Individuals with multiple long-term conditions are two and a half times more likely to die following COVID-19 infection compared to those without. Among children, the risk increases to nearly three times that of those without multiple long-term conditions.
A study involving 4,500 participants has provided valuable insights into the long-term quality of life of adults with congenital heart disease (CHD). Key findings include a high percentage of participants experiencing comorbidities, arrhythmias, and mood disorders, while quality of life is generally good or better for 84%.
Dartmouth chemists have developed a synthetic molecular switch that can trigger shape changes in liquid crystals, reflecting different colors. The switch is made up of triptycene and hydrazones that can flip on and off with a pulse of light, allowing for the creation of multicolored images and potential applications in energy-efficient...
Researchers have found that women are more likely to die from postoperative complications after high-risk cardiovascular surgery, with a failure to rescue rate of 10.7% compared to 8.6% for men. The quality of hospital where the procedure was performed did not affect this disparity.
Research suggests that heavy drinkers may experience long-lasting sensitivity to mechanical stimuli, leading to permanent allodynia. The study identified a potential drug target, endocannabinoid 2-AG metabolism, for treating neuropathic pain associated with chronic and excessive alcohol consumption.
A new treatment approach using immunotherapy has shown promising results in treating advanced Hodgkin lymphoma, with a remarkable 92% survival rate. The innovative clinical trial, led by Wilmot Director Jonathan Friedberg, also minimizes long-term side effects and toxicities.
A new study by Duke University finds that deep-diving whales confuse plastic debris with prey items, as its acoustic signature mimics squid. Researchers tested various types of plastic trash and found strong similarities in their acoustic signals compared to whale prey, highlighting the need for more sustainable materials.
A new project, 'Crowd-Assisted Human-AI Teaming with Explanations,' aims to develop an interactive AI system that leverages the collective strengths of human crowd workers and machine learning models. The researchers will use crowdsourcing platforms to recruit experts and non-experts to perform tasks, making the system more robust and ...
A comprehensive study found that patients with rheumatoid arthritis pay an average of $3,383 more per year on healthcare expenditures than those without the disorder. The disease also reduces mobility and quality of life, highlighting the need for better support systems and policies.
A new study reveals that islands are home to around one in three of the world's plant species, with 63,280 endemic species native to islands. The research provides a comprehensive assessment of vascular plants native and endemic to marine islands worldwide.
Astronomers at Caltech have discovered that the well-studied brown dwarf Gliese 229B is actually a pair of tightly orbiting brown dwarfs weighing about 38 and 34 times the mass of Jupiter. This resolves the long-standing mystery about its dimness.
A new CABI-led research study reveals low access to plant health services in South Sudan, hindering agricultural productivity. The findings highlight the need for strengthening government-led initiatives, service accessibility, and inclusivity in plant health systems to address climate change-induced pests.
The study found that monarchs are dying off during their fall migration south to Mexico, with roost sizes declining by as much as 80%. Climate change is not believed to be the primary cause, but rather a debilitating parasite and captive breeding may be to blame.
The article discusses how AI tools are transforming the architectural design process, enabling faster production of options for clients. Startups like Arqgen and SleepUp are leveraging generative design techniques to create innovative solutions for interior design and real estate development, respectively.
Global soil compound drought-heatwave (SCDHW) events are increasing, with a notable escalation from 1980 to 2023, driven by global warming. The severity of SCDHWs is concentrated in summer and more intense in the northern hemisphere.
A recent study employs zebrafish to model Nager syndrome, revealing the role of sf3b4 mutations in facial development and apoptosis. The research suggests that FGF8 plays a critical role in disease pathogenesis and provides a potential therapeutic strategy.
Researchers at the Hefei Institutes of Physical Science have observed a strong nonlinear magnetic second harmonic generation effect in two-dimensional CrPS4 monolayer. This is extremely rare among all known magnetic materials, suggesting a new mechanism for generating MSHG.
Researchers at UVA's School of Engineering and Applied Science have developed an AI-driven intelligent video analyzer capable of detecting human actions with unprecedented precision and intelligence. The system, called SMAST, promises to transform industries such as surveillance, healthcare, and autonomous driving.
Researchers at EPFL have developed the e-Flower, a flower-shaped 3D microelectrode array that enables real-time recording of neural activity from 3D neural spheroids. This breakthrough technology allows for more accurate and gentle monitoring of brain cells, paving the way for further research on brain organoids.
Researchers have developed a handheld, sound-based diagnostic system that can deliver precise blood test results in an hour with minimal finger prick of blood. The system uses functional negative acoustic contrast particles and a custom-built instrument to detect biomarkers in tiny amounts of blood.
