Researchers at VCU Massey Comprehensive Cancer Center developed a targeted therapy that effectively prevents prostate tumors from spreading to the bone. The small molecule inhibitor IVMT-Rx-4 blocks the function of MDA-9/Syntenin, preventing tumor growth and improving survival in models with bone metastasis.
Researchers observed nonrandom patterns of spike D614 reversions in SARS-CoV-2 delta and omicron BA.2 variants, suggesting a non-spontaneous mechanism. These reversions occurred disproportionately after peak transmission periods and showed geographic clustering.
A research team analyzed data from the Annals of the Joseon Dynasty and Mungwa Bangmok to characterize career patterns of over 14,600 Joseon officials. They found that functional recruitment systems led to stability, but concentrated power resulted in inequality and stratification, ultimately leading to a national decline.
Researchers determined the LH1-RC complex structure at high resolution, identifying a new membrane protein and non-heme Fe ion that may facilitate electron transfer. The findings provide insight into the photosynthetic complex and could contribute to genetically engineered phototrophic systems and bioremediation technologies.
Research reveals longer weekly home-visit rehabilitations (HR) significantly improve activities of daily living (ADL) among older adults, especially those requiring moderate to severe care. The study found that HR duration correlates with ADL improvement in this population.
Researchers have uncovered how BAP1 functions at the molecular level and present a novel therapeutic strategy to slow cancer progression. BAP1's role in DNA repair pathways and its potential as a biomarker for personalized treatment are also explored.
An international team is calling for a coordinated effort to map gene expression across every cell type and developmental stage of wheat. Spatial omics technologies can transform wheat research by revealing how individual cells respond to stress, regulate grain development, and control yield-related traits.
A new study reveals that declining floating-leaf plants release harmful nutrients, but also trigger a microbial process that converts simple organic matter into resilient, long-term carbon storage. This process enhances the lake's ability to sequester carbon through a microbial carbon pump.
The study measures ultrafast electron dynamics in hydrogen molecules, observing oscillations in hole localization that depend on the delay between attosecond pulses. Entanglement occurs at the expense of electronic coherence in the remaining ion.
Researchers investigated brain mechanisms that maintain balance between intimidation and physical aggression in mice. Projections from the lateral hypothalamus to the dorsal raphe nucleus play a critical role in preserving this balance. Increasing pathway activity led to increased attacks, while inhibiting it decreased attack bites.
The study highlights AI's strengths in idea generation, data analysis, and logical structuring but notes limitations such as fabricated references and superficial argumentation. Researchers call for strengthening capacity for critical use of AI while addressing risks like cognitive outsourcing.
Demographic changes are linked to increased household energy requirements, CO2 emissions, and financial burdens in Japan and the UK. Older single-person households have higher energy use and costs due to greater heating and cooling needs.
Researchers have developed an engineered enzyme that can efficiently break down polyurethane (PU) plastics, providing a sustainable solution to the growing problem of plastic waste. The enzyme, Aes72, was designed using advanced simulations and engineering techniques to enhance its catalytic efficiency.
Researchers have mapped a brain circuit specific to chronic pain, suggesting a promising route to treatment. Silencing this circuit eased chronic pain while preserving acute pain responses in mice. The discovery raises the possibility of developing drugs that target this circuit to ease chronic pain without impacting acute pain.
The NIH has renewed support for the USC-led AI4AD initiative, expanding its efforts to better classify Alzheimer's and related diseases, predict progression, and identify new treatment targets. The $12.6 million award will develop AI tools to uncover biological causes of Alzheimer's and improve disease diagnosis.
Researchers develop AI-driven approaches to tackle terahertz ultra-massive MIMO's challenges, including computational complexity and modeling difficulty. Foundation models leverage wireless channels as a common basis for transceiver modules, enhancing practicality and deployment environments.
A Griffith University study found that male and female leaders' emotional behavior influences employees' wellbeing, attitudes, and workplace behavior. Female employees prefer emotional support from female leaders, while male employees value task-focused support from male leaders.
A new study has confirmed that much of the deep mantle deformation occurs where researchers suspect there may be deeply subducted tectonic slabs. The research used an unprecedented database of over 16 million seismograms to analyze seismic anisotropy and provide a global map of the phenomenon.
Researchers have repurposed a bacterial DNA synthesis system to enable DNA to act as an active 'field agent' inside living cells. This allows for the creation of programmable DNA fragments that can regulate gene expression and control protein behavior.
