A study led by German Cancer Research Center researchers found that the WNT signaling pathway helps cancer cells suppress the immune system, promoting the development of malignant tumors. Restoration of CCL20 production slowed tumor growth in experimental models.
Researchers at Hopp Children's Cancer Center Heidelberg used PRAME-specific T-cell therapy to treat an advanced, therapy-resistant kidney tumor in a young patient. The treatment achieved complete tumor regression and no evidence of active cancer remains one year after infusion.
Researchers characterized T cells in bone marrow of multiple myeloma and acute myeloid leukemia patients, finding a specific gene signature that predicts immunotherapy success. The signature identifies tumor-reactive T cells that are partially primed but can be activated by therapies like bispecific antibodies.
Researchers studied mouse tumors and found genetic differences influenced cancer development pathways and stability, suggesting personalized medicine may benefit from genetic background consideration
Research reveals that blood vessel endothelial cells produce lipoprotein lipase (LPL), guiding activated T cells to enter tumors and fight cancer cells. LPL enables endothelial cells to present tumor-derived components, acting like a 'wanted poster' to alerting T cells to the presence of cancer cells.
Researchers at the German Cancer Research Center found that overweight individuals are associated with more than 10% of all cancer cases, nearly twice the previous estimate. The analysis considered accurate measures of body fat and methodological biases to reach this conclusion.
Researchers developed an AI-powered assistant, HemaGuide, that analyzes physician reports, combines with current guidelines and scientific literature, and generates treatment recommendations. The system has shown high accuracy across all types of blood cancers, aligning with expert decisions in nearly 82% of cases.
Researchers have developed a vaccine that activates the immune system against a common genetic mutation in malignant brain tumors. Patients who responded well to the vaccine had significantly better long-term prognoses, and the therapy was associated with improved survival rates and reduced disease progression.
Researchers have identified a key marker of highly aggressive and treatment-resistant colorectal cancer cells. Combining chemotherapy with TROP2-targeted therapies significantly improves effectiveness in laboratory trials.
A new analysis of German cancer registries reveals a slight increase in colorectal cancer cases among younger adults between 20 and 39 years old. The incidence rate is significantly lower in Germany compared to the US, with the rise being more moderate in Germany.
An AI system called Hetairos can classify brain tumors with over 100 molecular subtypes using standard microscopic tissue sections, delivering results within minutes. The system outperforms human experts in diagnosis accuracy, especially for rare tumor types.
Researchers at German Cancer Research Center discovered a previously unknown mechanism by which senescent cells protect themselves from oxidative stress and ferroptosis. Senescent cells produce large amounts of triglycerides, which store sensitive polyunsaturated fatty acids in cell membranes, making them resistant to ferroptosis.
Researchers identified four distinct subtypes of leukemia stem cells, each responding differently to treatments. The study provides new avenues to overcome venetoclax resistance and develop personalized treatment strategies for AML patients.
Chronic cellular stress drives liver cell cancer growth, suppressing immune response. Activated ATF6α makes tumors responsive to immunotherapy, opening up new therapeutic approaches.
Researchers developed an AI approach that enables knowledge transfer across species boundaries, allowing AI to learn from animal image data and apply it to human tissue. The method, called xeno-learning, overcomes the need for large amounts of annotated human image data, making surgical procedures safer and more precise.
Cells use two distinct strategies to precisely control inflammatory genes, combining loose, short-lived DNA contacts and control centers in the cell nucleus. These mechanisms enable finely tuned and flexible control of individual genes, allowing for rapid and coordinated inflammatory responses.
Researchers have demonstrated that mRNA technology can be used to transform the liver in mice into a temporary source of important immune regulatory factors that are naturally lost during aging. This restores the formation of new immune cells, allowing older animals to develop robust immune responses again and fight tumors effectively.
Researchers at the German Cancer Research Center discovered that about one-third of blood cells originate from embryonic precursors, which preferentially produce lymphocytes. The second system, from bone marrow stem cells, produces myeloid cells such as granulocytes or erythrocytes.
A recent study has found that certain painkillers can increase hepcidin production in liver cancer cells, leading to iron deficiency and anemia. The researchers discovered that diclofenac and paracetamol alter the activity of signaling pathways within cancer cells.
Researchers found that cancer cells in a tumor environment with acidosis can switch to more efficient energy production, using networks of mitochondria instead of fragmented structures. This adaptation helps cancer cells survive under adverse conditions, and could lead to new treatments targeting the energy metabolism of tumors.
Grid cells in the brain switch between internal maps depending on the situation, contradicting previous theories about their role in navigation. This flexible adaptation enables animals to find their way home without external landmarks.
A new study found that different EML4-ALK fusion variants have varying effects on tumor growth and response to targeted drugs. Researchers discovered that the V3 variant drives more aggressive tumors than the V1 variant, while some tumor suppressor genes only slow down V1 tumors.
Researchers develop a therapeutic vaccination concept using silica nanoparticles to target HPV-related tumors. The vaccine activates cytotoxic T cells to destroy cancer cells, with promising results in mice models.
Scientists have developed a method to reconstruct the temporal development of cancerous cells from a single tissue sample. This new technique, SCIFER, can detect aggressively growing clones and help identify individuals at risk for blood cancers like MDS.
A new smartphone-based stool test has been developed and tested for its effectiveness in detecting blood in the stool, a potential indicator of colon cancer. The study found that the app's sensitivity was just as good as traditional laboratory tests, with advanced mucosal changes detected in 28% of cases.