A new study uses deep learning to infer the frequency of atmospheric blocking events over the past 1,000 years, shedding light on their potential impact under climate change. The model was trained using historical data and large ensembles of climate model simulations.
A cohort study found no association between maternal COVID-19 exposure and abnormal neurodevelopmental screening results in children aged 24 months. Continued research is needed due to the developing fetal brain's sensitivity to maternal immune activation.
A team of researchers from the University of Florida Health has been awarded a significant grant to explore the use of combination antibiotics to combat antibiotic-resistant bacteria. The study aims to understand the molecular mechanisms behind bacterial resistance and develop new treatment strategies to tackle deadly superbugs.
A new study reveals that mild and asymptomatic SARS-CoV-2 infections can trigger immune responses in pregnant individuals, causing serious inflammatory responses in the developing fetus. The study also found that even without full infection, a pregnant individual's immunological response to infection may impact the fetus.
A 24-year study found that elevated carbon dioxide levels nearly tripled species losses attributed to nitrogen pollution in grasslands, reducing species richness by an average of 7-19%.
A peer-reviewed study published in NEJM Catalyst found Waymark's early intervention model significantly improved clinical outcomes for patients receiving Medicaid, reducing hospital and ED visits by 22.9%. The study also showed improved patient goal completion and care quality.
Researchers at Colorado State University have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. This new approach provides a less toxic and quickly reversible alternative to hydroxyurea, allowing for better insight into cell cycle arrest mechanisms.
A new methodology has been introduced that significantly enhances the accuracy of epidemiological estimates for infectious diseases like COVID-19. The approach adopts a history-dependent framework, eliminating biases in traditional models and allowing for more precise predictions of disease spread.
Research highlights molecular chaperones' role in maintaining tumor suppressor stability and functional integrity. This understanding is crucial for developing targeted therapies for multiple cancers.
A Danish nationwide study found an association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and increased breast cancer risk in females ages 15 to 49. The absolute breast cancer risk is low, but the study revealed an excess risk of 14 per 10,000 females, which did not increase with duration of use.
A new clinical trial has found that the mpox vaccine is safe and generates an immune response equivalent to adults, providing hope for adolescents affected by the virus. The study's interim results were presented at IDWeek2024 conference in Los Angeles.
A new model developed for predicting fault line slip also accurately forecasts landslides, providing a crucial tool for disaster preparedness. Researchers used data from monitored landslide sites in Northern California to validate the model's effectiveness.
Researchers created a single cell atlas of prenatal human skin, providing a molecular recipe for building skin. The study also led to the creation of a mini organ model that grows hair, offering insights into scarless skin repair and potential clinical applications in regenerative medicine.
A new paper by Rowena Crabbe explores how entrepreneurship can help marginalized groups surmount obstacles, including limited access to capital, social closure, and consumer discrimination. The research identifies conditions for success, such as self-employment, products for unmet needs, and processes that lower barriers.
Scientists at Osaka Metropolitan University have synthesized aza-diarylethenes that exhibit both photoswitching and thermal switching properties. These new molecules can be used as rewritable recording mediums, written with light or heat, and erased with visible light.
A new hemostatic sponge developed by UCF researchers can stop severe bleeding in under a minute, while also acting as an antibacterial agent. The liquid gel transforms into a spongelike foam upon exposure to the wound, applying pressure to restrict hemorrhage and promoting natural clotting.
Researchers discovered a new species of bacteria, Hardy ecospecies, that thrives on carnivore diets, contradicting the long-held assumption that modern humans are omnivores. The study found genetic variations in bacteria that inform us about our ancestors' diet.
The two-year progression-free survival rate was 92% on the N-AVD arm compared to 83% on the BV-AVD arm, with fewer side effects and lower mortality rates. The study's results support the use of nivolumab-AVD as a standard treatment for stage 3-4 classic Hodgkin lymphoma.
A new study found that kidney transplantation from HIV-positive donors to recipients with HIV is safe and effective, with comparable survival rates and risks of serious side effects. The study's results support the use of organs from HIV-positive donors as standard clinical practice for people with HIV in need of kidney transplantation.
Researchers detected ZEN in nearly all pregnant women's urine samples and 84% of placentas, highlighting the need for regulations to control mycoestrogen presence in food. Women with healthier diets had lower exposure levels, while those consuming ultra-processed foods showed increased ZEN concentrations.
