geode, measures how people with autism understand and interpret information, providing fresh insights into the autistic brain and refining therapy development. The game, which can be played by people across the autism spectrum, includes nonverbal players and was successful in collecting detailed data on sensory input ...
Researchers developed a graph-based approach to directly extract concise and accurate constitutive equations from solid material experimental data. The method outperforms mainstream empirical models in predictive accuracy while preserving explicit, physically interpretable mathematical formulations.
Researchers develop nanoparticles that target tumor-associated macrophages, reprogramming them to attract cancer-fighting T cells. The approach shows promise in reducing immune-suppressing macrophages and increasing cancer-fighting T cells, with potential for improving immunotherapy for solid cancers.
The Frontiers Science House roadshow brings together world leaders and climate experts to address unresolved scientific disputes and policy bottlenecks in governance of climate intervention technologies and power, rewired: building the climate-energy future. The event aims to facilitate discussions and find solutions to pressing issues...
Researchers at CU Anschutz have developed CAR T-cell therapy to target two pathways that help colorectal tumors grow and evade the immune system, B7-H3 and IL-8. The therapy aims to provide a more durable response than traditional chemotherapy.
Kyocera and Tohoku University developed a new technology integrating optical isolators onto silicon photonics chips using laser annealing. This method allows for localized heating, reducing damage to surrounding components. The technology resulted in an isolation ratio of 13.6 dB, confirming its operation as an optical isolator.
Researchers identified a mutant rice variety, chalk2, with increased amylose and protein content, reduced starch and lipid, and higher resistant starch content. SBEIIb enzyme plays a crucial role in regulating starch composition and resistant starch formation, leading to a chalky phenotype and reduced grain yield.
Long-term fertilization increases resource inputs, enhancing functional groups in soil food web. Organic inputs, particularly in combination with mineral fertilizers, primarily drive bottom-up regulation, promoting soil food web complexity and size.
Researchers used finite element analysis to study how eight species of armoured fish, placoderms, caught their prey 385 million years ago. They found that despite differences in jaw shape and size, both the largest and smallest placoderms had evolved strong jaws to handle hard bites.
Researchers developed an automated method to convert standard eye scans into an objective cataract biomarker. The method, tested on 1906 eyes, demonstrated exceptional diagnostic discrimination and strong correlation with a standard cataract grading system.
A new review in Science Bulletin outlines how multimodal AI can integrate molecular, cellular, and clinical data to refine treatment choices and predict side effects. The approach aims to address challenges in cancer treatment, including primary resistance and immune-related adverse events.
Researchers propose a new concept of societal listening to transform environmental data into public awareness and collective action. The concept connects environmental sensing to sensory experience, public imagination, and institutional responsibility, aiming to make environmental change perceptible and shareable.
A new study found that ocean acidification can undermine the health of diatoms, crucial organisms for oxygen production and carbon capture. The research highlights the need for better understanding of complex processes in seawater to find solutions for ocean conservation.
The study identifies potential seismogenic asperities along western Ordos margin faults by analyzing sparse earthquake segments, b-value anomalies, and crustal velocity structures. Regions with overlapping sparse earthquake segments and low b-value areas are interpreted as highly-stressed locked fault sections.
Plant roots change anatomy to adapt to microbes, influencing root-microbiome interactions and nutrient uptake. Researchers identified mechanisms that enable roots to remodel themselves in response to bacterial colonization, paving the way for developing new agricultural strategies.
A review of 15,886 scientific publications highlights the importance of early diagnosis and treatment in rheumatoid arthritis. Consistent treatment and regular monitoring of disease activity can prevent joint damage and improve patient quality of life.
A Finnish study found that remote workers sleep 15 minutes longer and spend 45 minutes more sitting and lying down than office workers. This increase in sedentary behavior is attributed to less standing and increased sitting in a home setting.
Researchers have proposed a superfluid helium-based qubit design that could reduce error rates by 100 times, making it more resilient to electromagnetic noise. The SHOQ device could work alongside existing superconducting technologies, enabling a hybrid quantum system with improved performance.
A new study found that a rare mutation in the fibronectin gene limits the accumulation of fibronectin in the blood-brain barrier, protecting against Alzheimer's disease. High levels of fibronectin were associated with vascular damage, inflammation, and disrupted communication between astrocytes and blood vessel cells.
Insilico Medicine executive team to speak at premier healthcare and AI Summits in New York, Riyadh, and Shanghai, showcasing latest breakthroughs in generative AI-driven drug discovery and anti-aging interventions.
Researchers at CiQUS have developed a new strategy to produce semiconducting covalent organic frameworks without doping, retaining high porosity and electrical conductivity. The approach uses radical molecules to generate charge carriers, facilitating charge transport and tuning electronic properties.