A global collaboration will create a comprehensive atlas of wheat biology using spatial omics, enabling researchers to decode integrated mechanisms of development and stress response. This technology aims to improve grain yield and quality for bread-making, addressing food insecurity and malnutrition.
Researchers found that increasing soil salinity slows biochar aging and limits microbial colonization. Biochar retains more carbon and shows greater structural stability in saline environments compared to low-salinity conditions.
A new scientific review highlights how biochar can transform tea farming by restoring soil health, reducing pollution risks, and improving both yield and quality. Biochar can increase tea yields by 10 to 40 percent while enhancing quality traits such as amino acids and polyphenols that influence flavor.
A new study finds that people with long COVID are at a higher risk of developing cardiovascular diseases, including cardiac arrhythmias and coronary artery disease. The study shows that women with long COVID have twice the risk of receiving a cardiovascular diagnosis compared to women without the condition.
Persistent inequalities remain a major barrier to achieving universal protection against life-threatening infections. The study found that PCV booster retention has dropped in England since the schedule change, disproportionately affecting children in more deprived areas.
Shisha tobacco has almost 1,000 cafes in the UK, popular among young people and ethnic minority groups. Shisha is considered 'every bit as bad for you as smoking cigarettes', with unique design features increasing toxin delivery.
A five-year field study shows that small, repeated additions of biochar combined with water-saving irrigation can significantly reduce methane emissions from rice paddies over time while maintaining strong crop yields. Continuous application maintained and strengthened methane reduction, producing net negative emissions in some cases.
A new study finds that hydrochar significantly enhances soil organic carbon and aggregation, offering a promising strategy for sustainable soil management. Hydrochar can simultaneously improve soil structure and increase carbon sequestration, making it a versatile solution for improving soil health in agriculture.
Researchers created a novel material by converting microalgae biomass into biochar and modifying it with amine functional groups, producing hybrid filters with enhanced purification performance. The new membranes achieved better pollutant rejection and improved resistance to fouling.
Researchers are testing whether SAINT, a non-invasive brain stimulation therapy, can quickly relieve symptoms of postpartum depression. The study aims to find faster and more effective treatments for women experiencing depression after childbirth.
A new study reveals traditional TV ads deliver less than expected impact, with promotions, recency, programming, and habits playing a crucial role in ad effectiveness. The research uses smart TV data to measure causal impact on consumer purchases, providing insights for advertisers and improving TV networks' measurement capabilities.
Binghui Wang, an Illinois Tech Assistant Professor of Computer Science, has been awarded the 2025 Distinguished Junior R&D Award by the IEEE Chicago Section for his groundbreaking research in AI security and trustworthy machine learning. The award recognizes Wang's impactful work on developing provably secure and trustworthy AI systems.
A new study found that older people who forego necessary dental procedures due to financial barriers may experience heart failure, a heart attack, a stroke, or dementia. The researchers suggest that alleviating upstream factors such as financial constraints could prevent chronic disease.
A gene-edited treatment has shown remarkable success against severe sickle cell disease, with 27 out of 28 patients achieving a functional cure and no painful crises. The therapy uses CRISPR/Cas12a technology to modify stem cells and increase levels of fetal hemoglobin.
Research by Prof. Sarah Kaplan found that social innovation accelerators showed no financial improvement for women-led businesses compared to male-led ventures. However, in more egalitarian contexts, accelerators were effective in supporting women entrepreneurs. The study highlights the need for accelerators to address broader ecosyste...
A study published in BMC Medicine found that extreme heat exposure is associated with low birth weight, affecting 18% of babies. Climate change is projected to increase this burden by 8-10% by the 2060s.
Gun violence researchers face challenges in accessing quality data and securing funding due to geopolitical influences. A multidisciplinary approach is necessary to tackle this complex issue, involving academia, investigative journalism, and civil society to capture gun violence information.
Researchers created personalized digital twins of patients' hearts to improve cardiac ablation outcomes for life-threatening arrythmias. The approach resulted in faster and more accurate procedures, reducing recurrences of arrythmias and increasing success rates compared to traditional methods.
A new study shows that two different cell populations can give rise to the same repeating structures in adult fish, challenging traditional explanations for serial homology. This discovery proposes a developmental perspective on serial homology, suggesting that cells from different germ layers can be equivalent and interchangeable.
