A cell-free protein synthesis system developed at Oak Ridge National Laboratory uses microfabricated bioreactors to produce therapeutic proteins for medicines and biopharmaceuticals. This technology simplifies the process, lowers cost, and enables point-of-care use.
A study analyzed 787 phase II/III clinical trials sponsored by the National Clinical Trials Network, finding that increased competition, planning to enroll a larger proportion of the available population, and lack of new agents were associated with poor accrual. The researchers developed a multivariable prediction model to identify tri...
Researchers create novel VTD mechanism for conventional propeller engine UAVs, allowing redirection of thrust to improve maneuverability. The proposed technique demonstrates improved performance in plateau missions with enhanced stability and control.
A Temple University study found that an opioid prescribing guideline significantly decreased prescription rates for minor conditions and chronic noncancer pain in acute care settings. The guideline was implemented in January 2013 and resulted in a high degree of statistical significance across all age groups and complaint categories.
The new oral drug Palbociclib has shown promise in combating various types of cancer beyond breast cancer, including lymphoma, sarcoma, and teratoma. Early trials have demonstrated its effectiveness in slowing tumor growth and improving survival rates in patients with these conditions.
The discovery of ancient tortoise and turtle fossils in the Andes Mountains suggests that the region was less than a kilometer above sea level 13 million years ago. The findings support alternative estimates to a recent study and provide insights into climate change caused by rising mountains.
A study found that plain packaging decreased overall perceptions of healthier tobacco brands by 12%, as well as reduced prestige perceptions among young Indigenous smokers. The findings support the effectiveness of health warnings in reducing global tobacco use, particularly among vulnerable populations.
The NASA GPM mission analyzed extreme weather in the US from December 2015, detecting heavy rainfall, tornado outbreaks, and record-breaking flooding. The analysis revealed a line of tornadic thunderstorms moving through the Midwest, generating two tornadoes and 14 deaths.
Pressure-retarded osmosis (PRO) technology is not feasible due to biofouling, which clogs membrane structures and feed channels. Researchers found that organic matter and bacteria in wastewater streams result in extreme biofouling development.
A study found that adolescents discharged from hospitals in England after an admission for violent, drug- or alcohol-related, or self-inflicted injuries have a higher risk of subsequent death and emergency re-admission up to a decade later. The risks were highest in 18-19 year olds with chronic conditions or living in deprived areas.
The Center for Sensorimotor Neural Engineering will receive funding to support research on implantable devices that promote brain plasticity and reanimate paralyzed limbs. The goal is to achieve proof-of-concept demonstrations in humans within five years, laying the groundwork for eventual clinical devices approved by the FDA.
Researchers have created a new type of membrane that can efficiently convert chemical reactions into electrical current, potentially revolutionizing the fuel cell industry. The development has the potential to replace internal combustion engines and reduce harmful emissions.
Scientists at the University of Minnesota and BioNano Genomics have developed a new method to analyze DNA sequences in nanochannels, enabling more accurate genome mapping. By analyzing the probability distributions of DNA barcode label separations, researchers can identify structural oddities and improve the accuracy of genome maps.
A study using mobile health technology has shown that patients taking kidney transplants can improve their medication adherence and blood pressure levels, leading to better patient outcomes. The innovative approach aims to reduce premature graft loss by providing personalized computer-automated monitoring systems.
A team of researchers developed a new imaging approach that provides images of a single cell with micrometer resolution using a contrast based on the cell's thermal properties. This technique allows for unprecedented sensitivity in detecting diseased conditions at the sub-cell scale and may aid in optimizing cryopreservation processes.
Clinical research experts discuss various topics, including the impact of personalized genomic data on healthcare systems, strategies to combat multidrug-resistant tuberculosis, and population approaches to reduce diabetes incidence. They also highlight the need for improved cancer diagnosis and treatment for neurodegenerative diseases.
A real-life neurosurgeon says the Spectre villain's use of a head clamp system and robotic drill was incorrect, as it would have triggered a stroke or massive hemorrhage. Dr. Michael Cusimano praised Blofeld's grasp of Neuroscience but noted he would have failed his neuroanatomy course.
The St. Jude Children's Research Hospital has developed ProteinPaint, a web application and dataset that provides an interactive tool for researchers worldwide to advance their understanding of pediatric cancer mutations. The tool offers critical information unavailable with existing visualization tools, allowing users to see the impac...
Researchers have revealed the mechanism behind the ferromagnetic properties of Cr-doped (Sb, Bi)2Te3 thin films, enabling electric current generation at room temperature without energy consumption. This breakthrough could lead to novel materials that operate efficiently in future devices.
A Veterans Affairs study of 738 Iraq war veterans found that those who fought during the insurgency phase were more than twice as likely to develop posttraumatic stress disorder (PTSD) compared to those who served in other phases. The finding holds true even after adjusting for demographic and deployment-related risk factors.
A prospective cohort study found that receiving an average of at least six potentially effective drugs per day was associated with a 36% greater likelihood of responding to treatment. The inclusion of more drugs, particularly pyrazinamide, was also linked to improved sputum culture conversion rates.
The 2011 flood caused by Tropical Storm Lee had a significant impact on the geomorphology of several large watersheds in north-central Pennsylvania. Channel widening and bank erosion were common, and huge volumes of gravel were transported during the flood. The study suggests that part of the reason for these changes was related to the...
A University of Washington study analyzed over 750 studies on marijuana and alcohol use, finding that legalization policies may lead to both substitution and complementary effects. The research highlights the difficulties in gauging the impact of a formerly illicit drug as it moves into the mainstream.
Exercising early in life can alter the microbial community for the better, promoting healthier brain and metabolic activity over a lifetime. A study published in Immunology and Cell Biology found that juvenile rats who exercised daily developed a more beneficial gut microbiome.
Researchers review challenges and advances in optimizing specific productivity of metabolic pathways in living cells. New tools for library generation, computational analysis, and high-throughput screening are discussed to improve pathway creation and screening.