Research shows broad consensus among ICU recommendations for elderly patients, with female clinicians agreeing more on multidisciplinary input, such as pharmacist involvement and dietitian advice. Male clinicians showed stronger agreement on life-sustaining therapy decisions.
Researchers at the University of Malaga have developed a new technology using magnetic nanoparticles to diagnose allergy to beta-lactam antibiotics, including amoxicillin. The new method accurately identifies false positives and provides a reliable alternative to higher-risk tests.
Several new nuclear medicine approaches are being developed and evaluated for their potential to improve cancer imaging and treatment. Researchers have made significant progress in targeting specific markers and molecules in cancer cells, including CD163, CEACAM5, and DLL3. These advancements offer promising avenues for developing more...
A recent study has identified a new mechanism for ameloblasts to create enamel's hidden architecture, with the amphipathic helix motif in ameloblastin playing a crucial role in organizing cell polarity and matrix patterning. The study found that the motif helps turn deposited enamel into a densely mineralized, prismatic material.
A new study examines air quality collected during smoke-free days and compares it to smoke-affected days in Reno, revealing elevated levels of pollutants like PM2.5, ozone, and PAHs. The research highlights the need for further health studies and regular air monitoring for toxic compounds in regions frequently impacted by wildfire smoke.
A nasal spray containing vesicles naturally released by cells may work against Alzheimer's, reaching the brain and counteracting neuroinflammation, protecting neuronal function and preserving memory. The treatment improves cognitive abilities by increasing proteins linked to neuronal plasticity and enhancing synaptic transmission.
This study decouples UV and thermo-oxidative degradation pathways in PEEK composites, revealing severe surface oxidation and performance deterioration under UV aging. Carbon fiber reinforcement mitigates UV-induced degradation, while PTFE/graphite solid lubricants maintain low friction through lubricating transfer films.
Researchers studied ancient wheat and barley genes to identify potential solutions for adapting crops to climate change. The study identified genes that have conserved functions across different species, opening up new avenues for varietal selection programmes.
Researchers evaluate 20 years of beat perception research, concluding that the foundations of this capacity are present at birth and refined by experience and culture. Newborns and primates show sensitivity to periodic structure and beat-based prediction, but human capacity is distinct.
The University of Tennessee Institute of Agriculture launches F.U.S.E. Animal Science, a five-year fellowship program that integrates research, Extension, and professional development for undergraduate students. The program will provide students with hands-on experiences and mentorship to develop skills in areas such as animal nutritio...
A new study has calculated the weight of 606 million buildings globally, revealing patterns in material-use efficiency across cities. Cities with dense, uniformly short buildings maximize floor space per person while minimizing materials used.
Researchers identified a way to predict Alzheimer’s symptoms years before onset by combining a blood test and genetic test. Combining p-tau217 and APOE gene tests can predict symptom onset in people at high risk, with those having the APOE4 gene likely to develop symptoms in 3-4 years.
Vikas Khanna, a leading sustainability scholar, has been appointed Chair of Civil and Environmental Engineering at Pitt. He will focus on integrating AI into curricula, developing public health and computing graduate pathways, and strengthening research in water, environment, and public health. Khanna has a strong track record of resea...
Researchers from Aarhus University have discovered 12 new enzymes that can break down polyurethane and nylon. The best candidate, CC PUR1, was found in a compost heap and has a wide binding cleft, making it more stable and effective at breaking down plastic. This breakthrough could improve the recycling of difficult-to-degrade plastics.
Diana Anderson, a neurologist and architect, has received a grant to develop a bioethics-based evaluation tool for long-term care facility design. The goal is to create healthier environments that support dignity, safety, independence, social connection and quality of life for older adults.
Researchers explore the potential of shadow AI in healthcare, voice analysis for early disease detection, and digital resurrection technologies for bereavement. A recent FDA approval also highlights the therapeutic benefits of video games for ADHD treatment, with potential for personalization and immersion in the future.
Researchers found that obesity prevents a biological process that kills cancerous cells, revealing a possible reason why obesity is a risk factor for breast cancer. The study discovered that a molecule called 9S-HODE, normally present in lean tissue, is less present in obese adipocytes, allowing cancerous cells to grow unchecked.
Researchers developed a hybrid positioning method combining satellite-broadcast corrections with ground-based network data to maintain centimeter-level accuracy for over 20 minutes after ground corrections are interrupted. The method achieved horizontal and vertical accuracies of 1.30 cm and 5.67 cm in tests using a 300-kilometer network.
Researchers propose a novel navigation method for high-altitude, high-speed vehicles using relative position vector measurements. The method achieves three-dimensional positioning accuracy better than 200m over 150 minutes, outperforming existing navigation methods.
Researchers propose a framework for packaging that senses, learns, and acts to reduce food waste and spoilage. The system uses AI to interpret signals from sensors embedded in the packaging, enabling real-time monitoring and adaptive responses to minimize waste and optimize food distribution.
