Researchers discovered a 'brinkmanship' game between rival genes in mammals that could explain why many fertilized eggs don't result in a new life. The study found that the stakes are raised, resulting in either the boldest gene triumphant or mutual self-destruction.
Data-model fusion (DMF) integrates model-based and data-driven methods to reduce limitations in smart manufacturing and digital engineering. It enhances interpretability and accuracy, with applications in product design, manufacturing, experimentation, testing, verification, and maintenance.
Modelling analysis reveals sediment levels and nitrogen concentrations will increase with development and forest conversion upstream. The study forecasts water quality degradation at drinking water intakes across the regional watershed.
UTHealth Houston researchers discovered an interaction between two proteins, BMAL1 and HIF2A, regulating the heart's response to injury after a heart attack. This study provides new avenues for treating heart attacks by considering the timing of drug administration.
Researchers analyzed over 1,700 ancient grape seeds to discover that grape cultivation in Italy began during the Late Bronze Age, with gradual domestication taking place over centuries. The study reveals that Italian wine heritage dates back to Western Europe's broader landscape.
A new study by Prof. Ariel Chipman provides a novel model for understanding the development and evolution of arthropod body plans, tracing patterns back to ancient embryonic processes. The research uncovers a deep evolutionary logic behind the segmented body plans that define the world's most diverse animal group.
The new electrolysis test centre at TU Graz enables researchers to conduct realistic tests on next-generation large engines, turbines, and fuel cell stacks. The facility produces up to 50 kilogrammes of hydrogen at full capacity.
Dr. Joseph Twicken receives the award for his work on data processing pipelines for NASA's Kepler and TESS missions, contributing to the discovery of nearly 3,000 exoplanets. The SETI Institute also honors Sophie Clark with its Research Experience for Undergraduates Award of Excellence.
Researchers argue that news media have failed to critically scrutinize Big Tech's impact on society. Alexandra Schwinges suggests a 'software update' for journalism, focusing on data journalism and cross-border collaboration to safeguard democratic values like transparency and accountability.
A study of 120,238 Ontario long-term care residents found that 20% became permanently unable to make everyday decisions, with 13% becoming totally dependent on care. Advance care directives reduced time spent living with severe disability.
Researchers at UCSF's AViDD Center have developed powerful drug candidates that outperformed Paxlovid in preclinical testing against SARS-CoV-2 and MERS. The compounds could inhibit coronaviruses in general, providing a head start against future pandemics.
Hyperbaric oxygen treatment has been shown to provide long-term relief for patients with late radiation-induced injuries, improving symptoms of urinary incontinence, bleeding, and severe pain. The treatment can lead to the healing of chronic injuries and allow patients to live a fully normal life.
Scientists studied charge transport through organic light-emitting diodes using electronic sum-frequency generation spectroscopy. The study found changes in spectral signal intensities when applying voltages, indicating different internal charge flow across the organic layers.
Researchers developed a non-invasive fluorescence imaging strategy to detect early signs of chemical reactions between polymer coatings and iron-containing metals. The technique revealed damaging carboxyl groups that can accelerate rusting on certain artifacts.
Bank filtration (BF) was shown to effectively enhance the permeate quality of gravity-driven membrane (GDM) filtration by removing turbidity, particulate organic matter, and micropollutants. This pretreatment also improved membrane stability and increased stable flux, making it a promising strategy for treating polluted source water.
The CHANCE collaboratory at Concordia University allows researchers to examine the social aspects of gambling behavior and its influence on gamblers' interactions with their environment. The facility features a simulated gaming space with interactive terminals, cameras, and conference rooms for discussion.
Researchers successfully treated atherosclerosis and fatty liver disease using DT-109 in nonhuman primates, which has potential as a dual therapy for two common conditions. The compound reduced the formation of atherosclerotic plaques and stopped critical processes that lead to vascular calcification.
Researchers at UC Berkeley created a platform called Oz that controls up to 1,000 photoreceptors in the eye at once, enabling the perception of a blue-green color named 'olo'. This breakthrough could provide new insights into human sight and vision loss, as well as answer basic questions about color vision.
Researchers at Mayo Clinic discovered a rare genetic variant that can directly cause metabolic dysfunction-associated steatotic liver disease. The MET gene malfunction leads to fat accumulation, inflammation, and scarring, potentially progressing to cirrhosis or liver cancer.
Dr. Ali Khademhosseini, TIBI Director, receives the 2025 MRS Mid-Career Researcher Award for his groundbreaking contributions to biomaterials science and tissue engineering. His research has revolutionized engineered tissue constructs for drug discovery and regeneration.
