Phyton Biotech has successfully transferred the manufacturing process for Corallopyronin A (CorA), a novel anti-infective agent with potent activity against filarial infections and bacterial infections. The technology transfer marks an important milestone in the Company's specialty GMP fermentation capabilities.
A new study from Queen Mary University of London finds that species turnover in ecosystems has significantly slowed down despite accelerating climate change. This slowdown is attributed to environmental degradation and the depletion of regional life pools, suggesting a loss of momentum in biodiversity.
Researchers identified interferon regulatory factor 7 (IRF7) as a central regulator of smooth muscle cell plasticity in atherosclerosis. This transition accelerates plaque growth and destabilization, offering new insight into the risk of plaque rupture and cardiovascular events.
The partnership aims to develop next-generation mRNA vaccines with enhanced stability and targeted delivery, providing broader protection against emerging pathogens. This collaboration combines Ethris' mRNA technology platforms with DZIF's vaccine research expertise to accelerate the development of variant-ready vaccines.
Researchers developed a blood-based DNA marker called protein epiScores to predict colorectal cancer recurrence and survival. Four markers were linked to increased risks of recurrence and death, with one marker associated with an 80% higher risk of death.
A new study reveals that China's construction sector is a significant driver of premature deaths due to ambient fine particulate matter (PM2.5) exposure. The research estimates that around 1.1 million premature deaths were caused by construction-related emissions in 2019.
A new study examines the economic and social legacies of historical exploitation, arguing that institutional reform, cultural restoration, and fairer international relationships are needed to address ongoing inequalities. The research frames reparations as a tool for long-term structural change, linking historical accountability to cur...
Research reveals that children and adolescents with juvenile fibromyalgia exhibit heightened sensitivity to sounds, bright lights, and multisensory stimulation. This hypersensitivity is closely tied to the disease's severity and brain function, providing new insights into its mechanisms.
Researchers have developed a planar micrometre-scale zinc–air battery that operates in a safe, near-neutral gel electrolyte, delivering high energy and power. The breakthrough enables the integration of onboard power sources into chip-scale systems, enabling fully autonomous micro-devices.
A study found that only planets with medium-level oxygen conditions during core formation can retain essential elements phosphorus and nitrogen, necessary for life. This limits the number of potentially habitable planets, as most solar systems have stars with different chemical compositions.
According to the latest ECDC report, 7,655 measles cases were reported across 30 countries in 2025, with eight fatalities. This represents a significant decrease from 35,000 cases in 2024 but is still almost double the number of cases in 2023.
The North American wild mountain sheep is losing its habitat to industrial mining, human activity, and climate change. The book highlights the risks faced by this species, which nearly collapsed in previous decades but now faces grave risks from disease and habitat loss.
Research evaluates various scaled decentralized system configurations, demonstrating their potential to outperform centralized systems in environmental sustainability. Carefully designed SDSs offer a sustainable pathway for wastewater management in dense cities by integrating treatment and local resource recovery.
Research team led by biologist Joost Woltering discovers how ancient genes from fish midline fins were 'redeployed' to establish the dorsal-ventral axis in human limbs, allowing for complex limb differentiation and adaptation for life on land.
A team of researchers led by Yoshiteru Maeno used magnetic resonance based on muons to investigate the superconducting state of strontium ruthenate. They discovered that the material exhibits spin-singlet superconductivity, which provides crucial insights into the behavior of unconventional superconductors.
Researchers from URV discovered that ultrasound can characterise visceral fat with high accuracy, a determining factor in metabolic risk. The study found a correlation between elevated visceral fat levels and the presence of prediabetes and metabolic syndrome.
Chronic ephedrine exposure disrupts brain development and behavior in adult fish, causing changes in locomotion, anxiety-like responses, and learning performance. Transcriptomic and neurochemical analyses reveal widespread molecular disruptions, including impaired synaptogenesis and neurotransmitter balance.
Research finds that deep-sea organisms can access nutrients from sinking organic particles under intense hydrostatic pressure. This discovery has implications for the global carbon cycle and climate processes.
