Researchers have discovered several novel downstream p53 targets that could lead to improved cancer therapies. The study highlights the critical role of p53 in preventing cancer and identifies two new genes, ALDH3A1 and NECTIN4, as potential targets for cancer treatment.
Researchers found that larger species have higher cancer rates than smaller ones, with some species even having better natural defences against cancer. The study challenged the long-standing Peto's paradox and provided insight into how superior mechanisms of cellular defence can evolve in larger species.
Researchers introduce a dual threshold classifier to interpret circulating tumor DNA levels, enabling earlier detection of disease progression and personalized treatment. The study confirms that ctDNA levels are superior to traditional biomarkers like CA15-3.
Researchers from Cleveland Clinic’s Genome Center linked human herpesviruses to Alzheimer's disease via transposable elements. They identified TEs activated in HSV-1 infected brains and found that commercially available drugs can reverse this pathway.
A new study found that combining physical warmups with short bursts of cognitive tasks enhances athletic performance. Researchers discovered a 'Goldilocks effect,' where the right balance between cognitive and physical activities is key to optimal performance.
A history of social isolation and alcohol use may influence how males and females respond to ketamine treatment. Female rats took ketamine more than males, while prior alcohol use increased female rat ketamine intake and changed synapse structure.
A new study reveals that most well-known national suicide prevention organizations do not have easily accessible resources targeting older adults, who are at the highest risk of suicide. The findings highlight the urgent need for targeted campaigns and tailored prevention programs that address the unique healthcare needs of older adults.
New research reveals aldosterone-producing adenomas harbor at least four distinct cell types, including cortisol-producing cells that contribute to unexpected health issues. The study also identifies potential role of lipid-associated macrophages in influencing hormone production and tumor growth.
Researchers at Helmholtz Munich identified distinct subtypes of white matter astrocytes, including one that can multiply and support brain repair. These findings raise possibilities for regenerative medicine and therapies for brain injuries and neurodegenerative diseases.
A Cornell University study used a computer model to predict the transmission of bird flu to backyard poultry when migratory mallards stop to rest. The researchers found that mallard ducks are natural carriers of avian influenza and can spread the disease to backyard poultry if they stop to rest in an area with high risk for introduction.
A new AI model measures how fast the brain ages by analyzing MRI scans, providing a more accurate picture of brain health. The tool closely correlates faster brain aging with increased cognitive decline and dementia risk, offering potential for early biomarkers and personalized treatment.
An international team led by IU School of Medicine has discovered a novel gene associated with an ultrarare neurodevelopmental disorder. The breakthrough was made using cutting-edge genomic technologies and enabled the diagnosis of a patient at Riley Hospital for Children's Undiagnosed Rare Disease Clinic.
Researchers analyzed gene expression profiles in rats undergoing extracorporeal membrane oxygenation, finding reduced inflammation and increased immune suppression with spontaneous breathing. The study suggests weaning off ventilator support during VV-ECMO may be beneficial for clinical practice.
Ebru Demir aims to study how groups of AI-driven microswimmers move in biological fluids for potential applications in drug delivery, fertility treatments, and other medical fields. Her research combines artificial microswimmers with machine learning to uncover the underlying physics governing their movement.
ETRI and ANL will develop new semiconductor technologies for detecting high-energy particles in space environments. The collaboration aims to secure global competitiveness in semiconductors and enhance technology industrialization.
Technion researchers discover Human Breast Milk Protein Corona, which influences nanoparticle permeability through the gastrointestinal tract. The discovery enables oral consumption of vaccines and medications, inspired by breast milk's unique properties.
A study published in the Journal of Food Composition and Analysis reveals most US infant formulas contain primarily added sugars, rather than naturally occurring lactose. This contradicts medical recommendations for babies under 2 years old, who require a diet closest to human breast milk.
A Chinese rover has discovered underground beach deposits in an area thought to have once been the site of an ancient sea on Mars. The deposits, which are similar to those found on Earth, suggest that Mars had a long-lived body of water with wave action to distribute sediments along a sloping shoreline.
A cohort study found no increase in sudden cardiac arrest/sudden cardiac death among young competitive athletes in the US, contradicting reports that linked COVID-19 infection and vaccination to the risk. The study suggests that many athlete cases shown in social media videos occurred before the pandemic, not due to COVID-19.
The National Center for Supercomputing Applications has been awarded a grant to continue its Research Experience for Undergraduates (REU) program, which provides students with hands-on experience in machine learning and deep learning projects. The program aims to develop open source machine learning models and tools and apply them to r...
