A study of nearly 400,000 women found menopause is inconsistently documented in electronic health records, with only 7% of women having it recorded. The study highlights the need for routine capture of reproductive health information to improve understanding of menopause and its impact on disease risk and health outcomes.
Researchers uncover the broad range of diseases caused by varicella zoster virus, including neurological and systemic issues, and highlight the need for better understanding and treatment of its manifestations. The virus can reactivate years after chickenpox and affect every organ, making diagnosis and treatment challenging.
Researchers at CU Anschutz and Indiana University School of Medicine identified a biological process that explains how colorectal cancer can cause severe muscle and bone loss. Blocking the production of a protein called IGFBP1 helped preserve muscle and bone, improving muscle strength in laboratory and preclinical models.
Researchers at CU Anschutz and CU Boulder developed a miniature microscope that allows observing and activating individual brain cells during natural movement. This advancement could accelerate research into brain behavior and neurological diseases.
Researchers at the University of Colorado Anschutz Cancer Center have identified a previously unknown metabolic weakness in high-risk myelodysplastic syndromes (MDS), a discovery that could lead to more targeted treatments for this aggressive blood cancer. The study found that high-risk MDS stem cells are unusually dependent on nicotin...
A nationwide study published in JAMA Pediatrics found that early antiviral treatment with oseltamivir reduced ICU admissions and shortened hospital stays for children hospitalized with influenza. The study of over 7,000 pediatric hospitalizations showed a 31% lower likelihood of ICU admission among treated children.
A study by CU Anschutz researchers found that nearly 40% of Colorado's 46 county jails lacked publicly available opioid treatment policies, hindering the implementation of life-saving treatments. The lack of transparency and comprehensive policies poses significant barriers to care for incarcerated people with opioid use disorder.
A CU Anschutz-led clinical trial found an automated oxygen delivery system helped hospitalized patients spend significantly more time in their target oxygen range compared to standard care. The system reduced exposure to both low and high oxygen levels, with no increase in serious adverse events.
A new study from the University of Colorado Anschutz found that oral semaglutide reduced heavy drinking and alcohol-related harm in adults with Alcohol Use Disorder. The medication, commonly used for diabetes and weight loss, showed consistent reductions in harmful real-world drinking behavior.
Researchers at the University of Colorado Anschutz Linda Crnic Institute discovered unique biological processes altered among individuals with Down syndrome who have different sets of co-occurring conditions. The findings mark an important step toward personalized treatment, enabling future targeted therapies and improved health outcomes.
A study found that many weight-loss clinics and medical spas continue to offer compounded GLP-1 medications after FDA shortages ended. Researchers identified some suppliers lacking sterile compounding licenses or recent disciplinary actions related to sterile compounding practices.
A comprehensive review finds that climate change affects waterborne diseases differently across bacteria, viruses, and parasites, highlighting the need for tailored public health approaches. The study recommends 'no-regrets' investments to reduce risk and promote community resilience.
The University of Colorado Anschutz, along with UCHealth and Children’s Hospital Colorado, have formed a strategic alliance with Bayer to accelerate medical discovery and expand patient access to investigational therapies. Initial focus areas include oncology, cardiovascular disease, and cell and gene therapy.
Researchers at CU Anschutz have developed a promising nonhormonal therapy for women experiencing Genitourinary Syndrome of Menopause (GSM), which affects the vulva, vagina, and urinary tract. The therapy restores estrogen signaling in vaginal tissue without exposing the rest of the body to estrogen.
A CU Anschutz study reveals reduced mitochondrial efficiency in healthy yet sedentary individuals, which may precede the development of major diseases like cancer, diabetes, and Alzheimer's. Regular exercise acts as a literal shield for cellular health, helping mitochondria seamlessly switch between burning fat and carbohydrates.
A new study published in JAMA Network Open projects that reductions in federal funding for syringe service programs could lead to substantial increases in mortality among people who inject drugs in the US. The study estimates up to 39,600 additional deaths over five years if federal support is reduced.
Researchers at the University of Colorado Anschutz have published a proof-of-concept study demonstrating that injectable semaglutide may offer meaningful reproductive benefits for women with PMOS, improving both reproductive and metabolic symptoms. The findings suggest that this medication could be a promising therapeutic option for wo...
Research from the University of Colorado Anschutz suggests that stress experienced by a father before conception may alter small molecular signals in sperm, shaping early development and later physical growth. The study found that increased levels of let 7f 5p in fertilized eggs mimic the biological effects of paternal stress.
The condition is recognized as a complex, multisystem disorder involving endocrine, metabolic, reproductive, dermatological, and psychological health. The new name, PMOS, is expected to reshape how the condition is diagnosed, treated, and researched globally.
Researchers at the University of Colorado Anschutz discovered that cancer drugs impact a specific protein regulating taste buds. This finding could lead to new treatments preserving taste function in cancer patients.