A legal petition has been filed with the USDA urging them to require warning labels on processed meat and poultry products due to their link to colorectal cancer. The Physicians Committee for Responsible Medicine argues that these products should be labeled as potentially carcinogenic despite passing inspection.
The International Society for Stem Cell Research's official journal has implemented enhanced measures to strengthen scientific rigor and reproducibility in published research. New requirements include a completed ISSCR Standards Checklist shared with peer reviewers, ensuring critical experimental details are fully disclosed. All manusc...
Researchers from NIST and University of Colorado, Boulder, have demonstrated highly stabilized fiber links for quantum networking. They achieved nanometer precision stabilization while separating the classical light from the quantum signal, enabling the transmission of quantum information reliably.
A study published in Neurology Open Access found that higher vitamin D levels in middle age are associated with lower levels of tau protein in the brain, a sign of dementia. The study suggests an association between vitamin D levels and lower tau burden, but highlights the need for further research.
Developing foundation models for analyzing spatial transcriptomic data tackles substantive problems like automation of preprocessing pipelines and performance on cell-type annotation tasks. FMs can accelerate biological discovery, reduce wet-lab experiments, and identify novel cell types.
A UBC Okanagan researcher has discovered that trees provide simple visual cues through branch movement, indicating rehydration or water stress. The study found that balsam fir branches drooped during dry periods and lifted when rehydrating, offering a potential low-cost indicator for tree hydration.
Researchers have developed a potential non-invasive treatment for melanoma using a stretchy, heat-activated skin patch that releases copper ions to kill cancer cells. The patch reduced melanoma lesions by 97% in a preliminary animal study, with no damage to surrounding tissue.
A new Simon Fraser University research reveals that thousands of British Columbia's endangered species are not receiving the necessary help to survive. The study found that only a few species have shown signs of recovery since 2008, while many more are declining due to lack of legislative protection.
A new study suggests that climate change will shift the balance of macromolecules in phytoplankton from proteins to carbohydrates and lipids, with a 20% increase expected by 2100. This could lead to an unbalanced diet for marine life, with implications for ocean health and human consumption.
A phase III clinical trial established a new treatment standard for patients with stage III colon cancer and deficient DNA mismatch repair. Immunotherapy drug atezolizumab showed significant benefits when added to chemotherapy, lowering the risk of cancer recurrence by 50%.
Paul Ohodnicki leads a team at Pitt developing medium frequency magnetics for high voltage grid applications, aiming to reduce cost and footprint by three-fold. The project uses $1.9 million in federal funds to design and manufacture transformers.
A new book by sociologist Amy McDowell examines how small talk can be used to block meaningful conversation in evangelical churches, leaving members feeling isolated and alienated. The study reveals that enforced 'biblical sameness' stifles diverse discourse and convinces minorities to conform to a restrictive majority view.
A study published in Neurology Open Access found that having infectious mononucleosis caused by the Epstein-Barr virus is associated with an increased risk of developing multiple sclerosis. After adjusting for other factors, researchers found that people with a history of mono were three times more likely to develop MS.
A new study published in Neurology found that high-dose influenza vaccination is associated with a nearly 55% reduced risk of developing Alzheimer's disease in people 65 years and older compared to the standard dose. This increased protection is stronger among women, highlighting the importance of flu vaccination for this vulnerable po...
The American Institute of Biological Sciences has published a report showcasing the winners of its 2025 Faces of Biology Photo Contest. The contest aims to highlight biological research through impactful imagery, with this year's first place winner receiving $250 and a one-year subscription to BioScience.
A new study reveals that even low concentrations of pharmaceuticals, microplastics, and other chemicals can subtly alter plant physiology and disrupt soil health, posing wider environmental and human health risks. The review emphasizes the need for stronger regulation and redesign of chemicals to make them safer.
The Global Virus Network is launching an expanded program for Florida high school students to prepare them for pandemic preparedness. The five-day summer program at the University of South Florida will provide students with hands-on experience in virology, global health, and scientific communication.
A new study published in Mayo Clinic Proceedings found that robotic bronchoscopy has a high sensitivity for malignancy (85%) and accuracy rate (76.9%), with a complication rate of 2.8%. The technology allowed for earlier detection of lung cancer, reducing diagnoses at advanced stages from 54% to 31%, and improved survival rates.
Researchers found that targeting MD2 could reduce tumor growth in a mouse model of prostate cancer bone metastasis. High MD2 expression was associated with metastasis, immune suppression, and increased resistance to PARP inhibitor therapy.