Researchers introduce a performance-based framework that integrates hydroclimate variability, hydrology, machine learning, community knowledge and feedbacks between physical and social systems. This approach enhances understanding of flood risks while emphasizing long-term community resilience.
Scientists have successfully imaged the dynamic assembly of bilayer covalent organic frameworks in solution, providing new insights into controlled stacking and moiré superlattice formation. The breakthrough enables the creation of large-area two-layer 2D COFs with unique electronic properties.
Researchers found that brewing tea can adsorb significant amounts of toxic heavy metals like lead and cadmium from drinking water. The study revealed that steeping time played the most significant role in removing metal ions, with longer steeping times resulting in more effective filtering.
The paper demonstrates the explicit and hidden presence of asymmetry in mathematics courses for K-12 teacher candidates. Digital tools are used to show how knowledge of asymmetry as an antithesis of symmetry brings new insights to studying mathematics for teaching.
A new study led by La Jolla Institute for Immunology scientists found that children who experience multiple dengue virus infections develop protective T cells, which help fight the virus. These T cells appear to be key to dengue virus immunity and may inform the development of a vaccine that prompts a similar response.
A new study suggests that mRNA COVID-19 vaccination may protect against post-COVID condition symptoms in children. The findings support the benefits of vaccination beyond acute protection, encouraging increased pediatric uptake.
Researchers found that climate change affects lake ecosystems in complex ways, with abrupt changes in algal biomass detected in a third of tested lakes. The study suggests that climate interacts with human activities like agriculture and urban runoff, leading to more vulnerable lakes.
Researchers found that young salmon migrate over longer distances at night to avoid predators, while seeking refuge near riverbanks during the day. Elevated water temperatures, dams, and poor water quality also threaten their survival.
Researchers found that a Lactobacillus-dominant uterine environment significantly improves pregnancy outcomes and increases pregnancy success rates. Disruptions in microbiota composition have been linked to conditions such as chronic endometritis, endometriosis, and recurrent implantation failure.
The BIG framework reduces computational demands by at least 20% while boosting efficiency in long-range exploration and navigation tasks. It optimizes exploration with geometric parameters, guides agents to target locations, and creates experience maps through spatio-temporal clustering.
A recent study by the University of Georgia found that financial stress can contribute to burnout and reduce job satisfaction. The researchers surveyed over 200 employees and discovered that current worries about money management increased levels of burnout, while expected future financial security improved views on one's job.
Researchers from Aarhus University found a machine-learning algorithm that can predict patients with high risk of developing schizophrenia or bipolar disorder within the next five years. The study analyzed electronic health record data and identified key factors, including words describing symptoms in clinical notes.
A new AI-powered tool, MELD Graph, has been developed to detect subtle brain abnormalities in children with epilepsy. The tool improves detection rates by 64% compared to human radiologists, reducing delays in diagnosis and treatment. This could lead to faster surgical interventions, improved outcomes, and reduced costs for the NHS.
A new study explores whether pairing food labels with odors affects how people perceive foods and promotes healthy shopping. The researchers found that odor-paired beverages were perceived more positively, suggesting that odors can improve label perception and potentially promote healthy food choices.
The study confirms the innovative Ambu aScope 5 Broncho is a rotatable scope compatible with electrocautery, ensuring safe procedures without complications or need for reusable scopes. Single-use flexible bronchoscopes have shown comparable performance to reusable ones in terms of functioning, cost, and environmental impact.
A clinical trial in rural China shows a telemedicine-based, village doctor-led care model significantly enhanced atrial fibrillation management. The study found lower rates of major cardiovascular events and higher adherence to evidence-based guidelines.
A new test called EpiAgePublic estimates biological age using only three DNA sites in the ELOVL2 gene, simplifying traditional methods while maintaining accuracy. The study found that EpiAgePublic accurately tracks aging patterns and can identify factors accelerating the aging process.
A new study warns that the risk of reaching 2.7°C of global warming is substantial, with cascading impacts on marine ecosystems and local infrastructure. The research calls for urgent action to reduce greenhouse gas emissions and invest in sustainable practices and climate adaptation strategies.
Scientists have cracked the code of meiotic DNA double-strand breaks, a crucial process for genetic diversity and chromosomal segregation. The study reveals that Mg2+ is essential for DNA cleavage activity and functions independently of ATP.
A recent study from the University of Kansas found that people tend to prefer AI chatbots when discussing sensitive or embarrassing topics like health information, due to their anonymity and nonjudgmental nature. However, when individuals are angry, they still prefer human interaction.