Researchers found that when pancreatic tumors touch the superior mesenteric vein, patients who undergo surgery first experience reduced survival rates. In contrast, those who receive chemotherapy before surgery have similar survival outcomes to those with non-vein touching tumors. The study suggests reclassifying tumors based on vein i...
CAR T-cell therapy is now available for eligible primary CNS lymphoma patients, thanks to Dana-Farber-led research. The FDA label update removes a prior exclusion and may expand treatment options for relapsed or refractory patients.
A new study found that strength training is the most effective tool for achieving 'high-quality' weight loss, reducing body fat while preserving and even increasing muscle mass. This type of exercise also reduces waist circumference, a key indicator of abdominal obesity and cardiometabolic risk.
A landmark study of nearly 1.2 million infants suggests that a vegan or vegetarian diet does not compromise infant growth by age two. The research found that infants from plant-based households follow growth trajectories nearly identical to their omnivorous peers, providing reassuring evidence for parents and pediatricians.
A team of scientists experimentally demonstrated deterministic entanglement-assisted quantum communication over 20.121 km in fiber channels, outperforming classical communication in metropolitan areas. They proposed an improved continuous-variable dense coding scheme to enhance transmission efficiency and reduce excess noise.
The REST-COAST project has developed a mobile app, My REST-COAST, to raise public awareness and engagement in coastal ecosystem restoration across Europe and Israel. The app provides interactive maps, site-specific biodiversity information, and gamified learning paths to encourage users to explore restoration strategies.
A study by NYU School of Global Public Health found that anxiety about aging contributes to accelerated epigenetic aging, with greater concern about declining health having the strongest association. This can lead to physical decline and increased risk of age-related diseases.
Researchers at KAIST have identified a new principle for catalyst design that allows ceria to selectively use different oxygen sources depending on the reaction environment. By adjusting the size of the catalyst, it can choose whether to use oxygen from the air or store it internally.
A recent study found that China's water-supply carbon emissions rose to 228 Mt CO2 by 2022 due to increased reliance on energy-intensive water sources. The research emphasizes the need for low-carbon alternatives and integrated governance to address the water-energy-carbon nexus.
The IPK research team developed a prediction model using large datasets, genomic markers, and environmental information to forecast wheat yield in specific locations. The model achieved improvements of up to 23% in predicting new hybrid performance, similar to getting a tailored suit that fits the environment.
Researchers propose a multi-channel TDC with Physically Unclonable Function (PUF) to generate unique fingerprints of ICs. This approach addresses security concerns in programmable devices and offers improved performance and lower cost.
A major study has shown that tumour stage at diagnosis is strongly linked to childhood cancer survival across six different cancers. Researchers analysed data from 9,883 children in 27 countries and found significant variation in three-year survival rates between regions, particularly in the UK and Ireland.
A new study found a combination of genetic, environmental, microbial and social factors influence childhood food allergies. Early-life factors like skin health, microbiome, and environmental exposures increase the risk of developing a food allergy by age six.
A research team created a novel low-viscosity organic-inorganic hybrid resin with high silica content and demonstrated glass 3D printing at significantly lower temperatures than traditional sintering. The new method reduces cracking and warping, enabling transparent silica conversion at 650–700 °C.
The surge in glacier tourism poses significant pressure on vulnerable ecosystems and local communities. Experts highlight the need for balancing tourism with conservation, awareness, and social equity to prevent maladaptation strategies from spreading.
A recent study by Brown University researchers found that Medicare's 'three-day rule' keeps patients in hospitals longer than needed without improving health outcomes or lowering Medicare costs. The reinstatement of the rule resulted in at least 2,000 additional hospital days.
A cross-sectional study investigates the effect of a smartwatch feature that alerts users about high blood pressure, impacting a significant portion of U.S. adults without diagnosed hypertension. The study reveals that nearly 1 in 5 participants received notifications and subsequently sought medical attention.
Scientists have discovered a network of interconnected microbiomes that span the globe, with certain 'generalist' microbes thriving in diverse habitats. These microbes facilitate the transfer of genes, creating connections between geographically distant habitats and exacerbating antimicrobial resistance.
