Researchers explore the connection between Alzheimer's and metabolic syndrome, finding links between insulin regulation, high blood pressure, and obesity. The study suggests that maintaining healthy blood fat levels may be crucial for brain health, paving way for potential therapeutic developments.
A single-dose breakthrough: PfSPZ-LARC vaccines offer high-level protection against malaria. By leveraging genetic engineering, the vaccine harnesses weakened parasites that replicate in the liver but halt progression to the blood stage.
The research team developed a soft-actuated cuff electrode that securely encases nerves without causing damage. The electrode features a three-dimensional structure that reduces direct contact with the nerve while enhancing adhesion, allowing for accurate neural signal detection.
The article discusses the need for bioanalytical assays to measure immune responses to oligonucleotide therapeutic drugs, especially when they include carriers or conjugates. Highly specific antibodies may enhance the development and production of ONTs, expanding studies on their safety and efficacy.
The Society for Cardiovascular Angiography and Interventions (SCAI) strongly supported the creation of an American Board of Cardiovascular Medicine, but the ABMS denied its proposal. This decision is a setback for establishing cardiology as its own distinct medical specialty.
New York University physicist Glennys Farrar introduces a theory explaining the origin of Ultrahigh Energy Cosmic Rays, created through Binary Neutron Star mergers. This process generates powerful magnetic outflows and gravitational waves, providing a groundbreaking tool for understanding cataclysmic events.
New Jersey Institute of Technology biologist Xiaonan Tai receives a $1.16 million NSF CAREER Award to study how groundwater influences forest survival during climate stress, integrating ecology and hydrology perspectives.
A new study from the University of Texas at Austin finds that AI can create high-quality business plans and even critique existing strategies. The research suggests that AI can enhance the speed, quality, and scale of strategic decision-making, potentially giving companies a competitive edge and enhancing performance.
Researchers from Rice University have developed an efficient lithium extraction method using solid-state electrolyte membranes, which can separate lithium from water and other ions with near-perfect selectivity. This breakthrough could make the production of EV batteries more sustainable by reducing reliance on traditional mining methods.
A unique case study reveals an unexpected discrepancy between Alzheimer's pathology and cognitive function in a woman with Down syndrome. The study highlights the need to expand inclusion criteria for therapeutic drug trials and uncover genetic or lifestyle factors that contribute to cognitive preservation.
The Expand Appalachia project aims to accelerate the identification and characterization of unconventional critical mineral resources throughout the region. The team will assess regional infrastructure, identify industries that could benefit from production, and develop strategies to boost economic growth and attract investment.
A recent study found that COVID-19 pandemic increased SNAP benefits reduced racial and ethnic disparities in food insecurity. However, non-SNAP participants experienced no decline in food insecurity, highlighting persistent gaps in nutrition support for this vulnerable population.
Researchers created a comprehensive database of Asian body movements to analyze emotional expression. The study used motion capture technology to record performances from six professional performers, showcasing various scenarios, emotions, and personal styles.
Researchers from the University of the Basque Country have developed a hybrid supercapacitor using carbon from Pinus radiata waste, offering a cost-effective and sustainable alternative for improving conventional lithium-ion capacitors. The system stores high-power energy and can withstand many charge-discharge cycles.
Researchers found a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells. By inhibiting glucose metabolism and lactate accumulation, they eliminated the neutrophils' ability to suppress immune responses.
A recent study found that a brief consumption of highly processed foods can alter the brain's sensitivity to insulin in healthy individuals, potentially leading to obesity and type 2 diabetes. This effect was observed even after returning to a balanced diet for one week.
Researchers have developed a high-temperature successive ion layer adsorption and reaction (HT-SILAR) strategy for producing high-quality, large-particle alloyed red quantum dots. This enables the creation of highly efficient QLEDs with exceptional color purity and stability.
A new study found that Black, Hispanic, and Asian people with private insurance pay significantly more out-of-pocket for maternity care than white people. The study analyzed data from over 87,000 pregnancies and deliveries, revealing disparities in coinsurance rates and resulting costs.
Researchers highlight the need for policymakers to learn from existing multistakeholder forums and implement 'real-world' changes to reduce greenhouse gas emissions and promote equity in Vietnam's food systems. The study suggests a holistic, cross-sectoral approach is necessary to address the issue.
Long non-coding RNAs (lncRNAs) play a critical role in metabolic and fibrotic pathways, influencing lipid metabolism, inflammation, apoptosis, and fibrogenesis. Targeting pathogenic lncRNAs or enhancing protective ones may provide a dual approach for MASLD treatment.
