Scientists create new two-step annulative p-extension method for synthesizing structurally diverse nanographenes, including curved and non-planar structures. The research expands the toolbox for chemists to access rare molecular fragments with unique properties.
Researchers distinguish multiple fluorescent proteins with overlapping emission colors by their lifetime using fluorescence lifetime imaging microscopy (FLIM). FLIM successfully distinguishes several fluorescent proteins with overlapping color emissions within plant cells, enabling simultaneous analysis of multiple proteins.
Researchers design a vapor-controlled reversible host–guest chemistry system that controls the optical and physical properties of a functional molecular liquid. The FML's optical and physical properties change immediately upon forming a host–guest complex, but can be restored by exposing it to hexane vapors.
Scientists have successfully created programmable supramolecular polymers in neutral lipid environments, such as triolein-rich lipid droplets. This breakthrough provides a new method for regulating cellular functions and has potential applications in treating diseases involving lipid droplets.
Researchers from Nagoya University developed a two-step synthetic method for dihydrodinapthopentalenes, conductive organic molecules with complex synthesis. The new mechanochemical method synthesizes DHDPs in 15 minutes with minimal solvent waste and structural constraints.
Researchers have developed a new methodology for selective molecular transformations of polycyclic aromatic hydrocarbons (PAHs), targeting the challenging L-region. This enables the creation of larger PAH structures and new nanographenes, increasing versatility in technological applications.
The 26th Nagoya Medal of Organic Chemistry will be held on January 24th, 2025, with gold medalist Professor Alois Fürstner presenting lectures on catalysis and metal-carbene chemistry. Silver medalist Professor Masayuki Inoue will discuss total synthesis of highly oxygenated natural products.
Researchers at Nagoya University have identified a chemical compound that regulates stomatal density in plants, reducing water loss through transpiration. The compound, Stomidazolone, inhibits stomatal development without affecting plant growth, offering a promising solution for drought-prone environments.
Scientists have developed a new compound, ZTA-261, which selectively binds to the thyroid hormone receptor beta (THRβ) to treat lipid disorders. Mice administered the drug showed decreased lipid levels in the liver and blood with fewer side effects compared to existing compounds.
Researchers discovered that male mosquitoes listen for specific sound frequencies made by females of their own species to avoid mating with the wrong species. This finding has implications for developing innovative mosquito control strategies using artificial flight sounds. The study aims to prevent mosquito populations from reaching u...
Researchers observe internal reproduction process of Arabidopsis plant, revealing mechanism behind female flower's selective attraction to a single male counterpart. The study also uncovers a repulsion signal that discourages additional pollen tubes from approaching.
Scientists at Nagoya University have discovered a novel regulatory mechanism controlling plant stomatal opening in response to red and blue light. Phosphorylation of Thr881 activates the plasma membrane proton pump, facilitating stomatal opening and enhancing photosynthetic activity.
Scientists develop antiaromatic molecules that exhibit absorption and fluorescence bands in the near-infrared region, enabling deep biological imaging and photothermal therapy. This breakthrough holds potential for diverse NIR luminescent materials and applications in fields like healthcare, optoelectronics, and materials science.
Researchers at Nagoya University have synthesized methylene-bridged [n]cycloparaphenylenes ([n]MCPPs) with varying ring sizes, exhibiting unique properties such as fluorescence and paratropic belt currents. The discovery has significant implications for studying magnetic properties of aromatic nanobelts.
Researchers developed an image analysis algorithm that can automatically measure Arabidopsis thaliana stomatal aperture with high accuracy and speed. The technology also includes a portable imaging device for non-destructive observation using intact plants, allowing for rapid measurement of subtle changes in stomatal aperture.
Researchers have elucidated a mechanism that makes tiny plant stem cells destined to give rise to stomata, cellular valves of plants. The discovery reveals two DNA codes and regulator proteins working together to lock in the fate of a plant cell.