A new study by Harvard researchers finds alarmingly high PFAS concentrations in fish tissues even up to 8 km from the military base. The results underscore the urgent need for more comprehensive monitoring of PFAS in aquatic ecosystems, particularly in regions where freshwater fishing is an important food source.
A study analyzed blood samples from individuals who received an mRNA vaccine booster to understand its circulation and breakdown in the bloodstream. The research found that higher levels of mRNA and fatty nanoparticles were linked to increased anti-PEG antibodies, suggesting potential issues with future mRNA treatments.
An international team has identified the sources of 70% of all known meteorite falls, revealing that 37% come from the Massalia family. The discovery was made possible by a telescopic survey and computer simulations of asteroid families' composition and evolution.
Researchers are creating microphysiological systems to simulate infection and treatment in vitro, linking human lung and brain tissue models. This project aims to explore the relationship between respiratory diseases and neurological symptoms, potentially leading to new treatments.
A recent poll found that 74% of people over 50 would not trust health information generated by artificial intelligence. Only 32% of older adults reported it's very easy to find something accurate online. Health systems, academic institutions, and government agencies can use the results to improve health information accessibility.
The new hubs and databases document past environmental events experienced by Arctic societies and provide a more complete picture of past change. They also present contemporary weather and ecological monitoring, cultural indicators, and oral histories to establish baselines of change in the Arctic environment.
Researchers at ETH Zurich have developed a method to study protein interactions using LiP mass spectrometry, identifying thousands of interaction interfaces between proteins. They found that stress situations alter around five dozen protein complexes and their interactions, with a key player being the SAGA complex.
A Korean research team developed an energy system model optimized for Korea's environment to predict the optimal proportion of hydrogen energy needed to achieve national carbon neutrality by 2050. The KIER-TIMES model suggests that hydrogen energy needs to account for 27% of overall energy supply, with forecasts indicating a rise to 25%.
The global aquaculture industry's growing appetite for farmed salmon imperils communities' access to affordable local fish like sardines and anchovies. The use of small pelagic fish as fishmeal and fish oil for farmed fish is a major issue, with 26% of global ocean catch dedicated to these 'reduction fisheries'.
Researchers found that the oral medication palbociclib stabilized tumor growth and reduced blood tumor marker levels in patients with peritoneal mucinous carcinomatosis, a form of appendix cancer often resistant to standard chemotherapy. The study's findings introduce a first targeted therapy for this rare disease.
A new study reveals that AI-driven chatbots may perpetuate racial and ethnic biases in pain assessment, leading to further inequalities in healthcare. Researchers found that Black patients were consistently underassessed for their pain compared to white patients, regardless of whether the rater was human or AI.
Research suggests standing for long periods does not improve cardiovascular health and may increase circulatory issues. Sitting for over 10 hours a day was found to increase cardiovascular disease risk, highlighting the need for regular movement throughout the day.
Researchers at Karolinska Institutet have mapped how microRNAs control cell development in the human embryo during the first days after fertilization. The atlas identifies crucial sncRNAs that guide embryonic growth and differentiation, shedding light on how to identify healthy embryos for improved fertility treatment.
Researchers used the upgraded Allen Telescope Array to scan a wide range of frequencies for narrowband signals that could indicate alien technology. Although no extraterrestrial signals were detected, the team refined their methods and gained valuable data for future searches.
Pro-B cells, a stage in B cell development, exhibit unusual plasticity when YY1 is knocked out. This enables them to generate T lineage cells, which help B cells produce antibodies. The study published in Genes & Development reveals the potential for regenerative medicine applications.
Researchers at Johns Hopkins University developed a fast and accurate blood test that can detect the earliest signs of a heart attack in minutes. The stand-alone test provides results in five to seven minutes, making it more accessible for first responders and people at home.
Researchers used spatial proteomics to analyze skin samples from patients with toxic epidermal necrolysis and identified a hyperactivated JAK/STAT pathway, revealing potential for JAK inhibitors to treat this condition. All seven patients treated with JAK inhibitors experienced rapid improvement and full recovery.
Researchers used DNA sequencing and artificial intelligence to detect anomalies in milk production, such as contamination or unauthorized additives. The new approach could improve dairy safety by identifying microbial signatures associated with anomalies.
Researchers have discovered a ferroelectric material that can adapt to light pulses on the nanoscale, creating networked nanodomains that can be reconfigured without requiring much energy. This discovery could lead to more energy-efficient computing systems and artificial neural networks.
The Max Planck Institute team has developed a strategy to extend mRNA lifespan by protecting it from degradation. This protects potentially health-promoting proteins, such as tumor suppressors and nuclear receptors, from premature breakdown.