Research at Technical University of Munich shows that molecular chaperones Hsp70 and Hsp40, as well as Hsp90, control the function of p53 by influencing its three-dimensional structure. This helps prevent cancer cells from growing.
A web-based intervention that included physical activity goals, disease self-management education, and a community forum reduced the risk of acute exacerbation in COPD patients. The reduction in exacerbations occurred despite no significant increase in physical activity levels compared to those receiving only a pedometer.
The Saranas Early Bird Bleed Monitoring System has been shown to detect bleeding events during endovascular procedures with a high degree of accuracy, reducing the risk of complications and mortality. The device was tested in 60 patients and detected bleeding in 63% of cases, with no device-related complications reported.
Researchers at EPFL have successfully synthesized a manganese-hydrogenase by incorporating a manganese complex into an iron-hydrogenase. The resulting semi-synthetic enzyme is active for the native reaction of iron-hydrogenase, marking a significant breakthrough in metalloenzyme design.
A USC study tracking Southern California children over 20 years found a 20% decrease in new asthma cases due to reduced PM2.5 levels. Nitrogen dioxide and particulate matter reductions also led to lower asthma rates.
Cholesterol levels in US children and adolescents decreased over two decades, with favorable changes observed in total cholesterol and triglycerides. However, only half of participants achieved ideal levels for all measures, highlighting the need for continued efforts to address childhood obesity.
Researchers at Texas A&M AgriLife Research reviewed plant population studies to update recommendations. They found that yield is optimized at around 15,000 plants per acre, but there is no yield benefit to high populations.
Researchers found that xenon gas treatment shortly after a head injury prevents early death and long-term cognitive impairment in mice. The treatment also protects brain tissue and reduces inflammation, which may lead to new treatments for people with TBI. This study provides promising results for future human trials.
Researchers at Far Eastern Federal University developed a technology to synthesize protein from amaranth grains and mushroom mycelium, enriching stock-raising feed. The new feed is biologically equivalent to the storage protein A1 isolated from amaranth, meeting the natural amino acid composition.
Researchers at University of Queensland developed a light beam device that can split light into multiple modes, increasing information density and potential for faster internet speeds. The device has applications in medical imaging, astronomy, and communication, enabling higher-quality images with greater detail.
A recent study found that children with cancer wait an average of 6.5 years longer than adults to access new drugs. Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center are advocating for improved pediatric trial timelines. The delay can lead to a lack of effective treatments for life-threatening diseases.
A new study found that large fish fences in tropical seas are causing extensive damage to habitats, including seagrass meadows, mangroves, and coral reefs. The research revealed that these fisheries catch over 500 species, many of which are babies or conservation concerns.
Researchers analyzed data from 234 patients undergoing minimally invasive laser surgery for epilepsy, finding that targeting specific brain regions such as the amygdala and hippocampal head improved seizure-free outcomes with minimal side effects. The study's results provide insights into the most effective approach for this type of su...
Scientists discovered a lineage of budding yeasts that has lost dozens of genes involved in DNA repair and cell cycle processes. These gene losses result in the yeast's genomes changing rapidly, leading to unique biological characteristics.
Researchers found significant increases in myo-inositol levels and generalized anxiety symptoms among children exposed to traffic-related air pollution. The study suggests a partial link between high TRAP exposure and increased anxiety, highlighting the potential impact on population health.
A new mathematical model developed at the University of Nebraska-Lincoln suggests that large collective of parasitic worms can kick-start a self-perpetuating cycle ensuring their survival. The study found that quantity of parasites alone determines whether they persist in a host, contrary to previous approaches.
Researchers have discovered that nerve fibers and associated Schwann cells are the origin of severely disfiguring neurofibromas in NF1 patients. The study found micro-lesions containing these nerve fibers and cells proliferate to form the bulk of the disfiguring neurofibromas.
A new method combines active ingredients in existing vaccines with a sugary gel, making them viable for eight weeks or more. This technology can replace the cumbersome cold chain and transport vaccines safely and cheaply to remote populations.
A new study found that court reporters transcribed African American English 82.9% accurately, falling short of the 95% requirement. This discrepancy can impact trial outcomes due to potential miscomprehension by jurors and judges.
Salto's new skills allow it to bounce like a pogo stick and jump through obstacle courses like an agility dog. Researchers hope the robot will aid in search-and-rescue missions by navigating rubble to find trapped people.