Researchers at Nagoya University have identified 2,6-dihalopurines as a new class of stomatal opening inhibitors, potentially involving LRX3-5 and RALF peptide. This discovery may lead to the development of new agrochemicals and chemical biology research applications.
The study reveals that SWEET13 transporter is necessary for pollen production, highlighting the importance of sucrose transport. Researchers used molecular docking and simulation to understand how SWEET13 selectively transports sucrose over gibberellin.
Researchers at Nagoya University identified the pheromone PGE2 involved in puffer fish spawning behavior, which is synchronized with the lunar cycle. The study found that applying PGE2 to puffer fish triggers their characteristic writhing motion during spawning.
Researchers develop a method to synthesize bare aromatic polymers using dendrimer support, enabling high solubility and transfer to other materials. This innovation opens up new possibilities for creating hybrid materials with unique properties.
Researchers successfully synthesized a Möbius carbon nanobelt with a twisted Möbius band topology, revealing unique properties and molecular motions. The breakthrough paves the way for developing nanocarbon materials with complex topological structures.
Researchers discovered that a transcription factor called MUTE induces a cell cycle inhibitor SMR4 to slow down the cell cycle, allowing for asymmetric division. A variant with excess SMR4 showed a longer cell cycle during symmetric division, revealing a crucial regulatory mechanism in plant stomatal development.
Scientists have developed a new live analysis system for plant stomata, allowing for rapid and affordable identification of desirable traits. This innovation has the potential to accelerate crop development for climate-resistance, addressing future food shortages.
Researchers at Nagoya University developed a new synthesis method for nanographenes, using polycyclic aromatic hydrocarbons as templates. This approach enables the creation of multiple nanographenes with varying characteristics, addressing the challenge of identifying relationship between structure and properties.
Kakshine is a new DNA fluorescent dye with unprecedented versatility, enabling super-resolution imaging of mitochondrial DNA in living cells and deep tissue imaging. Its applications include electrophoresis, quantitative PCR, and flow cytometry, making it a promising tool for DNA analysis.
Researchers from Nagoya University successfully capture images of female gamete formation in Arabidopsis thaliana, revealing how cell fate is determined and providing insights into plant adaptation. The study's findings have significant implications for understanding fertilization rates and environmental resistance in plants.
Scientists develop method to increase nutrient uptake and stomatal opening in rice, resulting in over 30% increase in crop yield. The technique uses a plasma membrane proton pump gene overexpression, reducing the need for fertilizers and improving carbon capture.
Researchers at Nagoya University and Groningen University develop a method to control the daily rhythm of human cells using light. They discovered two compounds, TH303 and TH129, that can lengthen the circadian clock period and found a way to reverse this effect by changing the compound's structure with light.
Researchers developed a rapid synthesis method for useful organic fluorine compounds, including gem-difluoroalkenes. This method uses triflones and Grignard reagents to produce the compounds efficiently and safely.
Scientists at Nagoya University developed a new method for visualizing microtubule dynamics and cell membrane protein endocytosis in living plant cells. They successfully used SNAP-tag to mark auxin transporters, allowing clear differentiation between newly synthesized and endocytosed proteins.
Scientists developed a new method to synthesize three-dimensional nanocarbons using palladium catalyst, enabling precise and practical creation of superior material properties. The octagonal structure is expected to lead to discovery and elucidation of novel properties and development of next-generation functional materials.
A team of scientists has developed a system utilizing image analysis and artificial intelligence to analyze the shape of large numbers of seeds from a single image. The trained model detected and segmented individual seeds with high accuracy and analyzed seeds of other crops, accelerating crop breeding and analysis.
Researchers identify celastrol as a potential therapeutic target for treating winter depression, a condition characterized by low mood and social withdrawal. The study uses medaka fish as an animal model to understand the underlying mechanisms of winter depression.
