Researchers discovered that melanoma cells employ 'frameshifting' to starve themselves of tryptophan, a key amino acid needed for protein production. This process allows cancer cells to survive and evade T cell attacks.
Weizmann Institute of Science researchers create framework to map smells based on molecular structure, enabling prediction of scent similarity. The system, developed by neurobiologists, computer scientists, and a master perfumer, can digitize and reproduce smells on command.
Researchers at the Weizmann Institute of Science reveal retrons, hybrid structures found in many bacterial species, are 'guards' that prevent viruses from spreading. These retrons activate a programmed cell death mechanism to protect the bacterial colony.
Acute liver failure is a rapidly progressing disease with an 80% mortality rate. Researchers identified three new subsets of liver cells that contribute to the condition's development, as well as signals from the gut microbiome. Selectively blocking these signals and depleting the microbiome led to marked improvement in liver function ...
Researchers at Weizmann Institute of Science identify key molecule regulating biomolecular messaging in nerve cells, which plays a role in chronic pain. Targeting this molecule, importin alpha-3, could provide new options for treating chronic pain with fewer side effects.
Researchers at Weizmann Institute of Science develop new technology to see inside tens of thousands of individual cells at once, identifying a subset of innate immune cells that collaborate with cancer. This breakthrough may lead to immunotherapy treatment for cancer.
Researchers at the Weizmann Institute of Science created artificial cells that produced viral parts, allowing for safe testing and development of diagnostic tools, drugs, and vaccines. The system consists of micrometer-sized compartments etched into a silicon chip, enabling controlled production of specific proteins.
Researchers propose a new method to read magnetic pole reversals by analyzing ice cores, which could be applied to other bodies in the solar system. The team created artificial snowfall with magnetic dust and froze it into hard ice, detecting a small but detectible magnetic moment that matched the applied fields.
Researchers discovered a high-energy parent state with unusual symmetry breaking in magic-angle twisted bilayer graphene, leading to the revival of Dirac electrons. The system exhibits asymmetric electronic compressibility and phase transitions near integer fillings.
Researchers at the Weizmann Institute of Science and Hebrew University of Jerusalem reconstructed ancient protein sequences that may resemble those of early life forms. They discovered a way these primitive proteins could have progressed to form living cells, with positively-charged amino acids playing a crucial role.
A study of mice in semi-natural settings reveals that oxytocin can increase aggressive behavior as well as friendliness, depending on the environment. The findings suggest a more nuanced view of oxytocin's effects and highlight the need for complex environments to translate research findings to human behavior.
Scientists at the Weizmann Institute of Science have successfully self-synthesized and assembled a ribosome subunit on a surface chip. The discovery opens up new possibilities for designing and testing complex molecular structures, including potential applications in vaccine development and drug production.
Researchers at the Weizmann Institute created a simple 'sniff test' that accurately predicts which brain-injured patients will regain consciousness. The test, which measures nasal airflow patterns in response to odors, showed 92% accuracy in predicting patient survival for at least three years.
Weizmann Institute researchers found that overexpression of specific immunoproteasome subunits in melanoma is tied to anti-cancer immune activity. The study's findings suggest that these biomarkers may improve patient matching to current immunotherapy treatments, leading to better outcomes.
A new computer algorithm can predict in early pregnancy or before pregnancy which women are at high risk of gestational diabetes. The study analyzed data on nearly 600,000 pregnancies and identified nine parameters that accurately predicted the risk of developing gestational diabetes.
Researchers at the Weizmann Institute of Science have developed a decoy molecule called Arenacept that can neutralize a range of viruses, including arenaviruses. The molecule is based on a rodent receptor and has been shown to be highly effective in binding strongly to viruses and recruiting the immune system to mount an attack.
Researchers at Weizmann Institute of Science have visualized electrons flowing through graphene, mimicking the flow of liquid through a pipe. This behavior has important implications for creating new electronic devices with reduced resistance.
A study by Weizmann Institute researchers reveals that around 4% of left-handed women have excellent senses of smell despite lacking olfactory bulbs in their brains. The findings challenge conventional theories on the necessity of olfactory bulbs for the sense of smell.
A study on mice has created a set of objective measurements for personality, revealing the connection between genes, behavior, and individual traits. The researchers found that each mouse had a unique personality that consistently informed its behavior.
A new study reveals that human brains process faces in a similar way to artificial intelligence systems, with unique activation patterns playing a key role in recognition. The researchers found parallels between the human visual system and deep neural networks, which can improve face recognition capabilities.
Researchers at the Weizmann Institute of Science and Germany's University of Cologne have identified two antibodies produced by vaccinated individuals that provide long-term immunity against Ebola. These antibodies, which target specific sites on the viral glycoprotein, demonstrate effective protection against the virus.
A study in mice showed that reducing a particular hormone signal can prevent the growth and spread of Ewing sarcoma, a bone cancer mainly found in teenagers. The findings suggest a potential treatment approach using existing drugs to neutralize glucocorticoid receptors.
The study found that tumor heterogeneity, not mutational burden, is a key factor in determining the success of immunotherapy for melanoma patients. Researchers developed an experimental system to systematically generate tumors with intermediate levels of genetic heterogeneity, leading to a high correlation between this factor and treat...
Researchers successfully recorded hippocampal ripples in humans, demonstrating their role in new memory engraving and recall. The findings suggest that synchronized neural activity is crucial for free recall.
A study published in Nature suggests that certain strains of gut microbes, particularly Akkermansia muciniphila, may slow the progression of amyotrophic lateral sclerosis (ALS) in mice. The researchers found that supplementing ALS-prone mice with this strain significantly improved their survival and reduced disease symptoms.
