University of Minnesota researchers have developed a contactless manipulation method using ultrasound waves, which can move larger objects without physical contact. This technique uses metamaterial physics to steer objects in desired directions, enabling control through sound reflection.
Researchers at Massachusetts General Hospital have identified a promising oral compound that stimulates bone formation in mice, increasing blood levels of calcium and vitamin D. The compound, SK-124, boosts bone formation and mass without short-term toxicity, offering new hope for preventing and treating osteoporosis.
A new study found that obeticholic acid can reverse cognitive impairment in patients with cholestatic liver disease, improving short-term memory and restoring brain function. The study used a rodent model of bile duct ligation-induced cholestasis and found that the drug significantly improved cognitive deficits.
A recent study published in the Journal of American Geriatrics Society found that a tailored activity program (TAP) significantly improved behavioral symptoms in Black families compared to white families. The program, which provides activities tailored to interests and abilities, also reduced caregiver distress.
Researchers investigate generating and performing terahertz structured light using flat photonic elements for object inspection and recognition tasks. Flat photonic elements offer advantages in creating non-diffracting beams that preserve internal structure, enabling high-resolution imaging with minimal background signal.
Researchers at Scripps Research have developed a general synthesis method for 1,2,3,5-tetrazines, a family of compounds with great promise for making new pharmaceuticals and chemical products. The new method is more efficient than previous approaches, requiring just five reaction steps to produce myriad versions of these compounds.
A new study found that impaired glymphatic system function is associated with Alzheimer's disease progression. Noninvasive MRI measures of the glymphatic system's volume and diffusivity were linked to amyloid beta deposition, neuronal damage, and cognitive impairment in patients with Alzheimer's.
Scientists at the University of Vienna uncover the connection between Pacific Ocean air mass transport and climate anomalies, including droughts in the Amazon and increased precipitation in the southeastern US. They also find that El Niño warms the Atlantic Ocean by transporting large amounts of heat.
Scientists developed a first model to predict canopy water content during drought and heat waves. The model could enable fire danger forecasting models that include vegetation in their calculations, making it easier to predict the spread of fires.
Researchers implemented a four-phase measurement-device-independent QKD protocol to overcome security loopholes in practical devices. The study achieved a secure key rate of 91 kbps over 50 km optical fiber, significantly improving security and transmission distance compared to previous protocols.
Rondaxe Lake's experience is just one of thousands worldwide as lakes lose oxygen due to warming, leading to conditions like hypoxia and anoxia. This phenomenon, exacerbated by seasonal stratification, threatens aquatic life and ecosystems.
A new antimalarial drug, tafenoquine, is found to require a higher dose of 450mg to achieve cure rates of 85% compared to the current 300mg dose of 70%. The study suggests that the single-dose tafenoquine is not as effective as optimal primaquine treatment in preventing vivax malaria relapses in all endemic regions.
A new University of Otago study found that only half of women with gestational diabetes were tested for type 2 diabetes within six months of giving birth. The study also highlighted ethnic and regional disparities in testing rates, with Māori women being particularly under-tested.
The proportion of hamstring injuries and associated lay-off days among male professional European footballers has doubled over the past 20 years. Nearly one in five injuries were recurrences, occurring within two months of return to play, with most injuries being structural and resulting in more lay-off days.
Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.
Researchers at Cornell University discover how to modulate the affinity of Cas proteins, enabling precise gene editing and reducing off-target effects. By modifying guide RNAs, they can tune Cas removal, contributing to future CRISPR applications.
A study by University of Bonn elucidates a key mechanism in the brain where neurons fine-tune their sensitivity to incoming signals. Special nerve cells called interneurons play an essential role, sending inhibitory action potentials to reduce sensitivity.
Ethereum's shift from proof-of-work to proof-of-stake has significantly reduced its energy requirements. This change offers a model for other cryptocurrencies to follow and reduce their environmental impact. Policymakers and consumers can support this move by implementing policies such as carbon-disclosure requirements and environmenta...
A new portable device can detect the low-intensity light emission from healthy plants, allowing researchers to measure their health and sustainability. This technology can help assess the impact of CO2 emissions, greenhouse gases, and extreme weather events on plant stress and inform strategies for sustainable agriculture.
A recent study found that non-Hispanic Black women with hormone receptor-positive/HER2-negative breast cancer have poorer outcomes compared to other racial groups, even when their genetic recurrence scores are similar. The research also showed that these disparities were observed despite similar tumor sizes and lymph node involvement.
