Researchers found that eEF1A2 is significantly overexpressed in gallbladder cancer and correlates with advanced lymph node metastasis and poor patient survival. Targeting the EEF1AKMT4-eEF1A2 signaling axis may suppress translation-driven tumor growth and halt lymphatic spread.
Researchers at MIT discovered that gene circuits can reshape DNA folding and affect gene expression in human cells. The study found that rearranging genes along a DNA strand, or 'gene syntax,' can amplify or suppress the expression of neighboring genes.
The study reveals that decision-making occurs through nested feedback loops, not sequential stages, and can be emulated to create more intelligent AI. This finding has the potential to improve AI's power efficiency and effectiveness.
Researchers identify strong Brønsted acid site (BAS) in fluorinated γ-Al₂O₃ using advanced solid-state NMR techniques. The site is present only on fluorinated alumina and exhibits exceptional robustness, enhancing catalytic activity and aromatization performance.
A physics-guided neural network called SGARNet is developed to address challenges in lensless multi-core fiber imaging. It reveals the frequency-domain characteristic of honeycomb artifacts and introduces a SpectralGate module to selectively suppress artifact-related components, preserving useful image details.
Researchers from Nagoya University developed a two-step synthetic method for dihydrodinapthopentalenes, conductive organic molecules with complex synthesis. The new mechanochemical method synthesizes DHDPs in 15 minutes with minimal solvent waste and structural constraints.
A research team has uncovered the atomic-scale understanding of how water drives structural reconstruction in oxide catalysts. The study reveals distinct hydroxylation pathways for different CoOx nanostructure initial structures in the presence of water.
A bimetallic NiFe catalyst was designed to overcome the activity-selectivity trade-off in furfural hydrogenation. The introduction of Fe creates synergistic active sites, boosting selectivity toward furfuryl alcohol from 38% to >90% at nearly full conversion.
Researchers examined two mechanisms of whole genome duplication in cells, finding that cytokinesis failure leads to more stable and viable cells, while mitotic slippage results in uneven chromosome distribution and reduced viability. The study suggests targeting chromosome separation could help limit survival of abnormal cells.
Researchers at UC Santa Cruz's Forest Fear Lab discovered that the dense upper story of the Amazon carries the cries of frightened birds to other animals, forming a shared information network. Small bird species are key drivers of this acoustic 'information highway,' with larger species also joining in.
A new rulebooks framework developed by Iowa State University researchers provides a principled way for autonomous systems to rank and reconcile competing goals. The framework avoids the issues of blending weighted trade-offs, allowing systems to clearly define which rules come first and choose the least harmful option.
A study at Saitama University found that subtle changes in molecular structure can significantly affect aggregation and interfacial behavior of sugar-based surfactants. The researchers demonstrated that the sulfur oxidation state alters the relationship between aggregation in water and surface tension.
A new review found that GLP-1 weight-loss drugs significantly reduced the risk of heart attacks, strokes, and premature death. The treatment also lowered rates of non-fatal heart attacks, hospital admissions for heart failure, and deaths from any cause.
A small trial found that once-weekly semaglutide injections reduced heavy drinking days by an average of 12 days in patients with alcohol use disorder and obesity. The study showed a 50% higher reduction than the placebo group, suggesting potential benefits for GLP-1s in treating alcohol use disorder.
The American Heart Association warns that healthcare affordability has reached crisis levels, with total spending approaching $5 trillion annually. The association proposes five guiding principles for action by lawmakers and policymakers to address the issue.
A growing gap in cervical cancer incidence rates between high- and low-income countries threatens to escalate unless prevention efforts are increased. Researchers urge universal vaccination for girls and boys, as well as catch-up campaigns, to close the gap and prevent nearly 37 million cases of cancer by the end of the century.
A study by Boston Children's Hospital researchers found that the US missed four out of seven measles elimination status indicators, with most at risk. The latest outbreak has spread continuously for over a year and affected 45 states since January 2025.
A new study published in the Journal of the American Heart Association found that methamphetamine use accounted for nearly 15% of heart attacks in a northern California study. People who suffered meth-related heart attacks were often young- to middle-aged men without traditional heart disease risk factors, highlighting the need for spe...
A recent study found an association between early-onset colorectal cancer and exposure to certain pesticides, particularly picloram. However, experts warn that further investigations are needed to confirm causality and establish a biological mechanism.
A new pretargeted radioimmunotherapy technique has been shown to be effective and safe in eradicating tumors from a preclinical colorectal cancer model. The multi-step theranostic approach delivers alpha-emitting radiation directly to tumors while limiting exposure to healthy tissues.