Researchers have successfully deployed underwater solar cells to generate 324 mWh of energy at 10 meters below sea level. The cells retained 96% of their initial efficiency after 300 days and showed exceptional long-term operational stability.
Researchers have developed an enzyme that can break down polyurethane in shoe foams, a significant step towards recycling plastic waste. The enzyme, based on a bacterium found in compost, can degrade polyurethane at lower temperatures and pressures than current recycling technologies.
State funding for suicide prevention has increased over the past five years, with spending growing from an average of $1.05 per resident in 2021 to $6.55 in 2025. States with telecom fees allocated significantly more funds to crisis services, suggesting a promising strategy to enhance infrastructure.
A study found that a common lupus-associated genetic variant strengthens antiviral immune responses while increasing the risk of autoimmunity. This genetic variant affects the IRF7 transcription factor, which plays a central role in the antiviral immune response.
A study found that lower birth volume, unprofitability, and for-profit status are risk factors for loss of hospital-based obstetric care in rural and urban hospitals. Many hospitals may be at high risk for future closure, highlighting the need for improved obstetric care infrastructure in rural areas.
Researchers develop a predictive learning-based pursuit strategy for the multiple-to-one orbital pursuit-evasion game, achieving a 95% capture success rate. The strategy combines evader action prediction with the Deep Deterministic Policy Gradient algorithm, converging faster and achieving higher rewards than conventional methods.
Researchers investigate interfacial water structure and reactivity in photocatalytic hydrogen evolution at TiO2 interfaces. Weaker water-TiO2 interactions and more flexible hydrogen-bond networks favor higher interfacial water reactivity, enabling photocatalyst design with improved performance.
Korea University Anam Hospital's Arrhythmia Center has been designated as a Center of Excellence for PFA, recognizing its extensive experience and training capabilities in treating atrial fibrillation. The center plans to share its expertise and contribute to the training of medical professionals, extending safe and effective treatment...
Researchers from McMaster University identified a molecular mechanism behind heparin-induced thrombocytopenia (HIT), a rare but life-threatening immune reaction. They discovered a previously unknown 'molecular switch' in platelet factor 4 (PF4) that controls whether it becomes a target for harmful antibodies.
Researchers identified six protein signatures in children as young as 8 that significantly influence the risk of developing cardiovascular-kidney-metabolic disease in adulthood. These protein signatures were also present in adults at high risk of irreversible cardiovascular-kidney-metabolic disease. The study suggests that early interv...
A study published in Nature Communications found that living in hotter, more polluted neighborhoods with limited green space increases the risk of frailty, PTSD, and depression among World Trade Center responders. In contrast, greener environments were associated with lower risks of these conditions.
Researchers found that chemotherapy and radiotherapy treatments change the genetic mutations in normal tissue, giving some cells an advantage. The study suggests that sequencing normal tissue from cancer patients could help understand how genes regulate tissue response to drugs and minimize damage to normal tissues.
A Korea University study found that an mRNA-based influenza vaccine elicits a more diverse and broader serum antibody repertoire than traditional vaccines. This leads to greater binding and neutralizing breadth against diverse influenza strains, suggesting potential for broader, longer-lasting protection.
Researchers developed nanostructures using MoOCl2, exhibiting polarization-controlled metal and dielectric resonances, with dielectric resonance exhibiting a higher quality factor and stronger photoemission signal
A new study on Li0.5VS2 reveals that electron-deficient σ bonds reorganize as the material passes through successive structural changes, leading to unusual electronic and magnetic behaviors. The findings show that chemical bonding can play an active role in shaping the properties of correlated materials.
A team at Rice University has developed a method to capture fluoride from environmental waste and recycle it into a useful reagent, silver fluoride. The process can recover 90% of the fluoride as silver fluoride, removing over 99.9% of the fluoride available in the PFAS.
Researchers have identified early signs of cardiovascular-kidney-metabolic disease (CKMD) in children as young as 8 years old that can be reversed with a new class of weight loss drugs. The study found that levels of certain disease-associated proteins in children decline in response to therapy with semaglutide, a GLP-1 receptor agonis...
A new interactive website allows anyone to explore the projected future of individual glaciers around the world, revealing when they'll disappear under different levels of global warming. The website provides a tangible example of the rapid disappearance of small Alpine glaciers, with some projected to disappear within the next few years.
A new protein language model, CLSS, brings together sequence and structure information to produce cohesive maps of protein relationships. The model successfully integrated sequence and structure data, reproducing expert-curated classifications and demonstrating strong performance in classification tests.
Researchers at Nagoya University have identified giant-nucleus cells as precancerous markers in the kidneys, which emerge in response to iron toxicity and BRCA1 mutations. These cells exhibit cancer-related gene activity and can signal early cancer development in surrounding tissue, with distinct biological profiles in BRCA1-mutant rats.