A recent study found early signs of cartilage breakdown in mice exposed to microgravity for 30 days. The researchers theorize that the lack of gravity's biomechanical forces leads to joint unloading, causing cartilage degradation. This could have significant implications for future astronauts on long-term space missions.
Researchers from the University of Münster find that the Moon's collision with Earth brought large quantities of water, essential for life. The discovery sheds light on the Moon's origin and its role in making Earth a habitable planet.
A USask-led research team is developing an artificial portable kidney that can be worn by patients with renal failure, reducing hospital visits and healthcare costs. The team aims to create a highly efficient dialysis membrane that mimics the human kidney's filtering properties.
A new study published in PLOS Medicine found that community-based adherence clubs for HIV patients resulted in higher losses from care over two years compared to clinic-based care. Despite this, health outcomes were similar between the two groups.
A study led by Boston University researchers discovered high levels of toluene and ethyl acetate in nail technicians' blood, but improved ventilation significantly reduced air pollutant exposure. The findings highlight the importance of active ventilation in reducing solvent levels in salon air.
A UK study of 93,000 adults with heart failure reveals diagnostic tests, drug prescriptions, and follow-up patterns are suboptimal, particularly for women and those over 75 years old. The research highlights the need for improved care systems to address these gaps in chronic disease management.
A new study published in the American Journal of Psychiatry supports the effectiveness and safety of esketamine nasal spray for treating moderate to severe depression in people who have not responded to previous treatment. The study found significant improvements in depression symptoms within 24 hours of taking the medication.
Researchers create molecular tethers to attach proteins to scaffolds, allowing for reversible functionalization while preserving activity. This approach enables precise control of protein signals, promoting tissue growth and differentiation.
Researchers have revived an old approach to the Riemann Hypothesis using Jensen-Polya polynomials, providing a new framework for understanding prime numbers. The approach reveals a method to calculate the polynomials all at once, opening up new avenues for solving other fundamental mathematical problems.
Researchers investigating the link between aging fat cells and Alzheimer's disease have found that fat cells play a crucial role in supporting neuronal growth and survival. The study suggests targeting a specific receptor, PPAR-γ2, could lead to a new treatment for Alzheimer's.
A breakthrough study reveals the anterior cingulate cortex plays a crucial role in synchronizing brain waves to retrieve long-term memories after two weeks. This discovery could lead to new treatments for Alzheimer's disease and other forms of dementia by understanding how our brains process and access older memories.
Andrea forms over western Atlantic on May 20, 2019, becoming 1st subtropical storm of 2019 Atlantic season. It is currently located 295 miles west-southwest of Bermuda, moving north at 5 knots with maximum sustained winds near 40mph.
Researchers from Boston University School of Medicine have discovered a previously unknown role of Serum Amyloid A (SAA) in rapidly removing lipid debris from damaged cells. This process is crucial for tissue healing and survival during acute events such as injury, infection, or inflammation.
Researchers discovered a novel noninvasive electrophysiological biomarker for Parkinson's disease using scalp electrodes and electroencephalography (EEG). The approach showed promise for developing wearable technology to monitor disease-related brain activity at home.
A new study from Caltech shows that anxious individuals flee danger sooner in slow-threat scenarios, but not in fast-threat situations. This suggests that anxiety is a prediction strategy that helps prevent future dangers.
Researchers analyzed over 298,000 online review ratings to find the key elements of job satisfaction and employee turnover in high-contact services. The study shows that career progression is a critical factor in staff turnover, while an increase in job satisfaction leads to higher profitability.
Sperm banks in the UK and Australia have used marketing strategies that rely on masculine archetypes to create value for a commodity they cannot legally buy. The use of these archetypes, such as the 'soldier' and 'everyday hero', has helped resolve donor shortages and procure sperm for free.
Scientists have developed a technique to produce highly ordered particle layers using tiny gold particles encapsulated in soft polymer beads. The resulting ultrathin superlattices exhibit collective resonances when excited by light, enabling potential applications in optoelectronics and nanophotonics.
Research suggests that e-cigarettes can diminish the body's ability to fight viruses, including those causing the flu. Cigarettes, on the other hand, appear to increase the risk of becoming sick from the flu due to different factors.
Researchers discovered a plant virus capable of delivering pesticide molecules deep into the soil, targeting pests like nematodes. The breakthrough could help farmers reduce pesticide use and minimize environmental harm.