Researchers at Johannes Gutenberg University Mainz developed a prototype that combines Brownian and reservoir computing to perform Boolean logic operations. This innovation uses metallic thin films exhibiting magnetic skyrmions to achieve energy savings through automatic system reset.
Scientists at Johannes Gutenberg University Mainz have developed a new class of materials for transporting spin waves over long distances in antiferromagnets. This breakthrough could significantly increase computing speed and reduce waste heat in microelectronic devices.
The US Department of Energy has awarded $35 million in grants to three joint projects between Nuclear Physics and Advanced Scientific Computing Research programs. These projects aim to optimize software tools for calculations of quantum chromodynamics, which describes the structure of protons and neutrons, using powerful supercomputers...
Researchers have developed a new X-ray technology that visualizes lung tissue microstructure, providing additional information for accurate diagnosis. Dark-field X-ray images can differentiate between diseased and healthy lung tissue, potentially replacing computed tomography (CT) for repeated examinations.
Australian children are spending too much time glued to screens and not enough on physical activity, with 80% of kids failing to meet national guidelines. A new review calls for a National Physical Activity Plan involving multiple sectors to address the issue.
Researchers at Oxford University and Exciton Science created stable perovskite solar cells with comparable stability to commercial silicon photovoltaics. The new synthesis process led to thin films of greater quality, reduced defects, and enhanced stability.
The Cochrane review analyzed data from 41 randomized controlled trials of 12 different COVID-19 vaccines, involving 433,838 people worldwide. The review found that most vaccines reduced the risk of COVID-19 infection and severe disease, with few reported side effects.
Researchers developed a disposable, fast, and reliable biosensor system to detect putrescine in beef samples, improving food safety. The system uses cell-free protein synthesis and is designed to be consumer-friendly, empowering individuals to check the quality of their food.
A new, low-cost battery made with sodium-sulphur holds four times the energy capacity of lithium-ion batteries and is cheaper to produce. This breakthrough has the potential to dramatically reduce costs and provide a high-performing solution for large renewable energy storage systems.
A new iPMA-type Hexa-technology in Magnetic Tunnel Junctions (MTJ) is showcased for improving ultra-low power consumption in IoT edge-devices and other applications. The 25 nm iPMA-type Hexa-MTJ technology satisfies BEOL design rules for X nm generation CMOS nodes, enabling seamless scaling.
A study published in the Hypertension journal suggests that bromocriptine, a Parkinson's disease medication, may help prevent heart disease in youth with Type 1 diabetes. The research found that teens with Type 1 diabetes who took bromocriptine had lower blood pressure and less stiff arteries after one month of treatment.
Researchers developed polymeric micelles to reprogram tumor microenvironment, enhancing nano-immunotherapy efficacy in mouse breast cancer models. The treatment response can be predicted from ultrasound shear wave elastography measurements prior to treatment initiation.
A new study from Aarhus University found that people diagnosed with mental disorders work 10.5 years less than the general population. The researchers analyzed data from over 5 million individuals in Denmark and found that all types of mental disorders are associated with a substantial loss of working life.
A new study of twins found that consistent exercise can change the molecules in the human body that influence gene behavior, leading to lower signs of metabolic disease. The study suggests that markers of metabolic disease are strongly influenced by how a person interacts with their environment, rather than just their inherited genetics.
Researchers found that red light is more efficient for growing plants while blue light is better suited for solar energy production. This breakthrough could guide global interest in agrivoltaics and identify potential applications for those systems.
Research shows that the Southwestern North American megadrought caused a significant reduction (~30%) in wave activity after its onset, which may be related to reduced storm generation and altered precipitation patterns. The findings demonstrate that regional changes in the lower atmosphere can impact the upper atmosphere.
A team of researchers applied game refinement theory to analyze the evolution of boss battles in the God of War game series, identifying underlying entertainment aspects. The study found that the main games had a peak challenge around final three boss battles, while non-main versions experienced maximum challenge in the middle.
A study suggests that visceral fat cells, rather than subcutaneous fat cells, are more susceptible to infection by the COVID-19 virus. This increased susceptibility leads to a higher viral load and production of pro-inflammatory cytokines, which can exacerbate severe disease.
Researchers used environmental DNA footprints to analyze insect biodiversity in four apple orchards, uncovering the importance of wild non-bee pollinators and multiple pest species. The study suggests that analyzing genetic footprints can provide a more comprehensive view of insect diversity, leading to new management strategies.
Treatment with acetylcholinesterase inhibitors, with or without memantine, may reduce mortality risk and length of stay for unplanned hospital admissions among individuals with dementia with Lewy bodies. The study analyzed data from the UK to support this association.
