A team of researchers has discovered a hitherto unrecognized role of mitochondria in maintaining cellular NAD levels. Decreased NAD levels are involved in ageing processes and various pathologies, but the study reveals that cells can generally tolerate reduced NAD levels without fatal consequences.
A new study detects pre-malignant pancreatic lesions using Diffusion Tensor Imaging (DTI), a form of MRI, which could enable early diagnosis and effective therapies. The detection was successful in both transgenic mice and human samples, opening the way to non-invasive diagnostic tools for PanINs.
Researchers at the University of Alabama at Birmingham have identified HIF1α as a key regulator that induces cancer-killing capacity in T cells under hypoxic conditions. In this study, they found that HIF1α-glycolysis is indispensable for IFN-γ induction in hypoxic T cells.
The Alliance of Hispanic-Serving Research Universities (HSRU) has received a $9.3 million grant from the U.S. Department of Defense to accelerate STEM education and research. The project, co-led by UCF and UTEP, aims to address the critical need for high-quality STEM talent in national defense.
Researchers found that international trade has caused over 90% of biodiversity loss in tropical regions due to agricultural land conversion. The study tracked land use changes between 1995 and 2022, revealing a significant impact on species loss in countries such as Brazil, Indonesia, and Madagascar.
A new study found that exposure to remote wildfire smoke drifting across the US led to a 20% increase in medical visits for heart and lung conditions. Patients who were older, non-smokers, and more socio-economically affluent were at higher risk on poor air quality days.
A new study shows targeted delivery of energy-disrupting gene therapy using nanoparticles shrinks glioblastoma brain tumors and aggressive breast cancer tumors in mice. The technology, mLumiOpto, induces light-activated electrical currents inside cells to disrupt mitochondria, leading to programmed cell death and DNA damage.
A new AI tool called PlacentaVision can rapidly evaluate placentas at birth to detect abnormalities associated with infection and neonatal sepsis. This could lead to improved health outcomes for both mothers and babies, particularly in areas with limited medical resources.
The ZEST trial found that patients with detectable circulating tumor DNA (ctDNA) were more likely to have aggressive disease characteristics. To improve outcomes, researchers recommend starting ctDNA testing during treatment rather than waiting for completion, and targeting high-risk patients with tailored therapies.
The Juno mission has discovered that Io's volcanoes are likely fueled by their own chambers of roiling hot magma rather than an ocean of magma. This finding solves a long-standing mystery about the moon's subsurface origins and provides new insights into Io's volcanic activity.
A new study from Karolinska Institutet and Queen Mary University of London has developed a method to divide HPV-positive women into three risk groups, based on the variant of the HPV virus and the amount of virus present in the self-test. This method could enhance cervical cancer screening for high-risk women.
A study found that climate- and land use change will alter the availability of wild traditional foods in the Russian Far East, affecting Indigenous Peoples' health and livelihoods. Rural households heavily rely on these foods for income, with losses predicted in central and southern areas.
A new study suggests that glacial rivers and lakes can consume large amounts of methane being flushed from under melting glaciers, reducing atmospheric methane emissions. This natural process, called oxidation, has the potential to mitigate the effects of climate change by up to 53%.
A new Stanford University study found that influenza viruses can persist in refrigerated raw milk for up to five days, raising concerns about potential transmission pathways. The researchers also discovered that the viral RNA remained detectable in raw milk for at least 57 days.
Research found that intermittent fasting inhibits hair growth in mice by causing oxidative stress on stem cells. A clinical trial showed a similar effect in humans, with a 18% reduction in hair growth speed.
A highly drug-resistant cholera strain has been identified in Yemen and later detected in Lebanon, Kenya, Tanzania, and the Comoros Islands, including Mayotte. The strain's spread highlights the need for strengthened global surveillance of the cholera agent to monitor its resistance to antibiotics.
Researchers aim to develop resilient soybean plants resistant to southern root-knot nematodes, causing $160 billion in damages annually. The project will screen hundreds of genetically diverse soybean lines worldwide to identify potential new sources of resistance.