Researchers have discovered that a giant planet, WASP-189b, echoes the composition of its host star, providing direct evidence for a foundational concept in astrobiology. The team's findings offer insights into how exoplanets form and evolve, and open new avenues for studying exoplanet atmospheres.
A molecular clock, governed by epigenetic marks, controls neuronal maturation in the brain. The balance between these signals ensures that maturation occurs at the right time and in the right order. Even in mature adult brain cells, hundreds of genes remain bivalent, suggesting a role in stress response and cell death.
A long-term public study found that phytochemicals from oregano and rosemary supported favorable gut health and growth performance in weaned pigs, preserving microbial diversity to improve nutrient utilization. The natural agents outperformed antibiotic growth promoters in terms of final body weight and gain-to-feed ratio.
Researchers developed a novel antibody that targets the 4lg isoform of B7-H3, overexpressed in many cancer types. The antibody, BetaBart, has potential use as a radio-theranostic treatment that brings targeted radiation to tumor cells.
The China–Italy laboratory medicine collaboration has been strengthened through a high-level meeting at Ruijin Hospital. The partnership aims to enhance the journal's global influence through international editorial collaboration, overseas offices, and high-quality academic content.
The Johns Hopkins team developed a therapeutic intranasal DNA vaccine against tuberculosis that accelerated disease clearance, improved treatment outcomes, and stimulated immune responses. The vaccine combines two genes to direct the immune system to fight drug-tolerant bacterial persisters, showing promise for treating TB.
A Kennesaw State University project is exploring AI-powered chatbots to help future teachers respond to how students think about math. The chatbots simulate classroom interactions, allowing student-teachers to practice responsive teaching and develop their skills in a more authentic way.
Thirty previously unpublished verses by Empedocles have been discovered on a papyrus fragment from the French Institute of Oriental Archaeology in Cairo. The ancient Greek philosopher's work reveals unexpected connections with other authors and philosophers.
Sergio Bernardini discussed journal development and international collaboration with the editorial team, emphasizing proactive academic publishing and global outreach. He encouraged thematic issues, forums, and collaborations to engage the laboratory medicine community.
Dr. Lori Marino receives the 2026 Drake Award for her groundbreaking work on intelligence evolution, recognizing her contributions to understanding complex life forms on Earth and beyond. Her research focuses on brain evolution, cognition, and self-awareness in various species.
Researchers developed a double-slit plasmonic platform-based fiber probe that combines easier light excitation, stronger tip enhancement, broadband stability, and controllable fabrication. The probe achieved 28.6 nm optical imaging resolution under ambient conditions and resolved structures smaller than the diffraction limit.
A phase 1/2 clinical study found that pralsetinib improved durable responses with manageable safety profiles in patients with advanced or metastatic RET fusion-positive non-small cell lung cancer. The overall response rate was 78% and median duration of response was longer in patients with the CCDC6-RET fusion gene.
A team from Emory University developed a simple method to test the accuracy of protein language models, which are used to analyze complex biological data. By comparing how these models 'embed' natural proteins versus synthetic ones, researchers can estimate their reliability and improve their performance.
Philosopher Dr Kirill Chepurin wins the award for his monograph on Schelling's concept of 'bliss', while art historian Dr Elisabeth Ansel receives the award for her essay on J.M.W. Turner and Carl Gustav Carus' visual translation processes.
The Ocean Discovery League has announced a global strategy to visually explore 10,000 strategically selected locations across the deep seafloor. By achieving this ambitious goal, scientists will unlock new discoveries about biodiversity, ecosystem function, and environmental change.
A survey study found that dog owners have difficulty recognizing subtle signs of pain in their pets. Only about half of owners correctly identified symptoms such as nighttime restlessness and clinginess as likely indicating pain.
A Rutgers study found that a protein called PHGDH can predict drug response in cancer patients and improves survival rates when combined with immunotherapy. High levels of PHGDH are associated with better responses to anti-PD-1 therapy, suggesting it could be a potential biomarker.
A new study finds that over a quarter of countries won't reach the UN's 2030 child mortality target on time, with sub-Saharan Africa heavily burdened. The global rate stands at 36.72 deaths per 1,000 live births, projected to meet the target until 2035.
