Researchers found that 95% of animal species vocalize at a rate between 0.45 and 4.99 Hz, with a peak at 2.8 Hz, suggesting a shared ancient constraint across species. This universal tempo may facilitate communication between species.
The ACT-CHIK project will conduct a Phase Ib/III clinical trial to evaluate the safety and immunogenicity of a measles-virus-based chikungunya vaccine in four African countries. The project also aims to strengthen Africa's vaccine ecosystem by transferring the vaccine manufacturing process to an African manufacturer.
A study published in Nature Health reveals a strong link between pesticide exposure and the risk of developing certain cancers. The research shows that pesticide exposure increases the risk of cancer by 150% in areas with high levels of pollution, and highlights early biological effects before cancer develops.
Researchers found that exposure to microbes induces a lasting immune memory in fibroblasts, protecting lungs from allergic reactions for months. This discovery opens up new possibilities for developing preventive strategies for respiratory allergies.
A study found that age, biological sex, and human genetic factors determine the quantity and specificity of antibodies produced in response to viral infections. The research has significant implications for vaccine and therapeutic design, as it shows that individual profiles can be tailored to improve treatment effectiveness.
A study reveals that senescence plays a paradoxical role in postpartum breast cancer, promoting tumor formation while also aiding tissue repair. Targeting senescent cells during mammary gland involution could potentially reduce the risk of this form of cancer.
The US administration's attacks on biomedical research and vaccination policies have severe consequences for healthcare protection and global public health. Certain scientific topics in infectious diseases and immunology have been deprioritized, and the US has withdrawn from major global public health programs.
Researchers identified over 200 distinct mutations associated with congenital deafness, including new and family-specific variants. The study provides guidance on communication methods and supports regular ophthalmological follow-up.
Researchers at Institut Pasteur found that aminoglycosides use sugar transporters to enter bacteria, increasing their effectiveness and potentially reducing the need for high doses. By doubling the number of transporters, they improved antibiotics' penetration rate and efficacy in even the most resistant E. coli strains.
Scientists from Institut Pasteur identified Salmonella enterica and Borrelia recurrentis in remains of 13 soldiers who retreated from Russia in 1812. The study suggests these two pathogens may have contributed to the high number of deaths in Napoleon's army.
Scientists at Institut Pasteur and Inserm developed a triple-therapy approach to treat blood cancers like lymphomas and leukemias. They induced necroptosis in malignant B cells, which activates the immune system to eliminate tumor cells.
A study in mice found that maternal consumption of emulsifiers can alter the gut microbiota of their offspring, leading to increased risk of chronic inflammatory gut disorders and obesity. The research highlights the importance of regulating food additives, particularly in powdered baby formulas, to prevent long-term health consequences.
A recent study reveals the diphtheria epidemic in Western Europe is primarily caused by contamination during migratory travel or in destination countries, not in the countries of origin. The researchers emphasize the importance of maintaining high levels of vigilance and public health support among vulnerable populations.
Scientists discovered a genetic change in Yersinia pestis that may have prolonged the duration of two major pandemics. The mutation, which reduces virulence, enables the bacteria to infect individuals for longer periods, potentially spreading farther in less densely populated environments.
Scientists have discovered that leprosy, caused by bacteria Mycobacterium lepromatosis, has been infecting humans in the Americas for at least 1,000 years. The study analyzed DNA from ancient human remains and recent clinical cases, confirming that the disease was already widespread in North and South America before European colonization.
Scientists identified specific immunogenetic characteristics in post-treatment controllers who maintain undetectable viral loads after stopping treatment. These genetic markers are associated with the existence of specific NK cell populations that better control infection, supporting their role in long-term HIV remission.
The MOPEVACLAS vaccine candidate is being tested in a Phase I clinical trial for its safety and immune response in humans. The vaccine targets Lassa fever, a hemorrhagic disease responsible for thousands of deaths worldwide each year.
A new rapid diagnostic test can accurately identify pregnant women with high levels of the hepatitis B virus, allowing for early detection and intervention. This breakthrough test could have a significant impact on hepatitis B management in low- and middle-income countries, reducing the spread of the infection.
The partnership aims to promote innovations based on scientific research and accelerate technology transfer. Bpifrance will provide digital tools and support schemes to the Institut Pasteur's researchers and startup partners.
The Institut Pasteur is committed to defending scientific facts and integrity, joining the global Stand Up for Science initiative. Professor Yasmine Belkaid emphasizes the universality of science, its foundation for humanity's understanding and response.
Enodia Therapeutics, launched by Institut Pasteur and Argobio, leverages AI to develop selective inhibitors of the Sec61/translocon molecular complex for treating cancer, inflammatory diseases, and viral infections. The company's breakthrough technology has earned a prestigious Golden Ticket Award from Pfizer.
Researchers at the Institut Pasteur have gained a better understanding of how mpox variants become resistant to tecovirimat. They found that the drug works by binding two phospholipases together, preventing viral particles from spreading. This knowledge will help develop new antiviral treatments effective across all mpox strains.
A new study developed a human microbiota modelling system capable of predicting each person's sensitivity to an emulsifier, such as carboxymethylcellulose (CMC), using a simple stool sample. The model identified a specific metagenomic signature of sensitivity to CMC, allowing for the prediction of individual susceptibility.
A highly drug-resistant cholera strain has been identified in Yemen and later detected in Lebanon, Kenya, Tanzania, and the Comoros Islands, including Mayotte. The strain's spread highlights the need for strengthened global surveillance of the cholera agent to monitor its resistance to antibiotics.
Countries that took measures early experienced lower excess mortality rates and coped better economically. A surveillance system capable of quickly tracking virus spread is crucial for effective response.
