Researchers found 276 differentially methylated markers specific to lung cancer in ctDNA, with a diagnostic prediction model successfully differentiating malignancy from benign disease. The study highlights the potential of DNA methylation as a biomarker for early diagnosis of non-small cell lung cancer.
The Biophysical Society has announced the winners of its annual Undergraduate Poster Award Competition (UPAC), recognizing 10 students for their outstanding presentations. The competition, which received 74 participants, aimed to promote growth in biophysics through its annual meeting and outreach activities.
New ESO observations have reduced the likelihood of a 2024 YR4 asteroid impact on Earth in 2032 to nearly zero. The asteroid's orbit was closely monitored with multiple telescopes, and precise measurements were made using ESO's VLT, allowing astronomers to constrain its orbit and rule out an impact.
The Lunar Thermal Mapper, built by researchers at the University of Oxford, will map surface temperature and composition of the lunar surface 12 times a day. The mission aims to shed light on the lunar water cycle and guide future robotic and human missions.
Researchers identified two distinct subpopulations of human tissue chondrocytes, HTC-1 and ProFC-2, which play pivotal roles in OA pathogenesis through apoptosis and inflammation. The study also highlights homeostatic chondrocytes, a subpopulation known for its protective effects against cartilage degeneration.
The mTOR pathway is crucial in the progression of diabetic nephropathy and offers potential directions for effective treatment strategies. Excessive activation of mTOR contributes to kidney injury by inhibiting autophagy, increasing oxidative stress, and promoting inflammation.
Researchers developed a submersible robot that leverages vortices to boost efficiency in autonomous underwater vehicles. By 'surfing' vortex rings, CARL reduces energy consumption by one-fifth compared to traditional methods.
Researchers developed two silver-based bimetallic clusters that increase Faradaic efficiency and yield of urea through charge polarization modulation. Ag14Pd outperforms Ag13Au5 in NO3RR, while Ag13Au5 excels in CO2RR with higher urea formation rates.
A new study from Rice University researchers introduces a theoretical framework that quantitatively predicts menopause timing by analyzing how ovarian follicles transition through different stages. The model explains why menopause occurs and sheds light on individual variability and cross-population differences, providing insights that...
Researchers have developed a battery that can harness ambient gamma radiation to produce strong electric outputs, enabling potential applications in space exploration and sensors. The prototype demonstrated a peak power output of 288 nanowatts using cesium-137 and 1.5 microwatts with cobalt-60.
Researchers at Microsoft Quantum Lab West Lafayette advanced complex layered materials for topological quantum computing. The team accurately measured the state of quasi particles, a crucial step towards realizing a topological quantum computer.
A retrospective study found that smoking negatively affects respiratory rehabilitation efficacy in COPD patients, leading to inferior pulmonary function improvements and reduced quality of life compared to non-smokers. Non-smokers showed significant gains in exercise capacity and sleep quality post-rehabilitation.
A recent study published in JAMA Network Open has found that higher adherence to the Mediterranean diet is associated with a modest reduction in the risk of obesity-related cancers. The findings suggest that further research is needed to clarify the mechanisms by which the Mediterranean diet may contribute to cancer prevention.
A novel carbon-neutral grout, CSRGF, has been developed by recycling waste fluids from geothermal energy harvesting plants, addressing environmental challenges in traditional grouting methods. The new material shows remarkable performance, with a 50% increase in liquefaction resistance and superior water-sealing properties.
A new study found that Neanderthals experienced a drastic loss of genetic variation approximately 110,000 years ago, leading to their eventual extinction. The research measured the morphological diversity in semicircular canals, which revealed lower diversity in classic Neanderthals compared to pre-Neanderthals and early Neanderthals.
Researchers are developing in-situ optical analysis technology to improve quality control and scalability of perovskite solar film production. The goal is to enable widespread rooftop installations, estimated to be worth £250bn in the UK alone.
Preoperative anemia is a recognized risk factor for adverse outcomes in CABG, but it does not affect the long-term survival advantage associated with CABG. This study provides evidence that surgical intervention can still be beneficial for ICM patients despite preoperative anemia.
Researchers at Weill Cornell Medicine develop two strains of mycobacteria with 'kill switches' that can be triggered to stop the bacteria after they activate an immune response. The new approach aims to accelerate vaccine development and overcome safety concerns.
A new study uses advanced lung MRI to detect regional blood flow abnormalities in children and adolescents with long COVID, which may explain persistent symptoms. The researchers found reduced blood flow patterns that correlated with fatigue symptom severity, suggesting a possible biological basis for ongoing symptoms.
