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Institute of Transformative Bio-Molecules (ITbM), Nagoya University


Plant's POEM: 'No need to fertilize, for increase in seed size'

Plant biologists at ITbM, Nagoya University, have made a key discovery that the contents in pollen tubes alone can increase the size of seeds, without the need for fertilization. This new plant phenomenon, named as POEM (pollen tube-dependent ovule enlargement morphology), shows that even in the absence of fertilization, release of the...

A fluorescent dye that survives in live cell STED imaging

Scientists at ITbM developed a new fluorescent dye, C-Naphox, with enhanced photostability to enable continuous live cell imaging by STED microscopy. The dye has demonstrated extreme photoresistance and no significant toxicity towards cells, opening doors to real-time biological event observation for extended periods.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalAngewandte Chemie International Edition·DateOct 25, 2015

Green light of hope to overcome Striga-triggered food insecurity in Africa

Researchers have identified the 'wake-up protein' responsible for germination of Striga seeds using a fluorescent probe, accelerating research to control Striga growth and prevent crop losses worth billions of dollars annually. The study reveals that Striga detects host crops through strigolactone receptors, leading to a devastating im...

Chromium-centered cycloparaphenylene rings for making functionalized nanocarbons

A team of chemists at Nagoya University has synthesized novel transition metal-complexed cycloparaphenylenes that enable selective monofunctionalization of CPPs. The discovery opens doors to the construction of unprecedented nanocarbons, including carbon nanotubes with new properties.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalJournal of the American Chemical Society·DateJan 26, 2015

Selective functionalization synthesizes chemotherapeutic natural products

Researchers at Emory University and Nagoya University developed a novel concise entry to dictyodendrins, a family of natural products with potential cancer chemotherapy and treatment for Alzheimer's disease. The study demonstrates sequential C-H functionalization can streamline the construction of complex structures.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalJournal of the American Chemical Society·DateJan 7, 2015

Ultrafast complex molecular simulations by 'cutting up molecules'

A novel ultrafast quantum chemical method called FMO-DFTB enables rapid simulations of complex molecular systems, achieving a huge improvement over traditional methods. The method has successfully evaluated large molecules including polypeptides, DNA segments, small proteins, and fullerite surfaces.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalJournal of Chemical Theory and Computation·DateDec 4, 2014

A new 'Kabuto-like' nickel catalyst forms bioactive frameworks from phenol derivatives

Researchers have developed a new nickel catalyst that catalyzes the cross-coupling reaction between carbonyl compounds and phenol derivatives to form alpha-arylketones, which are found in many biologically active compounds. The study has potential applications in synthesizing biologically active molecules and organic materials.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalAngewandte Chemie International Edition·DateMay 27, 2014