A University of Ottawa-led team identified a new entry route for SARS-CoV-2 using metalloproteinases, which may lead to more widespread cell infection and severe illness. The study suggests that variants like the Delta strain may prefer this entry method, while others like Omicron do not.
NASA will conduct a series of flights over various communities to test its Quesst Mission Supersonic STEM Toolkit and measure sound levels. The mission hopes to inform an overland supersonic sound standard, potentially cutting flight times in half.
A newly discovered immune response inside the nose fights off viruses, but is suppressed by colder temperatures, making an infection more likely to occur. The study offers the first biological mechanism to explain why viruses like COVID-19 spike in colder seasons.
Patients with hormone receptor-positive, HER2-negative tumors treated with ribociclib plus endocrine therapy had fewer adverse events and longer progression-free survival compared to those treated with combination chemotherapy. This treatment approach may allow for the avoidance of chemotherapy in aggressive patients.
ETRI developed a skin-attached telehaptic technology that provides vivid tactile experiences without physical contact. The device uses high-resolution composite sensors and piezoelectric actuators to reproduce materials, shapes, and textures in real-time.
Exposure to common workplace agents is associated with a heightened risk of developing rheumatoid arthritis, which can be exacerbated by smoking and genetic predisposition. The study found that certain agents, such as quartz dust and gasoline fumes, are strongly linked to an increased risk of ACPA-positive disease.
A new optimization model by GIST researchers reduces operating costs and load shedding in microgrids, achieving a 20% decrease in average ENS. The model accounts for variations and uncertainty in renewable energy supply using an ANN-based prediction model, with predicted power output accuracy of 9.7%.
The University of Colorado Anschutz Medical Campus and the US Department of Defense have co-hosted a summit on firearm suicide prevention. The CU faculty lead report outlines 10 recommendations to improve evidence-based interventions, including repealing prohibitions on questioning service members about personal firearms and implementi...
Researchers developed a small molecule inhibitor that successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer. The drug, MRTX1133, not only targets cancer cells but also cooperates with the immune system to produce a durable response to treatment.
A team of researchers created 3D-printed violins using modern materials and techniques, producing a darker, more mellow sound. The project aims to make music education accessible through the printing of affordable instruments.
Researchers found evidence that ankylosaurs used their tail clubs for social dominance and territorial battles, suggesting a complex behavior. The fossil of Zuul crurivastator revealed broken and healed spikes, indicating ritualized combat or 'jousting' among the dinosaurs.
A computer model simulates virtual groups of migrating animals and finds that sticking together is key to finding a destination, even when the magnetic compass is unreliable. The model showed that more than 70% of animals made it home simply by joining with others and following their lead.
Researchers from Brazil and UCLA used computational fluid dynamics/discrete element method to study barchan dune formation, shedding light on grain-scale dynamics. The study enables investigation of forces within dunes and grain motion, paving the way for predicting future dune fields on Earth and Mars.
A University of Otago study found that ice ages occurred every 41,000 years until 400,000 years ago, contradicting previous assumptions of a 100,000-year cycle. The research uses sediment cores and paleomagnetic analysis to reconstruct changes in the Earth's magnetic field.
Researchers found that tumor cells directly interact with blood vessel cells, altering their normal clockwise orientation to a counterclockwise position. This interaction may play a role in cancer metastasis and could be targeted for prevention and treatment.
Researchers analyzed data from over 80,000 primary care physicians and found no clear connection between MIPS scores and clinical performance. Doctors with low MIPS scores performed worse on some process measures but better on others, suggesting that the system may prioritize paperwork over patient outcomes.
Blackbird Studio C's ambient-anechoic portmanteau, ambichoic, reduces sound reflections, creating a balanced and immersive space for musicians and engineers. The studio's unique design utilizes primitive root diffusers to diffuse sound energy, resulting in a comfortable and engaging environment.
Researchers have developed a low-cost staining method to track coral larvae as they disperse and settle in coral reefs. The method uses colored dyes to differentiate between groups or species, facilitating conservation planning, behavioral ecology, and reef restoration experiments.
Astronomers have uncovered a nearby galaxy, HIPASS J1131–31, nicknamed 'Peekaboo,' which has characteristics reminiscent of galaxies in the distant, early universe. The tiny galaxy is only 20 million light-years from Earth and exhibits extreme metal-poor properties.
Researchers found that longer chromosomal arms are always thicker throughout eukaryotic species, providing insights into mitotic chromosomal structure. This study challenges current perspectives on mitotic chromosome formation and may lead to new ways to prevent chromosome miscarriage and cancer cell formation.