The HEAL Service Center at Lehigh University provides accessible, state-of-the-art mass spectrometry and analytical support to faculty, academic partners, and industry. The center offers advanced instrumentation and professional staff assistance for research and training.
Research suggests that hydrous and repeated mantle melting is key driver of gold enrichment in island arc magmas. The study found that high-degree melting leads to significant concentrations of gold, often several times higher than those found in mid-ocean ridge basalts.
Early land vertebrates exhibited distinct patterns of body size evolution, with amniote-lineage land vertebrates experiencing a relaxation of constraints, enabling them to expand their maximum body size limit. Lissamphibian precursors showed stronger constraints on body size evolution and relied on cutaneous CO2 excretion.
A new study reveals that walking is the most popular leisure-time physical activity among US adults, but urban residents are more likely to meet exercise guidelines. Rural residents tend to prefer activities like gardening and hunting, with lower rates of inactivity and guideline adherence.
A team of researchers at Binghamton University has developed a method to pinpoint discoveries that reshaped the course of science. The new metric uses neural embedding to analyze approximately 55 million scientific papers and patents, identifying major breakthroughs and simultaneous discoveries with greater accuracy.
Access to hospital-based obstetric care declined across the US as hospitals closed labor and delivery units between 2010-2021. Rural communities were hit hardest, with access dropping by over 50% in some areas.
A hormone called FGF21 reverses obesity in mice by signaling to the hindbrain, a region targeted by GLP-1 drugs. This finding provides insight into the naturally occurring hormone's benefits for weight loss and MASH treatment.
A study by the Max Planck Institute for Chemical Ecology found that an introduced bacterium can replace an ancient insect symbiont within a few generations. The beetles exhibited reduced reproduction rates, lower life expectancy, and altered immune systems after infection with the new bacterium.
Researchers from Purdue University and Menlo Microsystems developed a commercial microelectromechanical switch that operates reliably at cryogenic temperatures. The device showed lower operating voltage, lower on-resistance, and strong radio-frequency performance.
A recent study by Miquel Torrents-Ticó found that human attitudes play a crucial role in determining predator populations. In two Kenyan sites, human tolerance influenced spotted hyena distribution, with tolerated herders allowing predators to thrive. The findings suggest that coexistence is more likely when humans accept predators.
A new study examines the lives of apex predators in the Himalayas, finding that snow leopards, leopards, and wolves coexist by choosing distinct prey sources. The research highlights the importance of niche partitioning in facilitating the coexistence of these species in a shared space.
Researchers created a new type of microporous aerogel that overcomes limitations of conventional materials, enabling flexible and highly processable shapes. The material's flexibility arises from reversible van der Waals interactions between metal–organic polyhedra molecules.
A team of NYU Abu Dhabi and University of Denver researchers have identified a promising small molecule, SK-129, that could slow or stop the progression of serious brain diseases such as Parkinson's disease. The molecule works by preventing the aggregation and spread of a neuronal protein, which damages brain cells over time.
Researchers found that a single general factor, called the 'Q-factor', captures how people rate their relationship across multiple facets. This means that many prominent self-report relationship measures may not be as empirically distinct as assumed.
A new soft sensing system allows humanoid robots to perceive complex finger posture in real time, enabling precise movement and dexterous manipulation. The system features an omnidirectional bending sensor that tracks pitch and yaw at the finger joints, providing stability and repeatability for demanding actions.
A compact chip holder with integrated electrodes enables temperature control, electric actuation, pressure handling, and optical readout for nanofluidic systems. The platform supports studies on molecular transport, catalytic reactions, and protein aggregation in confined environments.
Researchers developed a Rydberg dipolar atom chain approach for low-frequency vector electric-field sensing. The technique encodes field amplitude and direction into the many-body dynamical response, offering traceability, micrometer-scale spatial resolution, and vector sensitivity.
The NIH grant will support the creation of a comprehensive long-term dataset on Hispanic and Latino brain aging, examining the factors that matter most for healthy cognitive aging. The study aims to understand how Alzheimer's disease, vascular injury, and other brain changes develop over time in Latino adults.
A team of researchers has developed rechargeable batteries using biomass-based materials, including sunflower seed shells, as an alternative to lithium-ion batteries. The batteries achieved competitive results with low environmental impact and can store sufficient energy.
Research warns AI can compromise creativity, critical thinking with overly automated learning systems; 'learning vaults' suggested to safeguard adaptive knowledge. HR teams must ensure continued access to first-hand learning and human interaction.
