A large clinical trial found that children whose mothers took a prenatal choline supplement had improved cognitive performance and social behavior. The supplement was shown to increase children's IQ by about eight points and reduce social withdrawal problems.
Researchers discovered how HSV-1 changes the brain's immune cells response to infection, potentially triggering chronic inflammation and Alzheimer's disease. The virus activates powerful antiviral defenses in microglia, which may compromise their ability to maintain a healthy brain.
Researchers found that prenatal psychotherapy can change infant brain structure and is linked to lower negative emotionality in early infancy. The study provides some of the strongest evidence to date that maternal mental health during pregnancy can have intergenerational effects on child development.
A large-scale clinical trial found that adults using continuous glucose monitors (CGMs) spent approximately 5 additional hours each day within their target blood sugar range compared to those receiving routine care. Nearly twice as many CGM users achieved an A1c level below 7%, a common treatment goal for people with diabetes.
CU Anschutz will evaluate emerging technologies and therapeutics for severe hemorrhage, including novel blood products and diagnostic technologies. The award aims to improve care for patients experiencing severe bleeding, including trauma patients and those with postpartum hemorrhage.
A study by CU Anschutz researchers has found a possible link between the APOE4 gene, fat in the brain, and inflammation, which may help explain how genetic risk factors for Alzheimer's disease affect the brain. The study suggests that the ApoE protein can change how brain immune cells handle fat and trigger inflammation.
A new study from CU Anschutz finds horseback riding improves hyperactivity, irritability, and emotional regulation in children with autism and psychiatric diagnoses. Horse-related activities also provide benefits for those unable to ride, enhancing communication and emotional regulation skills.
A new study from the University of Colorado Anschutz reveals how Prevotella melaninogenica reprograms immune cells to more effectively clear pneumonia-causing bacteria. The findings suggest that the lung microbiome may be part of the body's first line of defense against respiratory infections.
A study by CU Anschutz researcher found that dementia influences decisions on life-sustaining treatment, even when advance directives request it. Participants were 19 percentage points less likely to recommend life-sustaining treatment for patients with dementia than for those without, even with documented wishes calling for it.
CU Anschutz Pharmacy is launching Colorado STREAM, a five-year initiative with $25M in funding, to expand access to medications and whole-person health services in rural Colorado. The program connects community pharmacies with regional treatment centers, telehealth services, and other healthcare partners.
A Colorado study found nearly 1 in 10 petitions for extreme risk protection orders involved service members or veterans, often involving suicide threats, violence, and mental health crises. Temporary ERPOs were granted in 47 cases, with 76.6% being extended to full 365-day orders.
Researchers identified 3,775 proteins in red blood cells and mapped thousands of physical interactions, revealing a dynamic network that adapts quickly to low-oxygen conditions. The study provides new insight into how red blood cells respond to high-altitude exposure and strenuous exercise, as well as pathological hypoxia.
Researchers found that exosomes from people with shingles pain caused nerve cells to remain inflamed and transmit pain signals even after the virus clears the body. This discovery opens the door to new approaches for predicting, preventing, and treating post-herpetic neuralgia.
Researchers at CU Anschutz have developed CAR T-cell therapy to target two pathways that help colorectal tumors grow and evade the immune system, B7-H3 and IL-8. The therapy aims to provide a more durable response than traditional chemotherapy.
A systematic review found that hospital-based interventions can improve connection to outpatient treatment for patients with alcohol use disorder, but the evidence is limited and uncertain. The interventions that showed promise combined behavioral strategies and care coordination with medications for AUD or social support.
A study of nearly 400,000 women found menopause is inconsistently documented in electronic health records, with only 7% of women having it recorded. The study highlights the need for routine capture of reproductive health information to improve understanding of menopause and its impact on disease risk and health outcomes.
Researchers uncover the broad range of diseases caused by varicella zoster virus, including neurological and systemic issues, and highlight the need for better understanding and treatment of its manifestations. The virus can reactivate years after chickenpox and affect every organ, making diagnosis and treatment challenging.