Analysis indicates a potential east-west gradient of increased red meat allergy risk in the Mid-Atlantic US due to fragmented habitats. Tick bites may play a role in triggering this condition.
A recent psychological study found that high levels of toxic metals in mothers and newborns are associated with early childhood development problems. Breastfeeding during the first six months is generally considered favourable to an infant’s health, but exposure to toxic metals reduces its intensity and duration.
Researchers found that immune system influences stress and fear behaviors by changing how brain cells communicate, but treatment with psychedelics can target these interactions and reduce stress-induced fear. The study suggests that psychedelics could reshape treatment for inflammatory disorders like anxiety and depression.
Researchers at USTC directly observed ion acceleration through reflection off laser-generated magnetized collisionless shocks, demonstrating the role of shock drift acceleration. The experiment confirmed SDA's dominance over shock surfing acceleration, shedding light on cosmic particle origins and potential applications in fusion.
A new catalyst structure featuring mesoporous single-crystalline Co3O4 doped with atomically dispersed iridium (Ir) has been proposed as a potential pathway toward cost-effective hydrogen production. The material achieves efficient use of Ir while maintaining stability, reducing leaching during reaction.
A new study maps the daily movement of cyanobacteria in Florida's largest freshwater lake, revealing how these harmful algal blooms form and behave. The research provides critical insights into managing the risks associated with cyanobacteria blooms.
A new study by Columbia University Mailman School of Public Health researchers highlights the limitations of inflexible grant funding on community health centers (CHCs) in New York City. CHCs, which serve one in nine New Yorkers, operate on thin margins and struggle to provide comprehensive care due to restrictive state and local grants.
A study led by Helmholtz Munich found that epigenetic programs play a crucial role in DNA self-organization in early embryos. The researchers discovered multiple parallel regulatory pathways controlling nuclear organization, which can self-correct errors even after the first cell division.
Researchers identify colibactin, a bacterial toxin that alters DNA, as a potential trigger for early-onset colorectal cancer. Exposure to colibactin in childhood may imprint a distinct genetic signature on colon cells, increasing the risk of developing cancer before age 50.
Researchers at the University of Groningen discovered that mefloquine can enhance the effect of aminoglycosides to override faulty stop signals in proteins. This could lead to the development of new drugs tackling genetic diseases.
Researchers use microfabrication techniques to create tiny tattoos on tardigrades, which can survive freezing temperatures and radiation exposure. The technique allows for the creation of biocompatible devices and sensors that could advance medicine and biomedical engineering.
Research reveals Nubian women from the Kerma culture (2500-1500 BCE) carried heavy objects and children on their heads daily, using techniques like head straps known as tumplines. This study supports a growing perspective that sees the human body as a biological archive of lived experiences.
A team of researchers from Syracuse University and the University of Louisiana at Lafayette has discovered a new surface texture on sculpin fins that may enhance their grip in harsh environments. This finding could lead to the development of bio-inspired adhesives for robots, medical devices, and other applications.
A team of researchers from Goethe University and Kiel University has discovered a way to prevent the formation of harmful protein aggregates in cultured cells. The study found that linking TDP-43 with SUMO prevents its aggregation, suggesting a potential new approach for treating ALS and other neurodegenerative diseases.
Scientists found that anaerobic microbes in wetlands can remove up to 70% of methane in oxygen-deprived soils, but their ability to do so is threatened by rising temperatures. When scientists simulated a hotter future, methane emissions spiked under hotter temperatures alone.
Researchers analyzed DNA from four generations of a large family to understand genetic mutations and their transmission. They found that the rate of de novo mutations varied by over twenty-fold depending on genome location.
Researchers developed a new model called React-OT that can predict the transition state of chemical reactions in under a second with high accuracy. The model uses linear interpolation to generate better initial guesses, reducing the number of steps and computation time needed.
A 12-week randomized clinical trial shows varenicline combined with behavioral counseling effectively increased vaping abstinence in youth who vape nicotine but do not regularly smoke tobacco. This study provides hope for a novel treatment approach to help combat the growing youth vaping epidemic.
Researchers at HSE University discovered a way to control the color and brightness of glow emitted by rare earth elements. By adjusting the chemical environment, they altered the energy gap between electron levels, changing the luminescence spectrum.
A new type of connective tissue cell has been discovered that can hold back the growth of pancreatic cancer. The interferon response cancer-associated fibroblasts (ifCAF) have opposite properties to other CAF cells, which stimulate tumor development. This discovery may lead to new treatments for pancreatic cancer.