The American Heart Association and Major League Baseball partnered to provide Hands-Only CPR education to 30 MLB clubs, aiming to increase survival rates from sudden cardiac arrest. By learning lifesaving skills, baseball fans can help save lives in case of a cardiac emergency.
Pratyanik Sau, a senior at the University of Texas at Arlington, won an Outstanding Undergraduate Student Oral Presentation Award for his research on graphene using positrons. The study has implications for designing particle accelerators and fusion reactors.
A new AI image tool, INQUIRE, can aid in analyzing millions of wildlife images uploaded to the internet for insights into climate change impacts on species. Current AI algorithms can identify species but struggle with more complex questions.
Four EU-funded 6G projects launched in January 2025 will focus on sustainable energy-efficient networks and reducing environmental impact. The SUSTAIN-6G, 6G VERSUS, AMBIENT 6G, and SNS-CO OP projects aim to create a 6G future that benefits everyone, combining technological innovation with societal and environmental priorities.
Sage has acquired Mary Ann Liebert, Inc., expanding its portfolio of peer-reviewed journals in biotechnology and life sciences. The acquisition enhances reach and impact, ensuring high-quality science continues to make a difference.
The new book, 'Peace by Peace: Risking Public Action, Creating Social Change,' tells the stories of ordinary individuals who took small steps to make big changes in their local communities. Drift, a feeling of detachment and disconnection, is identified as a major challenge, but practical wisdom is proposed as a tool to counteract it.
Researchers used seismic data to discover glacial landforms in the North Sea, indicating an ice sheet expansion about 1 million years ago, linked to global cooling. The findings provide new insights into how past ice sheets responded to climate changes.
A study found that adding anthracyclines to taxane-based chemotherapy improved survival outcomes for HR-positive, HER2-negative breast cancer patients with high risk of recurrence. The OncotypeDX genomic test helped identify which patients could benefit from the addition.
A global taxonomy for physics laboratory classes aims to create a more equitable way to compare courses. Researchers found that lab courses emphasize technical skills and group work, with complex learning goals and varying equipment availability.
A multimodal machine learning model outperformed clinical and genomic models in predicting outcomes for HR-positive, HER2-negative breast cancer patients receiving CDK4/6 inhibitor combinations. The model integrated clinical and genomic factors to identify high-risk patients with a 6.5-fold difference in hazard ratio.
Researchers at Children's Hospital of Philadelphia and Stanford University have developed a new immunotherapy platform called TRACeR-I, which can more accurately recognize a wide variety of surface proteins expressed by cancer cells. This improved recognition enables the body's own immune system to target cancer cells more effectively.
Researchers found β-ionone alleviates ulcerative colitis symptoms by protecting the gut barrier and restoring microbial balance. The study suggests ION's therapeutic potential for UC management, offering an alternative to current drug treatments.
Key findings include the urgent need for technological advancements in power generation, transportation, and materials to reduce GHG emissions. Additionally, the authors propose innovative agricultural practices and AI-powered clean energy solutions to promote sustainable development.
The M87 black hole is observed to have a high-energy gamma-ray flare with an emission region of less than three light-days in size. The rapid variability in gamma rays suggests an extremely small flare region, which has different characteristics depending on the wavelength.
Researchers found that microglia clear amyloid-β plaques from the brain before plaque formation and may cause more plaques when homeostatic. In contrast, activated microglia help compact plaques in neurons, offering a protective role.
Researchers have made significant breakthroughs in treating liver cancer, with a new study revealing the potential of anti-CXCR4 therapy to reprogram the 'cold' microenvironment. The combination of anti-CXCR4 and PD1 blockades enhances intratumoral dendritic cell activation and immune responses against hepatocellular carcinoma.
Northwestern University's expertise in AI and astrophysics enables the development of cutting-edge artificial intelligence tools for the Giant Magellan Telescope. The partnership will enhance the telescope's capabilities to search for Earth-like planets, investigate energetic explosions, and explore galaxy-black hole relationships.
AI algorithms identify genetic mutations for early detection and targeted therapies, improving clinical decision-making. Despite challenges, AI has demonstrated significant impact in revolutionizing cancer detection and improving patient outcomes.