Researchers at the University of Colorado Anschutz Medical Campus found that primary care providers trained on advanced insulin technology or through telehealth can deliver similar positive results to specialists. The study focuses on Type 1 diabetes and highlights the potential for broader access to cutting-edge care.
A new study suggests that local practitioners are needed to bring together local knowledge and conservation practices for managing conflicts between humans and large carnivores. This approach recognizes the importance of Indigenous groups and traditional local communities in shaping policies on coexistence with these species.
Researchers at UC Irvine have developed a new family of antibiotics that targets two key areas of bacterial cells, offering a potential solution to the growing threat of antibiotic resistance. The new drug candidates may help eliminate the need for continuous redesign of new antibiotics.
Researchers developed a theoretical model predicting substantial increase in OLED brightness by leveraging polaritons, promising improved efficiency and brightness. The study proposes new materials discovery and architecture development to achieve single-molecule strong coupling or tailored molecules for polariton OLEDs.
A novel computational model enables prediction and improvement of multifunctional structures in 3D printing. Researchers have controlled internal structure to enhance mechanical resistance and electrical signal transmission.
A study by Barcelona Institute for Global Health estimates that increasing green spaces in the city could prevent 178 premature deaths per year. The proposed Green Corridors plan would lead to a 3.64% increase in green space, reducing mortality rates and heat-related deaths.
A recent study found that US physicians experienced lower mortality rates compared to the general population, but this benefit did not extend to female or racial and ethnic minority groups. The study highlights the need for renewed efforts to address health inequities within the healthcare workforce.
The FDA has approved a new treatment for Parkinson's disease that can adjust to the individual's brain activity, providing precise stimulation. This technology, known as adaptive deep brain stimulation (aDBS), detects patterns of brain activity and delivers tailored electric pulses to reduce symptoms.
The American College of Chest Physicians (CHEST) has developed an educational program and formal certification exam for nurse practitioners and physician assistants/associates in critical care. The program validates clinical expertise and demonstrates professional acumen, aiming to improve patient care.
A new USF study emphasizes the importance of protecting coastal marine ecosystems, particularly tidal flats, which provide critical habitats for fish populations and contribute to global seafood supplies. The team recommends adopting core strategies for boaters, anglers, wildlife managers, and policymakers to prioritize preservation.
A new study has focused on the safety of outdoor swimming during pregnancy, revealing large gaps in knowledge and highlighting the need for further research. Expert-led recommendations have been provided for pregnant people, including advice to only swim in cold water if a regular cold water swimmer before pregnancy.
Researchers discovered a gene cluster responsible for producing withanolides in ground-cherry plants, demonstrating epigenetic regulation of chemical defenses. The study provides insights into the production of diverse metabolites and potential development of alternative pesticides and therapeutics.
The Zhurong rover discovered hidden layers of rock under the Martian surface indicating an ancient northern ocean. This finding offers clear evidence that Mars once had a significant body of water and a more habitable environment for life.
Researchers have discovered that giraffes maintain species-specific gut flora, even when eating different sets of plants. This finding has significant implications for the conservation of endangered giraffe species, highlighting the importance of understanding their diets and habitats to ensure their survival.
Researchers at Johannes Gutenberg University Mainz have discovered that histone deacetylase 8 (HDCA8) inhibits the conversion of Schwann cells into their repair phenotype, slowing down peripheral nervous system recovery. Removing HDAC8 accelerates regeneration and restores sensory function.
Research reveals that even a single night of sleep deprivation can alter the profile of immune cells, similar to those found in individuals with obesity. This suggests that the immune system is highly sensitive to sleep patterns and may contribute to long-term inflammatory states and increased risk of disease.
Researchers found that cytomegalovirus infection significantly worsens necrotizing enterocolitis in mouse models, triggering inflammation and disrupting energy production. The study provides insight into the underlying mechanisms of NEC and may lead to the development of new treatments for this devastating condition.
The book, RE-HUMANIZE, offers actionable frameworks to help business leaders navigate the evolving landscape of digital work. It emphasizes the importance of preserving humanity in organizations, highlighting strategies for a digital division of labor that respects human dignity.
Researchers will use airborne GPR and ground-based TEM to collect rich geophysical data, estimating carbon storage and gas emissions in peatlands across a latitudinal gradient. The project aims to reduce uncertainty in these predictions and provide valuable information on how to better protect carbon stocks.
Researchers analyzed over 9,200 towns and cities in Africa from 1950-2020 using remote sensing data to understand the evolution of urban systems. The study verifies the universality of urban system laws in African cities and identifies specific rules governing population growth and land use.