Researchers developed an artificial intelligence model that selects the best phage cocktail for a given patient based on their genome. The model was tested on a new collection of E. coli strains responsible for pneumonia and showed high success rates.
The partnership aims to co-develop innovative technologies for enhanced health and economic outcomes. Key findings include the need for collaborative research to counter emerging challenges presented by tropical ID, and inform pandemic preparedness strategies.
Professor Yasmine Belkaid joins France's 'MAKE IT ICONIC. Choose France' campaign to promote the country's scientific excellence and innovation. As President of Institut Pasteur, she champions open and inclusive science, highlighting its impact on global medical research.
Depression alters neural circuits in the amygdala, leading to reduced activity in pleasant stimuli and increased activation in negative stimuli. This negativity bias contributes to depressive symptoms. Researchers found a potential treatment by reactivating neurons involved in positive encoding of environmental stimuli.
Researchers found that dogs slow down their speech rate when addressed by humans, while humans' speech rhythms meet in the middle. Dogs process human language only within the delta band (1-3 Hz) and with phonological content, debunking myths about prosody sensitivity.
A groundbreaking study published in Nature Medicine reports the first sustained remission of HIV infection following a bone marrow transplant in a patient without the CCR5-delta 32 mutation. Despite remaining susceptible to HIV, the virus remains undetectable nearly three years after antiretroviral treatment was stopped.
A study found that mosquitoes in Greater Paris can transmit five arboviruses within different time frames, with West Nile virus transmitted in as little as three days. The results highlight the importance of increased surveillance and control measures to prevent disease outbreaks during the Olympic Games.
Researchers identified a global climate indicator, Indian Ocean basin-wide index, that can improve predictions of dengue outbreaks several months in advance. This could facilitate efforts to tackle the rising infection threatening half the world's population.
A recent study published in Nature found that smoking has a lasting effect on the immune system, with certain defense mechanisms persisting for up to 10-15 years after quitting. The research used a large cohort of healthy volunteers and identified three key factors: smoking, latent cytomegalovirus infection, and body mass index.
A new study using an animal model has identified a window of opportunity for early treatment to promote long-term control and remission of HIV infection. Starting treatment four weeks after infection promotes viral control after discontinuation of treatment, highlighting the importance of early diagnosis and treatment.
A new metagenomics tool has improved the diagnosis of infections by detecting rare pathogens with high accuracy. The tool was tested on 742 samples from 523 patients and showed a diagnostic yield of over 25% in cases where infection was strongly suspected.
Researchers are shedding light on the molecular mechanisms underlying HIV replication and viral integration, opening new avenues for tackling the virus. Discoveries suggest that targeting the cell nucleus and harnessing innate immunity may be key to blocking viral replication and persistence.
Researchers found SARS-CoV-2 viruses persisting in lung cells for up to 18 months post-infection, despite undetectable upper respiratory tract presence. The study suggests a link between innate immunity failure and virus persistence.
Researchers discovered that only a small proportion of red blood cell precursor cells infected by Plasmodium vivax are likely to produce the parasite, confirming its ability to replicate outside the bloodstream. This finding raises new questions about malaria diagnosis and treatment strategies in Duffy-negative individuals.
A study of 50 children infected with Listeria monocytogenes at birth found that two-thirds had sequelae, mainly due to prematurity. Long-term screening and tailored support can be offered to inform science-based guidance for parents.
A significant post-COVID resurgence in invasive meningococcal disease has been observed in France, with a notable increase in cases among young people aged 16-24. The study reveals that the disease has returned to pre-pandemic levels, with some serogroups targeting different age groups.
Researchers at Institut Pasteur have identified the TMPRSS2 enzyme as the receptor that allows HKU1 virus to enter human cells. This discovery may help explain why SARS-CoV-2 causes more severe disease than other coronaviruses, and could lead to targeted therapies.
In Eritrea, a new artemisinin-resistant variant has been detected, accompanied by gene deletions that render rapid diagnostic tests ineffective. This emergence poses a significant threat to malaria control efforts in the Horn of Africa and beyond.
The study discovered complex microbiome dynamics where commensal and pathogenic microorganisms coexist, influencing the severity of bacterial pneumonia. The respiratory tract microbiome composition, pathogen load, and clinical interventions also play a crucial role in disease outcome.
Researchers investigated SARS-CoV-2 responses in 222 donors from Central Africa, Europe and East Asia. They found disparities in immune responses due to blood cell composition, latent cytomegalovirus infection and human genetic factors. These population differences may help improve patient management in future epidemics.
Researchers have identified a family of broadly neutralizing antibodies targeting the HIV-1 envelope protein, which may contribute to long-term remission from infection. These antibodies were found to induce the elimination of infected cells and impose a selective pressure on the virus, paving the way for new therapeutic approaches.
Scientists studied 470 sera from vaccinated or MPXV-infected individuals to elucidate mechanisms involved in post-infectious immune response. The study revealed the role of complement and analyzed immune responses in vaccinated or infected individuals, with robust levels of anti-MVA antibodies detected after infection or vaccination.
A multidisciplinary team of scientists has revealed the existence of a brain circuit involved in sensing and regulating inflammation. The circuit detects inflammatory hormones in the blood and organizes the immune response through the vagal complex and parabrachial nucleus.
A Swiss patient has achieved 20 months of HIV remission after a bone marrow transplant performed as part of cancer treatment. The patient's cells remained HIV-permissive despite the absence of a protective mutation, yet the virus was still undetectable after antiretroviral therapy was discontinued.
The study identified significant differences in antibiotic resistance trends and associated factors depending on bacterial species and antibiotic resistance to certain antibiotics. High health system quality was linked to low levels of resistance, while high temperatures were associated with increased resistance in Enterobacteriaceae.