Researchers at CU Anschutz and Indiana University School of Medicine identified a biological process that explains how colorectal cancer can cause severe muscle and bone loss. Blocking the production of a protein called IGFBP1 helped preserve muscle and bone, improving muscle strength in laboratory and preclinical models.
Researchers at CU Anschutz and CU Boulder developed a miniature microscope that allows observing and activating individual brain cells during natural movement. This advancement could accelerate research into brain behavior and neurological diseases.
Researchers at the University of Colorado Anschutz Cancer Center have identified a previously unknown metabolic weakness in high-risk myelodysplastic syndromes (MDS), a discovery that could lead to more targeted treatments for this aggressive blood cancer. The study found that high-risk MDS stem cells are unusually dependent on nicotin...
A nationwide study published in JAMA Pediatrics found that early antiviral treatment with oseltamivir reduced ICU admissions and shortened hospital stays for children hospitalized with influenza. The study of over 7,000 pediatric hospitalizations showed a 31% lower likelihood of ICU admission among treated children.
A study by CU Anschutz researchers found that nearly 40% of Colorado's 46 county jails lacked publicly available opioid treatment policies, hindering the implementation of life-saving treatments. The lack of transparency and comprehensive policies poses significant barriers to care for incarcerated people with opioid use disorder.
A CU Anschutz-led clinical trial found an automated oxygen delivery system helped hospitalized patients spend significantly more time in their target oxygen range compared to standard care. The system reduced exposure to both low and high oxygen levels, with no increase in serious adverse events.
A new study from the University of Colorado Anschutz found that oral semaglutide reduced heavy drinking and alcohol-related harm in adults with Alcohol Use Disorder. The medication, commonly used for diabetes and weight loss, showed consistent reductions in harmful real-world drinking behavior.
Researchers at the University of Colorado Anschutz Linda Crnic Institute discovered unique biological processes altered among individuals with Down syndrome who have different sets of co-occurring conditions. The findings mark an important step toward personalized treatment, enabling future targeted therapies and improved health outcomes.
A study found that many weight-loss clinics and medical spas continue to offer compounded GLP-1 medications after FDA shortages ended. Researchers identified some suppliers lacking sterile compounding licenses or recent disciplinary actions related to sterile compounding practices.
A comprehensive review finds that climate change affects waterborne diseases differently across bacteria, viruses, and parasites, highlighting the need for tailored public health approaches. The study recommends 'no-regrets' investments to reduce risk and promote community resilience.
The University of Colorado Anschutz, along with UCHealth and Children’s Hospital Colorado, have formed a strategic alliance with Bayer to accelerate medical discovery and expand patient access to investigational therapies. Initial focus areas include oncology, cardiovascular disease, and cell and gene therapy.
Researchers at CU Anschutz have developed a promising nonhormonal therapy for women experiencing Genitourinary Syndrome of Menopause (GSM), which affects the vulva, vagina, and urinary tract. The therapy restores estrogen signaling in vaginal tissue without exposing the rest of the body to estrogen.
A CU Anschutz study reveals reduced mitochondrial efficiency in healthy yet sedentary individuals, which may precede the development of major diseases like cancer, diabetes, and Alzheimer's. Regular exercise acts as a literal shield for cellular health, helping mitochondria seamlessly switch between burning fat and carbohydrates.
A new study published in JAMA Network Open projects that reductions in federal funding for syringe service programs could lead to substantial increases in mortality among people who inject drugs in the US. The study estimates up to 39,600 additional deaths over five years if federal support is reduced.
Researchers at the University of Colorado Anschutz have published a proof-of-concept study demonstrating that injectable semaglutide may offer meaningful reproductive benefits for women with PMOS, improving both reproductive and metabolic symptoms. The findings suggest that this medication could be a promising therapeutic option for wo...