A new study reveals that impaired protein recycling is the key factor in T cell exhaustion, allowing researchers to develop a 'tag and sort' fix to restore normal proteostasis. This approach boosts the potency of cell therapy against cancer.
Researchers present findings on sociodemographic disparities in hypertensive disorders of pregnancy, highlighting the need for better characterization and management of these conditions. Dr. Basma S. Faris discusses reframing PCOS as a chronic disease requiring longitudinal care.
Research led by University of Utah biologists shows that host genetics and sex influence how influenza viruses evolve. Female mice from a specific strain exhibit accelerated virulence gains compared to male mice.
A new study by Lee Gettler of the University of Notre Dame found that COVID-19 lockdowns had a limited lasting effect on fathers' involvement in childcare, contrary to initial reports. The 15-year longitudinal data showed no significant change in fathering behaviors before and after the pandemic, with most dads resuming their pre-pande...
The RURAL Cohort Study aims to understand why residents of rural communities experience higher rates of heart, lung, and blood-related diseases, as well as shorter life expectancy and less-than-optimal overall health outcomes. The study uses a custom-built mobile examination unit to bring research directly to the community doorstep.
Researchers found significant loss of neurons in the locus coeruleus, a second critical region involved in arousal and muscle tone regulation. This finding suggests an immune-mediated process and challenges the prevailing explanation for narcolepsy with cataplexy.
A new liquid biopsy method has been developed to predict the response to immunotherapy in high-risk breast cancers. The study found that repeated blood sampling can assess and predict the evolving antitumor immune response to therapy, offering a potential tool for guiding immunotherapy decision-making.
The São Paulo School of Advanced Science in FoodOmics aims to advance understanding of omics technologies in food and nutrition. The event will feature keynote lectures, workshops, and interactive sessions with renowned researchers from around the world.
Researchers at Rice University have developed a method to make perovskite-based photovoltaics more durable by adding two key ingredients, skipping the yellow phase and degrading slower. The films retain 98% of their initial efficiency even after 1,200 hours of exposure.
The review highlights how retrieval-augmented generation can improve the accuracy, transparency, and clinical reliability of AI tools in cancer care. RAG-enhanced systems produced more accurate results than standard AI models across multiple studies.
A new study published in Science Advances identifies IRS4 as a promising drug target for multiple solid tumors, offering hope for safer cancer treatments. By using AI and natural mutations, researchers prioritized targets with high therapeutic indexes to minimize toxicity.
A new randomized clinical trial shows that a low-fat vegan diet reduces greenhouse gas emissions by nearly three times more than a Mediterranean diet. The study also found significant improvements in key cardiometabolic outcomes, with the majority of environmental gains driven by eliminating meat, dairy, and eggs.
A new report highlights the catastrophic risks of nature loss on food systems, economies and societies. Chronic pressures like soil degradation and water scarcity are already reducing crop yields and increasing food prices.
Researchers at UBC Okanagan have made a groundbreaking discovery in wireless communication by developing nonlinear intelligent surfaces that can process electromagnetic waves more efficiently. These surfaces mimic neurons in computerized neural networks, enabling complex signal transformations and improved communication reliability.
A new study published in Current Developments in Nutrition shows that adopting a low-fat vegan diet can rapidly reduce environmental impact while improving metabolic health. The 12-week randomized clinical trial found dramatic reductions in greenhouse gas emissions and cumulative energy demand.
The new 21-bed ICU will increase access to advanced care and enable more Queens residents to receive care locally. Construction is expected to take approximately 16 months and will be funded in part by New York City and State as well as through Mount Sinai’s capital resources.
A new study by iC3 researchers found that Neogloboquadrina pachyderma shells can grow with different chemical compositions, affecting temperature estimates. This discovery could help improve reconstructions of past polar ocean conditions and provide more accurate climate records.
Researchers suggest treatment could start during pregnancy to prevent brain damage and reduce neurological harm. A new RNA-based therapy reduces abnormal electrical currents in patient-derived excitatory neurons.
A new study by Carnegie Mellon University researchers found that real-time feedback on collaboration metrics does not improve team performance and can even make it worse. By narrowing the feedback to a single metric, teams focused too much on that signal and neglected coordination strategy, leading to decreased overall performance.
This journal issue examines the evolution of traditional Chinese medicine through texts, practice, empire, and global cross-cultural exchange. Key findings include the gradual development of foundational concepts like the three yin-yang system and the concept of Du, as well as the role of medicine in political and social systems.