Researchers at Nagoya University's ITbM discovered two new compounds that target specific components of the circadian clock. KL101 and TH301 lengthen the period of the circadian clock and are expected to provide a promising foundation for treating obesity.
A team of researchers at Nagoya University has discovered a highly potent and selective molecule, SPL7, that can induce suicidal germination in Striga seeds, allowing for effective control over the parasitic weed. This breakthrough could alleviate Striga infestation and save crop losses worth billions of US dollars every year.
A team of researchers has developed a photostable fluorescent labeling agent for single molecule, multicolor, and 3D deep imaging in the near infrared region. The new dye, PREX 710, allows for long-term bioimaging of blood vessels in mice brains.
A team of researchers has discovered compounds that can regulate the circadian rhythm in human cells, including a well-known anti-aging supplement. The supplement was found to reduce jet lag symptoms in mice, providing hope for the treatment of circadian clock disorders arising from jet lag and shift work.
Researchers at Nagoya University have discovered new compounds that can control stomatal movements in plants, preventing leaves from drying up and suppressing withering. These compounds could lead to the development of agrochemicals for drought tolerance and extend the freshness of cut flowers.
Researchers at Nagoya University have developed a method to construct perfectly aligned molecular assembly structures on graphenes. The technique relies on atomic force microscopy (AFM) and induces symmetry breaking in molecular patterns, enabling precise control over molecular alignment.
Researchers have developed a water-soluble warped nanographene molecule that induces cell death when exposed to blue laser light, showing promise for fluorescent cell imaging and possibly eradication of cancer cells. The molecule exhibits green fluorescence under ultraviolet or blue light and has low cytotoxicity.
Researchers at Nagoya University have created a simple and efficient way to form nanographenes in a controlled fashion. The team's approach uses a palladium catalyst to connect benzene units at two points, forming a triangle-like structure that can be repeated to generate the desired molecule.
Researchers at Nagoya University and Tsinghua University have analyzed the crystal structure of LURE bound to its receptor protein PRK6, revealing a unique binding scheme that controls pollen tube growth. The study provides insights into the precise mechanism of direction control in fertilization.
Scientists at ITbM, Nagoya University have synthesized a new bioactive small molecule that increases stomata numbers on flowering plants without stunting their growth. The team's discovery could help elucidate the stomatal development mechanism in plants and increase crop plant productivity.
Researchers at Nagoya University have developed a new photostable fluorescent dye, PhoxBright 430 (PB430), to visualize cellular ultrastructure. PB430 enables continuous STED imaging and can be used for multicolor imaging of biological structures.
Scientists at Nagoya University developed a new material that conducts electricity and emits white light when exposed to electricity. The 'responsive porous host' method allows for predictable synthesis of stimuli-responsive materials with potential applications in memory devices, artificial muscles, and drug delivery systems.
Researchers successfully synthesized a carbon nanobelt, measuring 0.83 nm in diameter, using a novel synthetic strategy based on a macrocycle precursor. The breakthrough opens a new field of nanocarbon science and has potential applications in electronics and photonics.
Researchers at Nagoya University have discovered how plant parent genes cooperate to develop their offspring. The study shows that maternal and paternal factors work together to control the asymmetric division of the zygote, leading to the formation of roots or leaves.
Researchers at Nagoya University developed an organic catalyst that generates amino acid derivatives in high yields with precise stereochemical control. A slight structural change in the catalyst leads to inversion of a single stereocenter, enabling access to specific diastereomers.
Plant biologists have developed a new CRISPR/Cas9 vector that efficiently knocks out genes in Arabidopsis thaliana, improving the method for genome engineering in various plant species. This breakthrough enables the study of genetic functions and potential applications in crops like Brassica napus.
Researchers at Nagoya University have successfully visualized asymmetric cell division in fertilized plant cells using live cell imaging. The study reveals how the direction of this division determines the body axis of flowering plants, with a small cell forming on top and a large cell at the bottom.