Research from the University of Colorado Anschutz suggests that stress experienced by a father before conception may alter small molecular signals in sperm, shaping early development and later physical growth. The study found that increased levels of let 7f 5p in fertilized eggs mimic the biological effects of paternal stress.
The condition is recognized as a complex, multisystem disorder involving endocrine, metabolic, reproductive, dermatological, and psychological health. The new name, PMOS, is expected to reshape how the condition is diagnosed, treated, and researched globally.
Researchers at the University of Colorado Anschutz discovered that cancer drugs impact a specific protein regulating taste buds. This finding could lead to new treatments preserving taste function in cancer patients.
A study by University of Colorado Anschutz researchers found that structured engagement with Wikipedia improves public access to accurate, high-quality information. The study revamped the AAA Wikipedia page, increasing content, references and credibility.
A new report published in Nature Metabolism sheds light on fructose's distinct role in driving metabolic disease, separate from its caloric contribution. Fructose bypasses key regulatory steps, leading to increased fat synthesis and cellular energy depletion, which may contribute to metabolic syndrome.
Researchers developed an AI model to predict Barrett's esophagus recurrence after endoscopic eradication therapy. The tool shows high accuracy in identifying patients at risk and detecting when recurrence is likely to occur.
The University of Colorado Anschutz Gates Institute has achieved first-in-U.S. FDA clearance for a novel CAR T-cell therapy targeting aggressive leukemia cells, representing a potential new treatment approach for patients with hard-to-treat disease. The therapy will be evaluated in a Phase 1 clinical trial starting this summer.
Researchers discovered that even tiny amounts of PFDA cause visible facial changes and increase risk by 10% at low exposure levels. PFDA blocks key enzyme CYP26A1, disrupting retinoic acid metabolism and leading to abnormal facial development.
Researchers found that breast cancer cells trigger the lung's natural repair system, leading to chronic inflammation and promoting tumor growth. A repurposed drug, roflumilast, may slow this process by preventing the lung environment from aiding tumor growth.
Developed by CU Anschutz experts, the tool helps patients weigh treatment options and boosts confidence. The majority of patients reported it was helpful in their decision-making process, finding it useful and satisfied with the tool.
A new review outlines the scientific explanations behind ketogenic diets' therapeutic benefits for epilepsy, including their ability to strengthen brain energy systems, reduce inflammation, and protect neurons. The review highlights the need for further research, particularly in adults, to develop new therapies that mirror the diet's e...
Researchers identify three types of post-amputation pain: phantom limb pain, residual limb pain, and musculoskeletal pain, which behave differently and require personalized care. The study's findings suggest that prosthetic design can directly influence comfort during real-world movement, improving mobility and quality of life for indi...
A new study from CU Anschutz links chronic back pain to heightened brain responses to everyday sounds and finds that Pain Reprocessing Therapy can improve sensory amplification. The research found specific brain changes associated with sound hypersensitivity, which can be treated with psychological therapy.
Researchers identified molecular defect in taste receptor cells due to reduced levels of PLCβ2 protein, which strengthens the signal before transmission to the brain. Taste cells that detect salty and sour flavors are less affected.
Researchers found that veterans with prior concussions showed slower and less accurate eye movements, along with reduced performance on attention-based tasks. These subtle brain changes can be measured more than a decade after the original injury.
A new national study assesses the readiness of EMS agencies to care for children, identifying key areas for improvement. Having a pediatric emergency care coordinator is crucial for higher levels of readiness and better outcomes.
Researchers developed a single-item hoarding screen to quickly identify hoarding behaviors in patients with memory and brain disorders. The tool shows promise in flagging potentially serious hoarding behavior, especially in patients with behavioral variant frontotemporal dementia.
Researchers found that farming practices, unsafe sanitation, and domestic animals linked to infection risk. Household-level interventions are essential for accelerating elimination, especially when community-wide strategies fail near elimination.