Researchers at DKFZ discovered that EBV-infected B cells exhibit characteristics of 'homing cells,' allowing them to migrate and target specific tissues. This process is controlled by viral proteins EBNA2 and LMP1, which increase the activity of pro-inflammatory cytokines.
Researchers have identified where and when the most aggressive subgroups of childhood brain tumors develop, revealing that they arise from precursor cells of highly specialized nerve cells. The study suggests that genetic changes occur many years before clinical symptoms appear, paving the way for possible early detection methods.
Researchers at German Cancer Research Center found that hepatic stellate cells regulate liver metabolism, regeneration, and size. The study suggests new therapeutic approaches for liver diseases by targeting the positive functions of these cells.
Researchers at German Cancer Research Center discovered that PPIs can be activated by zinc-carrying proteins without gastric acid. This finding could help understand the side effects of PPIs and open new perspectives for their better use.
Researchers discovered that pancreatic cancer reprograms nerve cells to promote tumor growth. Blocking nerve function inhibited cancer growth and increased sensitivity to certain therapies.
Researchers at German Cancer Research Center discovered a guardian molecule, PROX1, that regulates cell identity and prevents cancer. PROX1's constant activity suppresses cancer driver genes, leading to reduced liver tumor growth.
Scientists at German Cancer Research Center develop innovative method for growing individual brain tumors in lab, mimicking original structure and molecular properties. The IPTO model accurately predicts patient response to chemotherapy and other drugs, offering a valuable tool for personalized medicine.
Scientists at German Cancer Research Center (DKFZ) have found that blocking Aldolase A enzyme can trap energy in liver cancer cells, leading to slowed tumor growth. The team demonstrated this in mouse and human cancer cell lines, suggesting a promising strategy for combating cancer cells.
The study reveals that epigenetic mechanisms, particularly DNA methylation, control the development of functioning blood vessels in the mouse placenta. In humans, this process is connected to a deficiency of the methyltransferase enzyme DNMT3A, which can contribute to placental insufficiency and fetal growth retardation.
Scientists cultivate stable tumor organoids directly from blood samples of breast cancer patients, revealing a molecular signaling pathway that ensures cancer cell survival and resistance to therapy. The team develops an approach to specifically eliminate these tumor cells in lab experiments.
Researchers analyzed chromosomal chaos in leukemia cells and found that genetic and non-genetic factors drive functional heterogeneity. They identified therapeutic targets and alternatives for resistant subclones, providing a model for early identification of leukemia stem cells.
Researchers have developed a novel vaccine that can trigger a targeted immune response against gliomas, the deadliest form of brain tumors. The vaccine targets specific mutations present in most glioma cells, making it effective against all tumor cells regardless of genetic differences.
Researchers developed AI chatbot UroBot to answer complex urology questions with high accuracy, exceeding human urologists. The model justifies its answers based on European Society of Urology guidelines and has been tested on 200 specialist questions, achieving an accuracy rate of 88.4%.
Scientists at German Cancer Research Center developed a convoy of millimeter-sized robots to transport heavy surgical instruments. The robotic unit successfully performed an electric surgical procedure on a bile duct obstruction experimentally.
Researchers have developed a risk assessment tool using deep learning to decipher rare genetic variants. The method, called DeepRVAT, predicts gene impairment and potential impact on health, improving disease diagnosis and personalized medicine.
Scientists have discovered that epigenetic changes can reprogram astrocytes into brain stem cells, which can potentially be used to replace damaged nerve cells in regenerative medicine. This breakthrough is made possible by the methylation of genetic material, allowing these special astrocytes to acquire stem cell properties.
Researchers have developed a highly sensitive mass spectrometry-based method to detect mutation-derived tumor neoepitopes, which are recognized by the immune system. The new protocol enables the detection of low-abundance peptides in minimal tissue samples, paving the way for personalized cancer immunotherapies.
A new HPV vaccine has been developed that protects against all cancer-causing HPV types and triggers cellular immune responses to eliminate infected cells. The vaccine's thermal stability and affordability make it an ideal solution for increasing vaccination rates in developing countries.
Researchers have developed an AI-based system that can predict the risk of prostate cancer more accurately than traditional methods. The new tool combines MRI images and deep learning to identify low-risk patients who may not need a biopsy, potentially sparing them from unnecessary procedures and reducing complications.
Scientists found islands of highly potent immune cells in the bone marrow close to glioblastoma tumors, which play a central role in defending against cancer. This discovery may lead to innovative therapies and could improve patients' chances of survival.
A randomized controlled trial found that structured exercise programs significantly improved the quality of life and reduced fatigue in women with metastatic breast cancer. The program, which included twice-weekly training sessions, also showed improvements in pain, shortness of breath, and social participation.
Scientists found no significant differences in mutation rates of DNA strands despite different replication processes. The accumulation of mutations is shaped by DNA accessibility on repair efficiency rather than damage location.
Researchers developed a predictive model using Danish health data to quantify individual cancer risks for 20 types of cancer, achieving an accuracy of 81% over a lifetime. The model enables risk stratification and can inform targeted early detection tests, potentially reducing unnecessary procedures and false positives.
A meta-analysis suggests combining microsatellite instability (MSI) and tumor-infiltrating lymphocytes (TIL) can optimize prognostic assessment in early-stage colorectal cancer. Patients with high MSI and TIL had the best prognosis, while those with low immune cells found in the tumor tissue had a poor outcome.
A new study suggests that longer screening intervals for prostate cancer are safe and effective when the initial PSA test is conducted at a young age. The PROBASE trial found that only 0.45% of men with low-risk PSA levels developed high PSA levels, indicating an increased risk of prostate cancer. This finding supports the idea of rais...