Researchers at IBS Center for Genome Editing demonstrate Cpf1's superior specificity in precision genome editing, generating mutant mice with targeted mutations. The study reveals that Cpf1 has virtually no off-target effects, opening up new possibilities for therapeutic treatments and agricultural products.
A new study by the IBS Center for RNA Research has found that poly(A) tail length is not linearly correlated with translation efficiency in somatic cells. The researchers used two techniques to compare poly(A) tail length and translation efficiency, finding a correlation between the two in a limited range.
Researchers at IBS Center for Vascular Health have created a new targeted agent to mitigate sepsis progression by strengthening and protecting blood vessels. This approach, utilizing the Tie2 receptor and anti-angiopoietin-2 antibody ABTAA, has shown enhanced survival rates in severe sepsis models up to 70%.
Scientists have created an optogenetic process that inhibits intracellular membrane vesicle trafficking, effectively pausing cellular activity. This innovation enables the observation and control of cell membranes, opening up new avenues for studying diseases like neurodegenerative disorders.
A team of scientists from Seoul National University and the Center for Correlated Electron Systems has made the first-ever observation of Cooper-pair density waves at an atomic level. The detection was achieved using Scanning Josephson Tunneling Microscopy, allowing researchers to directly measure Cooper-pairs in atomic resolution.
A team of chemists, led by Mu-Hyun Baik, has achieved the first-ever efficient activation of methane's C-H bond using a hybrid computational-experimental approach. The method enables the conversion of methane into liquid methanol, paving the way for petroleum independence and alternative fuel production.
Researchers at IBS created a wearable GP-based patch that allows accurate diabetes monitoring and feedback therapy using human sweat. The device enables systematic corrections of sweat glucose measurements by monitoring pH and temperature, reducing the need for painful treatments like insulin shots.
The IBS Center for Correlated Electron Systems has successfully created monolayer and multilayer samples of the magnetic Van der Waals material NiPS3. This achievement lays the foundation for the development of high-speed, low-energy consuming semiconductors that can be integrated into various devices.
A new study has shown that introducing probiotic Bifidobacterium longum KACC 91563 can reduce the effects of food allergies in mice. The probiotic works by releasing extracellular vesicles containing a protein called ESBP, which neutralizes mast cells responsible for allergic responses.
The IBS team developed a graphene-semiconductor catalytic nanodiode that enables the detection of hot electrons on platinum nanoparticles in real time. This breakthrough allows researchers to study the electronic effect on catalytic activity and potentially design improved catalytic materials with lower costs.
Researchers have developed a precise and fast responding tool to measure carbon monoxide (CO) and nitric oxide (NO) levels in the brain during seizure events. The dual sensor probe recorded clearly defined changes in CO/NO levels that changed in accordance with the seizure's phase changes.
Researchers from the Center for Nanoparticle Research design a novel therapeutic agent capable of impeding neuronal cell death associated with Alzheimer's disease. The treatment targets mitochondrial dysfunction and oxidative stress, offering new hope for treating this debilitating neurodegenerative disorder.
Researchers at IBS created multiplex Digenome-seq to detect errors in CRISPR-Cas9 processes. The tool uses cell-free genomic DNA and sgRNA to identify on- and off-target sites, providing precise analysis results.
Typical foods induce immune tolerance conditions in the small intestine by creating regulatory T cells, which inform the immune system on safe food antigens. This mechanism helps prevent food allergies and is crucial for maintaining gut health.
Researchers have identified a correlation between grain boundary misorientation angle and electrical transport properties in monolayer molybdenum disulfide. Increasing the merging angle of grain boundaries drastically improves electron flow, resulting in higher carrier mobility.
Scientists at IBS Center for RNA Research have elucidated the three-dimensional image of DROSHA, one part of the Microprocessor complex. This discovery confirms previous findings and reveals unique physical characteristics of DROSHA, including a 'bump' that may act as a measuring guide for cleaving pri-miRNA.
Scientists have reported a high-performance nanoparticle electrocatalyst for fuel cells, featuring durable and active PtFe nanoparticles coated with nitrogen-doped carbon shells. This breakthrough could lead to the development of more efficient and affordable fuel cell technology.
