Researchers have developed a novel method for generating metabolic profiles of individual cells, enabling the analysis of over 100 metabolites and lipids from thousands of cells per hour. The method, called SpaceM, uses a combination of fluorescence microscopy and mass spectrometry to analyze single-cell metabolism.
Researchers discovered hematopoietic stem cells in glioblastomas, which promote division of cancer cells and suppress the immune response. These blood stem cells stimulate tumor growth and produce immunosuppressive messengers.
Scientists discover a way to reactivate paralyzed immune cells against IDH-mutant gliomas, leading to improved vaccine effectiveness. The researchers identified the molecular mechanism behind the 'immune paralysis' caused by cancer-promoting metabolic products and found a substance that deactivates a key immune system regulatory molecule.
Researchers discovered that type 1 dendritic cells (cDC1) promote progression of non-alcoholic steatohepatitis (NASH) by inducing inflammatory and aggressive behavior in T cells. Blocking or genetically modifying cDC1 alleviates symptoms in mice, suggesting a potential new approach to prevent serious liver damage.
A clinical trial tested a mutation-specific vaccine against IDH1-mutated gliomas, a type of diffuse brain tumor. The vaccine proved safe and triggered the desired immune response in 93% of patients, with some experiencing pseudoprogression and tumor growth slowing.
Research found that immunotherapy using checkpoint inhibitors does not benefit patients with NASH-related liver cancer, and may even promote tumor growth. The study identified a biomarker to assess treatment efficacy in these patients.
Scientists detected novel pathogens in colorectal cancer patients near tumors, triggering chronic inflammation that promotes cancer development. BMMFs were more frequently found near malignant tumors than healthy tissue.
Researchers used induced pluripotent stem cells to identify correlations between genetic variants and altered expression patterns in human cells. The study found thousands of disease-associated genetic variants linked to specific diseases, including coronary heart disease and hereditary cancers.
Researchers found that vitamin D supplementation could reduce cancer mortality rates by around 13 percent, resulting in potential savings of €254 million per year. The study suggests that widespread vitamin D supplementation among Germans over 50 could prevent up to 30,000 cancer deaths annually and gain more than 300,000 years of life.
In mice, blood vessel cells produce factor that stimulates blood stem cells, maintaining their self-renewal capacity. However, production of this factor ceases with aging, leading to loss of self-renewal ability and weakening of the immune system.
Scientists have identified G3BP proteins as a crucial molecular mechanism that inhibits MTOR activity, leading to cancer cell migration and neuronal hyperactivity. Inhibiting MTOR with existing drugs shows promise in treating breast cancer and neurological disorders, such as epilepsy.
Researchers found that cancer cells promote blood clot formation to enter the brain tissue. Inhibiting clotting factors thrombin and von Willebrand factor reduced brain metastases in mice. The study suggests targeting this process with drugs for preventing brain metastases in high-risk patients.
A new method, nnU-Net, has been developed to configure self-learning algorithms for a large number of different imaging datasets, enabling the interpretation of three-dimensional imaging data and distinguishing between tumor and non-tumor tissue.
Scientists identified an antibody that blocks a signaling molecule in vascular system, causing tumor lymph vessels to die and preventing metastasis. This approach may lead to new ways to block the spread of tumor cells.
Researchers define two molecular subtypes of pancreatic carcinoma with distinct aggressiveness, differing in the origin and development. The study reveals a novel mechanism called viral mimicry that promotes cancer growth and metastasis.
The metabolic enzyme IL4I1 promotes tumor cell spread and suppresses the immune system, making it a promising target for cancer therapy. The study's findings may provide important information for the development of new immunotherapy concepts.
Scientists discovered that DNA lesions caused by chemicals are passed on unrepaired, leading to complex patterns of mutations. This phenomenon, known as lesion segregation, can drive tumor growth and development.
Researchers at the German Cancer Research Center found that CAR T cell production can be significantly reduced in an academic setting, from EUR 320,000 to around EUR 60,000. This could lead to substantial cost savings and faster treatment times for patients, as well as increased accessibility of this life-saving therapy.
Researchers found that skeletal muscles release interleukin-15, which helps to settle and activate T-cell precursors. This enables the immune system to fight chronic infections over long periods. Regular training may strengthen the immune system by increasing muscle mass.
Researchers at DKFZ successfully blocked a receptor that stimulates tumor growth and metastasis with an antibody, slowing down cancer progression. The study found that the antibody reduced metastases in treated mice without affecting blood vessel formation.
A genetic defect in 15% of children with medulloblastoma leads to disrupted protein production and metabolism, increasing the risk of cancer. The study identifies a new hereditary cause of medulloblastoma, which could lead to more effective treatment options for affected families.
Scientists identified a new control mechanism that enables stem cells to adapt their activity in emergency situations by modifying protein blueprints. Alternative polyadenylation regulates the amount of protein produced and controls protein isoform formation, affecting stability and localization.
Researchers discovered that cancer cells induce lung tissue inflammation, releasing signals CXCL9 and CXCL10, which aid metastasis growth. The interaction between detached cancer cells and fibroblasts is crucial for metastatic colonization.
Research by German Cancer Research Center and Hebrew University finds that intestinal bacteria reprogram DNA activity in gut mucosa cells, controlling healthy gut development and inflammation. Demethylating enzymes TET2 and TET3 play a key role in this process.
A systematic overview of viruses in cancer found HPV and EBV in 19 and 5.5 percent of cancer genomes respectively. The study also identified mechanisms by which viruses trigger carcinogenic mutations in DNA.