The US Cost of Dementia Project estimates total economic burden at $781 billion, accounting for lost earnings, diminished quality of life, and unpaid care. The project aims to inform evidence-based policies reducing dementia's financial impact.
Researchers found that human activity, including military conquests and agricultural practices, led to the sudden collapse of swamp forests in the Pearl River Delta region around 2.1 thousand years ago. This event marked the beginning of a decline in biodiversity, contributing to local extinctions of various species.
Researchers at Max Planck Institute developed a tunneling technique to probe superconducting gaps in H3S and D3S, discovering fully open gaps with values of approximately 60 meV and 44 meV. This achievement marks a revolutionary advance towards achieving high-temperature superconductivity.
A team of Singaporean scientists has released a comprehensive long-read RNA sequencing dataset, SG-NEx, to accelerate biomarker discovery and precision medicine. The dataset offers deeper biological insights into RNA complexity, enabling researchers to detect clinically relevant biomarkers and develop better treatments.
SiC-based pressure sensors offer promising solutions for extreme environments due to their wide bandgap, high carrier saturation drift rate, and strong chemical stability. The review highlights key technologies, including epitaxial layers, piezoresistive effect, ohmic contacts, etching, and sensor packaging.
Researchers identified piperacillin as an effective treatment for Lyme disease, which causes devastating symptoms in half a million individuals annually. The antibiotic works by targeting the bacteria's unique cell wall synthesis pattern, leading to its death without harming beneficial gut microbes.
A study found that less than one-third of US emergency departments screen for adverse social determinants of health, highlighting the need for expanded practices. The lack of policies requiring responses to positive screens is also a concern, emphasizing the need for infrastructure and resources to address identified social needs.
A novel biological pathway, the IL6 pathway, has been identified as central to calciphylaxis skin lesion initiation and progression. Blocking this pathway could prevent progression of skin ulcers and resolve pain in patients with calciphylaxis.
A systematic review reveals that spatio-temporal big data applications in transportation resilience studies are most developed in quantitative assessment, but significant gaps remain in real-time monitoring and early warning systems. The study identifies the need for improved data integration frameworks and interdisciplinary cooperatio...
Researchers unveiled a new class of topological insulator with an octupole phase protected by a three-dimensional momentum-space nonsymmorphic symmetry group. The discovery broadens the understanding of higher-order topological phases and provides new insights into band theory in the Brillouin real projective space.
A team of researchers has developed a comprehensive atlas of genetic change through generations, revealing that parts of the human genome change much faster than previously known. This discovery has significant implications for understanding human disease and evolution, including the roots of genetic diseases.
Researchers discovered that individuals with robust immune resilience at midlife can gain a 15.5-year survival advantage due to their ability to counter disease drivers and maintain healthy aging. The study highlights the importance of salutogenesis, or promoting health and well-being from birth to approximately age 70.
Capsule eliminates I/O overhead and optimizes performance by designing a subgraph loading mechanism and pipelined parallel strategy for large-scale graph neural network training, providing 22.24% memory usage and up to 12.02x performance improvement over existing systems
The latest ACS cancer prevention and early detection report reveals mixed progress in major cancer risk factors, preventive behaviors, and screenings among US adults. Smoking rates have continued to decrease, while breast and colorectal cancer screening have rebounded, but cervical cancer prevention remains a concern.
Researchers at Memorial Sloan Kettering Cancer Center have made significant breakthroughs in understanding Acute Myeloid Leukemia (AML) and early brain development. They identified a rare quiescent population of stem cells responsible for disease persistence and therapy resistance, as well as shedding light on gene expression patterns ...
A new study reveals that incorporating CPMAC into perovskite solar cells enhances energy efficiency and stability, reducing defects in the electron transfer layer and improving performance.
Researchers at Trinity College Dublin have found that the brain forms memories of cold experiences and uses them to control metabolism. The discovery may lead to new treatments for conditions such as obesity and cancer, which are influenced by thermoregulation and metabolism.
A new collaboration aims to develop an affordable and accessible monoclonal antibody therapeutic for CCHFV, treating thousands globally. USAMRIID discovered the antibody in mice, and LifeArc is supporting development of a fully humanized antibody.
Researchers from Bar-Ilan University discovered a link between protein modifications and extended lifespan in long-lived mammals. The study identified posttranslational modifications associated with increased resilience against age-related diseases, such as cancer and diabetes.
A study analyzing 17,500 individuals found that immune resilience counters factors of aging and mortality through TCF7 gene regulation, reducing mortality risk by 69% in midlife. This promotes salutogenesis, actively fostering health and well-being.