Researchers have identified an experimental molecule called OLE that can restore part of the brain's protective function against Alzheimer's disease. The compound helps microglia enclose and contain beta-amyloid plaques, reducing their size and toxicity.
Researchers have identified an experimental molecule called OLE that helps restore microglia's protective function against Alzheimer's disease. The compound reduces beta-amyloid plaque size and toxicity, improving cognitive performance in memory tests.
A new simulation- and AI-based approach reduces the time and data needed for brain MRI scans, achieving a high level of accuracy with only 10% of the data required. This breakthrough could translate to a significant reduction in scan time, enabling more patients to be treated in the same amount of time.
High-intensity interval training shows strongest vascular benefits in cardiovascular patients. HIIE consistently improves flow-mediated dilation and vasodilation, with combined high-intensity programs showing the largest estimated effects on endothelial function.
A team of researchers has identified a key mechanism in the degeneration of motor neurons in ALS, revealing that chaperone-mediated autophagy is significantly reduced in patients. This finding suggests that this cellular system may be a potential therapeutic target to slow disease progression.
Adolescents who follow social media tipsters report higher gambling intention and increased frequency. The study highlights the need for stronger regulation of tipster-related marketing and media literacy programmes to address persuasive strategies and improve risk awareness.
Researchers have identified the Prrx1 gene as a key regulator of metastatic potential in breast cancer tumors. This discovery helps explain why highly invasive cells do not always give rise to metastases, and how cells combine invasiveness and proliferation to become the most dangerous from a clinical perspective.
Researchers discovered a crucial connection between the two hippocampal hemispheres in mice, which is necessary for navigation and remembering locations. The study also found that this circuit is altered in mice carrying a genetic mutation associated with schizophrenia.
A study reveals dermcidin, a human body natural molecule, exhibits antiviral activity against the influenza virus. Higher baseline levels of dermcidin in individuals who don't develop flu-like symptoms may be associated with lower susceptibility to infection.
A study published in Cornea reveals that aniridia not only alters corneal structure but also affects sensory nerve function, leading to a progressive decline in corneal sensitivity. In adulthood, patients experience difficulty distinguishing stimulus intensity and reduced tear production, compromising eye defense mechanisms.
Researchers have identified a molecular mechanism that regulates the slow and sustained release of oxytocin within the brain, which is essential for modulating social interactions. This finding provides new insights into how hormonal signaling is regulated in the brain and opens avenues for research into neuropsychiatric disorders.
A hierarchical 3D LiDAR localization method improves robot positioning in large outdoor spaces even after seasonal changes. The method integrates deep learning techniques to extract discriminative local features from 3D point clouds, making it robust to environmental variability.
Chronic alcohol consumption alters endocannabinoid gene expression in reward- and decision-related brain regions, offering insights into addiction biology. This study reveals changes in CB1 and CB2 receptor genes, as well as GPR55 and FAAH enzymes, potentially leading to targeted therapeutic strategies.
A blind patient partially recovered natural vision through electrical stimulation of the visual cortex, independent of the implant. The recovery was sustained over time and remained even after the device was removed, suggesting individual factors may have contributed to this outcome.
A preclinical study shows that cannabidiol restores emotional behavior, reduces alcohol-related vulnerability, and reverses gut microbiota alterations caused by prenatal alcohol exposure. Female mice particularly benefited from CBD treatment, which normalized their emotional alterations and eliminated vulnerability to alcohol addiction.
Researchers have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis. Blocking the PAF-R receptor can help rebalance immune and inflammatory responses within the liver.
Researchers found that the skin relies on TRPM8 sensor for cold detection, while internal organs primarily use TRPA1 sensor. This difference explains variations in external and internal cold perception, and has implications for understanding thermal homeostasis and pathologies related to cold sensitivity.
A team of researchers has reconstructed how the cerebellum establishes its connections with the rest of the brain during earliest stages of life. The work describes the phases in which these neural connections emerge, expand, and are refined, offering a comprehensive map of cerebellar projections across the mouse brain.
Researchers identified a molecular mechanism linking early-life environments with memory by activating AP-1, which regulates genes involved in neuronal plasticity and learning. Early-life experiences produce long-lasting modulation of AP-1 activity, boosting gene networks that strengthen neuronal connections.
A new compound MCH11, a monoacylglycerol lipase inhibitor, shows promising effects in reducing alcohol consumption and motivation to drink in mice. The molecule exhibits anxiolytic and antidepressant properties with sex-dependent efficacy, correcting genetic alterations associated with alcohol use disorder.
Spanish researchers at UMH have developed a new generation of visual neuroprosthesis capable of bidirectional communication with the cerebral cortex. The system uses a small external camera to capture images, which are processed electronically and converted into electrical stimulation patterns sent to the occipital cortex. Participants...
The superior colliculus, an ancestral brain structure, enables the brain to distinguish objects from the background and detect relevant stimuli in space. It generates centre–surround interactions independently, allowing for the detection of contrasts, edges, and salient features.
Researchers have developed a blood test that detects Parkinson's disease by analyzing the activity of immune cells. The study found 22 genes whose expression was altered in patients with Parkinson's, suggesting potential diagnostic markers and insights into the disease's mechanisms.
A topical formulation has been shown to reduce the incidence of hand-foot neuropathy in cancer patients undergoing chemotherapy, improving quality of life. The cream, developed at UMH, acts directly on neurosensory pain receptors, reducing hypersensitivity and tolerance to chemotherapy.
A new study by Universidad Miguel Hernandez de Elche researchers reveals that brain slow waves are guided by neuronal excitability, not anatomy. The discovery uses advanced computational models to analyze local and global brain activity, shedding light on states like deep sleep and anesthesia.
