The cyclin-dependent kinase (CDK) inhibitor class of oral drugs has been found to be generally well-tolerated in treating hormone receptor-positive (HR+) metastatic breast cancer. The most common side effect is a temporary and dose-dependent decrease in white blood cells, which usually returns to normal with dosage adjustments.
A new study shows that females vaccinated before pregnancy and infected with Zika virus while pregnant bear pups who show no trace of the virus. Two vaccines provided substantial protection against Zika infection, reducing viral genetic material in fetuses and placentas.
Researchers explore optimal vessel design, speed and passenger capacity to reduce uncertainty in the industry. The study aims to provide technical evidence to support new safety codes for hydrogen fuel-cell vessels.
A study published in Cell Reports found that altering the levels of microRNA miR-128 can induce a more homogeneous subtype of glioblastoma cells, making them more responsive to treatment. This discovery opens the door for using miR-128 as a therapeutic agent.
Researchers at Ruhr-University Bochum have discovered that selenium can form bonds similar to those of hydrogen bonds, resulting in accelerated chemical reactions. The team's findings suggest that weaker bonds, such as hydrogens bonds, might be sufficient for activation or catalysis.
Scientists have developed a new method to track lithium ions as they travel in a battery, which could help address the safety hazard of battery failure. The researchers used fluorescence microscopy and found a fluorescent label sensitive to lithium ions, enabling them to image and track lithium ions in a battery-like environment.
Researchers have developed a hands-free musical instrument that can be controlled by thoughts, allowing people with motor disabilities to play music again. The Encephalophone collects brain signals and converts them into musical notes, providing a new avenue for rehabilitation and empowerment.
The UTA Institute of Urban Studies will study the best use of land just north of Dallas Love Field, considering options for an innovation hub, office park, or mixed-use park. The goal is to create a high-tech employment hub that complements air travel sectors.
A recent study published in the International Journal of Food Science and Technology found that commercial-scale extraction and purification processes do not alter the steviol glycosides in high-purity stevia extracts. The research, conducted at the University of Bonn, provides evidence for the naturality of stevia, a popular plant-bas...
A new series of studies reveals that self-actualization is linked to pursuing status and esteem, which can translate into 'fitness' and passing genes to future generations. This challenges traditional assumptions about self-actualization being 'above' basic physiological and social desires.
Researchers found that environmental disturbances can cause sudden population collapses, making extinction easier even for large populations. This has implications for predicting and controlling viral epidemics.
A study examined the risk of intellectual disability (ID) in children born to mothers treated with antidepressants and found a slightly elevated risk, but it was not statistically significant. The researchers suggest that other factors such as parental age and psychiatric history may contribute to the risk.
A recent study highlights the growing threat of cyber attacks on information systems, with 64% of organizations reporting successful medical file targeted attacks in 2016. The authors stress the need to acknowledge public health implications of information security to improve dialogue and protect patient care.
Patients who watched videos of themselves struggling to breathe while sleeping with sleep apnea used CPAP machines three hours more per night than those who saw no video. The effect was dramatic, with patients becoming determined to fix their condition after witnessing the severity of their own sleep apnea.
Researchers at the University of Liverpool have developed a novel approach to treating chronic myeloid leukemia (CML), which safely increases treatment success and reduces negative side effects. The study, led by Professor Richard Clark, shows that CML patients with stable responses to treatment can reduce their medication dosage befor...
Researchers found that participants perceived individuals with a 'good' moral disposition as more likely to act out of character, while those with immoral traits were less likely to change perceptions. This bias can have significant consequences for those with questionable characters or facing legal proceedings.
A new registry study highlights the unique characteristics of heart failure patients in Asia, including younger age and higher co-morbidity rates compared to Western populations. The study also reveals underutilization of potentially life-saving implantable cardiac defibrillators in Asia.
Researchers at NIH have discovered that HIV uses a protein on the cell surface to invade cells. By blocking this step, they found it prevents HIV genetic material from entering cells. The study could lead to the development of new drugs to prevent HIV infection by targeting the transfer of phosphatidylserine.
Researchers have identified an anti-CRISPR protein that can block the Cas9 component of CRISPR-Cas9 from interacting with DNA, reducing off-target cuts. This protein, AcrIIA4, was found to inhibit CRISPR-Cas9's ability to cut target DNA while still allowing on-target editing.
A new sub-population of immune cells plays a key role in the development of pulmonary fibrosis. Targeting these cells could lead to new treatments with fewer adverse effects.