Researchers developed an algorithm that analyzes immune cell responses to predict disease onset and progression. The algorithm uses 'first impressions' from early interactions between immune cells and bacteria to identify patterns that can be applied to real-time blood tests.
Researchers have identified over 7,000 structural variants in human gut microbiomes associated with disease risk and weight. These variants were found to be linked to a specific ability of bacteria to produce butyrate, a substance with anti-inflammatory effects.
Antifreeze proteins, typically preventing ice formation, have also been found to promote its growth at extremely low temperatures. This study, published in the Journal of Physical Chemistry Letters, provides insight into the basic processes of ice formation and suggests potential implications for understanding climate.
Researchers at the Weizmann Institute of Science discovered that gut immune cells operate under harsh conditions and use a more socialistic principle to select B cells with varying levels of antibody affinity. This unique process may lead to the development of more effective oral vaccines.
A new study found that plants adjust photosynthesis in response to rapid light changes using a sensory-like regulation system. The findings suggest that plants have evolved to prioritize long-term stability over short-term efficiency in the face of changing environmental conditions.
Researchers found that more efficient neural codes in humans and monkeys resulted in reduced robustness, potentially contributing to disorders like ADHD, anxiety, and depression. The study supports the 'washing machine' theory of brain evolution, suggesting a trade-off between efficiency and error resistance.
Researchers at the Weizmann Institute of Science found that clearing senescent cells, which contribute to inflammation and aging, improves health outcomes in mice. The study, led by Prof. Valery Krizhanovsky and Dr. Yossi Ovadya, offers hope for potential anti-aging therapies.
Researchers at Weizmann Institute of Science have revealed a previously unknown mechanism underlying anxiety. Targeting this biochemical pathway may help develop new therapies for alleviating the symptoms of anxiety disorders.
Researchers at the Weizmann Institute of Science have created a new method to sequence individual cells from patient blood or bone marrow, capturing specific gene programs active in each cell. This allows for more precise diagnosis and treatment of multiple myeloma by identifying unique genetic blueprints for each patient.
A novel technology for profiling protein turnover and degradation has been developed, revealing distinct evidence of a signature pattern in autoimmune disorders. The technique focuses on degraded proteins, providing clues about the state of protein monitoring and potentially leading to better diagnostic techniques.
A new study identified 'signposts' on cancer cells that can help the immune system recognize and kill them, potentially leading to higher recovery rates. The findings suggest a highly personalized approach to immunotherapy could improve treatment outcomes.
Researchers found that probiotics' effects on humans and microbiomes vary greatly from person to person. Personalized treatment was shown to have significant benefits in addressing adverse side effects of antibiotics. The study's results suggest a tailored approach to probiotic use, potentially leading to improved health outcomes.
Scientists at the Weizmann Institute of Science have successfully demonstrated a logic gate that enables the exchange of information between photons and atoms, a breakthrough necessary for scaling up quantum computers. This achievement paves the way for the development of more powerful quantum computing systems.
Researchers found altered nitrogen metabolism in many cancers, producing detectable changes in body fluids and contributing to new mutations. This dysregulation may facilitate early detection of cancer and predict immunotherapy success.
Researchers at the Weizmann Institute of Science have developed a new combination therapy using three drugs to block growth from without and within, potentially relieving resistance in lung cancer patients. The approach was successful in mice and may help extend the lives of thousands of lung cancer patients.
A study by Weizmann Institute researchers found that a gene normally protecting against cancer, p53, can switch allegiance in the tumor microenvironment, supporting cancer growth. Eliminating this protein from cancer-associated fibroblasts reduced their ability to promote tumor growth and metastasis.
Prof. Doron Lancet and colleagues propose a new chemical model that supports the 'Lipid World' concept, where lipids can store and transmit information, leading to compositional reproduction and Darwinian evolution. The researchers argue that life could emerge before DNA and RNA.
Weizmann Institute of Science researchers found a natural defense mechanism that prompts the body to alleviate intestinal inflammation. Boosting signals in certain cells, such as those making up the inner lining of the gut, may help treat inflammatory bowel diseases and potentially even colon cancer.
A new study suggests that adopting plant-based diets could increase global food production by 50-200 times, making it a game-changer for addressing hunger and food waste. By replacing animal-based foods with edible crops, researchers estimate that 350 million more people could be fed with the same land resources.
Researchers used NASA's Juno spacecraft data to reveal that Jupiter's colorful bands are not just surface phenomena, but significant strata extending 3,000 km deep. The analysis shows that Jupiter's atmosphere is only 1% of its total mass, a surprising discovery.
A large-scale study led by the Weizmann Institute of Science found that diet and lifestyle are the primary factors shaping our microbiome composition. The research suggests that understanding these influences may be key to improving health and treating common diseases.
Researchers develop method to grow tiny brain models from human cells, revealing physical forces behind brain folding and potential links to microcephaly, epilepsy, and schizophrenia.
Researchers have identified 10 previously unknown bacterial immune defense mechanisms, which may provide new insights into the evolution of human immunity. These systems include novel Toll-Interleukin Receptor domains and genes 'borrowed' from non-defensive bacterial systems.
Scientists discovered a sub-population of neurons in bats' brains that encode the specific location of other bats nearby. These 'social place cells' support the idea that our brains create a cognitive map not just of our location, but also one that includes social mapping.
Researchers used genetic barcoding to identify and quantify fish larvae in a coral reef ecosystem, revealing species distribution and dispersal patterns. The study solved several mysteries, including the invasion of a puffer fish into the Mediterranean, and provided new insights into the ecology of the reefs.