Researchers at Stanford University developed a prototype device that can produce ammonia from water vapor and nitrogen in the air using wind energy. The technology has the potential to eliminate the need for a century-old method of producing ammonia, which consumes 2% of global energy and contributes 1% of annual carbon dioxide emissions.
Researchers at the University of Bergen have developed mini-brains that can study disease processes caused by mitochondrial failure, potentially leading to new therapies for epilepsy and other brain disorders. The mini-brains offer a realistic model for exploring complex disease processes and testing treatment strategies.
Researchers compared urine NAA levels in patients with mild and typical Canavan disease, finding lower levels in those with the milder form. This discovery has potential for a rapid and cost-effective way to screen for CD incidence and severity.
A new study from the University of Adelaide has identified key markers that influence how commercial behaviour is perceived by courts, providing practical guidance for consumers, businesses, and legal professionals. The research clarifies the line between legal and illegal conduct in commercial law, highlighting the distinction between...
Researchers estimate that 1.72 billion people were within 50 km of shoreline in 2000, increasing to 2.2 billion by 2020, with the most significant increases occurring nearest the shoreline.
Researchers investigate how perturbed gene expression contributes to neurodegenerative disorders like Alzheimer's. Alternative polyadenylation, a mechanism regulating protein production, is being studied for its potential role in the disease.
A study published in Advanced Science found that ethyl lactate, a nonethanol ingredient in distilled spirits, can ameliorate fatty liver, inflammation, and acute-on-chronic liver injury in alcohol-associated liver disease. Ethyl lactate works by inducing fibroblast growth factor 21, which inhibits abnormal lipid metabolism.
A new database reveals significant gaps in hippo population knowledge, with fragmented populations relying on protected areas. The research calls for coordinated surveys and a centralized spatial database to improve conservation efforts.
The updated recommendations provide a comprehensive framework for healthcare professionals to deliver better care and move closer to ending the HIV epidemic. The guidelines emphasize tailored antiretroviral therapy, effective HIV prevention strategies like pre-exposure prophylaxis, and comprehensive care for people living with HIV.
Princeton engineers create soft plastics with programmed stretchiness and flexibility that are also recyclable and inexpensive. The material's internal structure is controlled to achieve stiffness and stretchiness in different regions of an object.
A new study found that a low omega-6, high omega-3 diet with fish oil supplements significantly reduced prostate cancer cell proliferation in men. The findings suggest that dietary changes could potentially delay or prevent the need for more aggressive treatments.
A team of scientists captured an astonishing image of a gamma-ray flare emanating from the supermassive black hole at the center of galaxy M87. The flare was tens of millions of times larger than the event horizon and lasted about three days, providing crucial insights into particle acceleration near black holes.
A new study reveals that plant-based drinks have lower nutritional quality than cow's milk due to chemical reactions during processing. The heat treatment used in UHT processing alters protein structures, leading to the loss of essential amino acids and increased sugar content.
A recent study found that post-COVID-19 condition (PCC) affects approximately 8.4% of US adults, with significant differences observed across various demographic groups. Currently, 3.6% of adults have PCC, and a notable 2.3% experience activity-limiting PCC.
A social work graduate has published her research on cognitive decline among refugees, finding that those who have experienced trauma are more likely to suffer from mild cognitive impairment. The study highlights the need for interventions that address these gaps in care and promote healthier aging.
A new framework evaluates tsunami risk to seaports and the global port network, estimating potential economic losses in trade caused by port disruptions. The study found that a Manila Trench tsunami could damage up to 15 international seaports under present-day sea-level conditions.
A new screening method combining laser analysis with AI identifies patients with breast cancer in its earliest stage, stage 1a. This non-invasive technique reveals subtle changes in the bloodstream that occur during the initial phases of the disease, outperforming existing early detection strategies.
The CNIC has developed a comprehensive set of genetic tools and mouse lines called iFlpMosaics, enabling accurate investigation of somatic mutations on cellular biology and disease. This toolkit facilitates the study of complex interactions between cells within their microenvironment.
