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Institute of Transformative Bio-Molecules (ITbM), Nagoya University


Live cell imaging of asymmetric cell division in fertilized plant cells

Researchers at Nagoya University have successfully visualized asymmetric cell division in fertilized plant cells using live cell imaging. The study reveals how the direction of this division determines the body axis of flowering plants, with a small cell forming on top and a large cell at the bottom.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalProceedings of the National Academy of Sciences·DateNov 29, 2016

Plant's POEM: 'No need to fertilize, for increase in seed size'

Plant biologists at ITbM, Nagoya University, have made a key discovery that the contents in pollen tubes alone can increase the size of seeds, without the need for fertilization. This new plant phenomenon, named as POEM (pollen tube-dependent ovule enlargement morphology), shows that even in the absence of fertilization, release of the...

A fluorescent dye that survives in live cell STED imaging

Scientists at ITbM developed a new fluorescent dye, C-Naphox, with enhanced photostability to enable continuous live cell imaging by STED microscopy. The dye has demonstrated extreme photoresistance and no significant toxicity towards cells, opening doors to real-time biological event observation for extended periods.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalAngewandte Chemie International Edition·DateOct 25, 2015

Green light of hope to overcome Striga-triggered food insecurity in Africa

Researchers have identified the 'wake-up protein' responsible for germination of Striga seeds using a fluorescent probe, accelerating research to control Striga growth and prevent crop losses worth billions of dollars annually. The study reveals that Striga detects host crops through strigolactone receptors, leading to a devastating im...

Chromium-centered cycloparaphenylene rings for making functionalized nanocarbons

A team of chemists at Nagoya University has synthesized novel transition metal-complexed cycloparaphenylenes that enable selective monofunctionalization of CPPs. The discovery opens doors to the construction of unprecedented nanocarbons, including carbon nanotubes with new properties.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalJournal of the American Chemical Society·DateJan 26, 2015

Selective functionalization synthesizes chemotherapeutic natural products

Researchers at Emory University and Nagoya University developed a novel concise entry to dictyodendrins, a family of natural products with potential cancer chemotherapy and treatment for Alzheimer's disease. The study demonstrates sequential C-H functionalization can streamline the construction of complex structures.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalJournal of the American Chemical Society·DateJan 7, 2015

Ultrafast complex molecular simulations by 'cutting up molecules'

A novel ultrafast quantum chemical method called FMO-DFTB enables rapid simulations of complex molecular systems, achieving a huge improvement over traditional methods. The method has successfully evaluated large molecules including polypeptides, DNA segments, small proteins, and fullerite surfaces.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalJournal of Chemical Theory and Computation·DateDec 4, 2014

A new 'Kabuto-like' nickel catalyst forms bioactive frameworks from phenol derivatives

Researchers have developed a new nickel catalyst that catalyzes the cross-coupling reaction between carbonyl compounds and phenol derivatives to form alpha-arylketones, which are found in many biologically active compounds. The study has potential applications in synthesizing biologically active molecules and organic materials.

SourceInstitute of Transformative Bio-Molecules (ITbM), Nagoya University·JournalAngewandte Chemie International Edition·DateMay 27, 2014