Copper-incorporated microvesicles promote healing, reduce inflammation, and enhance cell growth, offering a multifaceted solution for addressing dental diseases. The technology has vast implications for various fields of medicine, including wound healing and regenerative therapies.
A study developed by the US Department of Energy's Thomas Jefferson National Accelerator Facility aims to lower data center costs using machine learning. The Digital Data Center Twin (DIDACT) system detects anomalies and diagnoses their source using AI continual learning, reducing downtime for scientists processing data from experiments.
A new genetic testing technique is being developed to help young cancer patients receive more targeted and less toxic treatments. The test analyzes DNA released into the bloodstream by cancer cells, offering a less invasive way to monitor tumor progression and identify new treatment targets.
A gene therapy treatment has demonstrated significant promise in treating maple syrup urine disease (MSUD), a rare genetic disorder. The therapy prevented death and normalized growth in animal models, including a calf with the condition, and is being explored for potential use in humans.
A new study from Arizona State University sheds light on the relationship between hormones cortisol and testosterone and PTSD in a non-industrialized society. Researchers found that men with PTSD had lower testosterone levels when waking up compared to those without PTSD, but similar cortisol patterns.
Researchers explored the behavior of CFRP/UHPC-strengthened concrete beams under thermocyclic loading, finding increased uncertainty with drift ratio increases. The study proposed performance degradation factors to estimate energy dissipation capacity, aiding practical design and decision-making.
A study in Ghana found that babies are exposed to multiple languages from birth and receive direct and indirect input, challenging traditional views of multilingualism. The research highlights the importance of diverse linguistic environments in shaping children's language development.
Researchers developed an AI-driven approach to detect micro-expressions in ASD movies, achieving remarkable improvements in recognition accuracy. This innovative method provides clinicians with an objective tool to detect subtle emotional cues, enabling earlier and more accurate diagnoses.
A recent study published in JAMA Network Open reveals that using race-neutral lung function equations can identify more Black children with reduced lung function and increase asthma diagnosis rates. This is crucial as under-diagnosis can lead to delayed treatment and long-term health issues.
The Rice team created a low-cost, pump-free flow cytometer that uses gravity-driven slug flow to analyze cells with similar accuracy as conventional devices. The device is powered by AI and can count specific immune cells from unpurified blood samples within minutes.
The American Board of Cardiovascular Medicine strongly disagrees with the American Board of Medical Specialties' denial of its application to establish an independent board for cardiology. The ABCVM believes that a separate board is necessary for sustaining professional excellence and effectively caring for cardiovascular patients.
A recent study examines the correlation between different transmission-risk metrics and environmental factors in indoor spaces. The research found conflicting outcomes among five metric types, emphasizing the need to consider facility type and disease nature when evaluating non-pharmaceutical interventions.
Vacuum glazing technology shows great potential in improving thermal performance and reducing energy consumption in buildings. The review article highlights various fabrication methods, support pillar arrangements, and composite structures that contribute to its energy-saving benefits.
A McMaster University research team identified several small molecules in blood that inversely associate with developmental outcomes. The study highlights the complex connections between diet, gut health and a child's growth and cognitive milestones.
Researchers at University Hospitals Seidman Cancer Center have successfully repurposed fenofibrate, a cholesterol drug, to treat HPV+ cancers. The study found that fenofibrate restores the function of key tumor suppressor gene p53 and reactivates immune cells, offering a potential targeted therapy for these cancers.
The University of Illinois researchers have developed organic-material-based nanozymes that can detect histamine in food products with an affordable analytic performance profile. An integrated point-of-use platform allows for rapid detection of agricultural and biological molecules without laboratory equipment.
Hepatic biliary adenofibroma (BAF) is a rare, benign tumor with histological characteristics distinct from other biliary tumors. Emerging case reports suggest potential for malignant transformation and overlap with intrahepatic cholangiocarcinoma (iCCA), highlighting diagnostic challenges and need for further research.
The first draft of Italy's National Strategy for Quantum Technologies is available online for public consultation. The strategy aims to strengthen the country's position in quantum technologies, with contributions from research experts and stakeholders.
A research team at the University of Cologne has identified a specific form of the tau protein, 1N4R, responsible for mediating toxic effects of protein clumps in human brain cells. This breakthrough understanding could lead to new treatments for Alzheimer's disease.