A study by University of Colorado Anschutz researchers found that structured engagement with Wikipedia improves public access to accurate, high-quality information. The study revamped the AAA Wikipedia page, increasing content, references and credibility.
A new report published in Nature Metabolism sheds light on fructose's distinct role in driving metabolic disease, separate from its caloric contribution. Fructose bypasses key regulatory steps, leading to increased fat synthesis and cellular energy depletion, which may contribute to metabolic syndrome.
Researchers developed an AI model to predict Barrett's esophagus recurrence after endoscopic eradication therapy. The tool shows high accuracy in identifying patients at risk and detecting when recurrence is likely to occur.
The University of Colorado Anschutz Gates Institute has achieved first-in-U.S. FDA clearance for a novel CAR T-cell therapy targeting aggressive leukemia cells, representing a potential new treatment approach for patients with hard-to-treat disease. The therapy will be evaluated in a Phase 1 clinical trial starting this summer.
Researchers discovered that even tiny amounts of PFDA cause visible facial changes and increase risk by 10% at low exposure levels. PFDA blocks key enzyme CYP26A1, disrupting retinoic acid metabolism and leading to abnormal facial development.
Researchers found that breast cancer cells trigger the lung's natural repair system, leading to chronic inflammation and promoting tumor growth. A repurposed drug, roflumilast, may slow this process by preventing the lung environment from aiding tumor growth.
Developed by CU Anschutz experts, the tool helps patients weigh treatment options and boosts confidence. The majority of patients reported it was helpful in their decision-making process, finding it useful and satisfied with the tool.
A new review outlines the scientific explanations behind ketogenic diets' therapeutic benefits for epilepsy, including their ability to strengthen brain energy systems, reduce inflammation, and protect neurons. The review highlights the need for further research, particularly in adults, to develop new therapies that mirror the diet's e...
Researchers identify three types of post-amputation pain: phantom limb pain, residual limb pain, and musculoskeletal pain, which behave differently and require personalized care. The study's findings suggest that prosthetic design can directly influence comfort during real-world movement, improving mobility and quality of life for indi...
A new study from CU Anschutz links chronic back pain to heightened brain responses to everyday sounds and finds that Pain Reprocessing Therapy can improve sensory amplification. The research found specific brain changes associated with sound hypersensitivity, which can be treated with psychological therapy.
Researchers identified molecular defect in taste receptor cells due to reduced levels of PLCβ2 protein, which strengthens the signal before transmission to the brain. Taste cells that detect salty and sour flavors are less affected.
Researchers found that veterans with prior concussions showed slower and less accurate eye movements, along with reduced performance on attention-based tasks. These subtle brain changes can be measured more than a decade after the original injury.
A new national study assesses the readiness of EMS agencies to care for children, identifying key areas for improvement. Having a pediatric emergency care coordinator is crucial for higher levels of readiness and better outcomes.
Researchers developed a single-item hoarding screen to quickly identify hoarding behaviors in patients with memory and brain disorders. The tool shows promise in flagging potentially serious hoarding behavior, especially in patients with behavioral variant frontotemporal dementia.
Researchers found that farming practices, unsafe sanitation, and domestic animals linked to infection risk. Household-level interventions are essential for accelerating elimination, especially when community-wide strategies fail near elimination.
A new testing method uses omics markers to reveal the trajectory of recovery from trauma, enabling more-tailored care. The approach shows that organ failure and mortality can be predicted with high accuracy using biological signals found in blood.
A new study from CU Anschutz researchers found that regular physical activity can significantly lower post-ablation atrial fibrillation recurrence risk. Adults who engaged in moderate exercise for 30 minutes three times a week had markedly lower rates of AF recurrence compared to those who were less active.
Research at the University of Colorado Anschutz Linda Crnic Institute found significant alterations in liver metabolism among individuals with Down syndrome, including elevated bile acids and biomarkers of liver dysfunction. The study suggests that dietary interventions may help improve health outcomes.
Researchers discovered a link between increasing biomarker levels and cognitive decline, with a potential repurposed drug slowing damage. The study found exponential increases in UCH-L1 and GFAP levels with age, suggesting underlying neuroinflammation may contribute to Alzheimer’s disease.
A new study published in JAMA Health Forum estimates that ending federal funding for Housing First programs would result in 44,590 additional people experiencing homelessness within a year, a roughly 5% increase from 2024 levels. This could push tens of thousands of people back into homelessness almost overnight.
A multi-site study led by CU Anschutz researchers found that people with cystic fibrosis who start triple-drug therapy elexacaftor/tezacaftor/ivacaftor (ETI) can safely reduce many daily lung treatments while maintaining good health for years. The study showed a steady decline in the use of chronic respiratory therapies, including hype...
Researchers at CU Anschutz have discovered a novel therapy combination to offer new hope to ovarian cancer patients who do not respond to existing treatments. The combination of a PARP inhibitor and SM08502 boosts the effectiveness of treatment, even for patients resistant to PARP inhibitors.