Researchers at the University of Freiburg have discovered a new type of friction in proteins called anisotropic friction, which depends on direction. The discovery was made using single molecule experiments and simulations, revealing that friction increases with the pulling angle applied to a ligand from a protein.
Scientists at SENS Research Foundation have discovered a new class of broad-spectrum senolytic drugs that target the key vulnerability in destructive aging cells. These drugs are effective against both primary and secondary senescent cells, making them a promising approach for treating age-related diseases.
Researchers found record-low Antarctic sea ice in austral summer 2022 due to stronger positive sea surface temperature anomalies and unprecedented ozone reduction. The anomalies triggered the deepening of an Amundsen Sea Low, leading to sea ice retreat via horizontal wind anomalies.
A new study published by researchers at the University of North Carolina at Chapel Hill estimates $562 million in previously unquantified financial risks arising from property value changes and uninsured flood damages in eastern North Carolina. The research team developed a new modeling framework using data on homes sales, mortgage loa...
Research suggests astrocytes integrate external sensory inputs with internal states to modify calcium signaling towards neurons. This process could be crucial for behavioral responses and memory formation.
A new study reveals that lampreys use body-sensing feedback to regain swimming abilities after spinal injury, challenging the conventional view of neural regeneration. Mathematical models suggest that this technique could be applied to humans with spinal injuries or diseases affecting movement.
Researchers at Tohoku University discovered that the KAI2-ligand hormone initiates and terminates asexual reproduction in liverwort plants based on environmental factors. The team found that gemma formation starts from the inner region of the gemma cup and moves out to the periphery.
A study by Cedars-Sinai Medical Center found a 38% increase in sudden cardiac arrest among all Ventura County residents and a 77% increase among Hispanic residents during the first two years of the pandemic. Overall survival from sudden cardiac arrest declined from 15.3% to 10%.
A Penn State-led team has discovered a new physical mechanism explaining naturally occurring X-rays associated with lightning activity in the Earth's atmosphere. The researchers developed a mathematical model that explains how electric fields amplify electrons, driving the phenomenon of relativistic runaway discharges in air.
The latest issue of PLOS Biology features a special collection on biology-based solutions to reduce plastic pollution, carbon dioxide emissions, and produce food or energy more sustainably. Insect enzymes may degrade plastic waste, while photosynthetic algae can capture CO2 produced by industrial applications.
A new study suggests that ketamine could be a promising treatment option for children with traumatic brain injuries, particularly in reducing intracranial pressure. The research found that ketamine can lower ICP during crisis situations, which is crucial for preventing long-term neurologic impairment.
Researchers demonstrate direct experimental measurement of Zak phase from bulk band structure for a synthetic SSH model using frequency axis of light. The study showcases universal characterizing method for exploring topological phases of matter with experimental feasibility and reconfigurability.
A phase 2 study found a 92% disease control rate with the combination of belzutifan and cabozantinib in pre-treated advanced kidney cancer patients. The treatment has a manageable safety profile, providing a potential alternative for patients experiencing disease progression on immunotherapy.
Researchers from Heidelberg University discovered CO2 pulses in Australian atmosphere at end of dry season, triggered by soil microorganisms activated by heavy rainfall. This finding suggests dry regions have a significant influence on the global carbon cycle, contributing to climate modelling and understanding.
The NRG Oncology combined trial results indicate that pathologic complete response (pCR) is associated with improved survival outcomes for patients with localized soft tissue sarcoma. pCR can be used as a prognostic factor for clinical outcomes in future STS research, with patients achieving higher overall and disease-free survival rates.
Researchers found centenarians have distinct immune cell type composition and activity, enabling them to recover from disease and live exceptionally long. These findings provide a foundation for investigating mechanisms of immune resilience contributing to extreme longevity.
The Human Brain Project has achieved significant scientific breakthroughs, including world-leading 3D brain atlases and personalized medicine based on computational modeling. The project's legacy will leave a lasting impact on the research community.
Researchers at USC have developed a new technique called Hybrid Unmixing, which allows for simultaneous imaging of bright and dim labeled components within organic tissue. This enables accurate insights into cellular behaviors and metabolism, providing a comprehensive understanding of complex biological systems.
Research suggests that high doses of sucralose can lower activation of T-cells, an important component of the immune system, in mice. This finding could lead to a new way of using sucralose therapeutically to help dampen T-cell responses in patients with autoimmune diseases.
A new model of DNA flexibility has been developed, providing results of unprecedented quality and characterizing precision and efficiency at the computational level. The study presents a systematic and comprehensive analysis of DNA movement correlations and introduces a new method to capture them.
Researchers found that corridors with abundant mature trees and deadwood help pileated woodpeckers adjust to urban landscape fragmentation. The Little Miami River corridor is one of the best places for these birds in Hamilton County, Ohio.
