The XENON Collaboration detects low-energy solar neutrinos with unprecedented precision, expanding our understanding of neutrino physics and the search for dark matter. The observation demonstrates the power of advanced technologies in rare event physics, enabling new windows into the universe.
Transient intestinal inflammation can leave irreversible changes in the gut lining, leading to Crohn's disease and ulcerative colitis. Long-term inflammation rewires intestinal stem cells, preventing normal regeneration and creating chronic disease.
Scientists have discovered how certain DNA repair enzymes preferentially target specific genetic sequences, leading to the accumulation of mutations in vulnerable regions. This understanding has implications for cancer development and the evolutionary process.
A new immunotherapy for Alzheimer's disease has shown promising results in a Phase 1 clinical trial. The treatment aims to reverse immune aging and reduce biomarkers of neuronal damage, supporting further clinical development of this innovative strategy.
A recent study published in Cancer Research found that sildenafil, the active ingredient in Viagra, can restrict cancer metastasis by limiting cancer cells' access to cholesterol. Combining sildenafil with statins may enhance this effect, potentially improving survival rates among cancer patients.
Researchers at the Weizmann Institute of Science have successfully engineered a model plant to produce five psychedelic substances, including DMT and psilocybin, by identifying key genes and enzymes responsible for their production. The plant's ability to simultaneously produce multiple psychedelics has implications for treating mental...
Researchers successfully reconstructed the evolution of the virus-human interaction over the course of an entire pandemic. They identified that strong selection pressure leads to rapid emergence of highly contagious variants, similar to Omicron. This study offers hopes that scientists may predict how viruses evolve in the future.
A team of researchers from the Weizmann Institute of Science has developed a new approach to detecting alien biology, leveraging statistical patterns in molecular diversity. By analyzing groups of molecules rather than individual ones, the method can identify biological signatures even in samples with limited information.
Researchers found that mirror-image forms of chiral molecules behave differently due to asymmetric magnetic field strengths. This discovery supports a theory about how life began on Earth, proposing that magnetized surfaces played a key role in the emergence of biological molecules.
Activated memory B cells can recognize and target ovarian cancer cells, producing effective antibodies. The discovery advances the development of vaccines and therapies based on immune memory against cancer.
A common genetic alteration in prostate cancers enables tumors to bypass dependence on male hormones and instead rely on cortisol, leading to treatment resistance. Combination therapy targeting both androgen signaling and cortisol activity can suppress tumor growth and extend survival.
Researchers discovered that stem cells can mature into potent antimicrobial cells when infected with bacteria, sacrificing their own lifespan to prevent prolonged infection and promote tissue repair. This newfound mechanism may hold potential for understanding inflammatory diseases like Crohn's disease.
Researchers at Weizmann Institute and Washington University School of Medicine developed a CAR-T therapy that significantly reduced amyloid deposits and inflammation in a mouse model of Alzheimer's disease. The therapy holds promise for treating neurodegenerative disorders, including ALS and Parkinson's disease.
A mass mating event among yeast strains revealed specific preferences for partner selection. The study showed that yeast tend to choose partners that produce fitter offspring, with successful pairs exhibiting reduced genetic distance. This suggests an ancient and fundamental mechanism for mate choice in sexual reproduction.
The malaria parasite uses its own messenger RNA to disrupt the host's immune system, causing chaos and evading detection. By inserting its mRNA into monocyte nuclei, the parasite jams internal communications, shutting down immune protein production and triggering an immune response that fails to detect the parasites.
Scientists identify Lockin, Sequestin, and Acb5 protein families in phages, revealing how viruses silence bacterial immune systems. These findings shed light on the importance of communication disruption in the billion-year-long war between viruses and bacteria.
Researchers discovered that the microbiome of people living with HIV differs from uninfected controls, changing in response to the progression of the infection. The study suggests that HIV affects the immune system's natural antibiotic molecules, allowing certain bacteria to thrive in the gut.
Jupiter is found to be about 8 km less wide at the equator and 24 km flatter at the poles, requiring an updated understanding of the giant planet's size and shape. This research has broader implications for studying gas planets in general and provides new insights into Jupiter's powerful winds and interior structure.
A genetic atlas of a healthy human liver at 2 microns resolution shows eight distinct regions with unique roles, differing from other mammals. The findings help explain why certain liver regions are vulnerable to diseases like fatty liver disease and liver cancer.
Researchers have discovered that ice has been gradually accumulating on the Moon's poles for at least 1.5 billion years, with ancient 'cold traps' acting as efficient ice-traps for billions of years. The study identifies regions like Haworth Crater as prime targets for future landed missions to find water ice.
Researchers from Weizmann Institute of Science and Sheba Medical Center identified two drugs with the potential to treat KLA, a rare genetic disorder affecting the lymphatic system. The study used transparent zebrafish embryos to decipher the disease mechanism and find effective treatments.
A 2,800-year-old study using Carbon-14 dating reveals that the Siloam Pool and Dam were constructed as part of a comprehensive water management system for ancient Jerusalem. The findings point to early urban planning and impressive engineering skills in addressing climate change.
A new type of supernova has been discovered, offering a rare glimpse into the depths of massive stars. The star, dubbed SN2021yfj, had lost its outer layers while still 'alive,' revealing a previously unknown inner layered structure and exposing hidden sites where heavy chemical elements are formed.
Researchers discovered that disrupted brain-liver communication due to vagus nerve dysregulation leads to damage in liver metabolism and cachexia development. Targeted blocking of the right vagus nerve prevents cachexia's development, enhances chemotherapy response, and improves overall health and survival in mice.
Researchers from the Weizmann Institute of Science and Intel Labs have developed new algorithms that allow AI developers to combine the power of different AI models, speeding up large language model performance by 1.5-2.8 times. This enables faster collaboration between models, reducing processing power costs and improving overall effi...