The Deutsche Forschungsgemeinschaft will allocate funds for 14 new research units to drive cutting-edge scientific inquiry in Germany. These initiatives aim to boost collaboration and innovation across various disciplines.
The formation of freshwater lakes at the edge of Greenland's melting ice sheet is accelerating glacier flow, potentially increasing global sea-level rise. The lakes can destabilize glaciers, triggering movement and heightening ice loss.
The book chronicles two centuries of weather stories and observations, including Britain's longest continuous daily weather records. It highlights the diversity of British weather, from scorching summers to devastating floods, and shares insights into climate change.
A new study documents the rapid expansion of the Indo-Pacific crab Gonioinfradens giardi in the Ionian Sea, indicating a shift from sporadic occurrence to stable populations. The species' establishment raises concerns about its ecological role and interactions with native species.
Researchers discovered that DNA polymerases can generate highly sophisticated DNA sequences from scratch, with some exceeding 85,000 bases. By controlling the reaction conditions and temperature, scientists can steer the composition of the sequences produced.
The BBVA Foundation awards Carl Wunsch for his groundbreaking work revealing the ocean's central role in regulating Earth's climate. His innovative methods allow scientists to quantify ocean state under a changing climate, highlighting the need for a global ocean observing system.
A new AI chatbot helps patients access retinal detachment advice through personalized, real-time, clinically grounded conversations. The system outperformed leading large language models and includes accessibility features for people with low vision or limited English proficiency.
A genomic study found that cholera bacteria rapidly gain and lose defensive systems against a viral nemesis, ICP1, resulting in lower disease severity and reduced ability to spread globally. The study challenges the long-held belief that the Ganges Delta is the global source of cholera.
Researchers have confirmed that giant planets like Saturn operate under a unique magnetospheric regime, with a shifted cusp location due to its rapid rotation. This discovery alters models of magnetic reconnection and high-energy particle acceleration, revealing new insights into Saturn's auroral activity.
WorldFish Ventures aims to accelerate the scaling of aquatic food innovations through market-based approaches and strategic partnerships. The venture will focus on translating scientific breakthroughs into investable solutions that reach underserved markets more effectively and sustainably.
Researchers developed CausalBridgeQA, integrating causal inference into Multi-Hop Question Answering (MHQA) to address reasoning breakdowns and feature spurious correlations. The method significantly improves accuracy and robustness in complex questioning tasks.
Gravitational waves may have contributed to dark matter formation through stochastic gravitational waves during the early universe's formation. This new mechanism could lead to mass-free or nearly mass-free fermions that would acquire mass and form dark matter particles.
A University of Manchester Professor has been appointed as an Expert Reviewer for the NDA 2026 Review, led by Dr Tim Stone CBE. The review assesses the NDA's strategic planning, project delivery, and financial management to ensure value for money and highest safety standards.
Research at Tohoku University reveals that mushrooms adjust their communication levels in response to urine application, with increased flow when water is applied and decreased flow when urine is applied. The findings suggest that forest mushrooms can flexibly change their electrical information flow in response to various disturbances.
City St George's, University of London, is partnering with Paradigm Biopharmaceuticals to test a potential treatment for osteoarthritis. The partnership aims to investigate the mechanism of action of pentosan polysulfate sodium (iPPS) on bone marrow lesions, which are linked to pain in osteoarthritis.
The RFGDG framework uses a dynamic parameter aggregation strategy powered by Deep Reinforcement Learning to unify disparate feature representations and reduce redundancy across clients. This approach enhances global model accuracy and provides superior adaptability in multi-client environments.
Researchers at Aarhus University have developed an artificial virus-like DNA needle that can deliver molecules directly into cells. The technique uses DNA origami to assemble the needle and deliver its payload, potentially solving a major issue with many therapies being trapped inside cells.
Insilico Medicine will present four novel cancer inhibitors discovered via its Pharma.AI platform, targeting KRAS and Cbl-b pathways. ISM6166 and ISM3830 demonstrate robust anti-tumor activity against solid tumors with KRAS alterations and restored innate and adaptive immunity, respectively.
The research presents a comprehensive taxonomy of prompt engineering techniques, categorizing them by underlying principles and outlining a pipeline for designing effective prompts. This enables developers to optimize prompts for various applications, from creative content generation to high-stakes decision-making.