The brain chooses routes to process information by adjusting balance between slow (theta) and fast (gamma) rhythms, enabling flexible adaptation to context and cognitive demands. This flexibility allows the brain to select different sources of information, such as sensory stimuli or stored memory.
A new review in Microbial Biotechnology highlights microbes as allies in various industries, from food fermentation to biofuels. Films such as French Kiss and The Martian showcase microbes as positive forces, challenging the traditional villain stereotype.
The study reveals that enzymes KDM1A and KDM5C collaborate to prevent neurons from activating inappropriate genes, ensuring their proper function. This discovery opens new avenues to understand the origin of neurological disorders associated with intellectual disability.
Scientists have identified the mechanism linking a mutation in the Shank3 gene with alterations in social behavior, revealing that vasopressin plays a crucial role in regulating sociability and aggression. The study shows that targeting specific vasopressin receptors can restore social abilities without affecting aggression.
A specific group of neurons in the amygdala has been identified as a key player in anxiety, depression, and altered social behavior. Restoring balance to this area can reverse these behaviors in mice.
Researchers have identified genetic bottlenecks that explain the emergence of pandemic cholera strains. These specific combinations of genes and allelic variants grant an advantage in human intestinal colonization, allowing a small subset of Vibrio cholerae to become deadly pathogens.
A new study reveals how nymphaeol A, a bioactive compound in propolis, behaves within complex biological membranes. The molecule spontaneously inserts into the membrane, altering its structure and increasing fluidity, which may enhance its therapeutic effectiveness.
A study by the CSIC-UMH Institute of Neurosciences uncovers how flies' flight stabilizers, the halteres, take shape. The structure is stabilized by a sophisticated cellular system that connects its two surfaces through an internal framework.
A study by Universidad Miguel Hernandez de Elche found that sexual victimization occurs in approximately 20% of Spanish gamers, while hate-motivated incidents affect 20-30% of players. The research highlights the need for game developers to implement preventive measures and user protection tools.
A new mathematical model helps European policymakers reduce gender disparities by setting customized educational targets. On average, women outperform men in three of four indicators, with the largest gap concerning tertiary attainment.
A new method, CIBA, enables safe delivery of stem-cell-based treatments directly into the lungs of ECMO-supported patients. The technique has been proven to be well-tolerated and has shown potential for treating end-stage interstitial lung disease.
A study reveals widespread overlap between feeding grounds for seabirds, marine mammals, and regions with high wind potential. Researchers propose developing risk maps to predict conflicts and recommend expanding marine protected areas and strengthening spatial planning tools.
Researchers identified a conserved splicing mechanism controlling the production of different proteins from the same gene, crucial for neuronal function and development. The study sheds light on how neuronal identity is established and maintained through alternative splicing.
Researchers have discovered that the developing brain can reorganize its sensory maps in response to the absence of sensory stimuli from birth. The study found that the thalamic region adapts a genetic profile similar to that of the affected area, enabling cortical reorganization and functional changes.
Scientists have identified key corneal neurons involved in sensitivity and developed an experimental model to study nerve regeneration. The Ocular Neurobiology laboratory is participating in the RESTORE VISION project, which aims to improve eye health and quality of life for those affected by rare eye diseases.
A new study reveals the extreme vulnerability of young volcanic soils to wildfires in the Arequipa shrublands of Peru. The research found that vegetation and soil combustion, combined with post-fire erosion, have caused a severe loss of soil organic carbon, hindering ecosystem recovery.
Researchers at UMH develop a mathematical model with three allocation rules to improve revenue sharing on streaming platforms. The model aims to address the issue of opaque revenue distribution, prioritizing creators' needs and promoting fairness.
A new study reveals that microglia can be reprogrammed from a tumor-promoting state to one that strengthens antitumor responses, reducing brain metastases growth and enhancing immunotherapy responses. Researchers identified a key signaling pathway that, when blocked, reverses the protumoral function of microglia.
A team of experts has discovered that the ARID1A gene regulates a critical genetic program for cell migration, with ZIC2 identified as a crucial regulator in this process. This study expands our understanding of craniofacial development and provides valuable insights into the genetic causes of congenital diseases.
The study found decreased NMDA receptors in synapses and increased extrasynaptic membranes in Alzheimer's patients, suggesting neuronal toxicity-related activity. The novel protocol allows for precise analysis of these receptors in human postmortem brains, paving the way for new therapeutic approaches.
Researchers from Universidad Miguel Hernandez de Elche found that bisphenol analogs BPF and BPS, marketed as safer alternatives to BPA, accumulate in biological membranes and disrupt endocrine function. The study suggests these compounds pose health risks similar to those of BPA.
The international project will analyze temperature-sensitive proteins in animals adapted to different thermal environments to understand how they perceive temperature changes. The study aims to uncover the molecular mechanisms underlying cold perception in animals, enabling them to initiate physiological responses crucial for survival.
A recent study published in Nature Cancer has discovered that cancer cells exhibit opposing pro and antitumor programs, with the former promoting metastasis and the latter combating tumor growth. This finding opens new avenues for therapeutic strategies to target highly aggressive and therapy-resistant tumors.
Researchers at the Plasticity and Remodeling of Neural Circuits laboratory aim to stimulate myelin plasticity to regenerate affected nerve fibers in MS patients. The team will explore gene therapy, pharmacological approaches, and rehabilitation strategies to enhance myelin repair.
Scientists have successfully sequenced the genome of the spur-thighed tortoise, a threatened land turtle species, using a reference assembly method. The genome sequencing will enable conservation efforts and provide tools for protecting the species' populations.