Researchers discover regulatory mechanism that extends 'healthspan', the time an organism is at its optimal health, using C. elegans roundworms. Maximum velocity (MV) of wild-type worms at day 9 adulthood reliably predicts longevity and physical decline.
Researchers discovered 16 RNA-binding proteins whose depletion affects stem cell pluripotency and identified six RBPs making up the critical protein complex called small subunit processome (SSUP). Enhanced translational activity is crucial for ESC maintenance, while precise regulation of translation rates may influence stem cell determ...
Researchers created a plant-human hybrid protein OptoSTIM1 to modulate calcium channels, leading to improved memory in mice. The study showed a nearly twofold increase in fear stimulus response memory compared to non-light-stimulated mice.
A Korean team tunes black phosphorus' band gap to form a superior conductor, enabling mass production for electronic and optoelectronic devices. This breakthrough allows for great flexibility in device design and optimization.
Researchers created a high-performance transistor using black phosphorus, which can operate as both n-type and p-type materials without extrinsic doping. This could lead to thinner, more efficient alternative to silicon chips in electrical devices.
Korean scientists have successfully created a new class of radical compounds by reacting nitric oxide with N-heterocyclic carbenes. The resulting nitric oxide compounds show potential for targeted NO delivery, which could lead to new therapeutic applications in various human diseases.
Researchers from IBS and Seoul National University created ultra-thin wearable QLEDs with resolutions approaching 2,500 pixels per inch. The technology enables the display of high-definition full-color displays on human skin.
Researchers have discovered how Microprocessor, a complex of DROSHA and DGCR8, precisely determines cleavage sites on miRNA-containing primary transcripts. This process allows faithful initiation of microRNA biogenesis.
Researchers have created a novel and highly efficient thermoelectric alloy, nearly doubling industry standard efficiency. The new material achieves significant temperature changes, enabling potential applications in electrical vehicles and personal electronic devices.
Researchers at IBS successfully visualized real-time bond formation in a gold trimer complex using femtosecond TRXL, enabling the study of molecular vibration and rotation in solution. The technique allows for the observation of chemical reactions on a nanosecond timescale.
IBS researchers develop Digenome-seq to confirm CRISPR-Cas9's accuracy in human cells. The technique identifies on-target and off-target sequences, eliminating concerns about cancer-causing mutations.
A new method enhances direct methanol fuel cell efficiency by removing toxic heavy metal ions like Cr(VI) while converting to less toxic Cr(III). This allows for improved performance and increased power density.
Scientists have discovered a novel mechanism regulating maternal miRNAs in early embryos, with the enzyme Wispy playing a key role in miRNA adenylation and reducing its abundance. This finding provides new insights into the regulation of gene expression during embryonic development.
The IBS research team discovered that dsRNAs activate Protein Kinase R (PKR), regulating protein synthesis and mitotic processes. Disruption of PKR activation led to defects in cell division.
A team of scientists has discovered a compound named triptolide, isolated from the thunder god vine, which is far more potent than current therapies against hepatocellular carcinoma. The researchers used nanotechnology to improve delivery and reduce toxicity, showing increased efficacy in tumor accumulation and uptake into cancer cells.
Researchers identified a key clue to treating absence seizures by deleting the T-type calcium channel CaV3.3 in mice, which suppressed burst firing and increased tonic firing. This study challenges existing hypotheses and provides a foundation for developing effective treatment methods.
A research team has developed a cost-effective technology to synthesize heteroatom (S or N)-doped graphenes, which can be applied as high performance electrodes for secondary batteries and fuel cells. These materials enhance battery performance and drive down the cost of producing fuel cells.
A new technology called OptoTrk successfully induces cell differentiation in neurons using blue light, upregulating downstream cell signalling. This breakthrough allows for remote control of specific receptors without the need for other substances or time periods, enabling more precise investigations of neural networks.
Researchers at IBS developed polymer nanocapsules with metal nanoparticles, offering high stability, dispersibility and catalytic activity in water. This technology replaces toxic liquid solvents with environmentally preferable ones, enabling sustainable catalysis.