The EUnetHTA 21 project has developed guidelines and templates for joint HTA work at the EU level, tested in pilot assessments, and aims to improve HTA quality and reduce patient access inequalities. The results of the project will inform the implementation of the European HTA Regulation from 2025 onwards.
A new study from the University of Surrey found that multinational enterprises (MNEs) are actively contributing to environmental problems despite claiming to address them. The research team argues that there is an urgent need for MNEs to reassess their innovation strategies to align with the UN Sustainable Development Goals.
Researchers analyzed data from 11,797 adults with advanced solid cancers and found no difference in mortality rates during the shortage period. Prescription rates for cisplatin and carboplatin fell less than three percent overall, with alternative therapies helping mitigate the crisis.
The European Society of Cardiology emphasizes the importance of including heart and cardiovascular health in cancer treatment plans. Recent studies estimate that approximately one-third of patients experience mild toxicities, while 3% develop moderate toxicity. The ESC is launching a new conference to address this growing epidemic.
Scientists at Helmholtz Centre for Infection Research have developed ACTIMOT, a genetic method that amplifies and isolates biosynthetic gene clusters from bacteria to produce new bioactive natural products. The approach enables faster and easier access to previously hidden pharmaceutical potential.
Adult obesity trends in the US have declined for the first time in more than a decade, according to recent data. The South region experienced the largest decreases in body mass index and obesity prevalence, despite also facing high COVID-19 mortality rates among obese individuals.
A team of experts has discovered that the ARID1A gene regulates a critical genetic program for cell migration, with ZIC2 identified as a crucial regulator in this process. This study expands our understanding of craniofacial development and provides valuable insights into the genetic causes of congenital diseases.
A breakthrough in electrochemical CO2 reduction processes has been achieved through ligand engineering of copper nanoclusters. The study reveals that variations in intercluster interactions significantly impact the stability and selectivity of these nanoclusters, leading to more efficient carbon conversion technologies.
Researchers discovered that human SMC protein cohesin twists DNA in a left-handed way by 0.6 turns per step, regulating chromosome function and impacting health. This finding provides essential clues for resolving the molecular mechanism of twisted DNA looping.
Researchers at Osaka Metropolitan University developed a new technique for head and neck reconstruction that achieves 100% success rate in high-risk patients. The pedicled latissimus dorsi flap technique provides a reliable, fast, and minimally invasive option for complex tissue defects.
A team of researchers at USC will receive funding to test a novel approach to slowing age-related cognitive decline, targeting the brain's lymphatic system. The grant aims to delay the onset of Alzheimer's and Parkinson's disease by clearing waste buildup.
Sage has acquired Mary Ann Liebert, Inc., a renowned global media company publishing over 100 peer-reviewed journals in biotechnology and life sciences. The acquisition will enhance the reach and impact of Mary Ann Liebert's content, supporting the global research community.
Adding camrelizumab to neoadjuvant chemotherapy significantly improved pathological complete response in patients with early or locally advanced triple-negative breast cancer. The treatment showed substantial benefits, leading researchers to explore its potential as a neoadjuvant strategy.
Scientists at Monash University have discovered the structure of how LAG-3 interacts with its main ligand, providing a new targeted approach to improve immunotherapy's effectiveness for certain forms of cancer. This breakthrough could lead to the development of blocking LAG-3 therapeutics and further enhance cancer treatment.
Researchers identified 159 genetic studies and 37 key genes linked to reproductive traits such as age at first childbirth, menopause timing, and hormones like FSH and testosterone. Genetic factors play a significant role in broader health outcomes and influencing fertility.
Professor Minh Nguyen and Professor Carsten Sauer have received ERC Consolidator Grants to investigate financialization in Asia and gender-based wage differentials in Europe. Their projects aim to understand the impact of financial markets on working lives and labor market practices.
Researchers have created a novel breeding strategy to rapidly create climate-smart crops that can withstand heat stress. By optimizing carbon partitioning to sinks, they increased yields in staple grain and vegetable crops. The study showed improved fruit quality, sugar content, and yield resilience under heat stress conditions.