Researchers found that a mother's vaginal microbiome composition does not significantly affect the infant stool microbiome in early life. Factors such as breast milk and antibiotic exposure play a larger role in shaping the baby's gut microbiome.
A new study reveals that ants followed flowering plants as they left ancient forests, driving the evolution of thousands of ant species. The researchers used fossils, DNA, and habitat data to show how plants' spread influenced ants' habitats and behavior.
Researchers engineered a strain of E. coli to secrete proteins that block inflammation and inhibit tumor necrosis factor alpha, showing efficacy comparable to injected antibodies in mice with inflammatory bowel disease. The engineered bacteria offer a potential treatment for intestinal-based diseases with reduced side effects.
New research reveals SARS-CoV-2 spike protein mutations made the virus more rigid and improved its ability to transmit through nasal droplets and infect host cells. This could mean newer vaccines are effective for longer against emerging variants.
Ho Nyung Lee, a condensed matter physicist at ORNL, has been elected a Fellow of the Materials Research Society for his distinguished accomplishments in advancing materials research. He is recognized for his leadership and service to the community, particularly in precision synthesis and complex oxide thin films.
Researchers at Northwestern University have developed a new technology that boosts weak biochemical signals by over 1,000 times using plastic transistor amplification. This enables real-time health diagnostics and disease monitoring without complex electronics.
Researchers at University of Illinois have recalibrated climate change effects on salamanders, showing a somewhat more hopeful future. The study found that incorporating microclimate data at fine spatial scales reduced predicted habitat loss by 55-80% compared to using free-air temperature data.
A new study found that LGB preteens ages 10-14 reported 10.4 hours of daily recreational screen time, which was nearly four hours more than their straight peers. The researchers argue that parents should regularly talk to their children about screen usage and develop a family media use plan.
A recent study reveals that uneven future warming in the Indian Ocean can cause shifts in monsoon precipitation, with potential impacts on societies and ecosystems. The research identifies key mechanisms driving these changes, including winds and ocean currents.
Researchers at Tulane University found that social rank affects the stress response in adult female mice, particularly in how they respond to chronic social stress. The study revealed differences in brain areas activated by social encounters based on social status, with higher-ranking mice more susceptible to social isolation and lower...
Researchers used microfluidic devices to track what happens to cancer cells as they migrate and take root in the brain. They found that Dkk-1 triggers cancer cell migration, and reducing its levels near tumor cells may disrupt crosstalk between brain niche cells and cancer cells.
A recent study published in PLOS ONE found that academic institutions receive significantly lower royalty rates, total payments, and pre-commercial payments for biotechnology licenses compared to commercial firms. The disparities were observed even after accounting for differences in product stage development.
A novel copper-containing polymeric filter can effectively capture carbon dioxide from the air, converting it into sodium bicarbonate that can be released harmlessly into the ocean. The technology has garnered international attention and could be powered by renewable energy in the future.
A new study by Cedars-Sinai investigators found that ChatGPT can provide easy-to-understand information about basic knowledge, lifestyle, and treatments for cirrhosis and liver cancer. The AI system has the potential to play a role in clinical practice and empower patients with knowledge about their disease.
Researchers have developed a new microfluidic chip that enables the visualization of rare cell types and disease patterns in tissue. This method combines imaging and sequencing techniques, providing spatially resolved information about individual cells and their environment.
A study co-led by a University of Michigan researcher provides direct evidence for the consumption of yak milk, as well as horse and ruminant blood proteins. The discovery was made possible by the preservation of ancient DNA in permafrost, revealing intriguing protein sequences.
The study found that heat domes over Western North America contributed 50% of the observed high temperatures in 2021-like heatwaves. The intensities of these extreme heat events are projected to increase by 40-fold by the end of the century, emphasizing the need for climate mitigation and adaptation activities.
Bacteria have been found to produce superoxides under visible light, accelerating the oxidation of manganese ions and contributing to the formation of manganese oxides in the environment. This process is a significant natural source of manganese oxide and has implications for environmental pollution treatment.
A 3-year-old girl was infected with M. marinum after being bitten by an iguana while on holiday in Costa Rica. The toddler developed a ganglion cyst and eventually responded to treatment with rifampin and clarithromycin.
Two new species of poisonous birds have been discovered in New Guinea's rainforest, containing a neurotoxin similar to that found in South American poison dart frogs. Genetic changes in these bird species allow them to tolerate and store the toxin in their feathers, potentially serving as a defensive mechanism.
A new study identifies several cytokine markers associated with poor prognosis in New-Onset Refractory Status Epilepticus (NORSE) patients. The researchers found that the concentration of these inflammatory proteins was higher in NORSE patients than controls, and their increase was correlated with short-term and long-term neurological ...
A recent study published in Science reveals that domestic horses transformed human life in North America following their reintroduction. The research used archaeological materials, historical sources, and Indigenous knowledge to understand when, why, and how horses were integrated into Native Nations' lifeways.
