Duke University researchers successfully treated an adult mouse model of Duchenne muscular dystrophy using CRISPR gene editing. The treatment involved delivering the gene-editing system directly to the affected tissues through a non-pathogenic carrier called adeno-associated virus, overcoming several delivery challenges.
Researchers have identified saffron-based 'crocin' as a potential therapeutic agent against liver cancer, leveraging preclinical studies and network analyses. Crocin's mechanism involves regulating NF-kB, a key hub in liver cancer development, suggesting it as a promising target for early lesion prevention.
Tropical Cyclone Ula formed on Dec 30 and intensified with rain rates exceeding 83.6 mm per hour, generating rough surf and dangerous coastal conditions for Fiji and American Samoa.
Researchers developed a method to create ceramic materials using 3D printing with minimal cracking, enabling complex shapes and high temperatures. The resulting silicon carbide material can withstand 1,400°C temperatures without cracking, making it suitable for hypersonic vehicles and jet engines.
A new study by Sylvester researchers describes the immune system's response to tumor development, highlighting the stimulator of interferon genes (STING) signaling pathway's potential suppression of colorectal cancer. Impaired STING responses may enable damaged cells to evade the immune system.
Research reveals that a father's diet can impact the RNA of his sperm, which in turn can affect gene regulation in offspring. Studies found that high-fat diets and low-protein diets can lead to changes in specific small RNAs, including tRNA-Gly-GCC, which suppresses genes related to metabolic disorders.
Researchers developed new vaccine strains that are effective, stable, and non-infectious, addressing concerns about live virus escape and disease transmission. The new strains are suitable for mass production in the post-eradication world, reducing risk to humans and environment.
Researchers at Boston College have developed a new type of cross coupling chemical reaction using a third reactant, expanding on the pioneering Suzuki-Miyaura coupling method. The resulting 'conjunctive' reaction takes place efficiently and offers high selectivity.
Scientists used compounds to alter epigenetic marks in ant colonies, demonstrating lasting effects on behavior. Epigenetic modifications, such as histone acetylation, influenced caste-based systems and worker responsibilities.
Researchers used game theory to model the dynamics of farmer decisions and their effects on pest populations. The study found that farmers' perceptions of profit and loss, as well as communication networks, can influence pest control strategies.
Researchers found that compounds blocking histone deacetylases activated genes making one ant worker behave like another without changing their instructions. This study may provide insights into mechanisms behind behavioral disorders.
A new study reveals that random mutations can give rise to novel genes, leading to the evolution of new molecular functions. The researchers identified thousands of human-specific genes and found that certain macaque genome elements are less present than expected.
Researchers from Human Computation Institute and Cornell University propose a new vision of human computation that combines human and computer intelligence to solve complex, interconnected problems. This approach enables the construction of flexible collaborative environments that can address challenging issues.
Researchers have developed a CRISPR-Cas9 gene editing system to treat Duchenne muscular dystrophy (DMD), a debilitating genetic disease. By deleting exon 23 and restoring dystrophin protein levels, the therapy improved muscle function in mice with DMD, including cardiac and pulmonary health.
Scientists at UT Southwestern Medical Center successfully stopped the progression of Duchenne muscular dystrophy in young mice using a gene-editing technique. The treatment, delivered via adeno-associated virus 9 (AAV9), corrected the genetic mutation that causes the disease and led to improved muscle structure and function.
Researchers found that areas with high poverty levels were more likely associated with high Ebola transmission and spread. In contrast, lower socioeconomic status communities had a higher number of personal contacts, increasing the likelihood of transmission.
Dr. Christoph Aeppli and colleagues studied how petroleum released during the 2010 Deepwater Horizon oil spill transformed in the environment over six years, finding novel compounds with potential toxic effects on marine organisms.
A Penn-led team has discovered that caste-specific behaviors in ant colonies can be directly altered by changing the balance of epigenetic chemicals. The study found that compounds inhibiting histone acetylation increased foraging behavior in minors, while injecting these inhibitors into young major ants also boosted foraging activity.
Researchers created a new way to coat solid electrolyte around electrodes, solving problems of gasification and poor permeability. The breakthrough enables high-ion conductivity and air stability in all-solid-state lithium batteries.
Tropical Depression 9C formed in the Central Pacific on Dec. 31, with an elongated structure suggesting a weaker system. The depression is moving northwest at 3 mph, with little change in intensity expected due to strong easterly wind shear.
Scientists at IBS Center for RNA Research have elucidated the three-dimensional image of DROSHA, one part of the Microprocessor complex. This discovery confirms previous findings and reveals unique physical characteristics of DROSHA, including a 'bump' that may act as a measuring guide for cleaving pri-miRNA.