Increased visceral adipose tissue density and decreased skeletal muscle area are predictors of post-esophagectomy pulmonary complications. Decreased skeletal muscle density is associated with poorer overall survival. Routine morphomic analysis can help identify patients at risk and tailor perioperative care.
Researchers at UNC-Chapel Hill discovered that shaking bubbles creates a counterintuitive 'galloping' motion, allowing for controlled movement in unexpected ways. This breakthrough has significant implications for industries like cooling systems, surface cleaning, and biomedical applications.
Researchers at HZDR and TU Dresden developed a method to produce well-defined nanoparticles with controlled composition and structure, enabling the creation of complex materials with integrated functions. The team's innovative approach combined cation exchange with advanced synthetic, experimental, and theoretical methods.
A new integrated 3D imaging approach has revealed exquisite detail of the virus assembly process used by herpes simplex virus during replication. The research identified previously unknown functions of HSV-1 structural proteins and provided insights into the unmutated gene's usual role in viral assembly.
A team of scientists has developed a new method to monitor undersea sediment flows, allowing them to track the longest-runout sediment flows ever recorded. The study reveals that turbulent mixing with seawater influences the behavior of these powerful canyon-flushing turbidity currents over long distances.
The 5th International Polar Year (IPY-5) aims to study the Arctic and work towards climate solutions. Research emphasizes science diplomacy and international cooperation to address the climate emergency.
Ferulic acid significantly reduced cell viability in three human colon cancer cell lines, suppressing cell growth and migration. The compound induced cell cycle arrest and upregulated tumor suppressor proteins, suggesting its potential as a dietary strategy for colon cancer prevention.
A recent study led by Qian found that income, rather than proximity, is the dominant factor in determining who benefits most from public EV infrastructure. Wealthier individuals have more flexibility to spend time at charging stations while charging their vehicles, whereas lower-income communities struggle to integrate public charging ...
Emerging targeted therapies specifically targeting PIK3CA mutations show promise in preclinical and clinical trials, selectively inhibiting mutant PI3Kα without affecting normal PI3K activity. These novel treatments aim to overcome limitations of existing treatments by improving patient outcomes.
A follow-up study of over 20 years provides insight into the long-term effectiveness of TKA for knee disorders in a Chinese cohort, showing high prosthesis survivorship and patient satisfaction rates. The research addresses the lack of data on extended TKA follow-up for Chinese populations.
A recent study by LMU researchers has uncovered the important role of RORγt+ dendritic cells in the body's immune response. These immune cells can act flexibly, both preventing overreactions and triggering immune reactions, and their dual functionality opens the door to new treatment possibilities.
Complimentary press passes are available for NUTRITION 2025, exploring cutting-edge research on nutrition and public health. Media professionals can attend in person or access virtual newsroom materials before the meeting.
A University of Missouri survey found that 78% of nearly 500 teachers have considered quitting since the 2020 pandemic. Experienced teachers were more likely to consider leaving due to inadequate administrative support and excessive workloads.
Researchers argue that a new definition is needed to accurately describe dyslexia and provide specific support. The new definition retains the idea of difficulties with reading and spelling relative to age, ability, or educational expectations.
A University of Turku study reveals that mothers' weight and diet during pregnancy influence their child's motor skills up to age 5-6. Children of overweight or obese mothers are almost three times more likely to develop a developmental coordination disorder, highlighting the importance of healthy prenatal nutrition.
Researchers discovered synovial joints in ancient fish lineages, suggesting these features first evolved in jawed vertebrates. The study's findings shed light on the origins of humans' flexible joints and provide critical information for research into vertebrate skeletal architecture.
A new longitudinal study from Florida Atlantic University finds that students who exhibit off-putting behaviors are at elevated risk of antagonizing others and becoming involved in enemy relationships. Emotional reactivity and poor school performance are also strong predictors of later participation in an enemy relationship.
Evan Schneider, assistant professor at University of Pittsburgh, receives $75,000 grant to support her research on galaxy formation and gas dynamics. Her Cholla code, a GPU-based hydrodynamics model, has been used in early tests on exascale supercomputers.
Camille Bilodeau's project uses AI and molecular simulations to design peptide-covered surfaces for targeted applications, including new medicines, water desalination, and semiconductor manufacturing. Her research group aims to develop a rapid predictive tool to understand surface-water interactions of tethered peptides.
The review delves into genetic, epigenetic, and molecular mechanisms driving tumor metastasis, highlighting the roles of chromosomal instability, epigenetic modifications, and tumor microenvironment interactions. It also discusses the impact of specific genetic mutations and RNA modifications on metastatic behavior.