Researchers at KIT analyzed scientific papers using AI to identify emerging trends and relationships. The study suggests that large language models and machine learning can help reveal new avenues of research and opportunities for interdisciplinary cooperation.
A new UBC study found that global aquaculture production is increasingly relying on less beneficial species for food security, climate mitigation, and biodiversity. The industry's shift towards finfish has lower sustainability potential, while earlier systems like seaweed and shellfish had higher sustainability.
Researchers at Charité develop test to determine circadian rhythm using hair roots, revealing genetic and lifestyle factors influencing internal clock. The new method shows promise for tailoring therapies to individual rhythms, potentially improving treatment outcomes.
Researchers propose a novel approach to dataset acquisition in spatial data marketplaces, optimizing spatial coverage and connectivity under budget constraints. The proposed Budgeted Maximum Coverage with Connectivity Constraint (BMCC) algorithm achieves up to 68% larger spatial coverage with 89% speedups compared to existing methods.
Researchers propose adaptive protocol for GHZ states, combining short and long measurements to achieve high precision while maintaining dynamic range. This approach enables dual Heisenberg-limited scaling, surpassing older methods, and proves more resilient to noise and dephasing.
Research reveals a potential connection between gut microbiota and atopic diseases such as bronchial asthma and food allergies. Small intestinal bacterial overgrowth (SIBO) may contribute to the worsening of symptoms in these conditions. Further studies are needed to confirm this association.
Researchers challenge long-held assumptions about vegetation patterns in dryland ecosystems, finding that such patterns can actually indicate reduced ecosystem resilience. The new theoretical framework takes into account spatial constraints and environmental heterogeneities, revealing that ecosystem stability depends on specific enviro...
In this randomized clinical trial, mirtazapine effectively reduced methamphetamine use in adults with methamphetamine use disorder. The study's findings have important implications for the treatment of this condition, which currently lacks approved pharmacotherapies.
Scientists at the University of Manchester discovered a rare mathematical process underlying the formation of corrugations in soda cans. The sequence of buckles follows homoclinic snaking, a phenomenon where bumps or ripples appear one by one in a precise order.
A team of researchers discovered that inflammation in multiple sclerosis causes DNA damage to neurons essential for higher thinking and cognition. This finding provides a new direction for the field and highlights the importance of protecting grey matter neurons from damage.
Mohamed Abou-el-Enein, a USC physician-scientist, has received the Outstanding New Investigator Award and Best of Molecular Therapy Award from the American Society of Gene + Cell Therapy. His work focuses on translating scientific discoveries into clinical applications, with a particular emphasis on cell therapies.
A new study reveals that blocking the aryl hydrocarbon receptor (AHR) helps neurons regrow damaged axons and recover motor and sensory function. AHR acts as a key regulator that determines how neurons respond after injury, slowing down axon growth.
The review highlights LRRK2's diverse cellular functions and pathogenic mechanisms in various diseases, including Parkinson's disease and inflammatory disorders. Therapeutic strategies targeting LRRK2, such as kinase inhibitors and emerging approaches like PROTACs and gene therapy, show promise for correcting cellular imbalances and re...
A collaborative effort involving 865 researchers has published new empirical evidence on reproducibility, robustness, and replicability of social and behavioral sciences research. The SCORE program's outcomes will contribute to strengthening how research is interpreted and communicated.
Dr Amy Shirong Lu joins JMIR Serious Games as Editor-in-Chief with extensive research on digital health technologies and their impact on physical activity and cognitive health.
MDPI has opened its first US office in Philadelphia, serving as a central hub for scholarly engagement across the country. The new office will provide regional support to US scholars, manage scholar visits, and represent MDPI at conferences throughout the US.
A multi-site study found that AI scribes reduced electronic health record usage by 3% and clinical documentation time by 10%, with primary care physicians experiencing the greatest reductions. The technology also showed a slight increase in productivity, measured as 0.5 additional patient visits per week.
Current AI systems lack internal embodiment, a property that humans take for granted, which can lead to performance and behavior limitations. Researchers propose a dual-embodiment framework to guide future research in building safer and more aligned AI models.
Researchers at NIH have identified a novel opioid compound that shows potential as a therapy for both pain and opioid use disorder. The new drug, called DFNZ, has high pain-relieving effects without causing respiratory depression or addiction.
A 500-million-year-old fossil reveals the earliest known chelicerate with a claw, pushing back the evolutionary history of chelicerates by 20 million years. This discovery sheds light on the assembly of the chelicerate body plan and their early ecological context.