The Texas Tech University Health Sciences Center is conducting a randomized controlled trial to investigate the effectiveness of calcium and vasopressin in treating severely injured patients who experience significant blood loss. The study, known as CAVALIER, will enroll approximately 1,050 participants aged 18-90.
A new framework combines machine learning and blockchain to boost security, protecting data and computations. The MLOB framework achieves significant security enhancements while maintaining accuracy.
Scientists at St. Jude Children's Research Hospital have uncovered the mechanism by which retinoic acid selectively kills metastatic neuroblastoma cells, using a novel pathway to trigger cancer cell death. The findings have implications for future combination therapy approaches.
Dr. Paul Armsworth, a Distinguished Service Professor at the University of Tennessee, has received the SEC Faculty Achievement Award for his outstanding contributions to teaching, research, and service. His interdisciplinary approach to conservation biology bridges ecological and economic dimensions, considering public support for cons...
Differences in coinsurance rates associated with racial and ethnic disparities in out-of-pocket spending for maternity care. Changes to health plan benefit design could improve equity in maternal healthcare access and outcomes.
A recent study identified capacity gaps as a significant barrier to sustaining SNAP-Ed programs in schools. Designating school-community partnership coordinators and tailoring solutions to unique community needs can enhance program sustainability.
SLC transporters contribute to the development of hepatic steatosis by regulating lipid metabolism, particularly with SLC2A2, GLUT4, and GLUT5. These proteins influence processes like de novo lipogenesis and insulin resistance in hepatocytes.
The collaboration aims to close gaps in early recognition and management of IPF by equipping healthcare providers, public health professionals, and patients with necessary resources. The organizations will employ designated activities to build a knowledge base, develop survey tools, and create educational and awareness assets.
Ursodeoxycholic acid (UDCA) exhibits a broad range of hepatoprotective mechanisms, including antioxidant, anti-inflammatory, and anti-apoptotic properties, which may benefit various types of drug-induced liver injury. In hepatocellular DILI, UDCA reduces inflammation, alleviates ER stress, and protects against mitochondrial damage. In ...
Researchers modelled mantle convection to show African LLVP has older, better mixed material than Pacific LLVP, which is enriched in subducted oceanic crust. This difference affects heat extraction from Earth's core, posing a challenge for observations and models.
A recent study by Columbia University School of Nursing researchers found that primary care practices with nurse practitioners (NPs) are more likely to serve socioeconomically disadvantaged communities. Practices with NPs were also more common in low-income and rural areas.
Scientists have identified a new target to prevent cold sores by understanding how the herpes virus triggers its own immune response. The discovery has important implications for genital herpes caused by the same virus, with potential treatments in development.
A Cornell University study found that people who go against their better judgment feel greater feelings of control and culpalibility, even if they received input from an adviser. This effect may extend beyond small decisions to major life choices.
Researchers propose unified framework to map complex interactions within aeroengines and simulate dynamic changes. The new approach offers more objective, interpretable, and dynamic way to evaluate engine performance.
Scientists have identified key corneal neurons involved in sensitivity and developed an experimental model to study nerve regeneration. The Ocular Neurobiology laboratory is participating in the RESTORE VISION project, which aims to improve eye health and quality of life for those affected by rare eye diseases.
The study reveals that lysine lactylation plays a crucial role in regulating cardiac tissue development, particularly in energy metabolism and cell cycle regulation. The research identifies histone 4 lysine 12 lactylation (H4K12la) as a vital upstream regulatory element that influences downstream gene expression.
Researchers found that terrestrial snakes on Sado Island coexist by differentiating their activity time, habitat, and diet. Niche complementarity among species with overlapping food resources reduces overlap in other dimensions.
A recent UPV/EHU study reveals that ChatGPT use and plagiarism are linked to factors like student motivation and cultural norms, not just tool usage. The research found that 30% of dishonest behavior can be accounted for by these variables.
Tom Maniatis, a prominent molecular biologist, is warning of the impact of the NIH's planned 15% cap on indirect costs. He believes small independent institutions will be harmed, stifling technological innovation and scientific progress. The scientific community must act swiftly to prevent this from happening.
Researchers at Ohio State University developed an e-Taste system that uses sensors and chemical dispensers to simulate various tastes. In field testing, participants could distinguish between different sour intensities with high accuracy, paving the way for immersive virtual food experiences.
Researchers found significant concentrations of persistent organic compounds in lichens and mosses in the Irati forest, exceeding those in similar environments. The study suggests that urban and agricultural practices have impacted local air quality, emphasizing the need for controlling combustion processes to reduce PAHs.