Research team develops a new design strategy to enhance efficiency, stability, and stretchability of polymer solar cells. The discovery uses a three-dimensional aromatic-core tethered tetrameric acceptor, achieving significant improvements in performance and durability.
A multi-ancestry genome-wide study has identified 16 novel Alzheimer's disease-associated genetic signals, expanding the understanding of the disease in underrepresented groups. The study aims to improve predictions of Alzheimer's disease risk and guide new treatment targets for diverse populations.
A new study warns that blood tests for Alzheimer's disease are not reliable, particularly for Black patients. The test has lower sensitivity and specificity in Black participants, leading to a higher risk of false positives.
A study by Andreas Koeberle and colleagues reveals that certain natural substances can increase polyunsaturated fatty acids in cancer cell membranes, making them susceptible to ferroptosis, a type of cell death. This discovery creates new avenues for treating therapy-resistant tumours.
A new study from Australian National University reveals that mosquitofish males' problem-solving skills boost mating opportunities due to sexual selection. Smarter males mated with more females, producing more offspring than less-intelligent fish.
Research from UVA Health and the Flo app finds that many women experience perimenopause symptoms as early as their 30s, including anxiety, depression, and physical problems. The study sheds light on the often-ignored transition period leading to menopause and aims to improve care and support for women approaching this stage.
Researchers found genetic changes not exclusive to tumours and skin patches, suggesting additional factors are necessary for tumour development. The study identified a pattern of mutations in the NF1 gene that may explain why nervous system tissues are commonly affected.
Researchers at Columbia University developed a way for robots to autonomously model their own 3D shapes using a single camera, enabling them to understand and adapt to their movements. This breakthrough allows robots to overcome damage to their bodies, making them more reliable and resilient for various applications.
A new study published in Nature Communications suggests that the water-rich iron mineral ferrihydrite is responsible for Mars' iconic red color. The research, led by Brown University researchers, analyzed data from Martian orbiters and rovers, as well as laboratory simulations, to reach this conclusion.
Researchers at MD Anderson Cancer Center have developed a novel antibody-toxin conjugate that stimulates the immune system to recognize and attack cancer cells. The new approach combines the benefits of ADCs with immunotherapies, allowing the body's natural immune response to limit side effects and prevent tumor recurrence.
New analysis of spacecraft observations and laboratory techniques reveals that Mars's red colour is better matched by ferrihydrite, an iron oxide containing water. This discovery transforms our understanding of why Mars is red and suggests that the planet rusted earlier than previously thought.
A new Emory University study reveals that childhood trauma can physically alter the hearts of Black women, leading to worse vascular function and a higher risk of heart disease. Women are more vulnerable to this effect due to different forms of trauma exposure.
Regular psychological health screening during pregnancy and postpartum may improve maternal cardiovascular health outcomes. Integrating comprehensive mental health support into perinatal care is essential to reduce adverse pregnancy outcomes and long-term cardiovascular risks.
A study found that 10% of South Asian immigrants aged 45 and older in Canada had hypothyroidism. Higher dietary intake of fat, lower consumption of fruits and vegetables, and increasing age were associated with a higher risk of the condition. Early recognition and treatment are crucial to minimize preventable health impacts.
A new survey finds that rare disease households are using technology to bridge gaps in healthcare, including telehealth options and AI tools for research assistance. These connections are crucial for coping with the stress and uncertainty of rare diseases.
A new study on non-migratory birds found that environmental variability influences life history strategies, with fast-living birds prioritizing reproduction and long-lived birds hedging against bad years. Climate change may alter the odds of these bets, posing a challenge to species' adaptability.
Researchers have discovered that commonly prescribed medications can disrupt sterol biosynthesis in developing brains, potentially affecting neural development and function. The study highlights the need for reevaluating medication safety during pregnancy and early childhood.
A new deep learning approach called HikingTTE significantly improves hiking travel time estimation by considering individual walking ability and fatigue. The model outperformed conventional techniques, reducing Mean Absolute Percentage Error by 12.95 percentage points.
A Japanese version of the Esophageal Hypervigilance and Anxiety Scale has been developed and validated for clinical use in Japan. The scale, which evaluates symptom-specific hypervigilance and anxiety for esophageal symptoms, showed validity comparable to standardized mental and physical health surveys.
Scientists successfully identified fossil filaments of sulfur-oxidizing bacteria in gypsum samples from Algeria, providing a methodological framework for detecting biosignatures in Martian sulfate minerals. This technology could be integrated into future Mars rovers or landers.
Researchers outline critical safeguards needed to balance public health benefits with Indigenous data sovereignty rights. The study highlights the risks of DNA persistence in wastewater samples, which can reveal sensitive information about community health.