A team led by Ethan Garner describes the opposing and balanced enzymatic actions that keep B. subtilis from bulging wide while it builds up its inner cell wall and elongates.
A new analysis suggests that soda taxes serve as a 'net good,' with health benefits and reduced consumption for low-income individuals. Researchers estimate a nationwide soda tax would yield $7 billion in net benefits annually.
The study examines 38 specific measures aiming to improve air quality and finds either positive or unclear effects. However, the variability in study findings makes it challenging to draw general conclusions about what works and what doesn't.
A study from the University of Oregon suggests that specific angles and sharpness of brain waves in unfiltered EEG data may indicate Parkinson's disease. Researchers used raw, unfiltered beta waves to distinguish between patients on and off medication, providing a potentially new approach for diagnosis and treatment.
A study found that 38% of ICU clinicians invite family members into the room during procedures, with 90% reporting a positive experience. However, 35% express concerns about sterility, distraction, or legal permissibility, highlighting the need for addressing these issues to promote greater inclusion.
Researchers developed a novel laser-based measurement device to quantify rare CO2 variants, enabling accurate tracking of Earth's temperature. This breakthrough technology surpasses mass spectrometry in precision and can significantly shorten measurement times.
A team of scientists discovered that the elasticity of gels arises from the packing of clusters of particles in the gels. The researchers used graph theory to identify the boundaries between these clusters, which act as rigid units within the gel, determining its elastic modulus.
A recent study published in the New England Journal of Medicine found that benralizumab, an asthma drug, was ineffective in reducing exacerbations in patients with moderate to very severe COPD. The study involved over 3,000 patients and showed no significant decrease in COPD exacerbation rates among those receiving benralizumab.
Researchers from Immanuel Kant Baltic Federal University have discovered a quick and effective method for identifying Gypsy Moth caterpillars' sex. This breakthrough could lead to new ways to control the insect population, allowing forests to thrive once again.
Researchers outline detailed sequence of events where a GPCR encounters its downstream signaling partner, providing insights into fundamental mechanisms of drug-induced signaling. The new analysis technique can identify precise amino acids most central to GPCR function, enabling potential sites for precision drug targeting.
Researchers observed ravens exhibiting negative emotional contagion when watching demonstrator ravens with induced negative emotional states. The results suggest convergent emotional evolution in birds and mammals.
The new compact device can capture 30,000 sampling points with over 60 wavelengths, providing valuable insight into chemical makeup of scenes or samples. Researchers say it has the potential to increase crop production and inform disaster response using unmanned aerial vehicles.
Researchers used structured expert judgment to estimate probability distributions for future sea level rise, yielding long upper tails and a small but meaningful chance of exceeding 2m by 2100. The results suggest coastal communities should consider the possibility of 21st-century SLR in excess of 2m when developing adaptation strategies.
Researchers have developed a new technique called BiGluc, which enables the visualization of glucose metabolism in real-time in cancerous tumors. This non-invasive imaging method could lead to more effective cancer treatments by identifying the metabolic requirements of different tumors.
In a Phase 2 trial, RTB101 reduced the incidence of respiratory tract infections by 68.9% in adults with asthma over 16 weeks. The therapy was well-tolerated and effective during winter cold and flu season.
A California study reveals chronic Q fever cases may be more common than previously believed, with a higher case fatality rate than national averages. Meanwhile, a mass treatment campaign in Bolivia has effectively eliminated human fascioliasis, a parasitic worm disease once prevalent in up to 25% of the population.
Researchers found that high levels of PM10 reduced average tree growth by up to 37% and varied interannually with pollution levels during driest months. Trees exposed to higher levels of pollution grew less in trunk diameter development throughout their lives.
Parkin's activity depends on recruitment and activation by proteins such as PINK1 and MITOL. The discovery of MITOL's role in tagging damaged mitochondria could lead to improved therapies for Parkinson's disease.
A new AI system has been developed that can detect lung cancer with high accuracy, potentially leading to earlier treatment. The system uses deep learning to analyze low-dose chest computed tomography (LDCT) scans and performs better than human radiologists in detecting malignant nodules.
Researchers at the University of Notre Dame have developed a microfluidics platform using extracellular vesicles containing microRNAs for early-stage disease diagnosis, reducing test time by 13 hours.