Between 2021 and 2024, government organizations accounted for around one-tenth of the estimated $336 million spent on advertising to news websites publishing health misinformation. Pharmaceutical companies also made notable contributions.
The adoption of AI-powered scribes was associated with modest decreases in total electronic health record time and documentation time. This is due to automation of routine tasks allowing clinicians more time for high-value patient care.
A new catalytic strategy using hydroxyl-induced cobalt oxide enables efficient conversion of syngas to light olefins through Fischer-Tropsch synthesis. The catalyst achieved high CO conversion and light olefin selectivity, with carbon utilization efficiency reaching up to 13%.
This study introduces a novel method that couples buoyancy-driven convection with localized acoustic microstreaming to enhance macroscopic mixing and microscopic mass transfer. The results show significant advantages in high-viscosity media, including increased effective coverage area and mean flow velocity amplitude.
A new UAV perching system utilizes a magnetic tensegrity-enabled robotic gripper with an adaptive energy barrier, enabling low-power and stable aerial operations. The system demonstrates rapid closure and high holding capability, with improved performance on rough surfaces.
The American Society of Hematology has published clinical practice guidelines for diagnosing and managing severe acquired aplastic anemia, a rare and life-threatening bone marrow failure disorder. The guidelines highlight the importance of shared decision-making between patients and providers, as well as the need for additional researc...
A new study found that popular vitamin B3 derivatives, commonly taken by cancer patients to manage chemotherapy side effects, can actually make cancer cells more resistant to treatment. This means that supplements like NMN, NR, and NAM may be undermining treatment in critical ways.
A recent FAU study found that individuals with prior criminal behavior, low self-control, and favorable attitudes toward deviance are more likely to access the dark web. The research highlights the importance of understanding who accesses this platform and why, particularly for those intending to engage in illicit activities.
A recent study reveals that Alaskan permafrost is thawing rapidly, leading to increased runoff, carbon releases, and altered coastal ecosystems. The research focused on a Wisconsin-sized area of Alaska's North Slope, simulating daily river flows and coastal exports over 44 years.
A review by an international team of researchers highlights that air monitoring is essential for global public health strategies, as airborne antibiotic resistance genes can spread silently between humans, animals, and the environment.
The NCCN 2026 Annual Conference emphasized the need for holistic care for adolescents and young adults with cancer, highlighting unique challenges and the importance of supportive services. The conference also addressed global cancer care realities and future strategies, emphasizing the need for collaboration and investment to address ...
A team of researchers found that Gli2 and Gli3 function synergistically to regulate tooth root morphogenesis. Their study revealed a critical interaction between HH signaling and TGF-β signaling, which is essential for normal root development.
A study published in BMC Public Health found an association between antibiotic use and maternal mental health during pregnancy. Researchers analyzed data from over 94,000 pregnant women and discovered a stepwise pattern of psychological distress linked to increasing antibiotic exposure. The findings suggest that avoiding unnecessary an...
A new survey by Autism BrainNet reveals a significant disconnect between Americans' strong support for autism research and their limited understanding of postmortem brain donation. The survey found that 70% of respondents had never heard of brain donation, despite 92% agreeing its importance in advancing research.
A study published in Nature Health reveals a strong link between pesticide exposure and the risk of developing certain cancers. The research shows that pesticide exposure increases the risk of cancer by 150% in areas with high levels of pollution, and highlights early biological effects before cancer develops.
A new study suggests Saturn's magnetic field is asymmetrical, with cusps located most often between 13:00 and 15:00. The researchers believe rapid spin and heavy plasma from Enceladus drag the field lines to the right.
A team from UNIGE has created a molecular system that distinguishes and neutralises cancer cells with unprecedented precision, paving the way for autonomous, self-regulating drugs. The technology uses synthetic DNA strands to deliver potent drugs only where they are needed, reducing damage to healthy tissue.
A new study from Umea University reveals that adult children's unemployment is strongly associated with the depression risk of older parents in India. The research, based on extensive data from the Longitudinal Ageing Survey of India, shows a clear link between child employment and parental mental health.
A KIST-IAE joint research team developed a catalyst technology that maximizes the surface activity of 2D nanomaterial tungsten diselenide, enhancing the performance and durability of lithium-air batteries. The innovation converted the entire basal plane into an active catalytic site, significantly improving reaction rates.