The World Health Organization (WHO) has downgraded the status of Tamiflu due to limited evidence. A study published in The BMJ found that oseltamivir had no significant impact on complications, hospital admissions, or mortality from influenza. This decision comes after years of stockpiling and promotion of the drug.
Researchers from Imperial College London have used a new technique called 'optical clearing' to image adult heart tissue in 3D, revealing intricate networks of tiny blood vessels and collagen scaffold. This breakthrough could help doctors monitor the spread of stiff scar tissue and track patient responses to treatments.
A study of 179,007 children found no association between antidepressant medication use and intellectual disability when other factors were considered. The researchers estimated a relative risk but it became statistically insignificant after adjusting for parental age and underlying psychiatric disorder.
Researchers analyzed brain activity of 100 healthy Portuguese adults and found that those with better cognitive abilities had more stable and structured brain network states. This study provides new evidence linking brain network dynamics to cognitive performance in later life.
Men who are tall and obese have an increased risk of high grade prostate cancer and death from prostate cancer, according to a study published in BMC Medicine. The research found that height is not associated with overall prostate cancer risk but increases the risk of high grade disease and death by 21% and 17% respectively.
A new sunspot group has emerged on the sun, with its dark core larger than Earth, in a video captured by NASA's Solar Dynamics Observatory between July 5-11, 2017. This is the first sunspot to appear after two days of solar spotlessness during the sun's regular 11-year cycle.
Scientists have identified a phylogenetically old alga's hydrogen-producing enzyme, which shares characteristics with its bacterial counterpart. The study reveals that these enzymes are used for light-driven generation of hydrogen in green algae.
Researchers have solved the equation describing solid friction on granular materials for an arbitrary number of dimensions. Their results are in excellent agreement with numerical solutions in 2 and 3 dimensions, making the model applicable to various industries such as construction and pharmaceuticals.
A recent study published in the American Journal of Psychiatry found that ADHD medication use is associated with a lower risk of substance abuse in adolescents and adults. The study analyzed data from nearly 3 million people with ADHD and found a 35% lower risk in men and a 31% lower risk in women.
Astronomers used novel technique to analyze ETNO orbits, finding clustering of nodes at certain distances from the Sun. The results suggest a planet beyond Pluto, with its orbit potentially interacting with ETNOs.
Women who breastfed for 15 months or more have a reduced risk of developing multiple sclerosis (MS) compared to those with no breastfeeding. The study, published in Neurology, found that this association held true even when considering factors like age and ovulation.
Scientists at Imperial College London discovered a way to reprogram macrophages, immune cells that cause inflammation, by blocking a single enzyme. By targeting this broken metabolism, they reduced inflammation in rats and mice with human-like diseases.
Researchers used mathematical modeling to examine patterns in lung cancer metastases, revealing a preferential pattern for brain spread in patients with EGFR mutations. The findings suggest that Markov modeling could help predict metastatic spread and personalize treatment for non-small cell lung cancer patients.
Researchers found that exposure to a common visual illusion enhances ability to read fine print by improving visual acuity. Participants who saw clockwise spirals showed improved performance in reading letters at smaller font sizes.
A study in the journal Temperature found that high temperatures can lead to a 27% labor loss and 15% decrease in work time for grape-picking workers in European wine production. The research highlights the potential negative impact of global warming on the industry, which is a significant contributor to world GDP.
Researchers at Georgia Tech have developed energy-recycling stairs that store energy during descent and return it during ascent, easing the impact on knees and ankles. The device reduces knee impact by 37% and ankle stress by 26%, making it easier for people to use stairs without compromising their mobility.
Researchers from MIT's CSAIL have developed a new system called Home3D that allows users to watch 3D movies at home without glasses. The system converts traditional 3D movies into a format compatible with automultiscopic displays, which show multiple images simultaneously.
New research shows that social-emotional learning programs have immediate positive effects on children's mental health, social skills, and learning outcomes, which continue to benefit them years later. The study found higher graduation rates, lower drug use and behavior problems, and improved public health outcomes for program particip...
A study from the University of Washington found that only about three in five US firearm owners have received formal gun training, with notable gaps in content, particularly on warning signs of suicide. The lack of standardization and education on suicide prevention in firearm trainings has significant implications for public health.
Researchers at University of Missouri found that hormone replacement therapies can induce growth and metastasis in breast cancer by enriching specialized cancer cells like stem cells. The study suggests targeting these rare cells and immunotherapies to combat the disease.