A large prospective cohort study found that consuming 2-3 cups of caffeinated coffee daily or 1-2 cups of tea daily reduced dementia risk, slowed cognitive decline, and preserved cognitive function. Caffeine was identified as the active factor producing these neuroprotective results.
As glaciers shrink, they're drawing visitors for their beauty and symbolic meaning in a warming world. The study highlights both emotional responses and tensions between conservation, livelihoods, and environmental responsibility.
A global study found that a group of bacteria, CAG-170, consistently appeared in high numbers in the gut microbiomes of healthy individuals. This species has the capacity to produce Vitamin B12 and break down carbohydrates, suggesting it plays a crucial role in maintaining human health.
A study published in JAMA found that higher consumption of caffeinated coffee and tea is associated with a reduced risk of dementia. Moderate intake levels showed the most pronounced association, with better cognitive function also observed.
The study found that a novel subset of white blood cells becomes infected in the lung and produces type 1 interferon, which triggers cardiac damage. A modified mRNA treatment was shown to mitigate cardiac damage while preserving the immune system's protective response. The research offers great promise for developing new therapies to p...
Research highlights increased mortality risks among individuals with autism spectrum disorder, intellectual disability, or cerebral palsy compared to the general population. The study's findings can inform public health strategies to address health disparities and excess mortality associated with developmental disabilities.
A meta-analysis of childhood food allergy risk factors reveals a combination of major and minor factors, including genetics and antibiotic exposure. The study provides insights into the complex interplay of these factors in the development of food allergies in infants and children.
A new analysis found that wearing an Apple Watch with hypertension notifications can increase the probability of having hypertension in younger adults, while decreasing it in older adults. The study also revealed racial and ethnic disparities in cardiovascular health, highlighting the need for targeted screening and treatment.
A cross-sectional study of 4,043 registered nurses found that nonretired RNs are likely to return to work if hospitals address organizational issues driving them away. The top factors increasing their likelihood of returning were adequate staffing, flexible scheduling, and better wages or benefits.
The Horizon Europe project B-Cubed is offering a training series to turn raw biodiversity records into policy-relevant indicators using emerging tools and workflows. The six live sessions will empower researchers, policymakers, and conservation practitioners with practical skills for biodiversity data analysis.
Researchers found that chatbot-generated summaries changed sentiments in 26.5% of cases and hallucinated answers 60% of the time. Participants who read biased summaries were 84% likely to buy, compared to 52% for original reviews.
A study reveals that two key proteins, TSP1 and TSP2, play a central role in shaping the healing environment after injury, leading to abnormal bone growth. The findings suggest targeting these proteins may reduce harmful bone formation without interfering with healthy development.
A new genetic study found that domestic pig maternal lineages accelerated genetic turnover in wild boar populations after the Fukushima nuclear accident. This mechanism, likely occurring in other regions where feral pigs and wild boars interbreed, has practical implications for managing invasive species.
Scientists found that tumor-promoting fibroblasts attract nerve fibers through a vicious cycle of signaling and neurotransmitter release. This cycle promotes pre-cancerous growth and pulls in more nerve fibers, leading to a self-reinforcing loop. Disrupting this cycle may lead to new therapies for pancreatic cancer.
A randomized clinical trial found that time-restricted feeding reduced Crohn's disease activity by 40% and halved inflammation in adults with the condition. Participants practicing intermittent fasting also showed notable improvements in blood markers of inflammation and immune health, including lower levels of leptin.
Researchers developed simple DNA-based lateral flow assays for detecting feline parvovirus (FPV) and canine parvovirus (CPV) in pets. The tests demonstrated 100% sensitivity and reproducibility, enabling early identification of infections.
Researchers found that PSMA PET/CT scans can help guide treatment planning and improve long-term outcomes for patients with recurring prostate cancer. The study suggests that incorporating these scans into routine care may lead to better results and reduced side effects.
Researchers at Case Western Reserve University identified a link between gut bacteria and neurodegenerative diseases like ALS and FTD. They discovered that certain bacterial sugars cause immune responses that kill cells, paving the way for new treatments.