A study of over 2,500 tumor genomes reveals that most cancer cells use alternative mechanisms to lengthen their telomeres, increasing their lifespan. The researchers discovered unique variations in these telomere sequences and their integration into the genome, which may hold clues for developing targeted treatments.
Scientists from the German Cancer Research Center have identified a receptor on murine immune cells that activates a protective mechanism preventing unwanted immune responses against the body's own tissues. Dectin-1 binds to annexins on dying cells, suppressing the immune response and preventing autoimmune reactions.
Researchers have developed a new approach to study the bone marrow in unprecedented resolution, revealing previously unknown cell types and their local environments. The study provides a novel basis for studying blood diseases such as leukemias and has made its dataset publicly accessible for further research.
Researchers found that colon cancer cells deficient in p53 use the mevalonate pathway to survive, producing ubiquinone to synthesize new DNA. Statins inhibit this pathway, inducing apoptosis in cancer cells.
Researchers found that CD95 activation triggers apoptosis in individual cells, but stimulates growth in clusters of cancer cells. The study suggests new ways to transform growth-stimulating signals into cell death signals for cancer cells.
Researchers found that neurons in the brain form direct cell-to-cell contacts with aggressive glioblastoma cells, transmitting activation signals that drive tumor growth and invasion. Blocking this signal transmission can slow down tumor spread, offering new avenues for treatment.
Researchers discovered that chronic inflammatory processes in aging brains lead to lymphoma cells being retained in the brain tissue instead of being released back into the blood. The NF-kappaB signaling pathway and CCL19 play a crucial role in this process, allowing lymphoma cells to multiply and develop tumors.
Researchers discovered that leukemia stem cells suppress NKG2D-L proteins, evading the immune system. By inhibiting PARP1, these cells can be recognized and eliminated by NK cells.
A study identified Glycerol-3-phosphate dehydrogenase 1 (GPD1) as a molecular marker specific to dormant glioma stem cells. GPD1-producing cells are resistant to chemotherapy and radiation, and their activation leads to tumor relapse.
Researchers have developed a comprehensive database of synonymous mutations found in cancer, revealing their influence on cellular functions and disease processes. The SynMIC database contains information on 659,194 entries across 88 types of cancer, providing a valuable resource for cancer researchers.
Researchers discovered that MEK inhibitors activate Wnt signalling pathway in colorectal cancer cells, leading to accumulation of tumor cells with stem cell characteristics. This explains why these drugs are not effective in treating colorectal cancer.
A team of researchers developed an AI method for automated image analysis of brain tumors, which outperforms traditional radiological methods. The new approach enables more reliable and precise assessment of therapy response, improving overall survival predictions.
Scientists found that platelets play a key role in the development of fatty liver disease and liver cancer. Blocking platelet function or attaching to specific molecular sites may help prevent the condition.
Researchers identified three key genetic drivers of glioblastoma development, including the activation of telomerase. Early tumors exhibit concurrent genetic alterations, but recurrent tumors display distinct mutation patterns. This study highlights the need for new treatments to effectively target resistant subclones.
Researchers from German Cancer Research Center have successfully reconstructed biomolecules in their mirror-image form. This breakthrough could lead to the creation of mirror-image therapeutic proteins that are protected from biological breakdown and do not provoke immune responses.
Stem cell research reveals that aging brain stem cells enter a state of dormancy promoted by inflammatory signals, reducing their ability to regenerate neurons. However, blocking these inflammatory signals using antibodies increases dividing activity and improves neuron production.
A study using high-resolution MRI scans found that protein content in glioma tumors is associated with treatment response and patient survival. The research suggests that assessing tumor protein levels could help choose the best possible treatment strategy for patients.
Researchers at German Cancer Research Center discovered that stem cell genes remain active, allowing for reversible decision-making in becoming a neuron or reverting back to stem cell. Uncontrolled TOR activity can cause brain cancer, highlighting the importance of controlling this signal for future stem cell therapy developments
Scientists have successfully reprogrammed human blood cells into a new type of neural stem cell, similar to those in early embryonic development. This breakthrough could lead to the development of regenerative therapies for treating diseases of the nervous system.
Scientists at DKFZ developed XRNAX to analyze interactions between all RNA classes with cellular proteins. The new method identifies hundreds of previously unknown protein-RNA bindings and sheds light on diseases including cancer, ALS, and viral infections.
A recent study published in the American Journal of Clinical Nutrition found that intermittent fasting has no advantage over conventional calorie restriction diets for weight loss and improved health outcomes. The HELENA study, which followed 150 overweight participants for a year, showed similar results for both dietary methods in ter...
Researchers found that failing DNA repair systems lead to chromosome fragmentation and defective assembly in cancer cells. This can be treated with PARP inhibitors, which block another critical DNA repair enzyme, causing genetic damage that kills the cell.
Researchers found that a typical mutation in cancer cells blocks the body's immune response, even with immunotherapy. The tumor releases an oncometabolite that impairs T cell function, leading to re-programmed immune cells.
African trypanosomes confuse immune defense with sugar chains on surface proteins, increasing pathogenic properties. Scientists discover binding sites for sugars in multiple VSGs, hindering antibody binding and immune response.
Scientists at the German Cancer Research Center have discovered a protein called TXNIP that controls the aging process. TXNIP inhibits thioredoxin-1, an enzyme that protects DNA from oxidative stress and slows down aging processes.