A pilot study in Eritrea demonstrates the importance of mapping and assessing ecosystems and their services for sustainable policy and decision-making. The research team recommends making information on ecosystem services available to stakeholders and the public to enable responsible decision-making.
A new Rutgers study finds that childhood asthma diagnoses decreased by 52% in the US during the first year of the pandemic compared to previous years. Researchers attribute this decline to fewer colds and the practice of wearing masks, which may have reduced the risk of asthma triggers.
A new study finds that Latinx students experienced higher rates of depression and anxiety during the Covid-19 pandemic, with a risk of 1.5 to 2 times more likely than their peers. The study highlights the need for practical and efficacious programs to address the mental health needs of adolescents in school settings.
A team of experts at the University of Manchester has received €2.5million funding to design smarter robots that can understand humans' inner feelings through language. The project aims to develop robots that can engage meaningfully with older generations, helping them in everyday life.
Researchers develop unique method for applying angular momentum holography for information multiplexing, enabling unprecedented capacity for optical information processing. The new paradigm allows for spatially modulating waveforms and offers additional security locks, revolutionizing existing optical encryption schemes.
A UCalgary study found that a healthy gut microbiome can prevent deadly hospital infections in critically ill patients. The research showed that the gut microbiota and immune system work together to fight infection, with abnormal gut bacteria increasing the risk of severe infections.
A randomized controlled trial found that consuming lactation cookies had no significant effect on milk production in breastfeeding mothers. The study suggests that consumers should be cautious when considering products with unsubstantiated health claims.
A team of researchers has developed a new human-in-the-loop system to improve the accuracy and interpretability of deep neural networks. The system uses an interactive one-click method for annotating images, reducing the co-occurrence bias inherent in training datasets.
A new study led by Marshall University researchers has revealed that the Xie model for NKA receptor/signaling is a key player in regulating sodium balance. The study found that NKA signaling tonically inhibits sodium reabsorption in the renal proximal tubule, shedding light on a novel mechanism of body salt handling.
A study found racial and ethnic differences in insurance coverage after job loss during COVID-19. Newly unemployed Black and Hispanic adults saw no increase in Medicaid coverage, unlike their white peers.
A recent study found that hospitals serving more vulnerable childbearing populations tend to have inadequate nurse staffing levels, which can lead to poor maternal health outcomes. The researchers surveyed 3,471 registered nurses from 271 hospitals and discovered inconsistencies in nurse-to-patient ratios with national staffing standards.
A team of scientists developed a new approach to designing metasurfaces with high-accuracy functionalities using a tandem neural network and iterative algorithm. The design enables the creation of ultracompact devices with quantitative capabilities in imaging, detecting, and sensing applications.
Researchers have developed a new type of microscope objective inspired by the eyes of scallops, which can capture images in various immersion media, including liquids. This innovative approach uses a mirror instead of lenses and has been shown to provide excellent image quality in homogeneous fluids as well as in air.
A new paradigm in metasurface design and assembly is proposed, utilizing a knowledge-inherited neural network to inherit physical connections and network correlations among various metamaterials. The method achieves accurate designs for diverse applications, including satellite communication.
Researchers used functional MRI scanners to monitor brains of subjects watching real-life videos, finding that different parts of the brain work together to understand and remember situations. The study suggests the brain creates mental sketches of people that can be transposed from one location to another.
A national survey by Brigham researchers identified high levels of burnout, intent to leave the profession, and work overload among healthcare workers. Burnout was most prevalent among nurses (56%) and other clinical staff (54.1%), with 41% of nurses reporting intent to leave.
A new study by Oxford researchers has found vedolizumab to be effective in inducing remission in patients with chronic pouchitis after surgery for ulcerative colitis. The treatment improved remission rates and quality of life, making it a game-changer for these patients.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
Researchers found that exceptional weather conditions over several years are turning European forests brown. Characteristic weather patterns, such as prolonged dry periods and high temperatures, precede these events, with a legacy effect contributing to future low-forest greenness.
A low-cost, high-effective program provides community-based groups to teach women and partners about nutrition, caregiving, and health from pregnancy to age one. The study found significant improvements in brain development, cognitive skills, and language abilities at age two compared to usual healthcare.
Researchers at IISc have developed a novel ultramicro supercapacitor with enhanced electrochemical capacitance, exceeding 3000% increase in capacitance under certain conditions. The device uses Field Effect Transistors as charge collectors and solid gel electrolyte for improved electron mobility.
Researchers at Baylor College of Medicine discovered crucial steps that promote ciprofloxacin resistance in bacteria, pointing to potential strategies to extend antibiotics' effectiveness. The study found that RNA polymerase plays a major role in regulating DNA repair and identified a key molecule involved in modulating this response.
A systematic review and meta-analysis of 4.8 million participants found no significant association between daily low or moderate alcohol intake and all-cause mortality risk. However, increased risk was evident at higher consumption levels, starting at lower levels for women than men.