Researchers propose an AI framework, called interoceptive AI, that uses internal states to inform learning and decision-making in dynamic environments. This approach treats internal conditions as a continuous source of context, influencing what an agent learns, prioritizes, and does.
Researchers have estimated that the unknown absorber in Venus's clouds must absorb light very efficiently, occur at a high concentration, or both, with a required decadic absorption coefficient reaching approximately 1,278 cm-1 at 375 nm. This suggests that highly absorbing conjugated organic molecules could be the culprit, but the stu...
Research identifies aberrant ERBB4 expression in excitatory neurons as an early driver of Alzheimer's disease pathologies, including neuronal hyperactivity, synapse loss, and cognitive decline. Manipulating ERBB4 expression in mouse models reveals its role in driving disease features, including reactive gliosis and amyloid buildup.
Researchers developed a new molecular editing strategy that relocates the nitrogen atom within the pyridine ring, creating positional isomers. This approach preserves substituents while altering properties such as solubility and interactions with biological targets.
Researchers have discovered compact viral RNA elements that can stabilize mRNA, increasing protein production. These elements, called tailons, work by extending the poly(A) tail of mRNA, slowing its degradation. This breakthrough offers a simple way to develop longer-lasting and more efficient mRNA technologies for various applications.
Researchers identify a specialized lymphatic network in the brain that enables cerebrospinal fluid drainage, which declines with age but can be restored through intranasal VEGF-C delivery. This discovery provides new insights into brain waste clearance and its link to neurodegenerative disorders.
Researchers at the Institute for Basic Science have developed a new strategy for electrically controlling molecular quantum systems, enabling precise control of individual molecular spins. This breakthrough offers a practical approach to building future molecular quantum technologies.
Researchers discovered astrocytes actively preserve long-term memories by regulating Ank2 and BDNF signaling. This finding expands the understanding of how memories are stored in the brain.
Researchers have uncovered the structural basis of Argonaute assembly, revealing that chaperone proteins hold it in an open conformation allowing miRNA loading. The study also found that RNA plays a key role in guiding Argonaute folding.
Researchers identified a promising new strategy for reversing autism-related brain deficits by targeting a specific glycine transporter. The therapy restored NMDA receptor function in mouse models and human brain organoids, improving behavioral abnormalities such as social interaction and repetitive behaviors.
A deep learning model combines knowledge from different catalyst families to identify a top-performing green hydrogen catalyst. The AI correctly predicted the activity ranking of 12 tested catalysts within a previously unexplored material family.
A new study reveals that the Antarctic ice sheet responded sharply to climate change following a major shift in Earth's ice age cycles. The simulation found that below a critical atmospheric CO2 level, the amplitude of Antarctic ice variations increases in response to changes in temperatures.
A new analysis argues that current scientific methods may not be capable of reliably answering questions about AI consciousness. The study highlights the importance of developing more precise methods to investigate subjective experience, crucial for evaluating claims about animal welfare, AI ethics, or bioethics.
Researchers found that the gut responds to protein deficiency by activating a fast neural circuit and a slower hormonal signal, which selectively changes dietary priorities. The study reveals a previously unknown gut-brain signaling system that rapidly alters feeding behavior in animals.
Researchers developed a viable homozygous CHD8 mouse model, showing that stronger mutations can dramatically alter male–female autism patterns. The study revealed pronounced autism-related abnormalities in both sexes with severe mutations.
Researchers used machine-learning-enhanced molecular simulations to show pristine graphene is intrinsically hydrophobic. Water molecules adopt configurations characteristic of hydrophobic surfaces near graphene, and thicker layers are even more strongly hydrophobic.
Researchers found that DNA helicase HELQ promotes replication fork reversal to protect cells from toxic DNA crosslinks. This process enables stalled replication forks to reverse and stabilize, minimizing mutations and cell death. The study identifies HELQ as a critical regulator of genome integrity under replication stress.
Researchers discovered a small molecule, UNI418, that destabilizes key DNA repair proteins, making drug-resistant cancer cells vulnerable to PARP inhibitor therapy. This approach restores tumor sensitivity and improves treatment outcomes.
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Researchers have successfully created a high-efficiency quantum light source that emits bright lights even at room temperature using 2D semiconductors. The achievement is made possible by confining excitons in a tiny region via nanohole-induced confinement and neutralizing excess charges.
A research team led by LEE Doyun and KIM Yee-Joon found that the primary visual cortex encodes motion summaries and variability before higher brain regions transform them into category signals. This process, known as ensemble perception, allows the brain to capture the overall structure of a scene at a glance.
A new study reveals that astrocytes regulate inhibitory signaling in the cerebellum during development, enabling the emergence of flexible and precise motor coordination. In contrast, younger animals rely on neuron-derived tonic inhibition, which is replaced by astrocyte-derived tonic inhibition in late adolescence.
A team of researchers has developed a method to decode fluctuations in spontaneous pain intensity in individuals with chronic pain using extensively sampled functional MRI data. The study found that neural patterns underlying pain differ markedly between individuals, highlighting the importance of individualized brain-based biomarkers.
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum and transition onto microtubule tracks inside living cells. The study reveals that the ER plays an active role in steering intracellular traffic.
Researchers create a novel mathematical framework to control biological noise, enabling precise single-cell control. The 'Noise Robust Perfect Adaptation' technology suppresses stochastic fluctuations while maintaining stable average behavior, with promising applications in cancer therapy and synthetic biology.