Researchers created a digital twin to detect disease risk, initiate preventive treatment, and simulate effective treatments. The model uses extensive human data from the Human Phenotype Project to identify deviations from expected physiological changes in 17 body systems.
Researchers propose a novel method for detecting dark matter using thorium-229 nucleus properties, with potential to detect forces 10 trillion times weaker than gravity. The new approach aims to identify minute deviations in the absorption spectrum of thorium-229 to reveal dark matter's influence.
Researchers identified a family of RNA molecules, B2-SINEs, that stimulate growth in peripheral nerves and brain neurons after injury. These findings may lead to new treatments for nerve injuries and neurodegenerative diseases.
Researchers at Weizmann Institute of Science develop innovative blood test to detect leukemia risk and diagnose age-related conditions like MDS. The test may replace invasive bone marrow sampling procedure.
Researchers at Weizmann Institute of Science discovered that nerve cells can sense mechanical forces in fat tissue, regulating brown fat activity and influencing energy balance. Mice lacking this sensing ability were resistant to obesity and metabolic conditions.
Researchers at the Weizmann Institute of Science have discovered a coordinated network of four cell types crucial for preventing immune reactions to food. This network is initiated by ROR-gamma-t cells, which temporarily suspend tolerance mechanisms to combat infection, and then resume when the threat has passed.
Weizmann Institute researchers developed a nano-MRI device with a resolution of one nanometer, allowing for the imaging of individual molecules. This technology paves the way for high-resolution molecular imaging in materials and pharmaceutical industries.
Research reveals that mouse whiskers can 'hear' the world by generating sounds that are encoded in the auditory cortex. The study shows that mice use these sounds to recognize objects, even when touch sensation is abolished.
Researchers found that silencing Mitch, a key regulator of mitochondrial fusion, increases cellular respiration and burns more fats and carbohydrates. In human cells, deleting Mitch leads to increased muscular endurance and a decrease in fat accumulation.
Researchers at the Weizmann Institute of Science discovered that dormant breast cancer cells accumulate DNA mutations and experience widespread cellular damage, leading to dormancy. Increasing OVOL protein expression can halt cancer cell lifecycle and induce dormancy, but also enables them to reawaken more aggressively.
Researchers have observed the interactions between electrons and a unique atomic vibration in twisted graphene, called a 'phason', for the first time. The Quantum Twisting Microscope has provided unprecedented insight into electron-phonon dynamics, shedding new light on superconductivity and 'strange metallicity'.
Researchers analyzed massive audio recordings to create a dictionary of short melodies in English-language prosody, assigning functions and meanings. They discovered hundreds of basic patterns with linguistic functions, including conveying attitudes such as curiosity or surprise, and identified syntactic rules governing their order.
The CombPlex technology developed at Weizmann Institute allows for the simultaneous imaging and quantification of nearly two dozen proteins within individual cells. This breakthrough enables researchers to measure lots of proteins at the same time, crucial for understanding tissue function and disease processes.
Researchers from Prof. Yardena Samuels's lab developed a new approach to cancer treatment by manipulating cancer cells to produce dozens of suspicious proteins, leading to a powerful immune response that destroys human cancer cells and slows tumor growth in mouse models.
Researchers found that male worms fail to learn from experience and prioritize risk-taking over survival. In contrast, female worms quickly learned to avoid a disease-causing bacterium. The study discovered a neural receptor responsible for this difference, also present in humans.
Researchers at Weizmann Institute create innovative method to track rapid material changes using two laser beams, enabling precise reconstruction of optical delay changes. This advance could lead to the development of fastest processors possible, increasing data transmission speed.
A new study from Weizmann Institute of Science reveals an immune mechanism involving proteasome products, which can kill bacteria and offer a promising treatment for infections. The researchers discovered that certain peptides produced by the proteasome have antibacterial properties and can be used to develop personalized treatments.
A collaborative study reveals two distinct types of scarring, referred to as “hot” and “cold,” which require entirely different treatments for diseased hearts. The researchers found that hot fibrosis is driven by an immune response, while cold fibrosis is a self-maintaining process.
Thousands of proteins rely on their tails to become successfully embedded within the cellular membrane. Researchers discovered a protein called YidC that helps short tails cross the fatty membrane, enabling functional protein-tail integration.
A new Weizmann Institute study identified all proteins in a stool sample – those from the microbiome, human body, and food – revealing secrets of the intestines and their impact on human disease. The method, dubbed IPHOMED, decodes microbiome activity by showing which proteins come from bacterial strains and amounts.
Weizmann researchers create new method to analyze dendrites in lithium-ion batteries, finding optimal composition for safe energy storage. The study reveals 'golden ratio' for electrolyte balance, extending battery life and reducing fire hazard.
In a Weizmann Institute experiment, groups of ants demonstrated superior problem-solving skills compared to human groups and individuals. Humans struggled to improve performance when working together, relying on individual calculation rather than collective strategy.
Researchers discovered that aggressive breast cancer prompts nearby immune cells to build 'molecular bridges' between themselves, suppressing the immune response. An antibody treatment that blocks these bridges was shown to restore the immune system's ability to attack with force, inhibiting tumor growth in a mouse model.
Researchers at the Weizmann Institute of Science discovered the secret recipe for colorful animal crystals, finding that two simple molecules can create a wide range of complex biological characteristics. The zebrafish was found to be an ideal model organism, with its body covered in crystals with different shapes and optical properties.
Researchers created a biodegradable composite plastic using bacteria-friendly polymers and natural crystals, making it strong, edible and cheap to produce. The material has industrial potential and can be used to manufacture various products, including airplanes and cars.