Researchers have developed a coherent Raman spectroscopy method that directly detects ångström-scale molecular films at interfaces without plasmonic enhancement or electronic resonance. This approach suppresses strong substrate background signals, allowing for highly sensitive interfacial Raman spectroscopy.
A new study reveals a sharp rise in water bead ingestions among young children, with a 6,532% increase from 2019 to 2023. The majority of ingestions occurred in residences and among children under 3 years old, highlighting the need for primary prevention and education.
A KIT spin-off has developed a photoreactor panel that generates hydrogen directly from sunlight and water, avoiding expensive electrolyzers. The technology offers a simpler, more scalable approach to green hydrogen production, making it suitable for local on-site use or large-scale solar projects.
A new analysis confirms that a small number of plant species drive changes in community temperature profiles under warming temperatures. The study found that these dominant species remain influential even as warming increases, making it easier to manage for climate change by focusing on key contributors.
Researchers studying RNA pollution's impact on aging brains seek to develop therapeutic strategies for neurodegenerative diseases like Alzheimer's. Sanford Burnham Prebys scientist Anne Bang will use advanced robotics to test thousands of compounds.
Research suggests that high-intensity exercise is most effective in reducing sleep disturbances among older adults with mild cognitive impairment. Light activity also shows some benefits, while moderate exercise has little impact. Tailored exercise programs could help prolong quality of life for this growing demographic.
The new framework, published in PNAS Nexus, offers guidance for building human-AI teams that are effective, accountable, and aligned with human values. It focuses on reasoning, memory, and attention as core processes that can be distributed across people and AI systems.
A new study from the University of Mississippi found that younger teens are most likely to try psychoactive inhalants like nitrous oxide. The study also linked inhalant use to certain behaviors such as smoking tobacco and getting into fights, with teenage girls having the highest odds of developing inhalant use disorder.
Researchers at Weizmann Institute and Washington University School of Medicine developed a CAR-T therapy that significantly reduced amyloid deposits and inflammation in a mouse model of Alzheimer's disease. The therapy holds promise for treating neurodegenerative disorders, including ALS and Parkinson's disease.
Researchers found that blocking energy production pathways can slow tumor growth in group 3 medulloblastoma, an often-fatal form of pediatric brain cancer. An experimental therapy targeting energy metabolism has shown promise in reducing tumor growth in mice.
The partnership aims to bring academia and practice closer together, creating new momentum for research, teaching, and society. Researchers from Goethe University's Faculty of Sports Sciences are now based at Eintracht Frankfurt's Sportquartier im Stadtwald.
New research from West Virginia University finds that judges are adopting generative artificial intelligence in courtrooms, but remain committed to human control over judicial decision-making. Judges use AI for administrative tasks like document summarization and case organization, but prioritize legal reasoning and final judgment.
A new review highlights the emotional, physical, and financial challenges faced by caregivers of women living with ovarian cancer. Caregivers experience anxiety, depression, grief, and burnout, alongside practical barriers such as financial hardship and limited communication with healthcare providers.
A large language model exceeded physician baselines in clinical reasoning tasks, including emergency room decisions and identifying likely diagnoses. The study highlights the need for rigorous prospective trials to evaluate the impact of AI on clinical practice.
Researchers discovered a small molecule, UNI418, that destabilizes key DNA repair proteins, making drug-resistant cancer cells vulnerable to PARP inhibitor therapy. This approach restores tumor sensitivity and improves treatment outcomes.
Researchers have identified a newly discovered organelle, the hydrogenobody, which powers methane machine in livestock. The organelle produces hydrogen while regulating oxygen levels, supporting methanogenic archaea and amplifying methane emissions.
Researchers discovered that activated T cells secrete vesicles carrying DNA that enters immune and tumor cells to enhance the immune response against tumors. Preclinical experiments showed that this approach can boost T cell attacks against tumors and improve treatment outcomes.
Scientists at Heriot-Watt University have developed a new way to control the polarization of light, opening up new possibilities for medical tools and quantum technologies. The breakthrough achieves full control over light oscillation in real-time using only light, with no electronics or moving parts.
The FDA has merged two of OYE Therapeutics' Investigational New Drug applications, creating a more streamlined regulatory framework for development across related programs. This move is expected to improve regulatory efficiency, reduce duplicative development activity, and simplify operational execution.
Scientists discovered that evolution used the same genes, ivory and optix, to evolve near-identical colour patterns among distantly related butterfly and moth species. This finding suggests that life on earth may be more predictable than first imagined, with nature following a particular route.