A new detector for acetaldehyde in wine has been developed, offering a more practical and accurate method for winemakers to monitor this critical ingredient. The device, tested on nine different wines, produced results comparable to traditional methods but with simpler operation and real-time output.
A graduate research fellow investigates how fungi and fire enable pine savanna ecosystems to prosper, discovering mutualisms that promote equilibrium and fire adaptation. The study aims to understand the role of plant-fungal interactions in shaping ecosystem dynamics.
The study found that the red vizcacha rat's genome grew quickly due to the expansion of highly repetitive elements, rather than whole genome duplication. This mechanism is also thought to contribute to 'genomic baggage' in humans, influencing disease susceptibility.
Researchers in Erlangen and Jena have achieved high-precision measurement of the wave characteristics of focused, ultra-short light pulses. This will enable targeted influence on electrons and chemical reactions.
Researchers at Uppsala University develop a small-scale method to determine bioavailability of drugs within cells, facilitating early-stage drug development. The method takes into account how drugs 'disappear' when binding to cell components, offering a promising tool for pharmaceutical companies.
A new study reveals that high school principals have a significant impact on creating academic policies for students recovering from concussion. While many protocols exist for returning to sports, principals can help ease students back into their normal routine with accommodations such as frequent breaks and quiet testing environments.
A team of scientists is working on synthesizing a human genome from scratch, tackling the technical and ethical challenges that come with it. They have already made significant progress in building smaller genomes, such as those of microbes, but still face significant hurdles in constructing the complex human genome.
A new study published in Science Translational Medicine reveals that monitoring Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can be an early predictor of chronic lung allograft dysfunction (CLAD). This discovery fills the void for a reliable marker, opening new opportunities for diagnosis and prevention.
Kári Stefánsson to receive William Allan Award for his pioneering work on Icelandic population genetics and its impact on public education about genetics. His research has led to important insights into various diseases, including type 2 diabetes, prostate cancer, and schizophrenia.
A University of Oklahoma study reveals the complex relationship between wastewater injection and seismicity in Oklahoma. The research found that foreshocks correlated with wastewater injection rates and stress interactions between earthquakes, ultimately leading to the September 3, 2016, 5.8 magnitude earthquake near Pawnee, Oklahoma.
A nearly 2,240 square-mile iceberg broke off from Antarctica's Larsen C ice shelf between July 10 and 12. The event has reduced the ice shelf area by approximately 10 percent, sparking concerns about potential destabilization of the remaining ice shelf.
A recent study published in the British Journal of Surgery found that topical antibiotics are moderately effective but not justified due to limited information on adverse effects. The research highlights the need to fight antibiotic resistance and encourages a more cautious approach to their use.
Scientists identify a protein that suppresses the body's key antiviral reaction, leading to stronger or more virulent disease. A new prototype drug has been found effective in suppressing disease caused by influenza infection.
Researchers developed energy-recycling stairs that store user's energy during descent and return it during ascent, making stair negotiation easier for elderly and disabled individuals. This technology could be a more affordable alternative to elevators and stair lifts, allowing people to retain their ability to use stairs.
Researchers at the University of Copenhagen have developed a 'smart' atomic cloud that can neutralize Heisenberg's Uncertainty Principle, allowing for more accurate measurements at quantum level. This breakthrough could lead to new sensors and technologies, including better understanding of gravitational waves.
The FDA advisory committee voted unanimously to recommend approval of Novartis' CAR-T therapy Tisagenlecleucel, demonstrating impressive results in hard-to-treat leukemia patients. ACGT's funding played a crucial role in advancing the pioneering treatment.
Researchers found near-continuous tremor activity and 1,300 low-frequency earthquakes in the region, suggesting a connection to damaging earthquakes. The study used a novel 'beam back projection' method to track slow earthquakes minute-by-minute, revealing clusters of tremor sources with distinct properties.
A new web application provides historical climate data to farmers, allowing them to compare current year's conditions with past ten years. The app covers the Texas region and offers information on soil temperature, growing degree days, and precipitation.
Researchers studying coral connectivity patterns in the Gulf of Mexico aim to restore marine ecosystems damaged by the 2010 Deepwater Horizon oil spill. By analyzing genetic diversity and dispersal rates, scientists hope to identify critical areas for protection.
Tropical Depression 6E formed near southwestern Mexico on July 11, strengthening into Tropical Storm Fernanda within six hours. The storm showed cloud top temperatures as cold as -63 degrees Fahrenheit, indicating towering thunderstorms and heavy rainfall potential.