A new report by the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) emphasizes the critical role of businesses in halting and reversing biodiversity loss. Businesses can either drive transformative change or risk extinction, as they rely on and impact nature. The report provides methods and 100+ actions for bu...
A new software tool developed by MIT researchers can reliably and finely resolve eight distinct nerve bundles in live diffusion MRI scans, shedding light on neurodegenerative diseases like Parkinson's and Alzheimer's. The BrainStem Bundle Tool (BSBT) reveals distinct patterns of structural changes in patients with these conditions.
A 20-year follow-up study found that adults who completed cognitive speed training were less likely to be diagnosed with dementia, including Alzheimer's disease. The study, which included 2,802 participants, showed a 25% reduced incidence of dementia in the speed-training group compared to the control arm.
A new online tool provides information and tools for clinicians to respond to emerging patient care needs, enhancing trauma-informed healthcare for individuals with C-PTSD. The resource was co-developed by researchers and survivors, aligning with best practices and patient-centered research.
Dr. Paul Donlin-Asp will investigate the molecular functions and regulation of local SYNGAP1 protein synthesis, aiming to advance therapies for SYNGAP1-related Disorders. The project seeks to map mechanisms controlling SYNGAP1 protein production in neurons.
Researchers quantify interactions of P407 micelles in PBS to understand gelation behavior and release mechanisms. The study reveals stronger attractive forces between micelles in saline, affecting gel stability and structural fluctuations.
Researchers discovered that only observing the flow down to a specific scale is enough to reconstruct the full motion of fluid in two-dimensional turbulence, unlike three-dimensional systems. This finding has significant implications for modeling and prediction in atmospheric and ocean circulation.
A team from the University of Trento has identified an empty subsurface lava tube beneath Venus' surface, estimated to be approximately one kilometer in diameter and 375 meters deep. The discovery was made possible by analyzing Magellan's radar images and provides new insights into Venus' volcanic processes and geology.
A team of researchers used spectral data from the James Webb Space Telescope to study the HR 8799 star system, finding clear evidence of sulfur on three gas giant planets. This discovery suggests that these massive planets likely formed through core accretion, contradicting older models.
A new study published in Nature Communications found that people are more willing to help others when they experience poorer conditions. The researchers tested willingness to help in different contexts and found that people were more likely to stop what they were doing to help others in a poor environment than in a richer one.
Researchers are recruiting adults for a five-week study to accurately track their diets using wearable cameras, blood monitoring devices, and metabolomic analysis. The goal is to find reliable ways to measure diets, paving the way for better public health strategies to tackle diseases linked to poor diets.
Researchers at Stanford University developed a new method to quantify energy costs in non-equilibrium processes using machine learning and extremely small nanocrystals called quantum dots. This technique can determine the ultimate speed limits for devices or how efficient they can be.
More than 1,000 institutions have joined MDPI's Institutional Open Access Program (IOAP), spanning 59 countries. The agreements provide streamlined submission processes and discounted Article Processing Charges, increasing accessibility for global research communities.
A study found that historical redlining has a lasting impact on breast cancer survival, with disparities narrowing from 1995-2014 but increasing in 2015-2019. Redlining-associated mortality disparities were mostly seen in patients with less advanced tumors.
Chronic alcohol consumption alters endocannabinoid gene expression in reward- and decision-related brain regions, offering insights into addiction biology. This study reveals changes in CB1 and CB2 receptor genes, as well as GPR55 and FAAH enzymes, potentially leading to targeted therapeutic strategies.
Researchers discovered that brief intermittent intense exercise is a more effective treatment for panic disorder than relaxation therapy. The 12-week program showed significant reductions in Panic and Agoraphobia Scale scores, anxiety, depression, and panic attack frequency and severity.
A new guideline published in CMAJ advises hospitals to implement 21 recommendations to increase environmental sustainability in operating rooms. The guidelines include reducing energy use, using reusable devices, developing recycling programs, and rethinking disposal of unused supplies.