Early gastric cancer cells become self-sufficient by producing WNT7B, creating a self-sustaining loop and activating WNT signaling internally. This mechanism is triggered by MAPK signaling activation and has been validated in genetically engineered mouse models and human patient-derived organoids.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Researchers have discovered a new 'Island of Inversion' in the most symmetric region of the nuclear chart, where protons and neutrons equal each other. This finding challenges long-held assumptions about structural inversions and provides insights into fundamental forces that bind matter together.
New research suggests that ocean turbulence and horizontal stirring will dramatically increase in the Arctic and Southern Oceans due to human-induced Global Warming. The study uses ultra-high-resolution simulations to investigate how mesoscale horizontal stirring (MHS) responds to warming, revealing a pronounced future intensification ...
A new study reveals that ENSO could intensify rapidly over the coming decades and synchronize with other major climate phenomena, leading to stronger rainfall fluctuations in regions such as Southern California and the Iberian Peninsula. The amplified impacts will necessitate enhanced planning and adaptation strategies.
Researchers identify abnormal sugar modifications linked to depressive behaviors, offering potential diagnostic and therapeutic targets. Chronic stress disrupts sugar chains in the prefrontal cortex, triggering depression.
Researchers at CARS create detailed maps of chemical reactivity, discovering regions of unexpected outcomes and reconstructing intricate reaction networks. This new understanding enables control over the formation of different major products from a set of starting materials.
A new study reveals that global warming is accelerating the risk of multi-year droughts leading to extreme water scarcity. The frequency of Day Zero Droughts will increase sharply over the coming decades, affecting 750 million people globally by the end of this century.
A study published in Science Advances reveals that an autism-linked mutation disrupts brain circuits responsible for erasing fear memories, leading to PTSD-like symptoms. By reactivating specific neurons, researchers were able to reverse the behavioral and physiological abnormalities.
Researchers found that an astrocytic 'brake' mechanism, fueled by the neurotransmitter GABA, blocks spinal cord repair after injury. Inhibiting this pathway with the MAOB inhibitor KDS2010 enables recovery of spinal cord function in animal models.
Researchers have reimagined hemoglobin as an antioxidant protein in the brain, where it breaks down harmful reactive oxygen species. A new compound, KDS12025, selectively enhances this natural defense mechanism to protect against ALS, Parkinson's, Alzheimer's, and autoimmune disorders.
Researchers have developed a method to produce mirror-like graphite films with millimeter-sized grains, exceeding previous synthetic graphite's performance. The films demonstrate exceptional mechanical properties, thermal conductivity, and electrical conductivity, opening up new possibilities for high-tech applications.
Researchers at the Institute for Basic Science have discovered that excessive GABA produced by astrocytes impairs fear extinction in PTSD. A new brain-permeable drug called KDS2010 has reversed PTSD-like symptoms in mice, providing a promising therapeutic approach.
Researchers discovered a two-step mechanism where inhibitory neurons release nitric oxide to rapidly dilate blood vessels, followed by slower, localized vasodilation via astrocyte activation. This breakthrough sheds light on how neural signals are translated into blood volume changes in brain imaging.
A team of scientists has developed a high-resolution climate model that simulates global climate change at 9 km atmospheric and 4-25 km oceanic scales. The model demonstrates superior performance compared to lower-resolution models, providing detailed regional insights into future climate conditions.
Scientists have developed a new tool named scICE to tackle the stability problem in single-cell RNA sequencing data. The tool provides a way to validate clustering outcomes mathematically, ensuring higher confidence in conclusions drawn from single-cell data.
Researchers have discovered a new method to enhance brain waste clearance by precisely stimulating the lymphatics under skin on the neck and face. This non-invasive approach may offer a safer alternative to current treatments for age-related neurological disorders, such as Alzheimer's disease.
The CLOVE project aims to investigate Venus's atmospheric temporal variabilities and climate evolution with a series of CubeSats launched every three years over a 15-year period. The mission will provide valuable insight into volcanic activity, solar-atmosphere interactions, and planetary climate shifts.
Researchers have identified a four-amino-acid mini-exon in the PTPδ gene that plays a critical role in brain development and behavior. The study found that deleting this mini-exon led to anxiety-like behavior and reduced movement in mice, highlighting its essential role in maintaining synaptic balance.
Researchers have elucidated the molecular mechanism by which LEM-3 cuts DNA bridges during cytokinesis, a crucial step in cell division. The study found that LEM-3 is essential for resolving persistent DNA bridges and maintaining chromosomal stability.
Scientists have created a comprehensive bat organoid model to study zoonotic viruses, enabling early detection and drug testing for future outbreaks. The platform, comprising diverse bat species and organs, has led to breakthroughs in understanding virus behavior, isolation, and treatment.
A team of researchers developed Lp-Convolution, a novel method that uses multivariate p-generalized normal distribution to reshape CNN filters dynamically. This breakthrough improves the accuracy and efficiency of image recognition systems while reducing computational burden.
Researchers found that SIRT2, a previously unknown enzyme, plays a key role in excessive GABA production associated with Alzheimer's disease. This process leads to brain inflammation and memory impairment. By targeting SIRT2, scientists can selectively block its harmful effects on memory without affecting other brain functions.